ES2178656T3 - Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos. - Google Patents

Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos.

Info

Publication number
ES2178656T3
ES2178656T3 ES94931793T ES94931793T ES2178656T3 ES 2178656 T3 ES2178656 T3 ES 2178656T3 ES 94931793 T ES94931793 T ES 94931793T ES 94931793 T ES94931793 T ES 94931793T ES 2178656 T3 ES2178656 T3 ES 2178656T3
Authority
ES
Spain
Prior art keywords
bpi
antibiotics
administration
permebility
bactericide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931793T
Other languages
English (en)
Inventor
Jonathan Cohen
Ada H C Kung
Lewis H Lambert Jr
Roger G Ii Little
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Technology Ltd USA
Original Assignee
Xoma Technology Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd USA filed Critical Xoma Technology Ltd USA
Application granted granted Critical
Publication of ES2178656T3 publication Critical patent/ES2178656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Cash Registers Or Receiving Machines (AREA)

Abstract

LA PRESENTE INVENCION HACE REFERENCIA A METODOS Y COMPOSICIONES PARA TRATAR INFECCIONES POR BACTERIAS GRAM-NEGATIVAS, USANDO PRODUCTOS PROTEICOS BPI. EL COTRATAMIENTO, O ADMINISTRACION CONCURRENTE, DE PRODUCTOS PROTEICOS BPI CON UN ANTIBIOTICO EN EL TRATAMIENTO DE INFECCIONES POR BACTERIAS GRAM-NEGATIVAS MEJORA LA EFECTIVIDAD TERAPEUTICA DEL ANTIBIOTICO, INCLUYENDO EL AUMENTO DE LA EFECTIVIDAD TERAPEUTICA DEL ANTIBIOTICO, E INCLUYENDO TAMBIEN EL AUMENTO DE LA SUSCEPTIBILIDAD AL ANTIBIOTICO DE LAS BACTERIAS GRAM-NEGATIVAS Y LA REVERSION DE LA RESISTENCIA DE LA BACTERIA A LOS ANTIBIOTICOS.
ES94931793T 1993-09-22 1994-09-22 Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos. Expired - Lifetime ES2178656T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12565193A 1993-09-22 1993-09-22
US27340194A 1994-07-11 1994-07-11

Publications (1)

Publication Number Publication Date
ES2178656T3 true ES2178656T3 (es) 2003-01-01

Family

ID=26823793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931793T Expired - Lifetime ES2178656T3 (es) 1993-09-22 1994-09-22 Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos.

Country Status (12)

Country Link
US (2) US5523288A (es)
EP (1) EP0759774B1 (es)
JP (1) JPH09502987A (es)
AT (1) ATE218880T1 (es)
AU (1) AU695814B2 (es)
CA (1) CA2172245C (es)
DE (1) DE69430823T2 (es)
DK (1) DK0759774T3 (es)
ES (1) ES2178656T3 (es)
NZ (1) NZ275205A (es)
PT (1) PT759774E (es)
WO (1) WO1995008344A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
EP0759774B1 (en) * 1993-09-22 2002-06-12 XOMA Technology Ltd. Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic
US5447913A (en) * 1994-03-11 1995-09-05 Xoma Corporation Therapeutic uses of bactericidal/permeability-increasing protein dimer products
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
AUPN771596A0 (en) * 1996-01-25 1996-02-15 Mclean, Allan Joseph Methods of and compositions for potentiating the action of agents active on cell-wall sites of susceptible bacteria
PT914144E (pt) * 1996-05-10 2001-05-31 Univ Texas Utilizacoes terapeuticas de produtos de proteinas bip contra a meningococcemia humana
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
CA2255539C (en) * 1996-05-23 2005-09-27 Xoma Corporation Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6482796B2 (en) * 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6406880B1 (en) 1997-05-02 2002-06-18 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US7067500B2 (en) * 1997-05-02 2006-06-27 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
AU7365298A (en) * 1997-05-02 1998-11-27 Integrated Research Technology, Llc Betaines as adjudvants to susceptibility testing and antimicrobial thera py
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
WO1999052357A1 (en) * 1998-04-14 1999-10-21 Ribogene, Inc. Assays for inhibitors of bacterial translation initiation factor 3
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US6790661B1 (en) * 1999-07-16 2004-09-14 Verax Biomedical, Inc. System for detecting bacteria in blood, blood products, and fluids of tissues
US6696239B1 (en) * 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
AU2002241589B2 (en) * 2000-12-01 2007-07-19 Xoma Technology Ltd. Modulation of pericyte proliferation using BPI protein products or BPI inhibitors
MY138797A (en) 2000-12-15 2009-07-31 Vertex Pharma Bacterial gyrase inhibitors and uses thereof
US6835536B2 (en) * 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
JP4511173B2 (ja) * 2001-08-24 2010-07-28 マイジェニックス インコーポレイテッド 抗菌性および抗炎症性ペプチド
US20030232401A1 (en) * 2002-06-12 2003-12-18 Pugia Michael J. Bacterial test method by glycated label binding
US20040037895A1 (en) * 2002-08-23 2004-02-26 Alex Zhu Methods of treating involuntary facial spasms and facial wrinkles
WO2004065591A1 (en) * 2003-01-21 2004-08-05 Ecopia Biosciences Inc. Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals
US7655646B2 (en) * 2003-01-21 2010-02-02 Thallion Pharmaceuticals, Inc. Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals
WO2005024025A1 (en) * 2003-09-11 2005-03-17 Ecopia Biosciences Inc. Polyene polyketides and methods of production
WO2006047891A1 (en) * 2004-11-08 2006-05-11 Ecopia Biosciences Inc. Polycyclic aromatics and derivatives thereof and processes for their preparation
EP1741440A1 (en) 2005-07-08 2007-01-10 Mellitus S.L. Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders
US20080114054A1 (en) * 2006-11-14 2008-05-15 Rath Microbes Compositions and methods for reducing antimicrobial resistance of microbes
EP2601194B1 (en) 2010-08-03 2016-05-25 Merck Sharp & Dohme Corp. Fused-imidazoyl compounds useful as antimicrobial agents
JP6085829B2 (ja) * 2011-01-14 2017-03-01 スペロ トリネム， インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
WO2012112438A2 (en) * 2011-02-16 2012-08-23 The Penn State Research Foundation Anti-microbial agents and compositions and methods of production and use thereof
WO2012177707A1 (en) 2011-06-20 2012-12-27 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US20150150995A1 (en) * 2012-08-09 2015-06-04 Pono Corporation Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof
WO2014160814A1 (en) * 2013-03-26 2014-10-02 Rutgers, The State University Of New Jersey Synthetic and enhanced bacterial killing involving bicyclomycin
JP2018529689A (ja) * 2015-09-17 2018-10-11 ソウル大学校産学協力団Ｓｅｏｕｌ Ｎａｔｉｏｎａｌ Ｕｎｉｖｅｒｓｉｔｙ Ｒ＆Ｄｂ Ｆｏｕｎｄａｔｉｏｎ グラム陰性菌に対する抗菌活性を示す切断または折り畳まれたヘリックスペプチドまたはペプチド類似体およびその用途
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
US20210023101A1 (en) * 2017-07-19 2021-01-28 The University Of North Carolina At Chapel Hill Potentiation of antibiotic effect

