ES2174849T3 - Composiciones farmaceuticas con sabor agradable. - Google Patents

Composiciones farmaceuticas con sabor agradable.

Info

Publication number
ES2174849T3
ES2174849T3 ES93914418T ES93914418T ES2174849T3 ES 2174849 T3 ES2174849 T3 ES 2174849T3 ES 93914418 T ES93914418 T ES 93914418T ES 93914418 T ES93914418 T ES 93914418T ES 2174849 T3 ES2174849 T3 ES 2174849T3
Authority
ES
Spain
Prior art keywords
pct
drug
sec
date
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914418T
Other languages
English (en)
Inventor
Sanjay Bhardwaj
Marshall Hayward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2174849T3 publication Critical patent/ES2174849T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UNA COMPOSICION GRANULAR FARMACEUTICA Y METODO PARA ENMASCARAR EL SABOR AMARGO, MEDICAMENTOS DE SABOR DESAGRADABLE QUE COMPRENDE UN NUCLEO DEL MEDICAMENTO Y COMO AGENTE ENMASCARADOR DEL SABOR COPOLIMEROS DE ESTER METACRILATO. EL METODO COMPRENDE EL RECUBRIMIENTO DEL NUCLEO DEL MEDICAMENTO CON CAPAS SEPARADAS DE DISPERSIONES ACUOSAS DE LOS COPOLIMEROS. ADICIONALMENTE LA COMPOSICION DEL RECUBRIMIENTO PUEDE CONTENER PLASTIFICANTES Y EXCIPIENTES CONVENCIONALES. LOS GRANULOS DE LA PRESENTE INVENCION PUEDEN SER USADOS EN LA PREPARACION DE TABLETAS MASTICABLES QUE TIENEN BUEN SABOR Y BIODISPONIBILIDAD. SON COPOLIMEROS PREFERIBLES EL POLI(ETILACRILATO, EL METILMETACRILATO) EN LOS CUALES HAN SIDO INTRODUCIDOS GRUPOS AMONIO CUATERNARIOS PARA MODIFICAR LA PERMEABILIDAD DEL ESTER. EL SISTEMA DE RECUBRIMIENTO DE ESTA INVENCION LIBERA EL MEDICAMENTO POR DIFUSION Y ES INFLUENCIADO POR LA SOLUBILIDAD DEL MEDICAMENTO Y POR EL PH MEDIO.
ES93914418T 1992-06-04 1993-06-04 Composiciones farmaceuticas con sabor agradable. Expired - Lifetime ES2174849T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89328892A 1992-06-04 1992-06-04

Publications (1)

Publication Number Publication Date
ES2174849T3 true ES2174849T3 (es) 2002-11-16

Family

ID=25401342

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914418T Expired - Lifetime ES2174849T3 (es) 1992-06-04 1993-06-04 Composiciones farmaceuticas con sabor agradable.

Country Status (8)

