ES2174445T3 - Nueva clase de agentes transfectantes cationicos de los acidos nucleicos. - Google Patents
Nueva clase de agentes transfectantes cationicos de los acidos nucleicos.Info
- Publication number
- ES2174445T3 ES2174445T3 ES98928418T ES98928418T ES2174445T3 ES 2174445 T3 ES2174445 T3 ES 2174445T3 ES 98928418 T ES98928418 T ES 98928418T ES 98928418 T ES98928418 T ES 98928418T ES 2174445 T3 ES2174445 T3 ES 2174445T3
- Authority
- ES
- Spain
- Prior art keywords
- cluster
- inclusive
- hydrogen atom
- nucleic acids
- new class
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 125000002091 cationic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000006850 spacer group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical group [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052711 selenium Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Agente transfectante que comprende al menos una región hidrófila catiónica, acoplada con una región lipófila, caracterizada porque la citada región hidrófila catiónica tiene como fórmula general: en la que - y es un número entero igual a 0 o 1, siendo independientes entre sí los diferentes y, - X representa un átomo de oxígeno, de nitrógeno, de azufre o de selenio, - los agrupamientos Z representan, independientemente entre sí, un átomo de hidrógeno, un agrupamiento OR, en que R representa un átomo de hidrógeno, un agrupamiento metilo, o un agrupamiento (CH2)n- NR1R2, en el que n es un número entero elegido de 1 a 6 inclusive y R1 y R2 representan, independien- temente entre sí, un átomo de hidrógeno o un agrupamiento (CH2)q-NH2, pudiendo variar q de 1 a 6 inclusive, siendo independientes entre sí, los diferentes q, un agrupamiento (CH2)m-NR1R2, en el que m es un número entero elegido de 0 a 6 inclusive y R1 y R2 se definen como anteriormente, o bien un agrupamiento "espaciador" que permitala unión de la región hidrófila catiónica con la región lipófila, entendiéndose que al menos uno de los substituyentes Z es un agrupamiento "espaciador" y que al menos de los substituyentes Z portan un agrupamiento amino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9707014A FR2764304B1 (fr) | 1997-06-06 | 1997-06-06 | Nouvelle classe d'agents transfectants cationiques des acides nucleiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174445T3 true ES2174445T3 (es) | 2002-11-01 |
Family
ID=9507684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98928418T Expired - Lifetime ES2174445T3 (es) | 1997-06-06 | 1998-06-03 | Nueva clase de agentes transfectantes cationicos de los acidos nucleicos. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0986568B1 (es) |
| JP (1) | JP2002504815A (es) |
| KR (1) | KR20010013312A (es) |
| CN (1) | CN1259134A (es) |
| AT (1) | ATE214708T1 (es) |
| AU (1) | AU737579B2 (es) |
| BR (1) | BR9809953A (es) |
| CA (1) | CA2292837A1 (es) |
| DE (1) | DE69804302T2 (es) |
| DK (1) | DK0986568T3 (es) |
| ES (1) | ES2174445T3 (es) |
| FR (1) | FR2764304B1 (es) |
| HU (1) | HUP0004577A3 (es) |
| NO (1) | NO314147B1 (es) |
| PL (1) | PL337177A1 (es) |
| PT (1) | PT986568E (es) |
| WO (1) | WO1998055490A1 (es) |
| ZA (1) | ZA984845B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9383998A (en) * | 1997-09-08 | 1999-03-29 | Valentis, Inc. | Hydrophobic glycosylamine derivatives, compositions, and methods for use |
