ES2174288T3 - Composicion sinergica inmunosupresora que contiene un compuesto de 2,2'-bi-1h-pirrol. - Google Patents
Composicion sinergica inmunosupresora que contiene un compuesto de 2,2'-bi-1h-pirrol.Info
- Publication number
- ES2174288T3 ES2174288T3 ES97941995T ES97941995T ES2174288T3 ES 2174288 T3 ES2174288 T3 ES 2174288T3 ES 97941995 T ES97941995 T ES 97941995T ES 97941995 T ES97941995 T ES 97941995T ES 2174288 T3 ES2174288 T3 ES 2174288T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- replaced
- pirrol
- hydrogen
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001506 immunosuppresive effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002195 synergetic effect Effects 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- -1 POLYMETHYLENE CHAIN Polymers 0.000 abstract 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UN PRODUCTO QUE CONTIENE: (A) UN AGENTE INMUNOSUPRESOR (A) Y (B) AL MENOS UN COMPUESTO DE 2,2 - BI - 1H - PIRROL INMUNOSUPRESOR (B) QUE PRESENTA LA FORMULA (I), EN LA CUAL R1 ES HIDROGENO, FENILO, ALQUILO C1-C20 O ALQUENILO C2 -C20 , ESTANDO LOS GRUPOS ALQUILO Y ALQUENILO NO SUSTITUIDOS O SUSTITUIDOS CON 1 A 3 SUSTITUYENTES, QUE SON IGUALES O DIFERENTES, SELECCIONADOS INDEPENDIENTEMENTE ENTRE HALOGENO, ALCOXI C1-C6 , HIDROXI, ARILO Y ARILOXI; R2 ES HIDROGENO, ALQUILO C1-C6 , CIANO, CARBOXI O (ALCOXI C1-C6 )CARBONILO; R3 ES HALOGENO, HIDROXI O ALCOXI C1-C11 NO SUSTITUIDO O SUSTITUIDO CON FENILO; R4 ES HIDROGENO, ALQUILOCSUB,1 -C6 O FENILO; CADA UNO DE LOS R5 Y R6, QUE SON IGUALES O DIFERENTES, ES INDEPENDIENTEMENTE HIDROGENO, ALCANOILO C2 -C20 , ALQUENOILO C3-C20 , FENILO, ALQUILO C1-C20 O ALQUENILO C2 -C20 ; O DOS DE LOS R4, R5 Y R6 , TOMADOS CONJUNTAMENTE, FORMAN UNA CADENA DE POLIMETILENO C4-C12 , QUE NO ESTA SUSTITUIDA O ESTA SUSTITUIDA CON UN GRUPO ALQUILO C1-C12 , CON UN GRUPO ALQUENILO C2-C12 O CON UN GRUPO ALQUILIDENO C1-C12 ; O UNA SAL FARMACEUTICAMENTE ACETABLE DEL MISMO; EN FORMA DE UNA PREPARACION COMBINADA PARA SU UTILIZACION SIMULTANEA, SEPARADA O SECUENCIAL EN LA TERAPIA DE INMUNOSUPRESION, PRESENTADO DICHA PREPARACION UNA ACTIVIDAD INMUNOSUPRESORA POTENCIADA CON RESPECTO A LOS PRODUCTOS QUE CONTIENEN EL AGENTE INMUNOSUPRESOR (A) O EL COMPUESTO DE 2,2 - BI - 1H - PIRROL INMUNOSUPRESOR (B).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9619706.6A GB9619706D0 (en) | 1996-09-20 | 1996-09-20 | Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole comp und |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174288T3 true ES2174288T3 (es) | 2002-11-01 |
Family
ID=10800283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97941995T Expired - Lifetime ES2174288T3 (es) | 1996-09-20 | 1997-09-02 | Composicion sinergica inmunosupresora que contiene un compuesto de 2,2'-bi-1h-pirrol. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6291509B1 (es) |
| EP (1) | EP0866701B1 (es) |
| JP (1) | JP2000501118A (es) |
| KR (1) | KR19990067692A (es) |
| AR (1) | AR009086A1 (es) |
| AT (1) | ATE211909T1 (es) |
| AU (1) | AU4383197A (es) |
| BR (1) | BR9706790A (es) |
| CA (1) | CA2238043A1 (es) |
| DE (1) | DE69709618T2 (es) |
| EA (1) | EA000925B1 (es) |
| ES (1) | ES2174288T3 (es) |
| GB (1) | GB9619706D0 (es) |
| HU (1) | HUP9901988A3 (es) |
| MX (1) | MX9803920A (es) |
| NO (1) | NO982282L (es) |
| NZ (1) | NZ330655A (es) |
| PL (1) | PL326759A1 (es) |
| WO (1) | WO1998011894A1 (es) |
| ZA (1) | ZA978187B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0867701A1 (en) | 1997-03-28 | 1998-09-30 | Interuniversitair Microelektronica Centrum Vzw | Method of fabrication of an infrared radiation detector and more particularly an infrared sensitive bolometer |
