ES2177579T3 - Solucion acuosa de factor viii de bajo contenido en oxigeno. - Google Patents

Solucion acuosa de factor viii de bajo contenido en oxigeno.

Info

Publication number
ES2177579T3
ES2177579T3 ES94915307T ES94915307T ES2177579T3 ES 2177579 T3 ES2177579 T3 ES 2177579T3 ES 94915307 T ES94915307 T ES 94915307T ES 94915307 T ES94915307 T ES 94915307T ES 2177579 T3 ES2177579 T3 ES 2177579T3
Authority
ES
Spain
Prior art keywords
factor viii
oxygen
activity
water solution
solution contained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94915307T
Other languages
English (en)
Inventor
Thomas Osterberg
Angelica Fatouros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum AB filed Critical Biovitrum AB
Application granted granted Critical
Publication of ES2177579T3 publication Critical patent/ES2177579T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN FARMACO FINAL QUE CONTIENE UN FACTOR DE COAGULACION VIII EN UNA SOLUCION ACUOSA CON UNA CONCENTRACION REDUCIDA DE OXIGENO. DE ESTE MODO, LA ACTIVIDAD DEL FACTOR VIII SE PUEDE RETENER DURANTE SU ALMACENAMIENTO HASTA UN GRADO SORPRENDENTEMENTE ALTO. LA ACTIVIDAD DEL FACTOR VIII SE PUEDE RETENER DURANTE UN PERIODO PROLONGADO DE TIEMPO SI EL FARMACO FINAL CONTIENE ADEMAS UN GAS INERTE Y/O UN ANTIOXIDANTE. LA PRESENTE INVENCION TAMBIEN SE REFIERE A PROCESOS PARA REDUCIR LA CONCENTRACION DE OXIGENO DE LA SOLUCION ACUOSA Y A UN METODO PARA MEJORAR LA ESTABILIDAD DEL FACTOR VIII EN UNA SOLUCION ACUOSA MEDIANTE EL ALMACENAMIENTO DE LA SOLUCION BAJO UNA ATMOSFERA DE GAS INERTE. CON LA PRESENTE INVENCION SE PUEDE RETENER AL MENOS UN 50% DE LA ACTIVIDAD INICIAL DEL FACTOR VIII TRAS EL ALMACENAMIENTO DURANTE AL MENOS 6 MESES A UNA TEMPERATURA DE 2 A 10 (GRADOS) C Y A UN PH DE LA SOLUCION DE 6,5 A 8,5.
ES94915307T 1993-05-07 1994-03-24 Solucion acuosa de factor viii de bajo contenido en oxigeno. Expired - Lifetime ES2177579T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19939301581A SE9301581D0 (sv) 1993-05-07 1993-05-07 Protein formulation

Publications (1)

Publication Number Publication Date
ES2177579T3 true ES2177579T3 (es) 2002-12-16

Family

ID=20389868

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915307T Expired - Lifetime ES2177579T3 (es) 1993-05-07 1994-03-24 Solucion acuosa de factor viii de bajo contenido en oxigeno.

Country Status (24)

Country Link
US (1) US5962650A (es)
EP (1) EP0700299B1 (es)
JP (1) JP3751633B2 (es)
KR (1) KR100304143B1 (es)
CN (1) CN1113655C (es)
AT (1) ATE218354T1 (es)
AU (1) AU681883B2 (es)
CA (1) CA2161350C (es)
CZ (1) CZ293527B6 (es)
DE (1) DE69430745T2 (es)
DK (1) DK0700299T3 (es)
EE (1) EE03118B1 (es)
ES (1) ES2177579T3 (es)
FI (1) FI111910B (es)
HU (1) HU215263B (es)
NO (1) NO321769B1 (es)
NZ (1) NZ266031A (es)
PL (1) PL174866B1 (es)
PT (1) PT700299E (es)
RU (1) RU2142290C1 (es)
SE (1) SE9301581D0 (es)
SK (1) SK283002B6 (es)
WO (1) WO1994026286A1 (es)
ZA (1) ZA942251B (es)

