DK122291A - Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme - Google Patents

Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme Download PDF

Info

Publication number
DK122291A
DK122291A DK122291A DK122291A DK122291A DK 122291 A DK122291 A DK 122291A DK 122291 A DK122291 A DK 122291A DK 122291 A DK122291 A DK 122291A DK 122291 A DK122291 A DK 122291A
Authority
DK
Denmark
Prior art keywords
acceptable salts
physiologically acceptable
procedures
preparation
same
Prior art date
Application number
DK122291A
Other languages
English (en)
Other versions
DK170800B1 (da
DK122291D0 (da
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of DK122291D0 publication Critical patent/DK122291D0/da
Publication of DK122291A publication Critical patent/DK122291A/da
Application granted granted Critical
Publication of DK170800B1 publication Critical patent/DK170800B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK122291A 1988-12-22 1991-06-21 Substitueret benzimidazolderivat og fysiologisk acceptable salte og optiske enantiomerer heraf samt fremgangsmåde til fremstilling af samme, farmaceutisk præparat indeholdende derivatet, anvendelse af derivatet til fremstilling af et lægemiddel til hæmning af mavesyresekretionen hos pattedyr og til behandling af inflammatoriske mave-tarmkanallidelser hos pattedyr samt intermediære forbindelser til DK170800B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds
SE8804629 1988-12-22
SE8900740 1989-12-20
PCT/SE1989/000740 WO1990006925A1 (en) 1988-12-22 1989-12-20 New therapeutically active compound and a process for its preparation

Publications (3)

Publication Number Publication Date
DK122291D0 DK122291D0 (da) 1991-06-21
DK122291A true DK122291A (da) 1991-06-24
DK170800B1 DK170800B1 (da) 1996-01-22

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
DK122291A DK170800B1 (da) 1988-12-22 1991-06-21 Substitueret benzimidazolderivat og fysiologisk acceptable salte og optiske enantiomerer heraf samt fremgangsmåde til fremstilling af samme, farmaceutisk præparat indeholdende derivatet, anvendelse af derivatet til fremstilling af et lægemiddel til hæmning af mavesyresekretionen hos pattedyr og til behandling af inflammatoriske mave-tarmkanallidelser hos pattedyr samt intermediære forbindelser til

Country Status (32)

