ES2177540T3 - Utilizacion y produccion de un inhibidor de metastasis de un inhibidorde la adhesion celular que contiene un anticuerpo. - Google Patents

Utilizacion y produccion de un inhibidor de metastasis de un inhibidorde la adhesion celular que contiene un anticuerpo.

Info

Publication number
ES2177540T3
ES2177540T3 ES93904304T ES93904304T ES2177540T3 ES 2177540 T3 ES2177540 T3 ES 2177540T3 ES 93904304 T ES93904304 T ES 93904304T ES 93904304 T ES93904304 T ES 93904304T ES 2177540 T3 ES2177540 T3 ES 2177540T3
Authority
ES
Spain
Prior art keywords
inhibitor
antibody
cell adhesion
metastasis
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904304T
Other languages
English (en)
Inventor
Jyunko Hashino
Shinzo Oikama
Hiroshi Nakazato
Toshihiro Nakanishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2177540T3 publication Critical patent/ES2177540T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN ANTICUERPO MONOCLONAL CONTRA UN PEPTIDO QUE CONTIENE AL MENOS UNA SECUENCIA DE PEPTIDO DEL CAMPO N DE UNA GLICOPROTEIMA DE ANTIGENO CARCINOEMBRIONICO HUMANA Y UNA SECUENCIA PARCIAL O ENTERA DEL CAMPO III DE DICHA GLICOPROTEINA O UNA SECUENCIA HOMOLOGA CON ESTA; Y UN INHIBIDOR DE ADHESION CELULAR QUE CONTIENE EL ANTICUERPO CON EL INGREDIENTE ACTIVO. EL ANTICUERPO INHIBE LA ACTIVIDAD DE ADHESION DE CELULAS CANCEROSAS PARA ASI INHIBIR LA METASTASIS DE CELULAS CANCEROSA, QUE HAN SIDO DIFICIL DE INHIBIR EFICAZMENTE, Y POR LO TANTO ES EFICAZ COMO INHIBIDOR DE ADHESION CELULAR TAL COMO INHIBIDOR DE METASTASIS DE CANCER.
ES93904304T 1992-02-14 1993-02-12 Utilizacion y produccion de un inhibidor de metastasis de un inhibidorde la adhesion celular que contiene un anticuerpo. Expired - Lifetime ES2177540T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5955192 1992-02-14

Publications (1)

Publication Number Publication Date
ES2177540T3 true ES2177540T3 (es) 2002-12-16

Family

ID=13116505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904304T Expired - Lifetime ES2177540T3 (es) 1992-02-14 1993-02-12 Utilizacion y produccion de un inhibidor de metastasis de un inhibidorde la adhesion celular que contiene un anticuerpo.

Country Status (9)

Country Link
US (1) US5648078A (es)
EP (1) EP0584368B1 (es)
JP (1) JP3483556B2 (es)
AT (1) ATE217909T1 (es)
DE (1) DE69331942T2 (es)
DK (1) DK0584368T3 (es)
ES (1) ES2177540T3 (es)
PT (1) PT584368E (es)
WO (1) WO1993016193A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503462A (ja) * 1998-02-12 2002-02-05 マクギル ユニバーシティ Ｃｅａ／ｎｃａに基づいた癌分化療法
WO2004031238A2 (en) * 2002-10-03 2004-04-15 Mcgill Univeristy Antibodies and cyclic peptides which bind cea (carcinoembryonic antigen) and their use as cancer therapeutics
EP2569006B1 (en) * 2010-05-11 2018-06-27 Governing Council of the University of Toronto The n-domain of carcinoembryonic antigen and compositions, methods and uses thereof
US9753036B2 (en) * 2014-04-29 2017-09-05 Edp Biotech Corporation Methods and compositions for screening and detecting biomarkers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348376A (en) * 1980-03-03 1982-09-07 Goldenberg Milton David Tumor localization and therapy with labeled anti-CEA antibody
JPH0811075B2 (ja) * 1982-06-30 1996-02-07 雄治 松岡 単クローン性抗ｃｅａ抗体
JP2607492B2 (ja) * 1987-01-14 1997-05-07 サントリー株式会社 ヒト癌胎児性抗原
GB8800078D0 (en) * 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
JPH05119037A (ja) * 1991-08-08 1993-05-14 Suntory Ltd ヒト癌胎児性抗原の免疫測定法

Also Published As

Publication number Publication date
JP3483556B2 (ja) 2004-01-06
PT584368E (pt) 2002-10-31
DE69331942T2 (de) 2002-10-02
EP0584368B1 (en) 2002-05-22
DE69331942D1 (de) 2002-06-27
EP0584368A1 (en) 1994-03-02
EP0584368A4 (en) 1996-07-03
DK0584368T3 (da) 2002-06-17
ATE217909T1 (de) 2002-06-15
US5648078A (en) 1997-07-15
WO1993016193A1 (en) 1993-08-19

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