ES2182131T3 - Vacuna de pertussis acelular con toxoides de difteria y tetanos. - Google Patents

Vacuna de pertussis acelular con toxoides de difteria y tetanos.

Info

Publication number
ES2182131T3
ES2182131T3 ES97950137T ES97950137T ES2182131T3 ES 2182131 T3 ES2182131 T3 ES 2182131T3 ES 97950137 T ES97950137 T ES 97950137T ES 97950137 T ES97950137 T ES 97950137T ES 2182131 T3 ES2182131 T3 ES 2182131T3
Authority
ES
Spain
Prior art keywords
difteria
tetans
accelular
toxoids
pertussis vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97950137T
Other languages
English (en)
Inventor
Patrick Florent
Jean Stephenne
Christian Vandecasserie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
SmithKline Beecham Biologicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Biologicals SA filed Critical SmithKline Beecham Biologicals SA
Application granted granted Critical
Publication of ES2182131T3 publication Critical patent/ES2182131T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0016—Combination vaccines based on diphtheria-tetanus-pertussis
    • A61K39/0018—Combination vaccines based on acellular diphtheria-tetanus-pertussis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SUMINISTRA UNA VACUNA PARA LA DIFTERIA, EL TETANOS Y LA TOS FERINA QUE COMPRENDE UNA DOSIS BAJA DE TOXOIDE DE LA DIFTERIA (D), TOXOIDE DEL TETANOS (T), TOXINA DE LA TOS FERINA (PT), HEMAGLUTINA FILAMENTOSA (FHA) Y PERTACTINA (69K). LA VACUNA MANTIENE LA CAPACIDAD DE EVITAR LA TOS FERINA MIENTRAS QUE MUESTRA UNA REACTOGENICIDAD EXCEPCIONALMENTE BAJA. TAMBIEN SE SUMINISTRAN VACUNAS COMBINACIONALES QUE COMPRENDE ANTIGENOS ADICIONALES.
ES97950137T 1996-11-07 1997-11-04 Vacuna de pertussis acelular con toxoides de difteria y tetanos. Expired - Lifetime ES2182131T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9623233.5A GB9623233D0 (en) 1996-11-07 1996-11-07 Vaccine composition

Publications (1)

Publication Number Publication Date
ES2182131T3 true ES2182131T3 (es) 2003-03-01

Family

ID=10802615

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02075821T Active ES2240647T7 (es) 1996-11-07 1997-11-04 Vacuna de pertussis acelular con toxoides de difteria y tetanos.
ES97950137T Expired - Lifetime ES2182131T3 (es) 1996-11-07 1997-11-04 Vacuna de pertussis acelular con toxoides de difteria y tetanos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02075821T Active ES2240647T7 (es) 1996-11-07 1997-11-04 Vacuna de pertussis acelular con toxoides de difteria y tetanos.

Country Status (30)

Country Link
EP (2) EP1240905B3 (es)
JP (1) JP3980652B2 (es)
KR (1) KR100518044B1 (es)
CN (1) CN1130226C (es)
AR (1) AR011509A1 (es)
AT (2) ATE295178T1 (es)
AU (1) AU710475B2 (es)
BR (2) BRPI9712917B8 (es)
CA (1) CA2271008C (es)
CO (1) CO4910171A1 (es)
CY (2) CY2407B1 (es)
CZ (1) CZ295954B6 (es)
DE (3) DE69733285T3 (es)
DK (2) DK0941117T3 (es)
ES (2) ES2240647T7 (es)
GB (1) GB9623233D0 (es)
HK (1) HK1050473B (es)
HU (1) HU224126B1 (es)
IL (1) IL129530A (es)
LU (1) LU91183I2 (es)
NO (2) NO320186B1 (es)
NZ (1) NZ335384A (es)
PL (1) PL188460B1 (es)
PT (2) PT1240905E (es)
SA (1) SA98181128B1 (es)
SI (2) SI1240905T1 (es)
TR (1) TR199900979T2 (es)
TW (1) TW471971B (es)
WO (1) WO1998019702A1 (es)
ZA (1) ZA979984B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004314A1 (fr) * 1998-11-26 2000-05-31 Pasteur Merieux MSD Vaccin T.d. Polio rappel pour une population vaccinée ou sensibilisée
KR100374813B1 (ko) * 2000-04-07 2003-03-03 녹십자백신 주식회사 디프테리아, 파상풍 톡소이드, 정제백일해 및비형간염표면항원을 포함한 4가 혼합백신 및 그 제조 방법
GB0108364D0 (en) * 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
KR100401423B1 (ko) * 2001-01-10 2003-10-17 주식회사 엘지생명과학 혼합 백신의 제조 방법
JP5007425B2 (ja) * 2006-01-30 2012-08-22 財団法人ヒューマンサイエンス振興財団 百日咳ワクチンの安全性評価方法
GB0616306D0 (en) * 2006-08-16 2006-09-27 Novartis Ag Vaccines
GB0822633D0 (en) * 2008-12-11 2009-01-21 Novartis Ag Formulation
WO2011027222A2 (en) 2009-09-02 2011-03-10 Novartis Ag Immunogenic compositions including tlr activity modulators
AU2011295853A1 (en) 2010-09-01 2013-04-04 Irm Llc Adsorption of immunopotentiators to insoluble metal salts
WO2012117377A1 (en) 2011-03-02 2012-09-07 Novartis Ag Combination vaccines with lower doses of antigen and/or adjuvant
CN102363041A (zh) * 2011-11-17 2012-02-29 成都欧林生物科技股份有限公司 不含防腐剂疫苗的制作工艺
MX372965B (es) * 2012-03-08 2020-04-01 Glaxosmithkline Biologicals Sa Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo.
CN102793915B (zh) * 2012-07-25 2013-10-23 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013301312A1 (en) 2012-08-06 2015-03-19 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against RSV and B. pertussis
CN103100081A (zh) * 2012-12-26 2013-05-15 天津康希诺生物技术有限公司 一种多价联合疫苗
WO2014135651A1 (en) 2013-03-08 2014-09-12 Crucell Holland B.V. Acellular pertussis vaccine
MX2016001695A (es) 2013-08-05 2016-05-02 Glaxosmithkline Biolog Sa Composiciones inmunogenas de combinacion.
CN114748616A (zh) * 2022-05-23 2022-07-15 中国医学科学院医学生物学研究所 一种成人青少年用无细胞百白破联合疫苗及其制备方法
CN117417419B (zh) * 2023-01-10 2024-04-19 康希诺生物股份公司 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗
CN119524117B (zh) * 2025-01-23 2025-09-23 康希诺生物股份公司 免疫原性组合物、百白破联合疫苗及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI861417A0 (fi) 1985-04-15 1986-04-01 Endotronics Inc Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav.
US4895800A (en) 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
AP56A (en) 1987-01-30 1989-09-26 Smithkline Biologicals S A Hepatitis B virus surface antigens and hybrid antigehs containing them.
EP1088830A3 (en) 1987-06-22 2004-04-07 Medeva Holdings B.V. Hepatitis b surface antigen particles
DE3789866T2 (de) 1987-07-17 1994-09-22 Rhein Biotech Gesellschaft Fuer Neue Biotechnologische Prozesse Und Produkte Mbh, 40595 Duesseldorf DNA-Moleküle, die für FMDH-Kontrollabschnitte und Strukturgene für ein Protein mit FMDH-Aktivität kodieren, sowie deren Anwendung.
EP0414374B1 (en) 1989-07-25 1997-10-08 Smithkline Biologicals S.A. Novel antigens and methods for their preparation
GB9007024D0 (en) 1990-03-29 1990-05-30 Imperial College Novel vaccine
SG48365A1 (en) * 1992-05-23 1998-04-17 Smithkline Beecham Biolog Combined vaccines comprising hepatitis b surface antigen and other antigens

