ES2178384T3 - Metodos para separar un tocol de una mezcla que contiene tocoles. - Google Patents
Metodos para separar un tocol de una mezcla que contiene tocoles.Info
- Publication number
- ES2178384T3 ES2178384T3 ES99904266T ES99904266T ES2178384T3 ES 2178384 T3 ES2178384 T3 ES 2178384T3 ES 99904266 T ES99904266 T ES 99904266T ES 99904266 T ES99904266 T ES 99904266T ES 2178384 T3 ES2178384 T3 ES 2178384T3
- Authority
- ES
- Spain
- Prior art keywords
- tocol
- stumps
- mixture
- fatty acid
- separate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
Un método para separar un tocol de una primera mezcla de tocoles que comprende al menos un tocol, un primer ácido graso, y un compuesto esterificante, que comprende: (a) calentar la primera mezcla de tocoles que comprende el tocol, el primer ácido graso y el compuesto esterificante durante un tiempo y a temperatura suficientes para esterificar sustancialmente el primer ácido graso con el compuesto esterificante para producir una segunda mezcla de tocoles que comprende el tocol, primer ácido graso esterificado y primer ácido graso sin esterificar; (b) destilar la segunda mezcla de tocoles durante un tiempo y a temperatura suficientes para separar sustancialmente el primer ácido graso sin esterificar de la segunda mezcla de tocoles para producir una tercera mezcla de tocoles que comprende el tocol y ácido graso esterificado, con el primer ácido graso sin esterificar sustancialmente separado; (c) destilar la tercera mezcla de tocoles durante un tiempo y a temperatura suficientes para separar sustancialmente el tocol de la tercera mezcla de tocoles para producir una cuarta mezcla de tocoles que comprende el tocol y un componente distinto de tocol separados; y (d) extraer el tocol de la cuarta mezcla de tocoles con un disolvente de extracción que comprende un disolvente orgánico polar que es miscible con agua para producir un sistema líquido de dos fases que comprende una primera fase que contiene una mayoría del disolvente de extracción y una segunda fase, en la que la selectividad del disolvente de extracción por el tocol con respecto al componente distinto de tocol de la cuarta mezcla de tocoles es mayor que la unidad, y separar la primera fase de la segunda fase, con la condición de que el disolvente de extracción no sea un alcohol puro, en el que la etapa (b) se puede llevar a cabo antes que la etapa (c), o la etapa (c) se puede llevar a cabo antes que la etapa (b), en el que las etapas (b) y (c) se llevan a cabo después de la etapa (a) y antes que la etapa (d).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7296398P | 1998-01-29 | 1998-01-29 | |
| US7296298P | 1998-01-29 | 1998-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178384T3 true ES2178384T3 (es) | 2002-12-16 |
Family
ID=26753962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99904266T Expired - Lifetime ES2178384T3 (es) | 1998-01-29 | 1999-01-26 | Metodos para separar un tocol de una mezcla que contiene tocoles. |
| ES99904267T Expired - Lifetime ES2207931T3 (es) | 1998-01-29 | 1999-01-26 | Procedimientos para separar un tocotrienol de una mezcla a base de tocol y composiciones producidas segun dichos procedimientos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99904267T Expired - Lifetime ES2207931T3 (es) | 1998-01-29 | 1999-01-26 | Procedimientos para separar un tocotrienol de una mezcla a base de tocol y composiciones producidas segun dichos procedimientos. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6159347A (es) |
| EP (2) | EP1051412B1 (es) |
| JP (2) | JP2002501915A (es) |
| CN (2) | CN1295568A (es) |
| BR (2) | BR9908141A (es) |
| ES (2) | ES2178384T3 (es) |
| MY (1) | MY124273A (es) |
| WO (2) | WO1999038860A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6706898B2 (en) | 1998-01-29 | 2004-03-16 | Archer-Daniels-Midland Company | Methods for separating a tocopherol from a tocopherol-containing mixture |