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5028251A (es) * 1973-07-12 1975-03-22
JPS55134471A (en) * 1979-04-04 1980-10-20 Toshiba Corp Sales management system in small-scale computer constitution
CA1237671A (en) * 1983-08-01 1988-06-07 Michael W. Fountain Enhancement of pharmaceutical activity
JPS60128596A (ja) * 1983-12-15 1985-07-09 東芝テック株式会社 電子キヤツシユレジスタ
JPS619790A (ja) * 1984-06-25 1986-01-17 オムロン株式会社 電子式キヤツシユレジスタ
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
EP0652230B1 (en) * 1987-08-11 2005-12-14 New York University Biologically active bactericidal/permeability-increasing protein fragments
US5198541A (en) * 1987-08-11 1993-03-30 New York University Dna encoding bactericidal/permeability-increasing proteins
DE68929334T2 (de) * 1988-06-23 2005-08-18 Associates of Cape Cod, Inc., Falmouth Verfahren zumm Assay von Endotoxin-Konzentration
US5308834A (en) * 1989-02-14 1994-05-03 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and prevention thereof using a BPI protein
US5089274A (en) * 1989-02-14 1992-02-18 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
US5234912A (en) * 1989-02-14 1993-08-10 Incyte Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
US5334584A (en) * 1989-02-14 1994-08-02 Incyte Pharamaceuticals, Inc. Recombinant, non-glycosylated bpi protein and uses thereof
EP0563222B1 (en) * 1990-12-03 1998-02-25 New York University Biologically active bactericidal/permeability-increasing protein fragments
US5156665A (en) * 1991-01-03 1992-10-20 Rohm And Haas Company Antimicrobial compositions comprising iodopropargyl compounds and isothiazolones and methods of controlling microbes
AU2872792A (en) * 1991-09-26 1993-04-27 Incyte Pharmaceuticals, Inc. A new form of liposaccharide binding protein (lbp)
AU669723B2 (en) * 1992-05-19 1996-06-20 Xoma Corporation Improved methods for the preparation of endotoxin-binding proteins
AU4382193A (en) * 1992-05-19 1993-12-13 Xoma Corporation BPI-immunoglobulin fusion proteins
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
JP3946246B2 (ja) * 1993-02-02 2007-07-18 ゾーマ・コーポレイション 殺菌性／浸透性増大タンパク質（Ｂａｃｔｅｒｉｃｉｄａｌ／Ｐｅｒｍｅａｂｉｌｉｔｙ Ｉｎｃｒｅａｓｉｎｇ ｐｒｏｔｅｉｎ：ＢＰＩ）及び界面活性剤を含有する医薬組成物
EP0690721B1 (en) * 1993-03-12 1998-05-13 Xoma Corporation Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
US5348942A (en) * 1993-03-12 1994-09-20 Xoma Corporation Therapeutic uses of bactericidal/permeability increasing protein products
ES2123134T3 (es) * 1993-03-12 1999-01-01 Xoma Corp Peptidos biologicamente activos de dominios funcionales de la proteina bactericida aumentadora de la permeabilidad y usos de los mismos.
ATE202482T1 (de) * 1993-03-12 2001-07-15 Xoma Technology Ltd Therapeutische verwendungen von antibakteriellen/durchlässigkeitserhöhenden proteinprodukten
EP0759774B1 (en) * 1993-09-22 2002-06-12 XOMA Technology Ltd. Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic

Also Published As

Publication number Publication date
ATE218880T1 (de) 2002-06-15
AU8074094A (en) 1995-04-10
US5523288A (en) 1996-06-04
CA2172245C (en) 2003-04-08
DE69430823T2 (de) 2003-02-20
JPH09502987A (ja) 1997-03-25
HK1014155A1 (en) 1999-09-24
US6140306A (en) 2000-10-31
WO1995008344A1 (en) 1995-03-30
DE69430823D1 (de) 2002-07-18
DK0759774T3 (da) 2002-10-07
PT759774E (pt) 2002-11-29
NZ275205A (en) 1998-03-25
AU695814B2 (en) 1998-08-20
EP0759774A1 (en) 1997-03-05
EP0759774B1 (en) 2002-06-12
CA2172245A1 (en) 1995-03-30

Similar Documents

Publication Publication Date Title
PT759774E (pt) Metodo para o tratamento de infeccoes bacterianas gram-negativas por administracao de um produto de proteina bactericida indutora da permeabilidade (bip) e de um antibiotico
BR9913340A (pt) Composição, vacina, e, processos de gerar uma resposta imune, e de inibir a colonização microbiana em um animal
ES2074563T3 (es) Procedimiento de preparacion de compuestos y metodo para el tratamiento de la septicemia y/o el choque septico.
BR9711843A (pt) Uso de mupirocina para a fabricação de um medicamento para o tratamento de infecções bacterianas associadas com colonização da nasofaringe por organimos patogênicos
ATE329031T1 (de) Therapeutische zusammensetzungen zur behandlung von lawsonia intracellularis infektionen
BR9510423A (pt) Formulação lipossomal multilamelar de baixa rigidez processo de tratamento ou de profilaxia de uma infecção bacteriana em um animal e de uma variante mucoìde da mesma, uso da formulação lipossomal antibacteriana
ATE219684T1 (de) Anti gram positive bakterielle verfahren und mittel
DE69433901D1 (de) Verbindungen und pharmazeutische zusammensetzungen zur behandlung und prophylaxe bakterieller infektionen
BR0214132A (pt) Composto, processo para a preparação e uso do mesmo, composição farmacêutica, e, método para o tratamento do organismo animal humano ou não humano para combater infecção bacteriana
BR9609281A (pt) Método para o controle de bactérias gram-positivas resistentes a antibióticos e tratamento de infecções
BRPI0013010B8 (pt) formulação aquosa de cloreto de sódio de moxifloxacina, processo para sua preparação e aplicação da referida formulação, bem como preparado de combinação e aplicação de uma solução aquosa de cloridrato de moxifloxacina
ES2070266T3 (es) Vacuna contra la infeccion por escherichia coli.
BR0112919A (pt) Uso de óleos essenciais para combater infecção do trato gi por organismos semelhantes a helicobacter
PT90592A (pt) Processo para a preparacao do antibiotico galidermina e de composicoes farmaceuticas e cosmeticas que o contem
ES2174921T3 (es) Inhibidores de la proteasa del vih.
DE69631381T2 (de) Therapeutische und diagnostische agenzien zur behandlung mikrobieller infektionen
ATE259654T1 (de) Pharmazeutische präparate zur bekämpfung oder prophylaxe von mikroorganismen infizierten oberflächen
DK1675603T3 (da) Anvendelse af probiotiske bakterier i behandling af infektion
BR0006301A (pt) Macrólidos antibacterianos e pró-cinéticos
Schneider Common bacteria encountered in septic arthritis
RU94019991A (ru) Антибиотическая композиция
BR0100228A (pt) Macrolìdeos com 13 e 14 elementos antibacterianos e procinéticos e seus intermediários
CY1107038T1 (el) Μεθοδος θεραπειας βακτηριακων λοιμωξεων με χρηση της γεμιφλοξασινης ή ενος αλατος αυτης και ενος αντιβιοτικου β-λακταμης
ATE413170T1 (de) Medizinische zusammensetzung zur behandlung von infektionen mit arzneimittelresistentem staphylococcus aureus
ATE308895T1 (de) Behandlung von infektionen in tieren