| DE60044717D1 (de) | 1999-05-10 | 2010-09-02 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
| US20040014987A1 (en) | 2000-01-26 | 2004-01-22 | Gemin X Biotechnologies Inc. | Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases |
| US6407244B1 (en) | 2000-01-26 | 2002-06-18 | Gemin X Biotechnologies Inc. | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases |
| ES2304135T3 (es) | 2001-07-18 | 2008-09-16 | Gemin X Biotechnologies Inc. | Compuestos tipo pirrol, composiciones y metodos para tratar el cancer, tratar enfermedades virales y causar inmunosupresion. |
| KR100674222B1 (ko) * | 2005-07-11 | 2007-01-24 | 한국생명공학연구원 | 세라시아 마르세센스 ｂ-1231 ｋｃｔｃ 0386ｂｐ로부터분리한 프로디지오신을 유효성분으로 포함한 급성이식편대숙주병의 예방 및 치료용 조성물 |
| CN103387529B (zh) * | 2013-07-30 | 2016-03-30 | 中国农业科学院烟草研究所 | 抗tmv的三吡咯环类化合物及其制备方法和用途 |
| US10654801B2 (en) | 2016-04-08 | 2020-05-19 | Institute For Cancer Research | Prodigiosin analogs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9326284D0 (en) * | 1993-12-23 | 1994-02-23 | Erba Carlo Spa | Pyrrolydenemethyl-derivatives and process for their preparation |
-
1996
- 1996-09-20 GB GBGB9619706.6A patent/GB9619706D0/en active Pending
-
1997
- 1997-09-02 CA CA002238043A patent/CA2238043A1/en not_active Abandoned
- 1997-09-02 DE DE69709618T patent/DE69709618T2/de not_active Expired - Fee Related
- 1997-09-02 WO PCT/EP1997/004884 patent/WO1998011894A1/en not_active Ceased
- 1997-09-02 JP JP10514241A patent/JP2000501118A/ja not_active Withdrawn
- 1997-09-02 AT AT97941995T patent/ATE211909T1/de not_active IP Right Cessation
- 1997-09-02 BR BR9706790A patent/BR9706790A/pt not_active Application Discontinuation
- 1997-09-02 HU HU9901988A patent/HUP9901988A3/hu unknown
- 1997-09-02 US US09/068,555 patent/US6291509B1/en not_active Expired - Fee Related
- 1997-09-02 EA EA199800464A patent/EA000925B1/ru not_active IP Right Cessation
- 1997-09-02 KR KR1019980703722A patent/KR19990067692A/ko not_active Withdrawn
- 1997-09-02 PL PL97326759A patent/PL326759A1/xx unknown
- 1997-09-02 ES ES97941995T patent/ES2174288T3/es not_active Expired - Lifetime
- 1997-09-02 EP EP97941995A patent/EP0866701B1/en not_active Expired - Lifetime
- 1997-09-02 AU AU43831/97A patent/AU4383197A/en not_active Abandoned
- 1997-09-02 NZ NZ330655A patent/NZ330655A/xx unknown
- 1997-09-11 ZA ZA9708187A patent/ZA978187B/xx unknown
- 1997-09-17 AR ARP970104250A patent/AR009086A1/es unknown
-
1998
- 1998-05-18 MX MX9803920A patent/MX9803920A/es unknown
- 1998-05-19 NO NO982282A patent/NO982282L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE211909T1 (de) | 2002-02-15 |
| EA000925B1 (ru) | 2000-06-26 |
| EP0866701B1 (en) | 2002-01-16 |
| AR009086A1 (es) | 2000-03-08 |
| JP2000501118A (ja) | 2000-02-02 |
| GB9619706D0 (en) | 1996-11-06 |
| KR19990067692A (ko) | 1999-08-25 |
| ZA978187B (en) | 1998-03-03 |
| NO982282D0 (no) | 1998-05-19 |
| MX9803920A (es) | 1998-09-30 |
| NZ330655A (en) | 2000-01-28 |
| CA2238043A1 (en) | 1998-03-26 |
| AU4383197A (en) | 1998-04-14 |
| EP0866701A1 (en) | 1998-09-30 |
| DE69709618D1 (de) | 2002-02-21 |
| HUP9901988A3 (en) | 2000-09-28 |
| DE69709618T2 (de) | 2002-08-29 |
| HUP9901988A2 (hu) | 1999-10-28 |
| EA199800464A1 (ru) | 1999-02-25 |
| NO982282L (no) | 1998-07-20 |
| PL326759A1 (en) | 1998-10-26 |
| WO1998011894A1 (en) | 1998-03-26 |
| US6291509B1 (en) | 2001-09-18 |
| BR9706790A (pt) | 1999-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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