| AU5041400A (en) | 1999-05-24 | 2000-12-12 | America River Nutrition, Inc. | Tocotrienols and geranylgeraniol from LTiGTbixa orellanaLT/iGT byproducts |
| US6395915B1 (en) * | 1999-09-10 | 2002-05-28 | Technikrom, Inc. | Method for producing purified tocotrienols and tocopherols using liquid chromatography |
| US6706474B1 (en) * | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| US6838104B2 (en) * | 2000-12-20 | 2005-01-04 | Archer Daniels Midland Company | Process for the production of tocotrienols |
| US6867308B2 (en) | 2001-09-19 | 2005-03-15 | Archer-Daniels-Midland Company | Process for separation of tocopherols |
| US6890719B2 (en) * | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| US7461048B2 (en) * | 2003-07-21 | 2008-12-02 | Aureon Laboratories, Inc. | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
| US7416756B2 (en) * | 2003-09-10 | 2008-08-26 | Eastman Chemical Company | Process for the recovery of a phytolipid composition |
| KR20060134913A (ko) * | 2003-09-10 | 2006-12-28 | 이스트만 케미칼 컴파니 | 피토리피드 조성물의 회수 방법 |
| WO2005035490A2 (en) * | 2003-10-10 | 2005-04-21 | Yasoo Health, Inc. | PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS |
| MY173044A (en) | 2003-11-19 | 2019-12-20 | Carotech Bhd | Recovery of phytonutriens from oils |
| ES2619303T3 (es) | 2005-06-01 | 2017-06-26 | Edison Pharmaceuticals, Inc. | Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos |
| US7892734B2 (en) * | 2005-08-11 | 2011-02-22 | The Board Of Trustees Of The University Of Illinois | Aptamer based colorimetric sensor systems |
| WO2007100652A2 (en) | 2006-02-22 | 2007-09-07 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US7799554B2 (en) * | 2006-03-16 | 2010-09-21 | The Board Of Trustees Of The University Of Illinois | Lateral flow devices |
| US8415461B2 (en) * | 2007-01-19 | 2013-04-09 | The Board Of Trustees Of The University Of Illinois | Amphiphilic substances and functionalized lipid vesicles including the same |
| US8058415B2 (en) * | 2007-04-24 | 2011-11-15 | The Board Of Trustees Of The University Of Illinois | Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes |
| WO2008142433A1 (en) * | 2007-05-24 | 2008-11-27 | Loders Croklaan B.V. | Process for producing compositions comprising tocoherols and tocotrienols |
| WO2009012309A2 (en) * | 2007-07-16 | 2009-01-22 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for divalent copper ion detection |
| US8568690B2 (en) * | 2007-07-31 | 2013-10-29 | The Board Of Trustees Of The University Of Illinois | MRI contrast agents and high-throughput screening by MRI |
| US8367416B2 (en) | 2007-08-10 | 2013-02-05 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for mercury detection |
| US20090090894A1 (en) * | 2007-10-05 | 2009-04-09 | Bin Wang | Separation and extraction system |
| US20100105039A1 (en) * | 2008-06-03 | 2010-04-29 | Yi Lu | Label-free colorimetric detection |
| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| US8062893B2 (en) | 2008-10-10 | 2011-11-22 | The Board Of Trustees Of The University Of Illinois | Fluorescent sensor for mercury |
| ES2553557T3 (es) | 2008-10-28 | 2015-12-10 | Edison Pharmaceuticals, Inc. | Proceso para la producción de alfa-tocotrienol y derivados |
| CA2777479C (en) | 2009-04-28 | 2017-10-17 | Ptc Therapeutics, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| EP2445519A4 (en) | 2009-06-25 | 2012-12-26 | Ampere Life Sciences Inc | TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS USING TOCOTRIENOLS OR TOCOTRIENOLS ENRICHED EXTRACTS |
| US8815156B2 (en) | 2010-07-19 | 2014-08-26 | Andalyze, Inc. | Sensor housing and reagent chemistry |
| EP2734512B1 (en) | 2011-07-19 | 2019-11-20 | Bioelectron Technology Corporation | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| KR101489098B1 (ko) | 2012-01-25 | 2015-02-02 | 아사히 가세이 케미칼즈 가부시키가이샤 | 분리 방법 |
