ES2175179T3 - Derivados de bencimidazol sustituidos con naftilo como agentes anticoagulantes. - Google Patents

Derivados de bencimidazol sustituidos con naftilo como agentes anticoagulantes.

Info

Publication number
ES2175179T3
ES2175179T3 ES96944123T ES96944123T ES2175179T3 ES 2175179 T3 ES2175179 T3 ES 2175179T3 ES 96944123 T ES96944123 T ES 96944123T ES 96944123 T ES96944123 T ES 96944123T ES 2175179 T3 ES2175179 T3 ES 2175179T3
Authority
ES
Spain
Prior art keywords
bencimidazol
naftilo
anticoagulant agents
derivatives replaced
iia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96944123T
Other languages
English (en)
Inventor
Damian O Arnaiz
Brian D Griedel
Stephen T Sakata
Kenneth J Shaw
Zuchan Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlex Laboratories Inc
Original Assignee
Berlex Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories Inc filed Critical Berlex Laboratories Inc
Application granted granted Critical
Publication of ES2175179T3 publication Critical patent/ES2175179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS DE TIPO BENCIMIDAZOL NAFTILSUSTITUIDO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LA INVENCION SE REFIERE TAMBIEN A UNA COMPOSICION ANTICOAGULANTE QUE CONTIENE UN COMPUESTO DE TIPO BENCIMIDAZOL NAFTIL-SUSTITUIDO DESCRITO AQUI. EL NUEVO COMPUESTO O SU COMPOSICION TIENE ACTIVIDAD INHIBIDORA CONTRA EL FACTOR XA O IIA HUMANOS, SIENDO PUES UTIL PARA TRATAR UN ESTADO PATOLOGICO MEDIADO POR XA O IIA.
ES96944123T 1995-12-08 1996-12-05 Derivados de bencimidazol sustituidos con naftilo como agentes anticoagulantes. Expired - Lifetime ES2175179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/570,057 US5849759A (en) 1995-12-08 1995-12-08 Naphthyl-substituted benzimidazole derivatives as anti-coagulants

Publications (1)

Publication Number Publication Date
ES2175179T3 true ES2175179T3 (es) 2002-11-16

Family

ID=24278023

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96944123T Expired - Lifetime ES2175179T3 (es) 1995-12-08 1996-12-05 Derivados de bencimidazol sustituidos con naftilo como agentes anticoagulantes.

Country Status (22)

Country Link
US (1) US5849759A (es)
EP (1) EP0865281B1 (es)
JP (1) JP2000502082A (es)
KR (1) KR19990071974A (es)
CN (1) CN1110305C (es)
AT (1) ATE215371T1 (es)
CZ (1) CZ177698A3 (es)
DE (1) DE69620443T2 (es)
DK (1) DK0865281T3 (es)
ES (1) ES2175179T3 (es)
HU (1) HUP9904066A3 (es)
IL (1) IL124537A (es)
MX (1) MX9804597A (es)
NO (1) NO312673B1 (es)
NZ (1) NZ325449A (es)
PL (1) PL327169A1 (es)
PT (1) PT865281E (es)
RU (1) RU98112597A (es)
SK (1) SK282767B6 (es)
UA (1) UA49869C2 (es)
WO (1) WO1997021437A1 (es)
ZA (1) ZA9610315B (es)

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Also Published As

Publication number Publication date
HK1018208A1 (en) 1999-12-17
HUP9904066A2 (hu) 2000-03-28
CN1110305C (zh) 2003-06-04
ATE215371T1 (de) 2002-04-15
HUP9904066A3 (en) 2001-11-28
ZA9610315B (en) 1997-06-17
WO1997021437A1 (en) 1997-06-19
DK0865281T3 (da) 2002-07-29
DE69620443T2 (de) 2002-11-28
UA49869C2 (uk) 2002-10-15
EP0865281A1 (en) 1998-09-23
IL124537A0 (en) 1998-12-06
SK282767B6 (sk) 2002-12-03
CZ177698A3 (cs) 1998-09-16
NO312673B1 (no) 2002-06-17
PL327169A1 (en) 1998-11-23
KR19990071974A (ko) 1999-09-27
PT865281E (pt) 2002-09-30
US5849759A (en) 1998-12-15
MX9804597A (es) 1998-10-31
JP2000502082A (ja) 2000-02-22
SK74698A3 (en) 1998-12-02
AU1395697A (en) 1997-07-03
DE69620443D1 (de) 2002-05-08
NO982606D0 (no) 1998-06-05
AU700894B2 (en) 1999-01-14
RU98112597A (ru) 2000-10-20
NO982606L (no) 1998-08-10
NZ325449A (en) 2000-01-28
EP0865281A4 (en) 1999-07-28
EP0865281B1 (en) 2002-04-03
CN1209062A (zh) 1999-02-24
IL124537A (en) 2002-04-21

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