ES2177586T3 - Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento. - Google Patents

Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento.

Info

Publication number
ES2177586T3
ES2177586T3 ES95102343T ES95102343T ES2177586T3 ES 2177586 T3 ES2177586 T3 ES 2177586T3 ES 95102343 T ES95102343 T ES 95102343T ES 95102343 T ES95102343 T ES 95102343T ES 2177586 T3 ES2177586 T3 ES 2177586T3
Authority
ES
Spain
Prior art keywords
analyte
electrobiochemical
pair
electrode
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95102343T
Other languages
English (en)
Inventor
Itamar Willner
Arie Dagan
Shai Rubin
Ron Blonder
Azalia Riklin
Yael Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, Biosensor Applications Sweden AB filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of ES2177586T3 publication Critical patent/ES2177586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Hybrid Cells (AREA)

Abstract

UN SISTEMA ELECTROBIOQUIMICO PARA LA DETERMINACION DE LA PRESENCIA, Y OPCIONALMENTE CONCENTRACION, DE UN ANALITO EN UN MEDIO LIQUIDO, COMPRENDIENDO EL SISTEMA UN ELECTRODO QUE TIENE SOBRE EL INMOVILIZADO UN MIEMBRO DE UN PAR DE RECONOCIMIENTO, SIENDO EL OTRO MIEMBRO DEL CITADO PAR EL CITADO ANALITO, RESULTANDO LA PRESENCIA DEL CITADO ANALYTE EN EL MEDIO EN LA FORMACION DE UN PAR COMPLEJO, SIENDO UN COMPLEJO ENTRE EL CITADO MIEMBRO INMOVILIZADO Y EL CITADO ANALITO; EL SISTEMA COMPRENDE ADEMAS MOLECULAS "REDOX" (MOLECULAS DE REDUCCION-OXIDACION), CAPACES DE CAMBIAR SU ESTADO REDOX ACEPTANDO ELECTRONES PROCEDENTES DE, O DONANDO ELECTRONES A, EL ELECTRODO; PRODUCIENDO UN CAMBIO LA FORMACION DEL PAR COMPLEJO SOBRE EL ELECTRODO, SOBRE LA RESPUESTA ELECTRICA DEL SISTEMA, CON LO QUE PUEDE DETERMINARSE LA PRESENCIA, Y OPCIONALMENTE LA CONCENTRACION, DEL CITADO ANALITO EN EL MEDIO.
ES95102343T 1994-02-22 1995-02-20 Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento. Expired - Lifetime ES2177586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10872694A IL108726A (en) 1994-02-22 1994-02-22 Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor

Publications (1)

Publication Number Publication Date
ES2177586T3 true ES2177586T3 (es) 2002-12-16

Family

ID=11065843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95102343T Expired - Lifetime ES2177586T3 (es) 1994-02-22 1995-02-20 Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento.

Country Status (8)

