ES2178656T3 - Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos. - Google Patents

Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos.

Info

Publication number
ES2178656T3
ES2178656T3 ES94931793T ES94931793T ES2178656T3 ES 2178656 T3 ES2178656 T3 ES 2178656T3 ES 94931793 T ES94931793 T ES 94931793T ES 94931793 T ES94931793 T ES 94931793T ES 2178656 T3 ES2178656 T3 ES 2178656T3
Authority
ES
Spain
Prior art keywords
bpi
antibiotics
administration
permebility
bactericide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931793T
Other languages
English (en)
Inventor
Jonathan Cohen
Ada H C Kung
Lewis H Lambert Jr
Roger G Ii Little
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Technology Ltd USA
Original Assignee
Xoma Technology Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd USA filed Critical Xoma Technology Ltd USA
Application granted granted Critical
Publication of ES2178656T3 publication Critical patent/ES2178656T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cash Registers Or Receiving Machines (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

LA PRESENTE INVENCION HACE REFERENCIA A METODOS Y COMPOSICIONES PARA TRATAR INFECCIONES POR BACTERIAS GRAM-NEGATIVAS, USANDO PRODUCTOS PROTEICOS BPI. EL COTRATAMIENTO, O ADMINISTRACION CONCURRENTE, DE PRODUCTOS PROTEICOS BPI CON UN ANTIBIOTICO EN EL TRATAMIENTO DE INFECCIONES POR BACTERIAS GRAM-NEGATIVAS MEJORA LA EFECTIVIDAD TERAPEUTICA DEL ANTIBIOTICO, INCLUYENDO EL AUMENTO DE LA EFECTIVIDAD TERAPEUTICA DEL ANTIBIOTICO, E INCLUYENDO TAMBIEN EL AUMENTO DE LA SUSCEPTIBILIDAD AL ANTIBIOTICO DE LAS BACTERIAS GRAM-NEGATIVAS Y LA REVERSION DE LA RESISTENCIA DE LA BACTERIA A LOS ANTIBIOTICOS.
ES94931793T 1993-09-22 1994-09-22 Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos. Expired - Lifetime ES2178656T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12565193A 1993-09-22 1993-09-22
US27340194A 1994-07-11 1994-07-11

Publications (1)

Publication Number Publication Date
ES2178656T3 true ES2178656T3 (es) 2003-01-01

Family

ID=26823793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931793T Expired - Lifetime ES2178656T3 (es) 1993-09-22 1994-09-22 Metodo para tratar infeccion bacteriana gram-negativa por administracion de productos de proteina bactericida que aumenta la permebilidad(bpi) y antibioticos.

Country Status (12)

Country Link
US (2) US5523288A (es)
EP (1) EP0759774B1 (es)
JP (1) JPH09502987A (es)
AT (1) ATE218880T1 (es)
AU (1) AU695814B2 (es)
CA (1) CA2172245C (es)
DE (1) DE69430823T2 (es)
DK (1) DK0759774T3 (es)
ES (1) ES2178656T3 (es)
NZ (1) NZ275205A (es)
PT (1) PT759774E (es)
WO (1) WO1995008344A1 (es)