| EP2810940A1 (en) * | 2013-06-06 | 2014-12-10 | Sulzer Chemtech AG | A Process to Prepare A Tocopherol Concentrate |
| US9512098B1 (en) | 2014-02-03 | 2016-12-06 | Board Of Trustees Of The University Of Arkansas | Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates |
| AU2015217822B8 (en) | 2014-02-11 | 2018-04-05 | Evonik Operations Gmbh | Method for producing vitamin E-enriched, especially tocotrienol-enriched, compositions from natural oils |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| MY184673A (en) * | 2018-03-16 | 2021-04-15 | Palm Nutraceuticals Sdn Bhd | A process of preparing vitamin e concentrate |
| CN110251980B (zh) * | 2019-04-22 | 2021-03-23 | 中建安装集团有限公司 | 一种二恶烷水溶液中提纯优品级二恶烷的装置及方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2866797A (en) * | 1954-11-01 | 1958-12-30 | Gen Mills Inc | Improved process of isolating sterols |
| US3153055A (en) * | 1962-03-20 | 1964-10-13 | Eastman Kodak Co | Process for separating tocopherols and sterols from deodorizer sludge and the like |
| US3335154A (en) | 1963-06-04 | 1967-08-08 | Eastman Kodak Co | Separation of tocopherols and sterols from deodorizer sludge and the like |
| US4454329A (en) | 1980-07-04 | 1984-06-12 | The Nisshin Oil Mills, Ltd. | Process for preparation of tocopherol concentrates |
| US4480108A (en) * | 1983-08-01 | 1984-10-30 | Eastman Kodak Company | Process for separation of tocopherol homologues |
| JPS6048981A (ja) | 1983-08-29 | 1985-03-16 | Showa Denko Kk | 高純度トコフェロ−ルの製造方法 |
| JPS60149582A (ja) * | 1984-01-14 | 1985-08-07 | Mitsui Petrochem Ind Ltd | トコフエロ−ルの精製方法 |
| JPS60185776A (ja) | 1984-03-05 | 1985-09-21 | Riken Vitamin Co Ltd | トコフエロ−ルの精製濃縮法 |
| EP0171009B1 (en) | 1984-08-02 | 1991-05-22 | HENKEL CORPORATION (a Delaware corp.) | Purification of tocopherols by extraction |
| US4550183A (en) * | 1984-08-02 | 1985-10-29 | Henkel Corporation | Purification of tocopherols |
| JPS6160619A (ja) * | 1984-08-31 | 1986-03-28 | Eisai Co Ltd | 分散性粉末 |
| JPS6193178A (ja) * | 1984-10-12 | 1986-05-12 | Agency Of Ind Science & Technol | トコトリエノ−ル類の分離方法 |
| JPS61151186A (ja) * | 1984-12-24 | 1986-07-09 | Nisshin Oil Mills Ltd:The | トコトリエノ−ル類およびトコフエロ−ル類の濃縮法 |
| DE3615029A1 (de) | 1985-05-06 | 1986-11-06 | Henkel Corp., Minneapolis, Minn. | Methanol-extraktion von tocopherol |
| JPH029875A (ja) * | 1988-03-16 | 1990-01-12 | Bio Ind Kyokai | トコフェロール及びトコトリエノールの製造方法 |
| JPH03127730A (ja) | 1989-10-11 | 1991-05-30 | Kikaku Nijiyuuichi:Kk | ビタミンｅの製造方法 |
| MY108071A (en) * | 1990-05-23 | 1996-08-15 | Pentad Foods Int | Stabilization and recovery method for tocotrienol and tocopherol products. |
| US5487817A (en) * | 1993-02-11 | 1996-01-30 | Hoffmann-La Roche Inc. | Process for tocopherols and sterols from natural sources |
| JPH09502701A (ja) * | 1993-08-06 | 1997-03-18 | ヘンケル コーポレーション | トコフェロール類の回収 |
| US5512691A (en) * | 1994-11-07 | 1996-04-30 | Eastman Chemical Company | Process for the production of tocopherol concentrates |
| US5660691A (en) * | 1995-11-13 | 1997-08-26 | Eastman Chemical Company | Process for the production of tocotrienol/tocopherol blend concentrates |
| US5703252A (en) * | 1995-12-13 | 1997-12-30 | Henkel Corporation | Recovery of Tocopherols |
-
1999
- 1999-01-26 EP EP99904267A patent/EP1051412B1/en not_active Expired - Lifetime
- 1999-01-26 CN CN99802443A patent/CN1295568A/zh active Pending
- 1999-01-26 JP JP2000529327A patent/JP2002501915A/ja active Pending
- 1999-01-26 BR BR9908141-5A patent/BR9908141A/pt not_active IP Right Cessation
- 1999-01-26 ES ES99904266T patent/ES2178384T3/es not_active Expired - Lifetime
- 1999-01-26 WO PCT/US1999/001571 patent/WO1999038860A1/en not_active Ceased
- 1999-01-26 EP EP99904266A patent/EP1051411B1/en not_active Expired - Lifetime
