ES2178895T3 - Derivados de amida que son utiles como inhibidores de citoquinas. - Google Patents

Derivados de amida que son utiles como inhibidores de citoquinas.

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Publication number
ES2178895T3
ES2178895T3 ES99936814T ES99936814T ES2178895T3 ES 2178895 T3 ES2178895 T3 ES 2178895T3 ES 99936814 T ES99936814 T ES 99936814T ES 99936814 T ES99936814 T ES 99936814T ES 2178895 T3 ES2178895 T3 ES 2178895T3
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Spain
Prior art keywords
inhibitors
useful
cytokine
amide derivatives
cytokines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES99936814T
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English (en)
Inventor
Dearg Sutherland Brown
George Robert Brown
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AstraZeneca AB
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AstraZeneca AB
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de amida que son útiles como inhibidores de citoquinas. Se refiere a ciertos derivados de amida que son útiles como inhibidores de enfermedades mediadas por citoquinas. La invención se refiere asimismo a procedimientos para la preparación de los derivados de amida de la invención, a composiciones farmacéuticas que los contienen y a su utilización en procedimientos terapéuticos, por ejemplo en virtud de la inhibición de una enfermedad mediada por citoquinas. Los derivados de amida que se dan a conocer en la presente invención son inhibidores de la producción de citoquinas tales como el Factor de Necrosis Tumoral (en lo sucesivo TNF), por ejemplo TNFe alfa, y diversos miembros de la familia de interleuquinas (en lo sucesivo IL), por ejemplo, IL-1, IL-6 e IL-8.
ES99936814T 1998-08-04 1999-07-29 Derivados de amida que son utiles como inhibidores de citoquinas. Expired - Lifetime ES2178895T3 (es)

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AU5179199A (en) 2000-02-28
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HK1037608A1 (en) 2002-02-15
BRPI9912726B8 (pt) 2021-07-06
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BRPI9912726A (pt) 2001-05-02
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AU756292B2 (en) 2003-01-09
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