Country Link
US (1) US5942388A (es)
EP (1) EP0668502B1 (es)
JP (1) JP3583496B2 (es)
AT (1) ATE217966T1 (es)
DE (1) DE69526747T2 (es)
DK (1) DK0668502T3 (es)
ES (1) ES2177586T3 (es)
IL (1) IL108726A (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770179B1 (en) * 1993-05-10 2004-08-03 Universite De Montreal Biosensors comprising a covalently attached monomolecular biological conjugate layer and a transducing device
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
IL114692A (en) * 1995-07-21 1999-10-28 Yissum Res Dev Co Determination of an analyte in a liquid medium
IL116921A (en) 1996-01-26 2000-11-21 Yissum Res Dev Co Electrochemical system for determination of an analyte in a liquid medium
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
HUP9904222A3 (en) * 1996-10-07 2000-08-28 Schering Corp Assay for the detection of antibodies against p53
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
ATE290211T1 (de) * 1997-04-11 2005-03-15 Univ New Mexico Modulare anordnung zur reagenzlosen affinitätsseparation und detektion von analyten
JP4124830B2 (ja) * 1997-06-12 2008-07-23 クリニカル・マイクロ・センサーズ・インコーポレイテッド 分析物の検出のための電気的方法
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
AU757800B2 (en) * 1997-11-21 2003-03-06 Inverness Medical Switzerland Gmbh Improvements in or relating to electrochemical assays
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
JP3105868B2 (ja) * 1998-08-07 2000-11-06 新潟日本電気株式会社 トナー濃度検出装置及びプログラムを記憶した記憶媒体
US6281006B1 (en) * 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
JP4530541B2 (ja) * 1998-09-17 2010-08-25 クリニカル・マイクロ・センサーズ・インコーポレイテッド 被検体検出のためのシグナル検出法
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6468657B1 (en) * 1998-12-04 2002-10-22 The Regents Of The University Of California Controllable ion-exchange membranes
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
AU5646800A (en) * 1999-03-02 2000-09-21 Helix Biopharma Corporation Card-based biosensor device
US6787368B1 (en) 1999-03-02 2004-09-07 Helix Biopharma Corporation Biosensor method for detecting analytes in a liquid
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
JP3926625B2 (ja) 1999-07-26 2007-06-06 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子検出を用いる核酸の配列決定
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001272993B2 (en) 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
DE20017268U1 (de) * 2000-10-07 2001-03-29 DECHEMA Gesellschaft für Chemische Technik und Biotechnologie eV, 60486 Frankfurt Elektrochemische Messzelle zur Bestimmung der Zellzahl und Aktivität von biologischen Systemen
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
US6887667B2 (en) * 2000-12-28 2005-05-03 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to identify small variations of biomolecules
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
DE10141691A1 (de) * 2001-08-25 2003-03-13 Friz Biochem Gmbh Verdrängungsassay zur Detektion von Ligat-Ligand-Assoziationsereignissen
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US7074519B2 (en) * 2001-10-26 2006-07-11 The Regents Of The University Of California Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
US7687258B1 (en) * 2002-05-20 2010-03-30 Maki Wusi C Direct electric biological agent detector
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
US20040108226A1 (en) * 2002-10-28 2004-06-10 Constantin Polychronakos Continuous glucose quantification device and method
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
DE10300521A1 (de) * 2003-01-09 2004-07-22 Siemens Ag Organoresistiver Speicher
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
US20040142405A1 (en) * 2003-01-22 2004-07-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of detecting drug resistance
US20040191801A1 (en) * 2003-03-25 2004-09-30 Heeger Alan J. Reagentless, reusable bioelectronic detectors and their use as authentication devices
US8003374B2 (en) * 2003-03-25 2011-08-23 The Regents Of The University Of California Reagentless, reusable, bioelectronic detectors
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES
NZ547495A (en) 2003-10-29 2008-05-30 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
AU2004240178A1 (en) * 2004-08-20 2006-03-09 Commonwealth Scientific And Industrial Research Organisation Zwitterionic additives for electrochemical devices
JP2006133137A (ja) * 2004-11-08 2006-05-25 Eiichi Tamiya 被検物質の検出方法
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007061981A2 (en) 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
WO2007120299A2 (en) * 2005-11-29 2007-10-25 The Regents Of The University Of California Signal-on architecture for electronic, oligonucleotide-based detectors
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
EP2174135B1 (en) * 2007-07-26 2013-01-02 Agamatrix, Inc. Electrochemical analyte detection apparatus and method
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
ES2732948T3 (es) 2008-09-02 2019-11-26 Governing Council Univ Toronto Métodos que utilizan microelectrodos y dispositivos biosensores que incorporan los mismos
GB2463115B (en) * 2008-09-08 2013-04-10 Schlumberger Holdings Assemblies for the purification of a reservoir or process fluid
GB2463280B (en) * 2008-09-08 2011-02-02 Schlumberger Holdings Electro-chemical sensor
EP3467487A1 (en) * 2011-01-11 2019-04-10 The Governing Council Of The University Of Toronto Protein detection method
JP6019944B2 (ja) * 2011-12-28 2016-11-02 逢坂　哲彌 糖化合物固定化半導体センシングデバイス及び生物学的物質の検出方法
US20150031053A1 (en) 2012-02-10 2015-01-29 Alere Switzerland Gmbh Assay and method for determining insulin-resistance
CZ307792B6 (cs) * 2017-08-23 2019-05-09 Masarykova Univerzita Způsob stanovení přítomnosti analytu v kapalném vzorku a jeho použití
CN112213482B (zh) * 2020-09-30 2021-11-09 同济大学 基于免疫组化空间电化学检测样品中抗原含量的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328520D0 (en) * 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
US4591550A (en) * 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies
GB8417301D0 (en) * 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US5114674A (en) * 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US5135876A (en) * 1987-09-24 1992-08-04 University Of Utah Method and apparatus for the regulation of complex binding
US4927502A (en) * 1989-01-31 1990-05-22 Board Of Regents, The University Of Texas Methods and apparatus using galvanic immunoelectrodes
WO1990010655A1 (en) * 1989-03-13 1990-09-20 Allage Associates, Inc. Surface functionalized and derivatized conducting polymers and methods for producing same
JPH02298855A (ja) * 1989-03-20 1990-12-11 Assoc Univ Inc 固定化酵素とレドックス重合体を用いた電気化学的バイオセンサー
US4964972A (en) * 1989-03-30 1990-10-23 Yeda Research And Development Company Limited Ionic recognition and selective response in self assembling monolayer membranes on electrodes
WO1990012092A1 (de) * 1989-04-04 1990-10-18 Fritz Pittner Verfahren zum immobilisieren von proteinen, peptiden, coenzymen od.dgl. an einem träger
US5198367A (en) * 1989-06-09 1993-03-30 Masuo Aizawa Homogeneous amperometric immunoassay
JPH03170500A (ja) * 1989-11-29 1991-07-24 Fuji Photo Film Co Ltd 感光性色素蛋白質の配向化方法
JPH0795170B2 (ja) * 1990-08-21 1995-10-11 ダイソー株式会社 ポリビオロゲン修飾電極およびその用途
US5541069A (en) * 1992-02-28 1996-07-30 Quidel Corporation Assay having improved dose response curve
IL102930A (en) * 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes

Also Published As

Publication number Publication date
DK0668502T3 (da) 2002-08-19
DE69526747D1 (de) 2002-06-27
JP3583496B2 (ja) 2004-11-04
EP0668502A2 (en) 1995-08-23
EP0668502B1 (en) 2002-05-22
JPH07301615A (ja) 1995-11-14
EP0668502A3 (en) 1996-02-28
IL108726A0 (en) 1994-05-30
DE69526747T2 (de) 2002-10-10
IL108726A (en) 1999-12-31
US5942388A (en) 1999-08-24
ATE217966T1 (de) 2002-06-15

Similar Documents

Publication Publication Date Title
ES2177586T3 (es) Un procedimiento electrobioquimico, sistema y electrodos para determinar un miembro de un par de reconocimiento.
DE69712866D1 (de) Bestimmung eines analyten in einer probeflüssigkeit
WO1998038510A3 (en) Laboratory in a disk
ATE233897T1 (de) Biosensor mit ionendurchlässige kanäle aufweisender lipidmembran
ATE223498T1 (de) Elektrochemische erkennung von nukleinsäurehybridation
ATE331803T1 (de) Enzymkatalyse in gegenwart ionischer flüssigkeiten
DE69835516D1 (de) Elektrophoretische analyse von molekülen mit immobilisierten sonden
EP0691148A3 (es)
ATE386044T1 (de) Isolierung von nukleinsäuren
IL102930A (en) Electrobiochemical analytical method and electrodes
DE69727250D1 (de) Elektrochemische und photochemische elektroden und deren verwendung
KR0171534B1 (en) Method for activation of polyanionic fluorescent dyes in flow dielectric media with quaternary onium compounds
WO1999045374A3 (en) Purification and detection processes using reversible affinity electrophoresis
DE69326685D1 (de) Amplifikation von test reporters durch nukleinsäure replikation
ATE316423T1 (de) Mikrosystem zur dielektrischen und optischen manipulierung von partikeln
Kuijt et al. Sensitized and quenched phosphorescence as a detection mode in capillary electrophoresis
GR1003489B (el) Μεθοδος προσδιορισμου βιολογικων και χημικων παραγοντων μεσω της μετρησης των μεταβολων των ηλεκτρικων ιδιοτητων ακινητοποιημενων κυτταρων ή συστατικων αυτων (βιοηλεκτρικη μεθοδος αναγνωρισης)
Song et al. Simplified microchip electrophoresis for rapid separation of urine proteins
RU98116117A (ru) Определение анализируемого вещества в жидкой среде
EP1201767A3 (en) Method of analyzing double stranded DNA
RU93015440A (ru) Способ обнаружения полиароматических углеводородов в водных растворах
RU93053791A (ru) Железоселективный электрод