Also Published As

Publication number Publication date
EP0941117A1 (en) 1999-09-15
AR011509A1 (es) 2000-08-30
CN1130226C (zh) 2003-12-10
CO4910171A1 (es) 2000-04-24
DK1240905T5 (da) 2010-01-11
DK0941117T3 (da) 2002-11-18
ES2240647T3 (es) 2005-10-16
HUP9904287A3 (en) 2001-05-28
DE69733285T3 (de) 2010-03-25
KR20000053092A (ko) 2000-08-25
KR100518044B1 (ko) 2005-09-30
NO992156L (no) 1999-05-04
JP2001503422A (ja) 2001-03-13
NZ335384A (en) 2000-10-27
NO2006005I1 (no) 2006-05-08
CN1236321A (zh) 1999-11-24
HUP9904287A1 (hu) 2000-04-28
ATE295178T1 (de) 2005-05-15
BRPI9712917B1 (pt) 2019-12-03
PT1240905E (pt) 2005-09-30
CY2568B1 (en) 2008-07-02
WO1998019702A1 (en) 1998-05-14
PL188460B1 (pl) 2005-02-28
CA2271008A1 (en) 1998-05-14
CZ295954B6 (cs) 2005-12-14
SI0941117T1 (en) 2002-12-31
GB9623233D0 (en) 1997-01-08
LU91183I2 (fr) 2005-09-20
EP0941117B1 (en) 2002-08-28
DE69715031D1 (de) 2002-10-02
JP3980652B2 (ja) 2007-09-26
EP1240905A1 (en) 2002-09-18
DE69733285T2 (de) 2006-01-12
PT941117E (pt) 2002-12-31
ATE222773T1 (de) 2002-09-15
SI1240905T1 (en) 2005-10-31
PL333127A1 (en) 1999-11-22
CZ164099A3 (cs) 1999-10-13
AU5319698A (en) 1998-05-29
DE69715031T2 (de) 2003-05-08
NO320186B1 (no) 2005-11-07
DK1240905T3 (da) 2005-07-18
CA2271008C (en) 2008-07-22
EP1240905B3 (en) 2009-08-26
BRPI9712917B8 (pt) 2021-05-25
NO2006005I2 (no) 2010-04-12
ES2240647T7 (es) 2010-03-31
IL129530A0 (en) 2000-02-29
TW471971B (en) 2002-01-11
DE122005000046I1 (de) 2005-12-29
DE69733285D1 (de) 2005-06-16
HK1022638A1 (en) 2000-08-18
NO992156D0 (no) 1999-05-04
HK1050473A1 (en) 2003-06-27
BR9712917A (pt) 1999-12-07
AU710475B2 (en) 1999-09-23
HK1050473B (en) 2006-03-03
HU224126B1 (hu) 2005-05-30
ZA979984B (en) 1998-07-23
IL129530A (en) 2005-11-20
SA98181128B1 (ar) 2006-03-25
TR199900979T2 (xx) 1999-07-21
CY2407B1 (en) 2004-09-10
EP1240905B1 (en) 2005-05-11

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