ES2180932T3 - Derivados de camptotecina y su uso como agentes antitumorales. - Google Patents

Derivados de camptotecina y su uso como agentes antitumorales.

Info

Publication number
ES2180932T3
ES2180932T3 ES97905057T ES97905057T ES2180932T3 ES 2180932 T3 ES2180932 T3 ES 2180932T3 ES 97905057 T ES97905057 T ES 97905057T ES 97905057 T ES97905057 T ES 97905057T ES 2180932 T3 ES2180932 T3 ES 2180932T3
Authority
ES
Spain
Prior art keywords
rent
hydrogen
arilo
linear
camptotechine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97905057T
Other languages
English (en)
Inventor
Lucio Merlini
Sergio Penco
Franco Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2180932(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Application granted granted Critical
Publication of ES2180932T3 publication Critical patent/ES2180932T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN LA QUE: R 1 ES -CN, -CH(CN)R 4 , -CH=C(CN)-R 4 , -CH 2 -CH(CN)-R 4 , C(=NOH)-NH 2 , C(=NH)-NH 2 , -CH=C(NO 2 )-R 4 , CH(CN)-R 5 , -CH(CH 2 NO 2 )-R 5 ; 5 TETRAZOLILO, 2 - (4,5 - DIHIDROOXAZOLILO), 1,2,4 - OXADIAZOLIN 3 - IL - 5 - ONA; R 2 ES HIDROGENO; R 3 ES HIDROGENO, OR 6 ; R 4 ES HIDROGENO, ALQUILO C 1 -C 6 LINEAL O RAMIFICADO, CN, COOR 7 ; R 5 ES HIDROGENO, OR 8; R 6 ES HIDROGENO, ALQUILO (C 1 -C 6 ) LINEAL O RAMIFICADO, ARILO (C 6 -C 12 ), ALQUILO (C 1 -C 4 ) ALCOXI (C 1 -C 4 ) ALQUILO (C 1 C 4 ); A LQUILO (C 1 -C 4 ) ARILO (C 6 C 12 ), ARILO (C6 -C 12 ) ACILO (C 2 -C 4 ), AMINOALQUIL (C 1 -C 4 ), AMINOACILO (C 2 -C 4 ), GLICOSILO; R SUB,7 ES HIDROGENO, ALQUILO (C 1 -C 6 ) LINEAL O RAMI FICADO, ARILO (C 6 -C 12 ) ALQUILO (C 1-C 4 ), ALCOXI (C 1 -C 4 ) ALQUILO (C 1 -C 4 ), ALQUILO (C 1 -C 4 ) ARILO (C 6 C 12 ); R 8 TI ENE LOS MISMOS SIGNIFICADOS DE R 6 , INDEPENDIENTEMENTE DEL ULTIMO. ESTOS COMPUESTOS SON ACTIVOS COMO INHIBIDORES DE LA TOPOISOMERASA I Y SEPUEDEN UTILIZAR COMO FARMACOS ANTITUMORALES.
ES97905057T 1996-02-23 1997-02-19 Derivados de camptotecina y su uso como agentes antitumorales. Expired - Lifetime ES2180932T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali

Publications (1)

Publication Number Publication Date
ES2180932T3 true ES2180932T3 (es) 2003-02-16

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97905057T Expired - Lifetime ES2180932T3 (es) 1996-02-23 1997-02-19 Derivados de camptotecina y su uso como agentes antitumorales.

Country Status (22)

Country Link
US (2) US6130227A (es)
EP (1) EP0885230B1 (es)
JP (1) JP4171527B2 (es)
KR (1) KR100497906B1 (es)
CN (1) CN1107677C (es)
AT (1) ATE221071T1 (es)
AU (1) AU718361B2 (es)
BR (1) BR9707622B1 (es)
CZ (1) CZ289268B6 (es)
DE (1) DE69714220T2 (es)
DK (1) DK0885230T3 (es)
EE (1) EE03529B1 (es)
ES (1) ES2180932T3 (es)
HU (1) HUP9900987A3 (es)
IL (1) IL125856A (es)
IT (1) IT1282673B1 (es)
NZ (1) NZ331126A (es)
PT (1) PT885230E (es)
RU (1) RU2165935C2 (es)
SK (1) SK283217B6 (es)
UA (1) UA49005C2 (es)
WO (1) WO1997031003A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1087801B1 (en) * 1998-06-26 2002-01-16 Quanam Medical Corporation Topoisomerase inhibitors for prevention of restenosis
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
EP1044977B1 (en) * 1999-03-09 2002-05-02 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
GB2391941A (en) * 2001-04-11 2004-02-18 Emerald Biostructures Inc Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
ES2287495T3 (es) * 2002-03-01 2007-12-16 Pfizer Italia S.R.L. Forma polimorfa cristalina de clorhidrato de irinotecan.
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
RS52272B (sr) * 2005-12-21 2012-10-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Lečenje tumora otpornih na lek
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) * 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
CN117940432B (zh) * 2021-09-01 2025-12-23 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途
CN120554369A (zh) * 2024-05-24 2025-08-29 深圳微芯生物科技股份有限公司 喜树碱类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
DE69728152T2 (de) * 1996-08-19 2004-08-05 Bionumerik Pharmaceuticals, Inc., San Antonio Hoch-lipophile campothecin-derivate

Also Published As

Publication number Publication date
NZ331126A (en) 2000-02-28
EE9800259A (et) 1999-02-15
CN1211987A (zh) 1999-03-24
JP2000505448A (ja) 2000-05-09
US6130227A (en) 2000-10-10
RU2165935C2 (ru) 2001-04-27
HUP9900987A3 (en) 2000-01-28
DK0885230T3 (da) 2002-11-18
DE69714220T2 (de) 2002-11-14
UA49005C2 (uk) 2002-09-16
SK112798A3 (en) 1999-01-11
BR9707622B1 (pt) 2010-08-10
KR100497906B1 (ko) 2006-03-09
BR9707622A (pt) 1999-07-27
AU718361B2 (en) 2000-04-13
ATE221071T1 (de) 2002-08-15
CZ265298A3 (cs) 1999-01-13
SK283217B6 (sk) 2003-03-04
CN1107677C (zh) 2003-05-07
KR19990087110A (ko) 1999-12-15
DE69714220D1 (de) 2002-08-29
EP0885230A1 (en) 1998-12-23
JP4171527B2 (ja) 2008-10-22
IL125856A0 (en) 1999-04-11
IL125856A (en) 2001-08-26
HUP9900987A2 (hu) 1999-08-30
PT885230E (pt) 2002-12-31
US6306868B1 (en) 2001-10-23
EP0885230B1 (en) 2002-07-24
ITMI960338A1 (it) 1997-08-23
ITMI960338A0 (es) 1996-02-23
IT1282673B1 (it) 1998-03-31
EE03529B1 (et) 2001-10-15
WO1997031003A1 (en) 1997-08-28
CZ289268B6 (cs) 2001-12-12
AU1875397A (en) 1997-09-10

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