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SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
SE9501189D0 (sv) * 1995-03-31 1995-03-31 Pharmacia Ab Protein formulation
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US5925738A (en) * 1995-12-01 1999-07-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
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EP1820516B1 (en) 1999-02-22 2013-07-24 University of Connecticut Novel albumin-free factor VIII formulations
EP1194161B1 (en) * 1999-07-13 2005-11-23 Biovitrum Ab Stable factor viii compositions
JP3466516B2 (ja) * 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
JP2005530683A (ja) * 2001-12-21 2005-10-13 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体組成物
PL370656A1 (en) * 2001-12-21 2005-05-30 Novo Nordisk A/S Liquid composition of modified factor vii polypeptides
GB0207092D0 (en) 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
CN101912601B (zh) 2002-06-21 2012-08-29 诺和诺德医疗保健公司 因子vii多肽的稳定化固体组合物
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ES2382157T3 (es) * 2003-06-25 2012-06-05 Novo Nordisk Health Care Ag Composición líquida de polipépttidos del factor VII
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EP1656158B1 (en) 2003-08-14 2016-03-09 Novo Nordisk Health Care AG Liquid, aqueous pharmaceutical composition of factor vii polypeptides
EP2311437A1 (en) * 2003-12-19 2011-04-20 Novo Nordisk Health Care AG Stabilised compositions of factor VII polypeptides
PL1750733T3 (pl) 2004-05-03 2014-05-30 Univ Emory Sposób podawania świńskiego czynnika krzepnięcia VIII pozbawionego domeny B
US7494974B2 (en) 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
EP1982731B1 (de) * 2007-04-17 2010-06-16 Dr. Willmar Schwabe GmbH & Co. KG Verfahren zur Herstellung von lagerstabilen Lösungen aus Pelargonium-Extrakten
BRPI0814220B8 (pt) * 2007-07-11 2021-05-25 Novo Nordisk As purificação de fator viii usando uma resina multimodal ou de modo misto
EP2113564A1 (en) 2008-05-01 2009-11-04 Arecor Limited Protein formulation
WO2010020690A1 (en) 2008-08-21 2010-02-25 Octapharma Ag Recombinantly produced human factor viii and ix
KR101691070B1 (ko) * 2008-09-03 2016-12-29 옥타파마 아게 재조합에 의해 제조된 인자 ⅷ을 위한 신규한 보호 조성물
EP2385825B1 (en) 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations
DK3266463T3 (da) 2009-06-09 2024-01-08 Prolong Pharmaceuticals Llc Hæmoglobinsammensætninger
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EP4218412A1 (en) 2010-11-05 2023-08-02 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
BR112013011041B1 (pt) 2010-11-05 2021-05-25 Baxalta GmbH variante de fator viii, método para produzir uma variante de fviii, uso da variante de fator viii, e, composição farmacêutica
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
AU2012294269B2 (en) 2011-08-10 2016-11-24 Hemanext Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
CA2902061C (en) 2013-02-28 2023-08-08 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
ES2524516B1 (es) * 2014-05-29 2015-03-31 Grifols Worldwide Operations Limited Procedimiento de preparación de albúmina humana con nivel de oxígeno disuelto reducido
KR20250033333A (ko) 2015-03-10 2025-03-07 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
BR122022005103B1 (pt) 2015-04-23 2023-03-14 Hemanext Inc Dispositivo de armazenamento de sangue para armazenar sangue depletado de oxigênio e método para armazenar sangue depletado de oxigênio
PT3297641T (pt) 2015-05-18 2025-10-09 Hemanext Inc Métodos de armazenamento de sangue total e respetivas composições
CN109195632A (zh) 2016-05-27 2019-01-11 新健康科学股份有限公司 厌氧血液储存和病原体失活方法
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Also Published As

Publication number Publication date
HU9503171D0 (en) 1996-01-29
CN1122573A (zh) 1996-05-15
CA2161350A1 (en) 1994-11-24
AU6659794A (en) 1994-12-12
EP0700299A1 (en) 1996-03-13
KR960702317A (ko) 1996-04-27
CN1113655C (zh) 2003-07-09
KR100304143B1 (ko) 2001-11-22
ATE218354T1 (de) 2002-06-15
PT700299E (pt) 2002-11-29
CZ293527B6 (cs) 2004-05-12
AU681883B2 (en) 1997-09-11
FI955305L (fi) 1995-11-06
NO321769B1 (no) 2006-07-03
EE03118B1 (et) 1998-10-15
WO1994026286A1 (en) 1994-11-24
DE69430745D1 (de) 2002-07-11
DE69430745T2 (de) 2002-10-17
SK283002B6 (sk) 2003-01-09
JP3751633B2 (ja) 2006-03-01
SE9301581D0 (sv) 1993-05-07
ZA942251B (en) 1994-11-01
FI111910B (fi) 2003-10-15
EP0700299B1 (en) 2002-06-05
NZ266031A (en) 1997-04-24
CA2161350C (en) 2007-10-30
NO954457D0 (no) 1995-11-07
FI955305A0 (fi) 1995-11-06
PL174866B1 (pl) 1998-09-30
PL311567A1 (en) 1996-02-19
DK0700299T3 (da) 2002-09-23
RU2142290C1 (ru) 1999-12-10
JPH08509745A (ja) 1996-10-15
HUT73693A (en) 1996-09-30
SK138395A3 (en) 1997-02-05
CZ286995A3 (en) 1996-05-15
US5962650A (en) 1999-10-05
HU215263B (hu) 1998-11-30
NO954457L (no) 1995-11-07

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