ES2177767T3 - Analogos de suksdorfina, composiciones de los mismos y metodos para elaborar y usar los mismos. - Google Patents

Analogos de suksdorfina, composiciones de los mismos y metodos para elaborar y usar los mismos.

Info

Publication number
ES2177767T3
ES2177767T3 ES96906599T ES96906599T ES2177767T3 ES 2177767 T3 ES2177767 T3 ES 2177767T3 ES 96906599 T ES96906599 T ES 96906599T ES 96906599 T ES96906599 T ES 96906599T ES 2177767 T3 ES2177767 T3 ES 2177767T3
Authority
ES
Spain
Prior art keywords
alkyl
same
acyl
methods
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96906599T
Other languages
English (en)
Inventor
Kuo-Hsiung Lee
Mark Cosentino
Lan Xie
Mark Manak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Panacos Pharmaceuticals Inc
Original Assignee
University of North Carolina at Chapel Hill
Panacos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, Panacos Pharmaceuticals Inc filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of ES2177767T3 publication Critical patent/ES2177767T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

SE PROPORCIONAN COMPUESTOS, INCLUYENDO COMPOSICIONES Y METODOS PARA UTILIZAR ESTOS COMPUESTOS, PARA TRATAR INFECCIONES POR RETROVIRUS, DE CONFORMIDAD CON LA FORMULA (G 1) EN LA QUE M ES O O NH; Z ES O, NH O S; R{SUP,240} Y R{SUP,250} SON CADA UNO H, ALQUILO C{SUB,1-10}, ARILO C{SUB,110}, ALQUILO, AMIDA, O CH{SUB,2}COOR{SUP,260}, DONDE R{SUP,260} ES ACILO O ALQUILO C{SUB,1-10}; R{SUP,200}, R{SUP,210}, R{SUP,220} Y R{SUP,230} SON CADA UNO H, HALOGENO, HIDROXILO, NH{SUB,2}, NH 3} O CH{SUB,2}COO NH AN UN CICLO O HETEROCICLO C{SUB,5} USTITUIDO POR UNO O VARIOS DE LOS SIGUIENTES: HALOGENO, HIDROXILO, NH{SUB,2}, NH O ALQUILO, CO, CF{SUB,3}, OCF{SUB,3} O CH{SUB,2}COONH O, DONDE C{SUB,3} Y C{SUB,4} PUEDEN ESTAR UNIDOS MEDIANTE UN ENLACE SENCILLO O DOBLE; LAS CONFIGURACIONES EN 3'' O 4'' PUEDEN SER (R) O (S) Y R{SUP,240} Y R{SUP,250} SE ORIENTAN EN CIS {BE} O CIS REOSELECTIVIDAD PUEDE AUMENTARSE PREPARANDO ESTOS COMPUESTOS MEDIANTE DIHIDROXILACION CATALITICA ASIMETRICA.
ES96906599T 1995-02-21 1996-02-21 Analogos de suksdorfina, composiciones de los mismos y metodos para elaborar y usar los mismos. Expired - Lifetime ES2177767T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/392,558 US5637589A (en) 1993-10-29 1995-02-21 Suksdorfin, analogs, compositions thereof, and methods for making and using thereof

Publications (1)

Publication Number Publication Date
ES2177767T3 true ES2177767T3 (es) 2002-12-16

Family

ID=23551064

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96906599T Expired - Lifetime ES2177767T3 (es) 1995-02-21 1996-02-21 Analogos de suksdorfina, composiciones de los mismos y metodos para elaborar y usar los mismos.

