NO962543L - Cykliske amid-derivater som neurokinin A-antagonister - Google Patents

Cykliske amid-derivater som neurokinin A-antagonister

Info

Publication number
NO962543L
NO962543L NO962543A NO962543A NO962543L NO 962543 L NO962543 L NO 962543L NO 962543 A NO962543 A NO 962543A NO 962543 A NO962543 A NO 962543A NO 962543 L NO962543 L NO 962543L
Authority
NO
Norway
Prior art keywords
neurokinin
antagonists
amide derivatives
cyclic amide
compounds
Prior art date
Application number
NO962543A
Other languages
English (en)
Other versions
NO962543D0 (no
Inventor
Bhikkappa Ashokkumar Shenvi
Robert Toms Jacobs
Scott Carson Miller
Jr Cyrus John Ohnmacht
Chris Veale
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325654A external-priority patent/GB9325654D0/en
Priority claimed from GB9423248A external-priority patent/GB9423248D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO962543D0 publication Critical patent/NO962543D0/no
Publication of NO962543L publication Critical patent/NO962543L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelser med formel (l) hvor Q1, Q2, Q3 og Q4 har betydningene angitt i beskrivelsen, N-oksyder derav og farmasøytisk godtagbare salter derav er ikke- peptide antagonister av neurokinin A og er nyttige for behandling av astma etc. Farmasøytiske preparater, fremgangsmåter for fremstilling av forbindelsene med formel (l) og mellomprodukter er også beskrevet.
NO962543A 1993-12-15 1996-06-14 Cykliske amid-derivater som neurokinin A-antagonister NO962543L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939325654A GB9325654D0 (en) 1993-12-15 1993-12-15 Cyclic amide derivatives
GB9423248A GB9423248D0 (en) 1994-11-17 1994-11-17 Cyclic amide derivatives
PCT/GB1994/002726 WO1995016682A1 (en) 1993-12-15 1994-12-13 Cyclic amide derivatives as neurokinin a antagonists

Publications (2)

Publication Number Publication Date
NO962543D0 NO962543D0 (no) 1996-06-14
NO962543L true NO962543L (no) 1996-08-14

Family

ID=26304034

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962543A NO962543L (no) 1993-12-15 1996-06-14 Cykliske amid-derivater som neurokinin A-antagonister

Country Status (22)

Country Link
US (3) US5589489A (no)
EP (1) EP0734383B1 (no)
JP (1) JP3819934B2 (no)
CN (1) CN1142822A (no)
AT (1) ATE221064T1 (no)
AU (1) AU690951B2 (no)
BR (1) BR9408325A (no)
CA (1) CA2176036A1 (no)
CZ (1) CZ171796A3 (no)
DE (1) DE69431069T2 (no)
DK (1) DK0734383T3 (no)
ES (1) ES2179094T3 (no)
FI (1) FI962418L (no)
HU (1) HUT76275A (no)
IL (1) IL111970A (no)
NO (1) NO962543L (no)
NZ (1) NZ277291A (no)
PL (1) PL315035A1 (no)
PT (1) PT734383E (no)
SG (1) SG52667A1 (no)
SK (1) SK76396A3 (no)
WO (1) WO1995016682A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
DE69534213T2 (de) * 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9508786D0 (en) * 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
AU6133098A (en) * 1997-01-21 1998-08-07 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6281248B1 (en) 2000-02-16 2001-08-28 Magda Abdel Fattah Ahmed Composition for treating asthma
US6846814B2 (en) 2000-04-06 2005-01-25 Astra Zeneca Ab Neurokinin antagonists for use as medicaments
US7441688B2 (en) * 2003-11-04 2008-10-28 Reactive Nanotechnologies Methods and device for controlling pressure in reactive multilayer joining and resulting product
US20050142495A1 (en) * 2003-10-09 2005-06-30 David Peter Van Heerden Methods of controlling multilayer foil ignition
US7121402B2 (en) * 2003-04-09 2006-10-17 Reactive Nano Technologies, Inc Container hermetically sealed with crushable material and reactive multilayer material
PT1362844E (pt) 2001-01-26 2008-03-10 Btg Int Ltd Análogo da benzilamina
US7009049B2 (en) 2002-02-15 2006-03-07 Cytokinetics, Inc. Syntheses of quinazolinones
AU2003270015A1 (en) 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
US7166595B2 (en) 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
WO2003103575A2 (en) 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
CA2489367A1 (en) 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004009036A2 (en) 2002-07-23 2004-01-29 Cytokinetics, Inc. Compounds compositions and methods
WO2004034972A2 (en) 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
BRPI0410277A (pt) * 2003-05-13 2006-05-16 Reactive Nanotechnologies Inc método para simular um comportamento de uma distribuição de energia dentro de um conjunto contendo um material multicamada reativo, dispositivo de armazenamento de programa legìvel por uma máquina, método para unir, e, junta
EP1692112A4 (en) 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
US9359367B2 (en) 2012-07-09 2016-06-07 Lupin Limited Tetrahydroquinazolinone derivatives as PARP inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
EP0702681A1 (en) * 1993-06-07 1996-03-27 Merck & Co. Inc. Spiro-substituted azacycles as neurokinin antagonists
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives

Also Published As

Publication number Publication date
CN1142822A (zh) 1997-02-12
WO1995016682A1 (en) 1995-06-22
EP0734383A1 (en) 1996-10-02
JPH09506608A (ja) 1997-06-30
ATE221064T1 (de) 2002-08-15
US5589489A (en) 1996-12-31
AU1247195A (en) 1995-07-03
PT734383E (pt) 2002-12-31
JP3819934B2 (ja) 2006-09-13
FI962418A7 (fi) 1996-06-11
AU690951B2 (en) 1998-05-07
HUT76275A (en) 1997-07-28
PL315035A1 (en) 1996-09-30
IL111970A (en) 1999-03-12
EP0734383B1 (en) 2002-07-24
US5705505A (en) 1998-01-06
DE69431069T2 (de) 2003-05-08
SK76396A3 (en) 1996-12-04
CA2176036A1 (en) 1995-06-22
ES2179094T3 (es) 2003-01-16
US5965576A (en) 1999-10-12
SG52667A1 (en) 1998-09-28
CZ171796A3 (en) 1996-09-11
FI962418A0 (fi) 1996-06-11
NZ277291A (en) 1997-12-19
FI962418L (fi) 1996-06-11
BR9408325A (pt) 1997-08-19
DK0734383T3 (da) 2002-10-14
NO962543D0 (no) 1996-06-14
IL111970A0 (en) 1995-03-15
HU9601568D0 (en) 1996-08-28
DE69431069D1 (de) 2002-08-29

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