ES2182029T3 - Derivados de acido 4-(benzo-1,3-dioxolil) pirrolidin-3-carboxilico como antagonistas de endotelina. - Google Patents

Derivados de acido 4-(benzo-1,3-dioxolil) pirrolidin-3-carboxilico como antagonistas de endotelina.

Info

Publication number
ES2182029T3
ES2182029T3 ES97905897T ES97905897T ES2182029T3 ES 2182029 T3 ES2182029 T3 ES 2182029T3 ES 97905897 T ES97905897 T ES 97905897T ES 97905897 T ES97905897 T ES 97905897T ES 2182029 T3 ES2182029 T3 ES 2182029T3
Authority
ES
Spain
Prior art keywords
dioxolil
carboxilico
pirrolidin
benzo
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97905897T
Other languages
English (en)
Inventor
Andrew S Tasker
Steven A Boyd
Bryan K Sorensen
Martin Winn
Hwan-Soo Jae
Geldern Thomas W Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2182029T3 publication Critical patent/ES2182029T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UN COMPUESTO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, ASI COMO LOS PROCEDIMIENTOS PARA LA PREPARACION DEL MISMO E INTERMEDIOS PARA LA PREPARACION DEL MISMO Y UN METODO DE ANTAGONIZACION DE LA ENDOTELINA.
ES97905897T 1996-02-13 1997-02-10 Derivados de acido 4-(benzo-1,3-dioxolil) pirrolidin-3-carboxilico como antagonistas de endotelina. Expired - Lifetime ES2182029T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60072496A 1996-02-13 1996-02-13
US79450597A 1997-02-04 1997-02-04

Publications (1)

Publication Number Publication Date
ES2182029T3 true ES2182029T3 (es) 2003-03-01

Family

ID=27083691

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97905897T Expired - Lifetime ES2182029T3 (es) 1996-02-13 1997-02-10 Derivados de acido 4-(benzo-1,3-dioxolil) pirrolidin-3-carboxilico como antagonistas de endotelina.

Country Status (18)

Country Link
EP (1) EP0888340B1 (es)
JP (1) JP2000504727A (es)
CN (1) CN1079397C (es)
AR (1) AR005801A1 (es)
AT (1) ATE220673T1 (es)
AU (1) AU714597B2 (es)
BR (1) BR9707394A (es)
CA (1) CA2245684A1 (es)
CZ (1) CZ253698A3 (es)
DE (1) DE69714024T2 (es)
DK (1) DK0888340T3 (es)
ES (1) ES2182029T3 (es)
HU (1) HUP9902316A3 (es)
IL (1) IL125453A0 (es)
NZ (2) NZ503383A (es)
PT (1) PT888340E (es)
WO (1) WO1997030046A1 (es)
ZA (1) ZA971184B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162927A (en) 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
US7208517B1 (en) 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
US6124341A (en) * 1996-02-13 2000-09-26 Abbott Laboratories Endothelin antagonists
HUP0002681A3 (en) * 1997-06-17 2001-09-28 Abbott Lab Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same
TR200000993T2 (tr) * 1997-08-04 2000-12-21 Abbott Laboratories Endotelin antagonistleri.
KR100613196B1 (ko) 2000-07-19 2006-08-18 에프. 호프만-라 로슈 아게 메탈로프로테아제 억제제로서의 피롤리딘 유도체
WO2002017912A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Endothelin antagonists
RU2259825C9 (ru) * 2001-06-18 2006-04-10 БиоДием Лимитед Вещества, проявляющие антимикробную, антигрибковую, антипротозойную активности

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67665A (en) * 1991-11-05 1995-04-28 Smithkline Beckman Corp Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
WO1994002474A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Endothelin receptor antagonists
WO1996006095A1 (en) * 1994-08-19 1996-02-29 Abbott Laboratories Endothelin antagonists

Also Published As

Publication number Publication date
WO1997030046A1 (en) 1997-08-21
CZ253698A3 (cs) 1999-03-17
JP2000504727A (ja) 2000-04-18
CN1215401A (zh) 1999-04-28
IL125453A0 (en) 1999-03-12
PT888340E (pt) 2002-12-31
DE69714024D1 (de) 2002-08-22
AR005801A1 (es) 1999-07-14
EP0888340A1 (en) 1999-01-07
AU714597B2 (en) 2000-01-06
BR9707394A (pt) 1999-04-06
HUP9902316A3 (en) 2001-12-28
ZA971184B (en) 1997-08-27
AU2267897A (en) 1997-09-02
NZ503383A (en) 2002-02-01
DK0888340T3 (da) 2002-11-04
CN1079397C (zh) 2002-02-20
EP0888340B1 (en) 2002-07-17
ATE220673T1 (de) 2002-08-15
DE69714024T2 (de) 2003-03-20
CA2245684A1 (en) 1997-08-21
HUP9902316A2 (hu) 1999-11-29
NZ331124A (en) 2000-05-26

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