ES2176202T3 - Promotores eucarioticos sinteticos que contienen dos elementos inducibles. - Google Patents

Promotores eucarioticos sinteticos que contienen dos elementos inducibles.

Info

Publication number
ES2176202T3
ES2176202T3 ES93907705T ES93907705T ES2176202T3 ES 2176202 T3 ES2176202 T3 ES 2176202T3 ES 93907705 T ES93907705 T ES 93907705T ES 93907705 T ES93907705 T ES 93907705T ES 2176202 T3 ES2176202 T3 ES 2176202T3
Authority
ES
Spain
Prior art keywords
elements
promoters
inducible
synthetic
gen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907705T
Other languages
English (en)
Inventor
Jorge Filmus
Michel Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Sanofi Pasteur SA
Original Assignee
Aventis Pasteur Ltd
Aventis Pasteur SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur Ltd, Aventis Pasteur SA filed Critical Aventis Pasteur Ltd
Application granted granted Critical
Publication of ES2176202T3 publication Critical patent/ES2176202T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Soil Working Implements (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Multicomponent Fibers (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Electrotherapy Devices (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN PROMOTORES EUCARIOTICOS, INDUCIBLES, SINTETICOS PARA LA REGULACION DE LA TRANSCRIPCION DE UN GEN QUE CONSIGUEN NIVELES MEJORADOS DE EXPRESION DE PROTEINA Y NIVELES BASALES INFERIORES DE LA EXPRESION DEL GEN. DICHOS PROMOTORES CONTIENEN AL MENOS DOS CLASES DIFERENTES DE ELEMENTOS INDUCIBLES, USUALMENTE MEDIANTE LA MODIFICACION DE UN PROMOTOR NATIVO QUE CONTENGA UNO O MAS ELEMENTOS INDUCIBLES INSERTANDO EL OTRO DE LOS ELEMENTOS INDUCIBLES. EN CIERTAS CONFORMACIONES, SE SUMINISTRAN ELEMENTOS ADICIONALES SENSIBLES AL METAL (MRES) Y/O ELEMENTOS SENSIBLES A LOS GLUCOCORTICOIDES (GRES) A LOS PROMOTORES NATIVOS, PARTICULARMENTE LOS PROMOTORES HMT-IIA Y MMTV-LTR. UNO O MAS ELEMENTOS CONSTITUTIVOS PUEDEN SER FUNCIONALMENTE DESACTIVADOS PARA SUMINISTRAR LOS NIVELES BASALES INFERIORES DE LA EXPRESION DEL GEN.
ES93907705T 1992-03-30 1993-03-30 Promotores eucarioticos sinteticos que contienen dos elementos inducibles. Expired - Lifetime ES2176202T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206874A GB9206874D0 (en) 1992-03-30 1992-03-30 Generation of improved inducible mammalian expression vectors

Publications (1)

Publication Number Publication Date
ES2176202T3 true ES2176202T3 (es) 2002-12-01

Family

ID=10713085

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93907705T Expired - Lifetime ES2176202T3 (es) 1992-03-30 1993-03-30 Promotores eucarioticos sinteticos que contienen dos elementos inducibles.

Country Status (17)

