ES2171906T3 - Procedimiento de biotransformacion de compuestos colchicinoides en los correspondientes derivados 3-glucosilo. - Google Patents

Procedimiento de biotransformacion de compuestos colchicinoides en los correspondientes derivados 3-glucosilo.

Info

Publication number
ES2171906T3
ES2171906T3 ES97911171T ES97911171T ES2171906T3 ES 2171906 T3 ES2171906 T3 ES 2171906T3 ES 97911171 T ES97911171 T ES 97911171T ES 97911171 T ES97911171 T ES 97911171T ES 2171906 T3 ES2171906 T3 ES 2171906T3
Authority
ES
Spain
Prior art keywords
glucosilo
biotransformation
procedure
corresponding derivatives
colchicinoid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97911171T
Other languages
English (en)
Inventor
Ezio Bombardelli
Cesare Ponzone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2171906T3 publication Critical patent/ES2171906T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/11—Bacillus megaterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS COLCHICINOIDES QUE SON TRANSFORMADOS EN LOS CORRESPONDIENTES DERIVADOS 3 - O GLICOSILO, POR MEDIO DE CEPAS DE BACILLUS MEGATERIUM.
ES97911171T 1996-10-07 1997-10-02 Procedimiento de biotransformacion de compuestos colchicinoides en los correspondientes derivados 3-glucosilo. Expired - Lifetime ES2171906T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002063A IT1285777B1 (it) 1996-10-07 1996-10-07 Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati

Publications (1)

Publication Number Publication Date
ES2171906T3 true ES2171906T3 (es) 2002-09-16

Family

ID=11374985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97911171T Expired - Lifetime ES2171906T3 (es) 1996-10-07 1997-10-02 Procedimiento de biotransformacion de compuestos colchicinoides en los correspondientes derivados 3-glucosilo.

Country Status (20)

Country Link
US (1) US6150140A (es)
EP (1) EP0931161B1 (es)
JP (1) JP3428027B2 (es)
KR (1) KR100311067B1 (es)
CN (1) CN1094978C (es)
AT (1) ATE213782T1 (es)
AU (1) AU714810B2 (es)
CA (1) CA2252725C (es)
CZ (1) CZ295451B6 (es)
DE (1) DE69710744T2 (es)
DK (1) DK0931161T3 (es)
ES (1) ES2171906T3 (es)
HU (1) HU224896B1 (es)
IT (1) IT1285777B1 (es)
NO (1) NO319286B1 (es)
PL (1) PL187106B1 (es)
PT (1) PT931161E (es)
RU (1) RU2196826C2 (es)
SK (1) SK282344B6 (es)
WO (1) WO1998015642A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1295272B1 (it) * 1997-10-03 1999-05-04 Indena Spa Biotrasformazione di composti colchiconici nei corrispondenti 3- glicosilderivati
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
SG165175A1 (en) * 2004-05-12 2010-10-28 Indena Spa Biotransformation of colchicinoid compounds
PL1745140T3 (pl) * 2004-05-12 2010-01-29 Indena Spa Biotransformacja związków kolchicynoidowych
SI2128170T1 (sl) 2008-05-28 2011-04-29 Indena Spa Postopek za glikozidacijo kolhicina in tiokolhicina
WO2010138670A2 (en) * 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
EP2619315A2 (en) 2010-09-22 2013-07-31 Elysian Life Sciences Private Limited A microbial method for the biotransformation of colchicinoid compounds
WO2015097567A1 (en) 2013-12-23 2015-07-02 Alkaloids Corporation Process for the conversion of colchicinoids to their 3-glycosylated derivatives via their respective 3-demethyl analogues
CN105861601B (zh) * 2016-04-29 2019-05-24 中国药科大学 一种生物转化制备二氢去氢双松柏醇葡萄糖单糖苷(hmzg)的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1344157A (fr) * 1959-05-22 1963-11-29 Roussel Uclaf Nouvelles colchicines et leur procédé d'obtention
JPS5233195B2 (es) * 1971-09-30 1977-08-26
GB8701381D0 (en) * 1987-01-22 1987-02-25 Erba Farmitalia Antitumor agent
IE70073B1 (en) * 1990-12-14 1996-10-30 Ainsworth Tech Inc Communication system

Also Published As

Publication number Publication date
SK44599A3 (en) 2000-01-18
EP0931161A1 (en) 1999-07-28
EP0931161B1 (en) 2002-02-27
ATE213782T1 (de) 2002-03-15
AU4864897A (en) 1998-05-05
NO991633L (no) 1999-04-06
ITMI962063A1 (it) 1998-04-07
DE69710744T2 (de) 2002-09-05
DE69710744D1 (de) 2002-04-04
HK1019620A1 (en) 2000-02-18
JP2000508179A (ja) 2000-07-04
HUP9903806A3 (en) 2001-12-28
AU714810B2 (en) 2000-01-13
PT931161E (pt) 2002-07-31
NO991633D0 (no) 1999-04-06
HU224896B1 (en) 2006-04-28
CA2252725A1 (en) 1998-04-16
HUP9903806A2 (hu) 2000-03-28
NO319286B1 (no) 2005-07-11
PL331942A1 (en) 1999-08-16
KR20000022478A (ko) 2000-04-25
US6150140A (en) 2000-11-21
RU2196826C2 (ru) 2003-01-20
CA2252725C (en) 2008-03-18
CZ118799A3 (cs) 1999-07-14
WO1998015642A1 (en) 1998-04-16
CN1094978C (zh) 2002-11-27
SK282344B6 (sk) 2002-01-07
IT1285777B1 (it) 1998-06-18
KR100311067B1 (ko) 2001-12-17
CZ295451B6 (cs) 2005-08-17
PL187106B1 (pl) 2004-05-31
JP3428027B2 (ja) 2003-07-22
CN1218514A (zh) 1999-06-02
DK0931161T3 (da) 2002-06-10

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