| DE19942864A1 (de) * | 1999-09-08 | 2001-03-15 | Knoell Hans Forschung Ev | Neue O-(Aminoalkyl)-Derivate von Monosacchariden, Verfahren zu ihrer Herstellung und ihre Verwendung als antibakterielle Mittel |
| DE60232258D1 (de) * | 2001-08-29 | 2009-06-18 | Aventis Pharma Sa | Lipid-aminoglykosid konjugate zur transfektion |
| FR2829136B1 (fr) * | 2001-08-29 | 2006-11-17 | Aventis Pharma Sa | Derives lipidiques d'aminoglycosides |
| PL2027137T3 (pl) | 2005-06-08 | 2015-08-31 | Amicus Therapeutics Inc | Oczyszczanie imino- i aminocukrów |
| WO2008081686A1 (ja) * | 2006-12-28 | 2008-07-10 | Konica Minolta Holdings, Inc. | コレステロール誘導体、リポソーム、リポソームの形成方法およびｘ線用造影剤 |
| CN108779074A (zh) * | 2016-03-01 | 2018-11-09 | 分子传递有限公司 | 植物病毒移动蛋白和其使用方法 |
| JP7384832B2 (ja) * | 2018-05-16 | 2023-11-21 | トランスレイト バイオ， インコーポレイテッド | リボースカチオン性脂質 |
| JP2021534196A (ja) | 2018-08-23 | 2021-12-09 | シージェン インコーポレイテッド | 抗ｔｉｇｉｔ抗体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2774417B2 (ja) * | 1991-08-07 | 1998-07-09 | 株式会社ディ・ディ・エス研究所 | ペプチド骨格を有する分枝鎖型糖複合体及び微粒子キャリヤー |
| DE4329093A1 (de) * | 1993-08-30 | 1995-03-02 | Bayer Ag | Substituierte Aminoalkylglycoside |
| WO1996024334A1 (en) * | 1995-02-10 | 1996-08-15 | Nexstar Pharmaceuticals, Inc. | Lipid constructs for cytoplasmic delivery of agents |
-
1997
- 1997-06-06 FR FR9707014A patent/FR2764304B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-03 EP EP98928418A patent/EP0986568B1/fr not_active Expired - Lifetime
- 1998-06-03 AT AT98928418T patent/ATE214708T1/de not_active IP Right Cessation
- 1998-06-03 WO PCT/FR1998/001112 patent/WO1998055490A1/fr not_active Ceased
- 1998-06-03 JP JP50172299A patent/JP2002504815A/ja active Pending
- 1998-06-03 CA CA002292837A patent/CA2292837A1/fr not_active Abandoned
- 1998-06-03 BR BR9809953-1A patent/BR9809953A/pt not_active IP Right Cessation
- 1998-06-03 PL PL98337177A patent/PL337177A1/xx unknown
- 1998-06-03 AU AU80250/98A patent/AU737579B2/en not_active Ceased
- 1998-06-03 KR KR19997011307A patent/KR20010013312A/ko not_active Ceased
- 1998-06-03 PT PT98928418T patent/PT986568E/pt unknown
- 1998-06-03 DK DK98928418T patent/DK0986568T3/da active
- 1998-06-03 DE DE69804302T patent/DE69804302T2/de not_active Expired - Fee Related
- 1998-06-03 ES ES98928418T patent/ES2174445T3/es not_active Expired - Lifetime
- 1998-06-03 CN CN98805799A patent/CN1259134A/zh active Pending
- 1998-06-03 HU HU0004577A patent/HUP0004577A3/hu unknown
- 1998-06-04 ZA ZA984845A patent/ZA984845B/xx unknown
-
1999
- 1999-11-30 NO NO19995858A patent/NO314147B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004577A1 (hu) | 2001-04-28 |
| AU8025098A (en) | 1998-12-21 |
| CA2292837A1 (fr) | 1998-12-10 |
| HUP0004577A3 (en) | 2003-03-28 |
| KR20010013312A (ko) | 2001-02-26 |
| CN1259134A (zh) | 2000-07-05 |
| PL337177A1 (en) | 2000-08-14 |
| EP0986568A1 (fr) | 2000-03-22 |
| AU737579B2 (en) | 2001-08-23 |
| DE69804302T2 (de) | 2002-10-17 |
| FR2764304A1 (fr) | 1998-12-11 |
| NO995858D0 (no) | 1999-11-30 |
| ZA984845B (en) | 1998-12-29 |
| FR2764304B1 (fr) | 1999-07-16 |
| DK0986568T3 (da) | 2002-06-10 |
| DE69804302D1 (de) | 2002-04-25 |
| WO1998055490A1 (fr) | 1998-12-10 |
| EP0986568B1 (fr) | 2002-03-20 |
| PT986568E (pt) | 2002-08-30 |
| JP2002504815A (ja) | 2002-02-12 |
| BR9809953A (pt) | 2000-08-01 |
| NO314147B1 (no) | 2003-02-03 |
| NO995858L (no) | 1999-11-30 |
| ATE214708T1 (de) | 2002-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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