ES2179558T3 - Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina. - Google Patents

Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.

Info

Publication number
ES2179558T3
ES2179558T3 ES99101810T ES99101810T ES2179558T3 ES 2179558 T3 ES2179558 T3 ES 2179558T3 ES 99101810 T ES99101810 T ES 99101810T ES 99101810 T ES99101810 T ES 99101810T ES 2179558 T3 ES2179558 T3 ES 2179558T3
Authority
ES
Spain
Prior art keywords
phenyl
methyl
piperidino
butilamine
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99101810T
Other languages
English (en)
Inventor
Wolfgang Dr Dipl-Chem Grell
Andreas Dr Greischel
Gabriele Frau Dr Zahn
Michael Dr Mark
Marianne Knorr
Rupprecht Eckhard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority claimed from EP91911959A external-priority patent/EP0589874B1/de
Application granted granted Critical
Publication of ES2179558T3 publication Critical patent/ES2179558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE LA (S) - 3 - METIL - 1 - (2 PIPERIDINO - FENIL) - 1 - BUTILAMINA, SUS SALES, PREPARACION Y UTILIZACION, ASI COMO UN AGENTE PARA EVITAR LAS ALTERACIONES QUE OCURREN CON UNA DURACION ELEVADA Y ALTA DE LA TERAPIA DE LARGA DURACION DE LA DIABETES MELLITUS, CONTENIENDO COMO PRINCIPIO ACTIVO ACIDO (S) (+) - 2 - EPOXI - 4 - [N - [1 - (2 - PIPERIDINO - FENIL) - 3 - METIL - 1 - BUTIL]AMINOCARBONILMETIL] BENZOICO EN LUGAR DEL CORRESPONDIENTE RACEMATO.
ES99101810T 1991-06-21 1991-06-21 Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina. Expired - Lifetime ES2179558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91911959A EP0589874B1 (de) 1991-06-21 1991-06-21 Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums

Publications (1)

Publication Number Publication Date
ES2179558T3 true ES2179558T3 (es) 2003-01-16

Family

ID=8209133

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99101810T Expired - Lifetime ES2179558T3 (es) 1991-06-21 1991-06-21 Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.
ES91911959T Expired - Lifetime ES2136600T3 (es) 1991-06-21 1991-06-21 Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91911959T Expired - Lifetime ES2136600T3 (es) 1991-06-21 1991-06-21 Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion.

Country Status (4)

Country Link
EP (1) EP0965591B1 (es)
AT (2) ATE223391T1 (es)
DE (1) DE59109240D1 (es)
ES (2) ES2179558T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004101540A2 (de) * 2003-05-14 2004-11-25 Cilag Ag Verfahren zur herstellung von phenylessigsäurederivaten
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3320583A1 (de) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH01131143A (ja) * 1987-11-16 1989-05-24 Earth Chem Corp Ltd ｄ，ｌ−カルニチンニトリルクロライドの光学分割法

Also Published As

Publication number Publication date
DE59109240D1 (de) 2002-10-10
ATE223391T1 (de) 2002-09-15
EP0965591A1 (de) 1999-12-22
ATE184279T1 (de) 1999-09-15
ES2136600T3 (es) 1999-12-01
EP0965591B1 (de) 2002-09-04

Similar Documents

Publication Publication Date Title
AR241183A1 (es) Procedimiento para la preparacion de nuevos acidos naftiridin-, quinolin- y benzoxazin-carboxilicos.
ES2125927T3 (es) Nuevo metodo de producir 9-((glicilo substituido)amino)-6-desmetil-6-desoxitetraciclinas substituidas en la posicion 7.
ES533916A0 (es) Un metodo para producir acidos 1,4-dihidro-4-oxo-quinolin-3-carboxilico
DK0481522T3 (da) Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE
SE8404019D0 (sv) Oftalmiskt medel
DK0519327T3 (da) N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt
ES8800222A1 (es) Procedimiento para la obtencion del acido 2,6-dicloro-5-fluor-piridin-3-carboxilico
DE3875792D1 (de) Neues herbizid, seine herstellung und seine verwendung.
ES457791A1 (es) Procedimiento para la obtencion de sales de piridinium-2-al-doxima bis-cuaternarias.
AU1395283A (en) 1-carboxyalkanoylindoline-2-carboxylic acid esters
DE69326302D1 (de) Pleuromutilin-derivate
ES2179558T3 (es) Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.
ATE49410T1 (de) 1-aryl-5-alkoximinoalkylamino-pyrazole.
DK0387489T3 (da) Anvendelse af 2,2,6,6-tetramethyl-4-aminopiperidinamider som fungicider
EP0341081A3 (en) Novel amino acid derivatives
DK535780A (da) Iminderivater af estere af 3-formylcyclopropan-1-carboxylsyresamt deres fremtilling og anvendelse
ES8407024A1 (es) Procedimiento para la obtencion de enantiomeros dextrogiro de derivados de acido fenoxipropionico
ES481264A1 (es) Procedimiento para fabricar derivados del acido arilacetico.
ES550040A0 (es) Un metodo para producir derivados de acido 2-(4-amino susti-tuido-3-oxo-2-isoxazolidinil)-5-oxo-2-tetrahidrofuran-carbo-xilico
ATE25383T1 (de) Indoloquinolizinderivate, verfahren zu ihrer herstellung und ihre therapeutische anwendung.
NO932158D0 (no) Nye benzyl- og benzhydrylalkoholer
DK114486D0 (da) Piperazinylmethyl-1,2,4-triazolylmethylcarbinoler, fremgangsmaade til fremstilling deraf og deres anvendelse som plantebeskyttelsesmidler
DK284085A (da) Isoxazoloquinolinonderivater, deres fremstilling og anvendelse
FI852710A0 (fi) Fenyletylaminopropiofenon-derivat, foerfaranden foer deras framstaellning och dessa innehaollande laekemedel.
ATE47588T1 (de) N-acylaminosaeurederivate, verfahren zu ihrer herstellung und ihre verwendung.