ES2176251T3 - Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf). - Google Patents

Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf).

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Publication number
ES2176251T3
ES2176251T3 ES94922940T ES94922940T ES2176251T3 ES 2176251 T3 ES2176251 T3 ES 2176251T3 ES 94922940 T ES94922940 T ES 94922940T ES 94922940 T ES94922940 T ES 94922940T ES 2176251 T3 ES2176251 T3 ES 2176251T3
Authority
ES
Spain
Prior art keywords
tnf
cyclic amp
amp phosphodiesterase
inhibiting
necrosis factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94922940T
Other languages
English (en)
Inventor
Garry Fenton
Tahir Nadeem Majid
Malcolm Norman Palfreyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Aventis Pharma Ltd
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Filing date
Publication date
Priority claimed from GB939315581A external-priority patent/GB9315581D0/en
Priority claimed from GB939315632A external-priority patent/GB9315632D0/en
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of ES2176251T3 publication Critical patent/ES2176251T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

ESTA INVENCION VA DIRIGIDA A UN COMPUESTO [DI(ETER O TIOETER) ETEROARIL O ARIL FLUORO SUSTITUIDO] O UN OXIDO-N DEL MISMO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, UTIL PARA INHIBIR LA PRODUCCION DE EFECTOS FISIOLOGICOS DE TNF EN EL TRATAMIENTO DE UN PACIENTE AFECTADO DE UNA ENFERMEDAD ASOCIADA CON UN EXCESO FISIOLOGICAMENTE DETRIMENTAL DE UN FACTOR DE NECROSIS TUMORAL (TMF). LOS COMPUESTOS DENTRO DEL AMBITO DE LA PRESENTE INVENCION TAMBIEN INHIBEN LA FOSFODIESTERASA AMP CICLICA, Y SON UTILES EN EL TRATAMIENTO DE UN ESTADO DE ENFERMEDAD ASOCIADO CON CONDICIONES PATOLOGICAS MODULADAS MEDIANTE LA INHIBICION DE LA FOSFODIESTERASA AMP CICLICA, INCLUYENDO TALES ESTADOS DE ENFERMEDAD, ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES, EN PARTICULAR DEL TIPO IV DE FOSFODIESTERASA AMP CICLICA. LA PRESENTE INVENCION VA POR TANTO DIRIGIDA A SUS USOS FARMACOLOGICOS PARA INHIBIR LA FOSFODIESTERASA AMP CICLICA Y/O TNF, COMPOSICIONES FARMACOLOGICAS QUE INCLUYEN LOS COMPUESTOS Y METODOS PARA SU PREPARACION.
ES94922940T 1993-07-28 1994-07-28 Compuestos utilizados como inhibidores de pde iv y del factor de necrosis tumoral(tnf). Expired - Lifetime ES2176251T3 (es)

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PT711282E (pt) 2002-11-29
JP2010195787A (ja) 2010-09-09
JP4521283B2 (ja) 2010-08-11
JPH09501155A (ja) 1997-02-04
ATE218549T1 (de) 2002-06-15
EP0711282B1 (en) 2002-06-05
US7652144B2 (en) 2010-01-26
JP2005225868A (ja) 2005-08-25
JP3775685B2 (ja) 2006-05-17
CA2160928A1 (en) 1995-02-09
US8129537B2 (en) 2012-03-06
US20030013713A1 (en) 2003-01-16
US20040171618A1 (en) 2004-09-02
US6472412B1 (en) 2002-10-29
DE69430747T2 (de) 2003-03-06
DE69430747D1 (de) 2002-07-11
CA2160928C (en) 2005-07-05
US20060084809A1 (en) 2006-04-20
EP0711282A1 (en) 1996-05-15
WO1995004045A1 (en) 1995-02-09
ZA945609B (en) 1995-05-12
US7045660B2 (en) 2006-05-16
US20080132706A1 (en) 2008-06-05
IL110492A0 (en) 1994-10-21

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