ES2183636T3 - 4'-sustituido-4', 5'-dihidropsoralenos y sus usos terapeuticos. - Google Patents

4'-sustituido-4', 5'-dihidropsoralenos y sus usos terapeuticos.

Info

Publication number
ES2183636T3
ES2183636T3 ES99962909T ES99962909T ES2183636T3 ES 2183636 T3 ES2183636 T3 ES 2183636T3 ES 99962909 T ES99962909 T ES 99962909T ES 99962909 T ES99962909 T ES 99962909T ES 2183636 T3 ES2183636 T3 ES 2183636T3
Authority
ES
Spain
Prior art keywords
substituted
mammal
aromatic ring
nitrogen form
heterocyclic aromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99962909T
Other languages
English (en)
Inventor
Ned D Heindel
Marilyn S Whittemore
Christophe Guillon
Robert D Rapp
Jeffrey D Laskin
Thomas E Mcneel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buckman Laboratories International Inc
Original Assignee
Buckman Laboratories International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buckman Laboratories International Inc filed Critical Buckman Laboratories International Inc
Application granted granted Critical
Publication of ES2183636T3 publication Critical patent/ES2183636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un 4¿-sustituido-4, 8-dimetil-4¿, 5¿-dihidropsoraleno de la **fórmula** donde R es hidrógeno, un halógeno, CN o un grupo acilo; T es un halógeno, CN, un carboxilato, un grupo carboalcoxi o un grupo definido por NR1R2 o (N+R1R2R3)Xn; R1 y R2 independientemente son un alquilo C1-C6, o R1 y R2 junto con el nitrógeno forman un anillo heterocíclico de 5-8 elementos, o cuando T es un grupo definido por (N+R1R2R3) X-, R1 y R2 junto con el nitrógeno forman un anillo heterocíclico o un anillo heterocíclico aromático de 5-8 elementos; R3 es hidrógeno, un alquilo C1-C12, o, cuando R1 y R2 junto con el nitrógeno forman un anillo heterocíclico aromático, R3 es un vínculo doble dentro del anillo heterocíclico aromático; X- es un halogenuro; y sales farmacéuticamente aceptables.
ES99962909T 1998-11-30 1999-11-30 4'-sustituido-4', 5'-dihidropsoralenos y sus usos terapeuticos. Expired - Lifetime ES2183636T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11033698P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
ES2183636T3 true ES2183636T3 (es) 2003-03-16

Family

ID=22332461

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99962909T Expired - Lifetime ES2183636T3 (es) 1998-11-30 1999-11-30 4'-sustituido-4', 5'-dihidropsoralenos y sus usos terapeuticos.

Country Status (10)

Country Link
US (1) US6177424B1 (es)
EP (1) EP1144417B1 (es)
AT (1) ATE223418T1 (es)
AU (1) AU1925500A (es)
CA (1) CA2352258A1 (es)
DE (1) DE69902821T2 (es)
ES (1) ES2183636T3 (es)
MX (1) MXPA01005363A (es)
PT (1) PT1144417E (es)
WO (1) WO2000032603A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119950493B (zh) * 2025-03-14 2025-08-15 自然资源部第三海洋研究所 3,4-二氢补骨脂素在制备预防或治疗类风湿关节炎的药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130568A (en) 1976-09-14 1978-12-19 Hoffmann-La Roche Inc. 8-Methoxypsoralen derivatives
US4124598A (en) 1976-10-20 1978-11-07 Hoffmann-La Roche Inc. Psoralens
US4196281A (en) * 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4294822A (en) 1980-07-29 1981-10-13 Thomas C. Elder, Inc. 5-Aminoalkyl-4,4,8-trialkylpsoralens
US4950770A (en) 1987-06-16 1990-08-21 Elder Pharmaceuticals, Inc. Psoralens aminomethylation
US5356929A (en) * 1989-01-23 1994-10-18 Lehigh University Reduced and quaternized psoralens as photo-activated therapeutics
US5216176A (en) 1989-01-23 1993-06-01 Lehigh University 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
US5625079A (en) * 1993-06-28 1997-04-29 Cerus Corporation Synthesizing psoralen compounds useful as intermediates
US5399719A (en) 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood

Also Published As

Publication number Publication date
AU1925500A (en) 2000-06-19
WO2000032603A1 (en) 2000-06-08
DE69902821T2 (de) 2003-01-09
ATE223418T1 (de) 2002-09-15
DE69902821D1 (de) 2002-10-10
PT1144417E (pt) 2002-12-31
CA2352258A1 (en) 2000-06-08
EP1144417A1 (en) 2001-10-17
MXPA01005363A (es) 2004-04-21
US6177424B1 (en) 2001-01-23
EP1144417B1 (en) 2002-09-04

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