- 1999-01-26 ES ES99904267T patent/ES2207931T3/es not_active Expired - Lifetime
- 1999-01-26 WO PCT/US1999/001570 patent/WO1999038859A1/en not_active Ceased
- 1999-01-26 US US09/237,406 patent/US6159347A/en not_active Expired - Fee Related
- 1999-01-26 US US09/237,384 patent/US6224717B1/en not_active Expired - Fee Related
- 1999-01-26 JP JP2000529328A patent/JP2002501916A/ja active Pending
- 1999-01-26 CN CNB998024449A patent/CN1221542C/zh not_active Expired - Fee Related
- 1999-01-26 BR BR9907278-5A patent/BR9907278A/pt not_active IP Right Cessation
- 1999-01-28 MY MYPI99000291A patent/MY124273A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1051411B1 (en) | 2002-08-28 |
| JP2002501916A (ja) | 2002-01-22 |
| BR9907278A (pt) | 2000-10-24 |
| WO1999038860A1 (en) | 1999-08-05 |
| WO1999038859A1 (en) | 1999-08-05 |
| CN1314901A (zh) | 2001-09-26 |
| EP1051411A1 (en) | 2000-11-15 |
| JP2002501915A (ja) | 2002-01-22 |
| US6159347A (en) | 2000-12-12 |
| ES2207931T3 (es) | 2004-06-01 |
| MY124273A (en) | 2006-06-30 |
| BR9908141A (pt) | 2000-11-28 |
| EP1051412A1 (en) | 2000-11-15 |
| US6224717B1 (en) | 2001-05-01 |
| CN1221542C (zh) | 2005-10-05 |
| EP1051412B1 (en) | 2003-09-24 |
| CN1295568A (zh) | 2001-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2178384T3 (es) | Metodos para separar un tocol de una mezcla que contiene tocoles. | |
| ES2901132T3 (es) | Método para la producción de cannabinoides a partir de tipos de cáñamo industrial | |
| AR038901A1 (es) | Metodos extractivos para purificar sucralosa | |
| KR950032045A (ko) | 비누화된 금잔화 함유수지로부터 얻는 루테인의 분리, 정제 및 재결정방법 | |
| DK1073694T3 (da) | Trans-xanthophyllesterkoncentrater med forøget renhed og fremgangsmåder til fremstilling af samme | |
| BR9407179A (pt) | Processos de recuperação tocoferóis a partir de uma mistura gordurosa compreendida de ácidos graxos e tocoferóis de evaporação para a separação de alquil ésteres inferiores de ácido graxo de uma mistura que compreende adicionalmente tocoferóis e esteróis e de separação de um ou mais compostos de tocoferol de um ou mais compostos de esterol | |
| DE69637253D1 (de) | Verfahren zur isolierung von polyhydroxyalkanoaten aus pflanzen | |
| DK1123368T3 (da) | Fremgangsmåde til ekstraktion af lipider fra væv fra marine og akvatiske dyr | |
| ES2185796T3 (es) | Extraccion con disolventes de polihidroxialcanoatos de la biomasa. | |
| KR950014311A (ko) | 자연 발생 마크롤라이드의 회수를 위한 추출 방법 | |
| ES2088134T3 (es) | Procedimiento para la elaboracion de un insecticida almacenable rico en azadirachtin; a partir de semillas de neem. | |
| BR0007665A (pt) | Métodos para a separação de um tocoferol a partir de uma mistura contendo tocoferol e suas composições | |
| ES2158460T3 (es) | Procedimiento de extraccion de fenoles catequicos a partir de diferentes especies de potentilla, extracto obtenido y su utilizacion. | |
| EA199800552A1 (ru) | Извлечение токоферолов | |
| AR075144A1 (es) | Procedimiento para obtener una fraccion enriquecida en esteres de acidos grasos funcionalizados, a partir de semillas de plantas oleaginosas | |
| RU2003117227A (ru) | Способ переработки растительного сырья | |
| KR960010666A (ko) | O, s-디메틸 n-아세틸포스포르아미도티오에이트의 정제방법 | |
| JPS5510421A (en) | Treating method for waste sulfuric acid containing toluene sulfonic acid derivative | |
| KR880005953A (ko) | 카르복실산의 수용액으로부터 카르복실산을 추출분리하는 방법 | |
| DE50203259D1 (de) | Verfahren zur Herstellung von C4-C12-Fettsäuren | |
| KR950032021A (ko) | 이산화탄소를 이용하여 산성 유기 화합물을 이의 염으로부터 방출시키는 방법 | |
| DE60135136D1 (de) | Extraktionsmethode | |
| ES2164903T3 (es) | Procedimiento de extraccion y de aislamiento de la 10-desacetilbaccatina iii. | |
| DE59800322D1 (de) | Verfahren zur Herstellung von 5-Nitro-isophthalsäuredi-c1-c4-alkylestern | |
| IG | Comparative studies of bile salts. 10. Bile salts of the King penguin, Aptenodites patagonica. |