Country Link
US (1) US5578316A (es)
EP (1) EP0650353B1 (es)
JP (1) JP3839467B2 (es)
AT (1) ATE217789T1 (es)
CA (1) CA2137265C (es)
DE (1) DE69331948T2 (es)
ES (1) ES2174849T3 (es)
WO (1) WO1993024109A1 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5837277A (en) * 1992-06-04 1998-11-17 Smithkline Beecham Corporation Palatable pharmaceutical compositions
AU1655595A (en) * 1994-04-29 1995-11-09 Mcneil-Ppc, Inc. Solid pharmaceutical dosage form containing flavored film coating
US5853756A (en) * 1995-01-11 1998-12-29 J. B. Chemicals & Pharmaceuticals Limited Controlled release formulations of Ranitidine
AUPN969796A0 (en) * 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
JP2000508339A (ja) * 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
DE19648576C2 (de) * 1996-11-23 1999-08-12 Lohmann Therapie Syst Lts Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
AU9664498A (en) * 1998-09-24 2000-04-10 Procter & Gamble Company, The Chewable compositions containing dextromethorphan
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
IN191482B (es) * 1999-03-19 2003-12-06 Ranbaxy Lab Ltd
WO2001035930A1 (en) * 1999-11-16 2001-05-25 Ranbaxy Laboratories Limited Taste masked oral compositions
KR20030047873A (ko) * 2000-02-29 2003-06-18 테바 파마슈티컬 인더스트리즈 리미티드 클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
JP2001253826A (ja) * 2000-03-09 2001-09-18 Maruzen Pharmaceut Co Ltd 内服用剤
ATE266407T1 (de) * 2000-10-30 2004-05-15 Lupin Ltd Schnell zerfallende cefuroxim axetil enthaltende arzneizusammensetzung mit verzögerter wirkstoffabgabe
JP4938204B2 (ja) * 2001-02-27 2012-05-23 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 貯蔵安定性を改良するための、医薬品配合物用被覆材料および結合材料
US7914811B2 (en) * 2001-06-29 2011-03-29 Mcneil-Ppc, Inc. Brittle-coating, soft core dosage form
WO2003020241A2 (en) * 2001-09-05 2003-03-13 Vectura Limited Functional powders for oral delivery
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
CO5400144A1 (es) 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
US20030220351A1 (en) * 2002-05-24 2003-11-27 Gilbert Gonzales Enteric coated caffeine tablet
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
US20070154550A1 (en) * 2003-08-28 2007-07-05 Potdar Arti Pharmaceutical composition comprising anticonvulsant with taste mask coating
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
US8609198B2 (en) * 2004-07-21 2013-12-17 Hewlett-Packard Development Company, L.P. Pharmaceutical dose form with a patterned coating and method of making the same
US20070036843A1 (en) * 2005-01-28 2007-02-15 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
AU2007261098A1 (en) * 2006-06-19 2007-12-27 Mcneil-Ppc, Inc. Enteric coated particles containing an active ingredient
SG184086A1 (en) * 2010-03-15 2012-10-30 Taisho Pharmaceutical Co Ltd Pigment composition
JP6012604B2 (ja) * 2010-09-27 2016-10-25 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 酸性有効成分のための保護コーティング
US9795576B2 (en) 2010-09-27 2017-10-24 Basf Se Protective coatings for acidic active ingredients
ES2687027T3 (es) 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
EP3446713A3 (en) * 2012-05-02 2019-05-15 Capsugel Belgium NV Aqueous dispersions of controlled release polymers and shells and capsules thereof
US20160256399A1 (en) 2013-11-04 2016-09-08 Capsugel Belgium Nv Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
JP6572244B2 (ja) 2014-02-25 2019-09-04 オービス バイオサイエンシズ， インク．Ｏｒｂｉｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 味覚マスキング薬製剤
CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
WO2017138878A1 (en) * 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
ES2874669T3 (es) 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
CN108601739B (zh) 2016-02-09 2022-01-04 阿尔比里奥公司 考来烯胺丸剂及其制备方法
CN111032019B (zh) 2017-08-09 2022-07-05 阿尔比里奥公司 考来烯胺颗粒、口服考来烯胺制剂及其用途
CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
PL3810581T3 (pl) 2018-06-20 2025-04-28 Albireo Ab Modyfikacje kryształu odewiksibatu
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
JPH07551B2 (ja) * 1987-01-14 1995-01-11 久光製薬株式会社 マイクロカプセル製剤の製造法
KR960011236B1 (ko) * 1987-05-08 1996-08-21 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 제약학적 조성물 및 고체 제형
JPH0774151B2 (ja) * 1987-10-12 1995-08-09 三井東圧化学株式会社 薬物の好ましくない官能的性質を隠蔽した散剤の製造方法
FR2624732B1 (fr) * 1987-12-21 1991-02-15 Synthelabo Formulation pharmaceutique a liberation prolongee
DE68903605T2 (de) * 1988-05-04 1993-04-01 Smith Kline French Lab Kautablette.
US4925675A (en) * 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
EP0425699B1 (en) * 1989-05-11 1994-08-17 Chugai Seiyaku Kabushiki Kaisha Oral preparation which can be released at suitable region in intestine
JPH0674206B2 (ja) * 1989-12-28 1994-09-21 田辺製薬株式会社 放出制御型製剤およびその製法
JP2856485B2 (ja) * 1990-03-07 1999-02-10 旭化成工業株式会社 顆粒含有錠
US5084287A (en) * 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
CA2068402C (en) * 1991-06-14 1998-09-22 Michael R. Hoy Taste mask coatings for preparation of chewable pharmaceutical tablets

Also Published As

Publication number Publication date
EP0650353A4 (en) 1996-02-28
EP0650353B1 (en) 2002-05-22
CA2137265A1 (en) 1993-12-09
US5578316A (en) 1996-11-26
DE69331948D1 (de) 2002-06-27
EP0650353A1 (en) 1995-05-03
CA2137265C (en) 2003-10-28
ATE217789T1 (de) 2002-06-15
JP3839467B2 (ja) 2006-11-01
JPH07507549A (ja) 1995-08-24
WO1993024109A1 (en) 1993-12-09
DE69331948T2 (de) 2002-11-28

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