Country Status (9)

Country Link
US (3) US5637589A (es)
EP (1) EP0810861B1 (es)
AT (1) ATE218338T1 (es)
AU (1) AU4993496A (es)
CA (1) CA2213519C (es)
DE (1) DE69621598T2 (es)
ES (1) ES2177767T3 (es)
PT (1) PT810861E (es)
WO (1) WO1996025930A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IN190036B (es) * 1998-05-29 2003-05-31 Council Scient Ind Res
CA2335617C (en) * 1998-06-24 2009-12-15 Novirio Pharmaceuticals Limited Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
AU3910700A (en) 1999-03-22 2000-10-09 Immugen Pharmaceuticals, Inc. Treatment of immune diseases
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
ATE260269T1 (de) 1999-11-05 2004-03-15 Cytovia Inc Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung
KR100365293B1 (ko) * 2000-04-17 2002-12-18 한국과학기술연구원 알릴화된 방향족 화합물 및 피라노쿠마린 화합물의 제조방법
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
US6768007B2 (en) 2001-03-13 2004-07-27 Panacos Pharmaceuticals, Inc. Substituted 3′,4′-di-O-camphanoyl-(+)-cis-khellactone analogs, compositions thereof, and methods for using thereof
US6858607B1 (en) 2001-05-16 2005-02-22 Cytovia, Inc. 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2002092594A1 (en) * 2001-05-16 2002-11-21 Cytovia, Inc. Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2002092076A1 (en) * 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
WO2003080043A1 (en) * 2002-03-18 2003-10-02 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
EP1513515A2 (en) * 2002-05-16 2005-03-16 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN100349887C (zh) * 2002-05-16 2007-11-21 西托维亚公司 取代的4－芳基－4h－吡咯并[2,3－h]色烯和类似物及其药物组合物和用途
US20040162337A1 (en) * 2003-01-30 2004-08-19 Fong Wang Fun Chemical compounds having therapeutic activities in treating cancer
WO2006026853A1 (en) * 2004-09-07 2006-03-16 Bioniche Life Sciences Inc. Prickly ash preparations and uses thereof as antiviral agents
CA2668452A1 (en) 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
CN101407522A (zh) * 2007-10-12 2009-04-15 中国人民解放军军事医学科学院毒物药物研究所 邪蒿素及其衍生物的制备方法
US20090111836A1 (en) * 2007-10-31 2009-04-30 City University Of Hong Kong Angular Pyranocoumarins, Process for Preparation and Uses Thereof
CN111184715B (zh) * 2020-02-25 2022-11-08 中山大学附属第七医院(深圳) 佛手苷内酯在制备hiv-1潜伏感染逆转剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980699A (en) * 1957-12-20 1961-04-18 S B Penick And Company Dihydropyranocoumarin derivatives and process for their production
US5089634A (en) * 1984-08-20 1992-02-18 Georgia Tech Research Corporation Isocoumarins with cationic substituents
US5324648A (en) * 1987-04-28 1994-06-28 Georgia Tech Research Corporation Substituted isocoumarins as serine protease inhibitors and anti-inflammatory agents
JPH03503635A (ja) * 1988-03-01 1991-08-15 ジ・アップジョン・カンパニー ヒトにおいて逆転写酵素を抑制するクマリン類
US5177073A (en) * 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
JPH03227923A (ja) * 1990-01-30 1991-10-08 Sawai Seiyaku Kk ひと免疫不全ウイルス疾患処置剤
CA2098609A1 (en) * 1990-12-28 1992-06-29 Raymond T. Bartus Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
WO1992018123A2 (en) * 1991-04-10 1992-10-29 Octamer, Inc. A method for inhibition of retroviral replication
HU219914B (hu) * 1992-09-21 2001-09-28 BIOGAL Gyógyszergyár Rt. Eljárás flavíliumszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
WO1994014789A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
WO1995029920A1 (en) * 1994-04-29 1995-11-09 The University Of North Carolina At Chapel Hill Khellactone derivatives and related compounds, process for their preparation and their use as antiviral and immunostimulating agents

Also Published As

Publication number Publication date
EP0810861A1 (en) 1997-12-10
ATE218338T1 (de) 2002-06-15
CA2213519A1 (en) 1996-08-29
US5847165A (en) 1998-12-08
WO1996025930A1 (en) 1996-08-29
PT810861E (pt) 2002-11-29
US5726204A (en) 1998-03-10
DE69621598T2 (de) 2003-08-14
CA2213519C (en) 2009-01-06
DE69621598D1 (de) 2002-07-11
EP0810861B1 (en) 2002-06-05
AU4993496A (en) 1996-09-11
US5637589A (en) 1997-06-10
EP0810861A4 (en) 1998-07-08

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