BR9707622A - Derivados de camptotecina e sua utilizaçao como agentes contra tumores - Google Patents

Derivados de camptotecina e sua utilizaçao como agentes contra tumores

Info

Publication number: BR9707622A
Authority: BR; Brazil
Prior art keywords: pct; camptothecin derivatives; agents against; against tumors; date aug
Prior art date: 1996-02-23

Application number

BR9707622A

Other languages

English (en)

Other versions

BR9707622B1 (pt

Inventor

Lucio Merlini

Sergio Penco

Franco Zunino

Original Assignee

Inst Nazionale Per Lo Studio E

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-23

Filing date

1997-02-19

Publication date

1999-07-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9707622(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-02-19 Application filed by Inst Nazionale Per Lo Studio E filed Critical Inst Nazionale Per Lo Studio E

1999-07-27 Publication of BR9707622A publication Critical patent/BR9707622A/pt

2010-08-10 Publication of BR9707622B1 publication Critical patent/BR9707622B1/pt

Links

206010028980 Neoplasm Diseases 0.000 title 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
-1 4,5-dihydrooxazol-2-yl Chemical group 0.000 abstract 1
229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

BRPI9707622-8A 1996-02-23 1997-02-19 derivados de camptotecina, bem como composição farmacêutica compreendendo os mesmos. BR9707622B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI000338A IT1282673B1 (it)	1996-02-23	1996-02-23	Derivati della camptotecina e loro uso come agenti antitumorali
PCT/EP1997/000786 WO1997031003A1 (en)	1996-02-23	1997-02-19	Camptothecin derivatives and the use thereof as antitumor agents

Publications (2)

Publication Number	Publication Date
BR9707622A true BR9707622A (pt)	1999-07-27
BR9707622B1 BR9707622B1 (pt)	2010-08-10

Family

ID=11373368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9707622-8A BR9707622B1 (pt)	1996-02-23	1997-02-19	derivados de camptotecina, bem como composição farmacêutica compreendendo os mesmos.

Country Status (22)

Country	Link
US (2)	US6130227A (pt)
EP (1)	EP0885230B1 (pt)
JP (1)	JP4171527B2 (pt)
KR (1)	KR100497906B1 (pt)
CN (1)	CN1107677C (pt)
AT (1)	ATE221071T1 (pt)
AU (1)	AU718361B2 (pt)
BR (1)	BR9707622B1 (pt)
CZ (1)	CZ289268B6 (pt)
DE (1)	DE69714220T2 (pt)
DK (1)	DK0885230T3 (pt)
EE (1)	EE03529B1 (pt)
ES (1)	ES2180932T3 (pt)
HU (1)	HUP9900987A3 (pt)
IL (1)	IL125856A (pt)
IT (1)	IT1282673B1 (pt)
NZ (1)	NZ331126A (pt)
PT (1)	PT885230E (pt)
RU (1)	RU2165935C2 (pt)
SK (1)	SK283217B6 (pt)
UA (1)	UA49005C2 (pt)
WO (1)	WO1997031003A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69900689T2 (de) *	1998-06-26	2002-08-29	Quanam Medical Corp., Santa Clara	Topoisomerase inhibitoren zur restenose-prevention
US7105492B2 (en)	1999-03-09	2006-09-12	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Camptothecin derivatives having antitumor activity
EP1044977B1 (en) *	1999-03-09	2002-05-02	Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.	Camptothecin derivatives having antitumor activity
AR025587A1 (es)	1999-09-13	2002-12-04	Hoffmann La Roche	Formulaciones en dispersion que contienen inhibidores de lipasa
AU2002258787A1 (en) *	2001-04-11	2002-10-28	Emerald Biostructures, Inc.	Screening methods for identifying ligands
RU2319482C2 (ru) *	2001-11-23	2008-03-20	Чугаи Сейяку Кабусики Кайся	Способ идентификации противоопухолевых целевых ферментов
PL372318A1 (en) *	2002-03-01	2005-07-11	Pharmacia Italia S.P.A.	Crystalline polymorphic form of irinotecan hydrochloride
TW200306314A (en) *	2002-04-16	2003-11-16	Tanabe Seiyaku Co	Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) *	2003-06-27	2006-06-27	Research Triangle Institute	7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) *	2003-07-14	2005-01-15	Ist Naz Stud Cura Dei Tumori	7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AR046579A1 (es) *	2003-11-12	2005-12-14	Smithkline Beecham Corp	Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
PL1962850T3 (pl) *	2005-12-21	2012-07-31	Sigma Tau Ind Farmaceuti	Leczenie lekoopornych nowotworów
WO2007095389A2 (en) *	2006-02-17	2007-08-23	Novacea, Inc.	Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh)	2006-03-10	2010-12-08	中国科学院上海药物研究所	一类喜树碱衍生物及其应用
ITMI20061474A1 (it) *	2006-07-26	2008-01-27	Indena Spa	Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) *	2011-04-07	2014-07-02	宁波天衡药业股份有限公司	一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) *	2014-01-15	2018-06-19	上海海和药物研究开发有限公司	一种9-烯丙基喜树碱衍生物的合成方法
WO2023030364A1 (zh) *	2021-09-01	2023-03-09	上海弼领生物技术有限公司	一种喜树碱类化合物、其制备方法和用途
CN120554369A (zh) *	2024-05-24	2025-08-29	深圳微芯生物科技股份有限公司	喜树碱类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4399282A (en) *	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
JPS58154582A (ja) *	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法
US5459269A (en) *	1992-06-18	1995-10-17	North Carolina State University	14-halo-camptothecins
US5726181A (en) *	1995-06-05	1998-03-10	Bionumerik Pharmaceuticals, Inc.	Formulations and compositions of poorly water soluble camptothecin derivatives
IL127800A (en) *	1996-08-19	2005-11-20	Bionumerik Pharmaceuticals Inc	Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them

1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
1997
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active Expired - Fee Related
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Ceased
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SK283217B6 (sk)	2003-03-04
CN1211987A (zh)	1999-03-24
CZ265298A3 (cs)	1999-01-13
RU2165935C2 (ru)	2001-04-27
SK112798A3 (en)	1999-01-11
US6306868B1 (en)	2001-10-23
ITMI960338A1 (it)	1997-08-23
ITMI960338A0 (pt)	1996-02-23
EP0885230A1 (en)	1998-12-23
NZ331126A (en)	2000-02-28
AU1875397A (en)	1997-09-10
US6130227A (en)	2000-10-10
HUP9900987A2 (hu)	1999-08-30
WO1997031003A1 (en)	1997-08-28
KR19990087110A (ko)	1999-12-15
BR9707622B1 (pt)	2010-08-10
ATE221071T1 (de)	2002-08-15
IL125856A0 (en)	1999-04-11
EE03529B1 (et)	2001-10-15
IL125856A (en)	2001-08-26
UA49005C2 (uk)	2002-09-16
DK0885230T3 (da)	2002-11-18
EP0885230B1 (en)	2002-07-24
AU718361B2 (en)	2000-04-13
EE9800259A (et)	1999-02-15
ES2180932T3 (es)	2003-02-16
DE69714220T2 (de)	2002-11-14
HUP9900987A3 (en)	2000-01-28
DE69714220D1 (de)	2002-08-29
CZ289268B6 (cs)	2001-12-12
IT1282673B1 (it)	1998-03-31
KR100497906B1 (ko)	2006-03-09
CN1107677C (zh)	2003-05-07
JP4171527B2 (ja)	2008-10-22
JP2000505448A (ja)	2000-05-09
PT885230E (pt)	2002-12-31

Legal Events

Date	Code	Title	Description
2004-09-28	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2007-04-10	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-10-20	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2010-08-10	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/08/2010, OBSERVADAS AS CONDICOES LEGAIS.
2013-10-08	B22O	Other matters related to patents and certificates of addition of invention: legal action concerning patent	Free format text: INPI-52400.061587/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132263-70.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: GILEAD SCIENCES, INC, HRISSANTHI IKONOMIDOU, INNOGENETICS N.V., ISTITUTO NAZIONALE PRE LO STUDIO E LA, CURA DEI TUMORI, ITALFARMACO S.P.A.
2013-10-29	B24H	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)	Free format text: EXTINCAO DEFINITIVA - ART. 78 INCISO IV DA LPI
2014-04-08	B19A	Notification of judicial decision: notification of judicial decision	Free format text: INPI-0132263-70.2013.4.02.5101 SECAO JUDICIARIA DO RIO DE JANEIRO-13A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO52400.061587/2013-47 AUTOR:INPI-INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL REU(S):GILEAD SCIENCES INC.,HRISSANTHI IKONOMIDOU, INNOGENTICS NV, ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI E ITALFARMACO SPA DECISAO:HOMOLOGO O ACORDO FIRMADO PELAS PARTES JULGANDO EXTINTO O PROCESSO COM RESOLUCAO DE MERITO, FORTE NO ART.269, III DO CODIGO DE PROCESSO CIVIL.
2020-11-24	B24F	Patent annual fee: publication cancelled	Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2234 DE 29/10/2013 POR TER SIDO INDEVIDA.
2021-08-24	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE AS ANUIDADES 15A ATE 20A.

Publication	Publication Date	Title
PT885230E (pt)	2002-12-31	Derivados de camptotecina e sua utilizacao como agentes antitumorais
PT998460E (pt)	2004-07-30	Novos derivados de tetrazole
DE69811645D1 (de)	2003-04-03	Phtalazinonen
BR9707233A (pt)	1999-07-20	Fenantridinas
ZA200108204B (en)	2004-05-26	Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors.
BG102616A (en)	1999-04-30	Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
NO20004419L (no)	2000-10-20	Ny anvendelse
DK0920426T3 (da)	2004-02-02	Hidtil ukendte thiazolderivater med phosphodiesteraseinhiberende virkning
TR200201245T2 (tr)	2004-08-23	Kanser tedavisi için onkolitik kombinasyonlar.
DE60124387D1 (de)	2006-12-21	Synergistische kombination zur behandlung von kolorektalkarzinom
PL339073A1 (en)	2000-12-04	Derivatives of benzoxazine and benzothiazine and their application in therapeutic agents
TR200103125T2 (tr)	2002-04-22	Otizmin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri.
TR200302134T4 (tr)	2004-01-21	2-metil-tiazolidin-2,4-dikarboksilik asit ve/veya bunun fizyolojik olarak uygun tuzlarının anti-kanser ajanları olarak kullanımı.
NZ504614A (en)	2002-12-20	Echinocandin derivatives and application as anti-fungal agents
DE69818988D1 (de)	2003-11-20	9,10-diazatryclo[4.2.11 2,5]decan- und 9,10-diazatricyclo[3.3.1.1 2,6]decanderive mit analgetischer wirkung
PT958290E (pt)	2002-11-29	Derivados de 1,4-di-hidropiridina e seu uso em terapia
ECSP993045A (es)	1999-10-06	Derivados de acridina, procedimiento para su preparacion y su utilizacion como analgesico
ES1044566Y (es)	2000-09-16	Broche perfeccionado.
PT1200099E (pt)	2003-08-29	Composicao sinergetica compreendendo derivados de daunorubicina e compostos antimetabolito