Country Link
US (1) US5559027A (es)
EP (1) EP0633941B1 (es)
JP (1) JP2701983B2 (es)
KR (1) KR100208311B1 (es)
AT (1) ATE217649T1 (es)
AU (1) AU667532B2 (es)
BR (1) BR9306167A (es)
CA (1) CA2128602C (es)
DE (1) DE69331931T2 (es)
DK (1) DK0633941T3 (es)
ES (1) ES2176202T3 (es)
FI (1) FI113548B (es)
GB (1) GB9206874D0 (es)
NO (1) NO316451B1 (es)
PT (1) PT633941E (es)
RU (1) RU2128225C1 (es)
WO (1) WO1993020218A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071695A (en) * 1992-02-21 2000-06-06 Creative Biomolecules, Inc. Methods and products for identification of modulators of osteogenic protein-1 gene expression
US5512483A (en) * 1993-05-21 1996-04-30 Mcgill University Expression vectors responsive to steroid hormones
JPH07163368A (ja) * 1993-12-15 1995-06-27 Hayashibara Biochem Lab Inc 組換えｄｎａとその組換えｄｎａを含む形質転換体
CA2191583C (en) * 1994-06-07 2007-03-27 Engin Ozkaynak Methods and compositions for modulating morphogenic protein expression
AU8574898A (en) 1997-07-14 1999-02-08 Valentis, Inc. Method for the identification of synthetic cell- or tissue-specific transcriptional regulatory regions
US6673768B1 (en) 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
FR2772786A1 (fr) * 1997-12-18 1999-06-25 Inst Nat Sante Rech Med Sequences nucleotidiques chevauchantes, et leur utilisation dans le cadre de la detection de xenohormones ainsi que dans des compositions pharmaceutiques
JP2002537311A (ja) * 1999-02-19 2002-11-05 オクタジーン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ホルモン−ホルモン受容体の複合体および核酸構築物、並びに遺伝子治療におけるそれらの使用
US8008459B2 (en) * 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
US7341847B2 (en) * 2003-04-02 2008-03-11 Agency For Science, Technology And Research Promoter construct for gene expression in neuronal cells
US7951532B2 (en) 2003-11-12 2011-05-31 Children's Hospital Medical Center Method of screening a midkine modulating agent
KR100647490B1 (ko) * 2004-10-04 2006-11-23 사회복지법인 삼성생명공익재단 저산소 조건 및 다른 스트레스에 특이적으로 반응할 수있는 키메라 인핸서 요소를 포함하는 벡터, 상기 벡터를포함하는 약제학적 조성물 및 상기 조성물을 이용하는 방법
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP2065421B1 (en) * 2006-09-04 2014-05-07 Bio-Energy Corporation Polyester polyol
RU2370280C2 (ru) * 2007-10-08 2009-10-20 Институт физико-химической биологии им. А.Н.Белозерского СПОСОБ СУПЕРПРОДУКЦИИ В РАСТЕНИИ АНТИТЕЛ ПРОТИВ ОНКОГЕНА HER2/neu
WO2010089387A1 (en) 2009-02-09 2010-08-12 Morphosys Ag Production of oligoclonal mixtures of immunoglobulins in single cells
WO2011146833A1 (en) 2010-05-20 2011-11-24 Evolva Inc. Method of producing isoprenoid compounds in yeast
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
SG11202005024QA (en) 2017-11-30 2020-06-29 Friedrich Miescher Institute For Biomedical Res Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium
AU2021240417A1 (en) * 2020-03-26 2022-10-20 AskBio Inc. Forskolin-inducible promoters and hypoxia-inducible promoters

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE72583T1 (de) * 1981-11-23 1992-02-15 University Patents Inc Steuerung der dna-sequenzen-transkription.
AU642959B2 (en) * 1990-01-18 1993-11-04 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Vector with multiple target response elements affecting gene expression
ES2152920T3 (es) * 1990-02-09 2001-02-16 Salk Inst For Biological Studi Composiciones receptoras de retinoides y metodos.

Also Published As

Publication number Publication date
KR100208311B1 (ko) 1999-07-15
WO1993020218A1 (en) 1993-10-14
BR9306167A (pt) 1998-01-13
NO943610L (no) 1994-11-30
KR950700420A (ko) 1995-01-16
PT633941E (pt) 2002-10-31
RU94042389A (ru) 1997-03-10
JP2701983B2 (ja) 1998-01-21
GB9206874D0 (en) 1992-05-13
US5559027A (en) 1996-09-24
NO943610D0 (no) 1994-09-29
DK0633941T3 (da) 2002-06-17
DE69331931T2 (de) 2002-09-12
CA2128602A1 (en) 1993-10-14
CA2128602C (en) 2008-01-22
AU3883393A (en) 1993-11-08
FI113548B (fi) 2004-05-14
NO316451B1 (no) 2004-01-26
FI944451L (fi) 1994-09-26
EP0633941B1 (en) 2002-05-15
FI944451A0 (fi) 1994-09-26
AU667532B2 (en) 1996-03-28
RU2128225C1 (ru) 1999-03-27
DE69331931D1 (de) 2002-06-20
ATE217649T1 (de) 2002-06-15
EP0633941A1 (en) 1995-01-18
JPH07501456A (ja) 1995-02-16

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