Country Link
US (2) US5008278A (da)
EP (1) EP0449940B1 (da)
JP (1) JP2793906B2 (da)
KR (1) KR910700249A (da)
CN (1) CN1028231C (da)
AR (1) AR248136A1 (da)
AT (1) ATE127799T1 (da)
AU (1) AU634741B2 (da)
BG (1) BG60102B2 (da)
CA (1) CA2005986C (da)
DD (2) DD296078A5 (da)
DE (1) DE68924273T2 (da)
DK (1) DK170800B1 (da)
EG (1) EG19303A (da)
FI (2) FI913035A0 (da)
GR (1) GR1002252B (da)
HR (1) HRP920831A2 (da)
HU (2) HU205927B (da)
IE (1) IE894048L (da)
IL (1) IL92798A0 (da)
LT (2) LT3980B (da)
LV (1) LV10187B (da)
NZ (1) NZ231872A (da)
PH (1) PH27400A (da)
PL (1) PL161150B1 (da)
PT (1) PT92648B (da)
RO (1) RO110494B1 (da)
RU (2) RU2073676C1 (da)
SE (1) SE8804629D0 (da)
WO (1) WO1990006925A1 (da)
YU (1) YU46806B (da)
ZA (2) ZA899794B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
DK1078628T3 (da) * 1994-07-08 2009-02-23 Astrazeneca Ab Tabletteret flerenhedsdoseringsform
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
ES2373864T3 (es) * 1998-04-20 2012-02-09 Eisai R&D Management Co., Ltd. Composición estabilizada que contiene un compuesto de tipo bencimidazol.
SE9900274D0 (sv) * 1999-01-28 1999-01-28 Astra Ab New compound
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
RU2232159C2 (ru) * 1999-07-29 2004-07-10 Регентский Совет Университета Калифорнии Производные бензимидазола и фармацевтические композиции, содержащие пролекарство ингибитора протонного насоса
AU782538B2 (en) 1999-10-20 2005-08-04 Eisai Co. Ltd. Method for stabilizing benzimidazole compounds
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
WO2003063840A2 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
EP1487820A1 (en) * 2002-03-26 2004-12-22 Dr. Reddy's Laboratories Ltd. Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
TWI367759B (en) * 2003-02-20 2012-07-11 Santarus Inc A novel formulation, omeprazole antacid complex-immediate release, for rapid and sustained suppression of gastric acid
AU2004257864A1 (en) * 2003-07-18 2005-01-27 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
RU2325960C2 (ru) * 2005-09-22 2008-06-10 Белорусский Национальный Технический Университет Способ получения товарной продукции на литейно-прокатном комплексе металлургического мини-завода
EP2046334B1 (en) 2006-07-25 2014-05-21 Vecta Ltd. Compositions and meth0ds for inhibiting gastric acide secretion using derivatives of small dicarboxylic acids in combination with ppi
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
KR20110079641A (ko) 2008-09-09 2011-07-07 아스트라제네카 아베 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US428098A (en) 1890-05-20 Electric railway
US727150A (en) 1902-06-18 1903-05-05 Peter Paul Keller Adjustable hanger for incandescent lamps.
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (da) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3215503A1 (de) 1982-04-26 1983-11-03 Zängl GmbH, 8000 München Elektrisch beheiztes schneidgeraet
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
US5008278A (en) 1991-04-16
CA2005986C (en) 1999-08-03
ATE127799T1 (de) 1995-09-15
AR248136A1 (es) 1995-06-30
YU242689A (en) 1991-04-30
DE68924273D1 (de) 1995-10-19
DK170800B1 (da) 1996-01-22
DE68924273T2 (de) 1996-02-15
LT3914B (en) 1996-04-25
GR890100838A (el) 1991-03-15
CN1043713A (zh) 1990-07-11
LV10187B (en) 1995-04-20
ZA899795B (en) 1990-08-29
DK122291D0 (da) 1991-06-21
HU205926B (en) 1992-07-28
RO110494B1 (ro) 1996-01-30
HRP920831A2 (en) 1995-12-31
WO1990006925A1 (en) 1990-06-28
EP0449940B1 (en) 1995-09-13
PL161150B1 (en) 1993-05-31
FI913035A7 (fi) 1991-06-20
US5039808A (en) 1991-08-13
DD296079A5 (de) 1991-11-21
GR1002252B (en) 1996-04-23
CA2005986A1 (en) 1990-06-22
LTIP1721A (en) 1995-07-25
JPH04502461A (ja) 1992-05-07
LT3980B (en) 1996-06-25
FI913035A0 (fi) 1991-06-20
BG60102B2 (bg) 1993-10-29
IE894048L (en) 1990-06-22
JP2793906B2 (ja) 1998-09-03
FI954768A7 (fi) 1995-10-06
IL92798A0 (en) 1990-09-17
SE8804629D0 (sv) 1988-12-22
AU4817590A (en) 1990-07-10
FI954768A0 (fi) 1995-10-06
HU901084D0 (en) 1991-09-30
RU2073676C1 (ru) 1997-02-20
KR910700249A (ko) 1991-03-14
LTIP1726A (en) 1995-07-25
FI954768L (fi) 1995-10-06
HU205927B (en) 1992-07-28
PT92648B (pt) 1995-09-12
CN1028231C (zh) 1995-04-19
AU634741B2 (en) 1993-03-04
RU2042673C1 (ru) 1995-08-27
PH27400A (en) 1993-06-21
YU46806B (sh) 1994-06-10
NZ231872A (en) 1992-03-26
ZA899794B (en) 1990-08-29
HUT57202A (en) 1991-11-28
LV10187A (lv) 1994-10-20
PT92648A (pt) 1990-06-29
EP0449940A1 (en) 1991-10-09
DD296078A5 (de) 1991-11-21
EG19303A (en) 1994-11-30

Similar Documents

Publication Publication Date Title
DK122391A (da) Terapeutisk aktiv, substitueret benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme
NO882732D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
DK233586A (da) 5-substituerede 1,3-thiazolidon-2,4-dion forbindelser og farmaceutiske praeparater indeholdende disse
FI872864L (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
NO904694L (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
NO901684D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater.
DK122291D0 (da) Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme
NO890921D0 (no) Fremgangsmaate for fremstilling av aminosyrederivater.
NO162965C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa-(2-okso-2,4,5,6,7,7a-heksahydrotieno-(3,2-c)-5-pyridyl)-fenyl-eddiksyre-derivater.
FI885460L (fi) Menetelmä suun kautta annettavaksi tarkoitetun, aktiiviyhdistettä kontrolloidusti vapauttavan farmaseuttisen formulaation valmistamiseksi
NO871295D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
MX162676A (es) Procedimiento para la preparacion de derivados de 2-(piridilalquensulfinii.)benzimidazoles n-substituidos
NO870049L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
NO883122D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive arylamid-derivater.
DK122191D0 (da) Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme
NO874850D0 (no) Fremgangsmaate for fremstilling av benzotiadiazinforbindelser og farmasoeytisk akseptable salter derav.
NO891114L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater.
DK0544760T3 (da) Farmaceutiske præparater indeholdende 5-difluormethoxy-2- (3,4-dimethoxy-2-pyridyl)methylsulfinyl benzimidazol og at anti-helicobactermiddel til behandling af gastrointestinale lidelser
NO884175L (no) Fremgangsmaate for fremstilling av terapeutiske aktive heterocykliske derivater.
NO167802C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazepinderivater.
IT8721436A0 (it) "derivati di 2,3,4,5,6,7 esaidro 2,7 metano 1,5 benzossazonina (rispettivamente 1,4 benzossazonina), procedimento per la loro preparazione e prodotti medicinali che contengono questi composti.
NO913644D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
NO167511C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte tieno(3,4-d)imidazolderivater.
SE8900685D0 (sv) New compounds
ATE23161T1 (de) 3-deazaguanin-sulfonsaeuresalze.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed