ATE216381T1 - 8-alkoxychinoloncarbonsäurehydrat mit ausgezeichneter stabilität und ein verfahren zu seiner herstellung - Google Patents

8-alkoxychinoloncarbonsäurehydrat mit ausgezeichneter stabilität und ein verfahren zu seiner herstellung

Info

Publication number
ATE216381T1
ATE216381T1 AT95938644T AT95938644T ATE216381T1 AT E216381 T1 ATE216381 T1 AT E216381T1 AT 95938644 T AT95938644 T AT 95938644T AT 95938644 T AT95938644 T AT 95938644T AT E216381 T1 ATE216381 T1 AT E216381T1
Authority
AT
Austria
Prior art keywords
excellent stability
alkoxyquinoloonecarbonic
production
acid hydrate
piperazinyl
Prior art date
Application number
AT95938644T
Other languages
English (en)
Inventor
Toyomi Matsumoto
Masamoto Hara
Kunio Miyashita
Yukihiro Kato
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18290056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE216381(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of ATE216381T1 publication Critical patent/ATE216381T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
AT95938644T 1994-12-21 1995-12-05 8-alkoxychinoloncarbonsäurehydrat mit ausgezeichneter stabilität und ein verfahren zu seiner herstellung ATE216381T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33556994A JP3449658B2 (ja) 1994-12-21 1994-12-21 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
PCT/JP1995/002477 WO1996019472A1 (en) 1994-12-21 1995-12-05 8-alkoxyquinolonecarboxylic acid hydrate with excellent stability and process for producing the same

Publications (1)

Publication Number Publication Date
ATE216381T1 true ATE216381T1 (de) 2002-05-15

Family

ID=18290056

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938644T ATE216381T1 (de) 1994-12-21 1995-12-05 8-alkoxychinoloncarbonsäurehydrat mit ausgezeichneter stabilität und ein verfahren zu seiner herstellung

Country Status (15)

Country Link
US (1) US5880283A (de)
EP (1) EP0805156B1 (de)
JP (1) JP3449658B2 (de)
KR (1) KR100381644B1 (de)
CN (1) CN1137890C (de)
AT (1) ATE216381T1 (de)
AU (1) AU694946B2 (de)
CA (1) CA2208704C (de)
DE (1) DE69526453T2 (de)
DK (1) DK0805156T3 (de)
ES (1) ES2173982T3 (de)
HU (1) HU227795B1 (de)
PT (1) PT805156E (de)
TW (1) TW393479B (de)
WO (1) WO1996019472A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19820801A1 (de) * 1998-05-09 1999-11-25 Gruenenthal Gmbh Orale Arzneiformen mit reproduzierbarer Wirkstofffreisetzung von Gatifloxacin oder pharmazeutisch verwendbaren Salzen oder Hydraten
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
TWI287987B (en) * 2000-08-14 2007-10-11 Senju Pharma Co Cytokine inhibitor
US6413969B1 (en) * 2000-09-13 2002-07-02 Bristol-Myers Squibb Company Gatifloxacin pentahydrate
JP2002363172A (ja) * 2001-06-05 2002-12-18 Showa Denko Kk ５−アルキルオキサゾリジン−２，４−ジオンの製造方法
US6589955B2 (en) 2001-06-20 2003-07-08 Bristol-Myers Squibb Company Pediatric formulation of gatifloxacin
ATE307583T1 (de) * 2002-04-08 2005-11-15 Reddys Lab Ltd Dr Wasserfreie kristalline formen i und ii der 1- cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3- carbonsäure (gatifloxacin)
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
US7423153B2 (en) 2002-05-10 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin
EP1645274A1 (de) * 2002-05-10 2006-04-12 Teva Pharmaceutical Industries Ltd. Verfahren zur Herstellung von Gatifloxacinform Omega
KR20040106518A (ko) * 2002-05-10 2004-12-17 테바 파마슈티컬 인더스트리즈 리미티드 가티플록사신의 신규한 결정 형태
EP1471911A1 (de) 2002-06-14 2004-11-03 Teva Pharmaceutical Industries Ltd. Neue kristalline formen von gatifloxacin
JP2006508909A (ja) * 2002-08-06 2006-03-16 テバ ファーマシューティカル インダストリーズ リミティド ガチフロキサシンの新規な結晶形
US7531656B2 (en) 2002-08-14 2009-05-12 Teva Pharmaceuticals Usa, Inc. Synthesis of gatifloxacin
EP1485097A1 (de) * 2002-12-12 2004-12-15 Teva Pharmaceutical Industries Limited Kristalline formen von gatifloxacin und herstellungsverfahren
WO2004087688A1 (en) * 2003-04-02 2004-10-14 Hetero Drugs Limited Novel crystalline forms of gatifloxacin
AU2003304118A1 (en) * 2003-05-19 2004-12-03 Hetero Drugs Limited Purification methods of gatifloxacin and a novel form of gatifloxacin
WO2005021000A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Solid oral dosage forms of gatifloxacin
ES2232311B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Forma cristalina de gatifloxacino.
ES2232310B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Formula cristalina no higroscopica de gatifloxacino.
US7781585B2 (en) 2004-06-04 2010-08-24 Matrix Laboratories Ltd Crystalline forms of Gatifloxacin
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20060247255A1 (en) * 2005-05-02 2006-11-02 Patel Satishkumar A Method for preparing a stable gatifloxacin composition
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
CA2621616A1 (en) * 2007-02-19 2008-08-19 Alcon Research, Ltd. Topical gatifloxacin formulations
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2009064792A1 (en) * 2007-11-16 2009-05-22 Cumbre Pharmaceuticals Inc. Quinolone carboxylic acid-substituted rifamycin derivatives
JP2013510097A (ja) * 2009-11-03 2013-03-21 リウ、リー タンシノンｉｉａスルホン酸ナトリウム水和物、並びにその調製方法及び使用
CN102757419B (zh) * 2012-08-08 2015-03-11 四川百利药业有限责任公司 一种加替沙星的纯化方法
CA2904387C (en) 2013-03-15 2021-12-07 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
AU2017310520A1 (en) 2016-08-12 2019-03-21 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
WO2021141672A2 (en) 2019-11-15 2021-07-15 Silk Technologies, Ltd. Stable formulations of silk-derived protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
FI871419L (fi) * 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboxylsyraderivat, deras framstaellning och anvaendning.
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
KR100228572B1 (ko) * 1992-01-31 1999-11-01 이병언 퀴놀론카르복실산 유도체 수화물 결정

Also Published As

Publication number Publication date
EP0805156A4 (de) 1998-04-15
JPH08176143A (ja) 1996-07-09
JP3449658B2 (ja) 2003-09-22
PT805156E (pt) 2002-09-30
CA2208704C (en) 2005-05-03
DE69526453T2 (de) 2002-12-12
DE69526453D1 (de) 2002-05-23
US5880283A (en) 1999-03-09
HUT77945A (hu) 1998-12-28
AU694946B2 (en) 1998-08-06
CN1171108A (zh) 1998-01-21
EP0805156A1 (de) 1997-11-05
WO1996019472A1 (en) 1996-06-27
CA2208704A1 (en) 1996-06-27
KR100381644B1 (ko) 2003-08-30
DK0805156T3 (da) 2002-05-06
TW393479B (en) 2000-06-11
CN1137890C (zh) 2004-02-11
HU227795B1 (en) 2012-03-28
AU3994695A (en) 1996-07-10
EP0805156B1 (de) 2002-04-17
ES2173982T3 (es) 2002-11-01

Similar Documents

Publication Publication Date Title
DE69526453D1 (de) 8-alkoxychinoloncarbonsäurehydrat mit ausgezeichneter stabilität und ein verfahren zu seiner herstellung
ATE145891T1 (de) Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür
ES533916A0 (es) Un metodo para producir acidos 1,4-dihidro-4-oxo-quinolin-3-carboxilico
AT388729B (de) Alpha-alkyl-4-amino-3-chinolinmethanole und 1-(4-aralkylamino-3-chinolinyl)-alkanone, ein verfahren zur ihrer herstellung und deren verwendung
DE3767672D1 (de) Chinazolinonderivat und verfahren zu seiner herstellung.
ATE506356T1 (de) Verfahren zur herstellung von 3-halo-4,5-dihydro- 1h-pyrazolen
ATE201025T1 (de) Verfahren zur herstellung von cephalosporinen und zwischenprodukte in diesem verfahren
ATE53583T1 (de) Beta-carbolin-3-carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung.
ATE348810T1 (de) Verfahren zur herstellung von 2-aminomethyl- halogen-pyridinen
ATE385232T1 (de) Verfahren zur herstellung von 3, 3', 6, 6'- tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'- tetraalkylen-5, 5'-dihalo-2, 2' biphenolen
ATE167668T1 (de) Verfahren zur herstellung von guaniden
ATE138654T1 (de) Verfahren zur herstellung von 1-carbamoyl- pyrazolen
EP1338596A4 (de) Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ
ATE270287T1 (de) 2,3-dihydro-1h-isoindolderivate, verfahren zu ihrer herstellung und ihre verwendung als hemmer der serotoninwiederaufnahme
ATE310734T1 (de) Verfahren zur herstellung von n-substituierten 2, 6-dialkylmorpholinen
ATE554094T1 (de) Verfahren zur herstellung von 3-cephem- verbindungen
ATE138376T1 (de) Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzen
ATE234820T1 (de) Aminoalkyloxime, verfahren zur dessen herstellung,ihre verwendung als medikamente und zwischenprodukte
ATE265421T1 (de) Verfahren zur herstellung von midodrin
DE69928610D1 (de) Verfahren zur Herstellung von 2-Carbamoyl-Pyridinen
ATE160337T1 (de) Verfahren zur herstellung von säurechloriden
ATE205178T1 (de) Verfahren zur herstellung von 3,4-dihydroxy-3- cyclobuten-1,2-dion
DE60001965T2 (de) Verfahren zur herstellung von 3,5-dichloropyridin
ATE168110T1 (de) Verfahren und zwischenprodukte zur herstellung von 5-oxaspiro (2.4> heptan-6-on
ATE299498T1 (de) Verfahren zur herstellung von imidazolderivaten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification