ES2180576T3 - Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas. - Google Patents

Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas.

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Publication number
ES2180576T3
ES2180576T3 ES94915447T ES94915447T ES2180576T3 ES 2180576 T3 ES2180576 T3 ES 2180576T3 ES 94915447 T ES94915447 T ES 94915447T ES 94915447 T ES94915447 T ES 94915447T ES 2180576 T3 ES2180576 T3 ES 2180576T3
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peptides
lhrh
peptidic
immunogenic
auxiliary
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ES94915447T
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Anna E Ladd
Chang Yi Wang
Timothy Zamb
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United Biomedical Inc
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United Biomedical Inc
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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Abstract

ESTA INVENCION SE REFIERE A PEPTIDOS DE LA HORMONA DE LIBERACION DE LA HORMONA LUTEINIZANTE INMUNOGENICOS QUE LLEVAN A LA SUPRESION DE LA ACTIVIDAD DE LA LHRH EN MACHOS O HEMBRAS. CUANDO A LAS RATAS MACHO SE LES INMUNIZO CON ESTOS PEPTIDOS, LA TESTOSTERONA DEL SUERO CAYO Y LOS ORGANOS DEPENDIENTES DE LOS ANDROGENOS SE ATROFIARON SIGNIFICATIVAMENTE. ESTOS PEPTIDOS SON UTILES PARA INDUCIR LA INFERTILIDAD Y PARA EL TRATAMIENTO DE LA HIPERPLASIA PROSTATICA, CARCINOMAS DEPENDIENTES DE ANDROGENOS, CARCINOMAS PROSTATICOS Y CARCINOMAS TESTICULARES EN MACHOS. EN HEMBRAS, LOS PEPTIDOS SON UTILES PARA EL TRATAMIENTO DE LA ENDOMETRIOSIS, DE LOS TUMORES UTERINOS BENIGNOS, DE QUISTES OVARICOS FUNCIONALES RECURRENTES Y SINDROME PREMENSTRUAL (SEVERO) ASI COMO PARA LA PREVENCION O TRATAMIENTO DEL CANCER DE MAMA DEPENDIENTE DE ESTROGENOS. LOS PEPTIDOS DE LA INVENCION CONTIENEN UN EPITOPE DE CELULAS T AUXILIAR Y TIENEN LA LHRH EN EL TERMINO C. EL EPITOPE DE CELULAS T AUXILIAR AYUDA A ESTIMULAR LA RESPUESTA INMUNE CONTRA LA LHRH. LOS PEPTIDOS CONTIENEN OPCIONALMENTE UN DOMINIO DE INVASINA QUE ACTUA COMO INMUNOESTIMULADOR GENERAL. EN OTRO ASPECTO, ESTA INVENCION SE REFIERE A PEPTIDOS SINTETICOS INMUNOGENICOS QUE TIENE UN DOMINIO DE INVASINA, UN EPITOPE DE CELULAS T AUXILIAR Y UN HAPTENO PEPTIDICO Y A METODOS DE UTILIZACION DE ESTOS PEPTIDOS PARA EL TRATAMIENTO DE ENFERMEDADES O PARA PROPORCIONAR UNA INMUNIDAD PROTECTORA. LOS HAPTENOS PEPTIDICOS DE LA INVENCION INCLUYE LHRH, AMILINA, GASTRINA, UN PEPTIDO DE LIBERACION DE GASTRINA, UN PEPTIDO IGE CH4, PEPTIDOS DE CHLAMYDIA MOMP, PEPTIDOS DEL VIH V3 Y PLASMODIUM BERGHEI.
ES94915447T 1993-04-27 1994-04-28 Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas. Expired - Lifetime ES2180576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5716693A 1993-04-27 1993-04-27
US22927594A 1994-04-14 1994-04-14

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ES2180576T3 true ES2180576T3 (es) 2003-02-16

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ES94915447T Expired - Lifetime ES2180576T3 (es) 1993-04-27 1994-04-28 Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas.

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EP (1) EP0708656B1 (es)
JP (2) JP3795914B2 (es)
AT (1) ATE221387T1 (es)
AU (1) AU687805B2 (es)
CA (1) CA2161445C (es)
DE (1) DE69431114T2 (es)
DK (1) DK0708656T3 (es)
ES (1) ES2180576T3 (es)
FI (1) FI955101A7 (es)
NO (1) NO316121B1 (es)
WO (1) WO1994025060A1 (es)

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EP0708656A4 (en) 1999-06-23
DE69431114T2 (de) 2003-03-13
FI955101A7 (fi) 1995-12-21
ATE221387T1 (de) 2002-08-15
NO954279L (no) 1995-12-27
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FI955101A0 (fi) 1995-10-26
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EP0708656B1 (en) 2002-07-31
NO954279D0 (no) 1995-10-26
AU6670294A (en) 1994-11-21
CA2161445A1 (en) 1994-11-10
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AU687805B2 (en) 1998-03-05
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