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PT759774E (pt) * 1993-09-22 2002-11-29 Xoma Technology Ltd Metodo para o tratamento de infeccoes bacterianas gram-negativas por administracao de um produto de proteina bactericida indutora da permeabilidade (bip) e de um antibiotico
US5447913A (en) * 1994-03-11 1995-09-05 Xoma Corporation Therapeutic uses of bactericidal/permeability-increasing protein dimer products
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
AUPN771596A0 (en) * 1996-01-25 1996-02-15 Mclean, Allan Joseph Methods of and compositions for potentiating the action of agents active on cell-wall sites of susceptible bacteria
DE69703689T2 (de) 1996-05-10 2001-05-10 Xoma Technology Ltd., Berkeley Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
NZ332954A (en) * 1996-05-23 2000-07-28 Xoma Corp Use of BPI protein products to treat humans with hemorrhage due to trauma
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6482796B2 (en) * 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6406880B1 (en) 1997-05-02 2002-06-18 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
CA2288457A1 (en) * 1997-05-02 1998-11-12 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US7067500B2 (en) * 1997-05-02 2006-06-27 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
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AU3642199A (en) * 1998-04-14 1999-11-01 Ribogene, Inc. Assays for inhibitors of bacterial translation initiation factor
US6013631A (en) * 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US6790661B1 (en) * 1999-07-16 2004-09-14 Verax Biomedical, Inc. System for detecting bacteria in blood, blood products, and fluids of tissues
US6696239B1 (en) * 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US20020173464A1 (en) * 2000-12-01 2002-11-21 King George L. Modulation of pericyte proliferation
DE60131015T2 (de) 2000-12-15 2008-07-10 Vertex Pharmaceuticals Inc., Cambridge Bakterielle gyrase-hemmer und deren verwendung
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
AU2002328203C1 (en) 2001-08-24 2009-01-08 Migenix Inc. Antimicrobial and anti-inflammatory peptides
US20030232401A1 (en) * 2002-06-12 2003-12-18 Pugia Michael J. Bacterial test method by glycated label binding
US20040037895A1 (en) * 2002-08-23 2004-02-26 Alex Zhu Methods of treating involuntary facial spasms and facial wrinkles
US7655646B2 (en) * 2003-01-21 2010-02-02 Thallion Pharmaceuticals, Inc. Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals
AU2004206046B2 (en) * 2003-01-21 2009-12-17 Thallion Pharmaceuticals Inc. Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals
CA2484638C (en) * 2003-09-11 2008-03-25 Ecopia Biosciences Inc. Polyene polyketides and methods of production
WO2006047891A1 (en) * 2004-11-08 2006-05-11 Ecopia Biosciences Inc. Polycyclic aromatics and derivatives thereof and processes for their preparation
EP1741440A1 (en) * 2005-07-08 2007-01-10 Mellitus S.L. Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders
US20080114054A1 (en) * 2006-11-14 2008-05-15 Rath Microbes Compositions and methods for reducing antimicrobial resistance of microbes
EP2601194B1 (en) 2010-08-03 2016-05-25 Merck Sharp & Dohme Corp. Fused-imidazoyl compounds useful as antimicrobial agents
RU2609259C2 (ru) * 2011-01-14 2017-01-31 Сперо Тринем, Инк. Пиримидиновые ингибиторы гиразы и топоизомеразы iv
WO2012112438A2 (en) * 2011-02-16 2012-08-23 The Penn State Research Foundation Anti-microbial agents and compositions and methods of production and use thereof
CN103702994B (zh) 2011-06-20 2016-03-23 沃泰克斯药物股份有限公司 旋转酶和拓扑异构酶抑制剂的磷酸酯
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
WO2014026143A1 (en) * 2012-08-09 2014-02-13 Pono Corporation Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof
WO2014160814A1 (en) * 2013-03-26 2014-10-02 Rutgers, The State University Of New Jersey Synthetic and enhanced bacterial killing involving bicyclomycin
JP2018529689A (ja) * 2015-09-17 2018-10-11 ソウル大学校産学協力団Ｓｅｏｕｌ Ｎａｔｉｏｎａｌ Ｕｎｉｖｅｒｓｉｔｙ Ｒ＆Ｄｂ Ｆｏｕｎｄａｔｉｏｎ グラム陰性菌に対する抗菌活性を示す切断または折り畳まれたヘリックスペプチドまたはペプチド類似体およびその用途
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
US20210023101A1 (en) * 2017-07-19 2021-01-28 The University Of North Carolina At Chapel Hill Potentiation of antibiotic effect

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Also Published As

Publication number Publication date
US5523288A (en) 1996-06-04
CA2172245A1 (en) 1995-03-30
ATE218880T1 (de) 2002-06-15
AU8074094A (en) 1995-04-10
DE69430823T2 (de) 2003-02-20
EP0759774B1 (en) 2002-06-12
WO1995008344A1 (en) 1995-03-30
DK0759774T3 (da) 2002-10-07
NZ275205A (en) 1998-03-25
US6140306A (en) 2000-10-31
HK1014155A1 (en) 1999-09-24
JPH09502987A (ja) 1997-03-25
CA2172245C (en) 2003-04-08
PT759774E (pt) 2002-11-29
EP0759774A1 (en) 1997-03-05
DE69430823D1 (de) 2002-07-18
AU695814B2 (en) 1998-08-20

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