ES2177586T3 - Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento. - Google Patents

Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento.

Info

Publication number
ES2177586T3
ES2177586T3 ES95102343T ES95102343T ES2177586T3 ES 2177586 T3 ES2177586 T3 ES 2177586T3 ES 95102343 T ES95102343 T ES 95102343T ES 95102343 T ES95102343 T ES 95102343T ES 2177586 T3 ES2177586 T3 ES 2177586T3
Authority
ES
Spain
Prior art keywords
analyte
electrobiochemical
pair
electrode
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95102343T
Other languages
English (en)
Inventor
Itamar Willner
Arie Dagan
Shai Rubin
Ron Blonder
Azalia Riklin
Yael Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, Biosensor Applications Sweden AB filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of ES2177586T3 publication Critical patent/ES2177586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Hybrid Cells (AREA)

Abstract

UN SISTEMA ELECTROBIOQUIMICO PARA LA DETERMINACION DE LA PRESENCIA, Y OPCIONALMENTE CONCENTRACION, DE UN ANALITO EN UN MEDIO LIQUIDO, COMPRENDIENDO EL SISTEMA UN ELECTRODO QUE TIENE SOBRE EL INMOVILIZADO UN MIEMBRO DE UN PAR DE RECONOCIMIENTO, SIENDO EL OTRO MIEMBRO DEL CITADO PAR EL CITADO ANALITO, RESULTANDO LA PRESENCIA DEL CITADO ANALYTE EN EL MEDIO EN LA FORMACION DE UN PAR COMPLEJO, SIENDO UN COMPLEJO ENTRE EL CITADO MIEMBRO INMOVILIZADO Y EL CITADO ANALITO; EL SISTEMA COMPRENDE ADEMAS MOLECULAS "REDOX" (MOLECULAS DE REDUCCION-OXIDACION), CAPACES DE CAMBIAR SU ESTADO REDOX ACEPTANDO ELECTRONES PROCEDENTES DE, O DONANDO ELECTRONES A, EL ELECTRODO; PRODUCIENDO UN CAMBIO LA FORMACION DEL PAR COMPLEJO SOBRE EL ELECTRODO, SOBRE LA RESPUESTA ELECTRICA DEL SISTEMA, CON LO QUE PUEDE DETERMINARSE LA PRESENCIA, Y OPCIONALMENTE LA CONCENTRACION, DEL CITADO ANALITO EN EL MEDIO.
ES95102343T 1994-02-22 1995-02-20 Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento. Expired - Lifetime ES2177586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10872694A IL108726A (en) 1994-02-22 1994-02-22 Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor

Publications (1)

Publication Number Publication Date
ES2177586T3 true ES2177586T3 (es) 2002-12-16

Family

ID=11065843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95102343T Expired - Lifetime ES2177586T3 (es) 1994-02-22 1995-02-20 Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento.

Country Status (8)

Country Link
US (1) US5942388A (es)
EP (1) EP0668502B1 (es)
JP (1) JP3583496B2 (es)
AT (1) ATE217966T1 (es)
DE (1) DE69526747T2 (es)
DK (1) DK0668502T3 (es)
ES (1) ES2177586T3 (es)
IL (1) IL108726A (es)

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Also Published As

Publication number Publication date
EP0668502A3 (en) 1996-02-28
DK0668502T3 (da) 2002-08-19
JPH07301615A (ja) 1995-11-14
EP0668502A2 (en) 1995-08-23
US5942388A (en) 1999-08-24
DE69526747D1 (de) 2002-06-27
EP0668502B1 (en) 2002-05-22
IL108726A0 (en) 1994-05-30
IL108726A (en) 1999-12-31
DE69526747T2 (de) 2002-10-10
JP3583496B2 (ja) 2004-11-04
ATE217966T1 (de) 2002-06-15

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