TR200201509T2 - Farmasötik olarak aktif benzazol türevleri. - Google Patents

Farmasötik olarak aktif benzazol türevleri.

Info

Publication number
TR200201509T2
TR200201509T2 TR2002/01509T TR200201509T TR200201509T2 TR 200201509 T2 TR200201509 T2 TR 200201509T2 TR 2002/01509 T TR2002/01509 T TR 2002/01509T TR 200201509 T TR200201509 T TR 200201509T TR 200201509 T2 TR200201509 T2 TR 200201509T2
Authority
TR
Turkey
Prior art keywords
benzazole derivatives
pharmaceutically active
derivatives
unsaturated
saturated
Prior art date
Application number
TR2002/01509T
Other languages
English (en)
Inventor
Halazy Serge
Church Dennis
Camps Montserrat
Gaillard Pascale
Gotteland Jean-Pierre
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of TR200201509T2 publication Critical patent/TR200201509T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mevcut bulus, özellikle farmasötik olarak aktif bilesikler olarak kullanim için benzazol türevleri yani sira bu gibi benzazol türevlerini ihtiva eden farmasötik formülasyonlar ile ilgilidir. Bahsedilen benzazol türevler JNK yolunun etkin modülatörleridir ve özellikle JNK2 ve/veya 3'ün etkin ve selektif inhibitörleridir. Mevcut bulus ayrica yeni benzazol türevleri yani sira bunlarin preparasyon metotlari ile ilgilidir. X, O, S, ya da NR , R , H ya da bir doymamis ya da doymus C1-C6 alkil; G, bir doymamis ya da doymus pirimidinil grubudur.
TR2002/01509T 1999-12-24 2000-12-20 Farmasötik olarak aktif benzazol türevleri. TR200201509T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99811207A EP1110957A1 (en) 1999-12-24 1999-12-24 Benzazole derivatives and their use as JNK modulators

Publications (1)

Publication Number Publication Date
TR200201509T2 true TR200201509T2 (tr) 2002-09-23

Family

ID=8243214

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2003/02320T TR200302320T4 (tr) 1999-12-24 2000-12-20 Benzazol türevleri ve bunların jnk modülatörleri olarak kullanımları
TR2002/01509T TR200201509T2 (tr) 1999-12-24 2000-12-20 Farmasötik olarak aktif benzazol türevleri.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2003/02320T TR200302320T4 (tr) 1999-12-24 2000-12-20 Benzazol türevleri ve bunların jnk modülatörleri olarak kullanımları

Country Status (32)

Country Link
US (2) US7259162B2 (tr)
EP (2) EP1110957A1 (tr)
JP (1) JP4782344B2 (tr)
KR (2) KR100736012B1 (tr)
CN (1) CN1252067C (tr)
AR (1) AR029215A1 (tr)
AT (1) ATE254123T1 (tr)
AU (1) AU780241B2 (tr)
BG (1) BG65986B1 (tr)
BR (1) BR0016911A (tr)
CA (1) CA2394809C (tr)
CZ (1) CZ300984B6 (tr)
DE (1) DE60006580T2 (tr)
DK (1) DK1240164T3 (tr)
EA (1) EA007152B1 (tr)
EE (1) EE05456B1 (tr)
ES (1) ES2206351T3 (tr)
HR (1) HRP20020496B1 (tr)
HU (1) HU229625B1 (tr)
IL (2) IL150346A0 (tr)
MX (1) MXPA02006242A (tr)
NO (1) NO323146B1 (tr)
NZ (1) NZ519423A (tr)
PL (1) PL356634A1 (tr)
PT (1) PT1240164E (tr)
RS (1) RS51008B (tr)
SI (1) SI1240164T1 (tr)
SK (1) SK287546B6 (tr)
TR (2) TR200302320T4 (tr)
UA (1) UA73151C2 (tr)
WO (1) WO2001047920A1 (tr)
ZA (1) ZA200204427B (tr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083648A1 (fr) 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
WO2003010164A1 (en) 2001-07-23 2003-02-06 Applied Research Systems Ars Holding N.V. Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
SI1450792T1 (sl) * 2001-12-07 2006-12-31 Applied Research Systems Benzazolni derivati za zdravljenje sklerodermije
DE60318567T2 (de) * 2002-04-25 2009-02-19 Laboratoires Serono S.A., Coinsins Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems
CN1656079A (zh) 2002-05-31 2005-08-17 卫材株式会社 吡唑化合物和含有该化合物的药物组合物
US7465736B2 (en) 2002-06-14 2008-12-16 Laboratoires Serono S.A. Azole methylidene cyanide derivatives and their use as protein kinase modulators
US7582429B2 (en) 2002-10-23 2009-09-01 University Of Utah Research Foundation Amplicon melting analysis with saturation dyes
US7855212B2 (en) 2003-05-08 2010-12-21 Merck Serono Sa Pyridinyl acetonitriles
HRP20070527T3 (en) * 2003-09-12 2007-12-31 Laboratoires Serono Sa Benzothiazole derivatives for the treatment of diabetes
EP1668004A1 (en) * 2003-09-12 2006-06-14 Applied Research Systems ARS Holding N.V. Benzoxazole acetonitriles
WO2005026155A1 (en) * 2003-09-12 2005-03-24 Applied Research Systems Ars Holding N.V. Benzimidazole acetonitriles
JP5080241B2 (ja) * 2004-04-08 2012-11-21 メルク セローノ ソシエテ アノニム Ｊｎｋ阻害剤およびスクロスポリンを含んでなる組成物
US7387887B2 (en) * 2004-04-20 2008-06-17 University Of Utah Research Foundation Nucleic acid melting analysis with saturation dyes
US9657347B2 (en) 2004-04-20 2017-05-23 University of Utah Research Foundation and BioFire Defense, LLC Nucleic acid melting analysis with saturation dyes
US7803824B2 (en) 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
JP5144271B2 (ja) * 2004-11-17 2013-02-13 アレス トレーディング ソシエテ アノニム ベンゾチアゾ−ル製剤、及びそれらの使用
ATE537164T1 (de) 2004-12-21 2011-12-15 Merck Serono Sa Zyklische sulfonylaminoderivate und deren verwendung als mmp-hemmer
ATE516279T1 (de) 2005-01-31 2011-07-15 Merck Serono Sa N-hydroxyamidderivate und ihre verwendung
US20060223807A1 (en) * 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
KR20080044836A (ko) * 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
EP1933860A2 (en) 2005-09-01 2008-06-25 Ares Trading S.A. Treatment of optic neuritis
US9598669B2 (en) 2005-12-29 2017-03-21 Anthrogenesis Corporation Composition for collecting placental stem cells and methods of using the composition
EP2026802A2 (en) * 2006-06-02 2009-02-25 Laboratoires Serono SA Jnk inhibitors for treatment of skin diseases
CN101541522B (zh) * 2006-08-28 2012-07-18 丹塞姆空气调节有限公司 用于制造热交换器的方法
JP2010518812A (ja) 2007-02-12 2010-06-03 アンスロジェネシス コーポレーション 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにｃｄ３４＋、ｃｄ４５−胎盤幹細胞の濃縮細胞集団
WO2010019606A1 (en) * 2008-08-12 2010-02-18 Sirtris Pharmaceuticals, Inc. Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators
KR20110059740A (ko) * 2008-09-29 2011-06-03 텔리크 인코포레이티드 키나아제 억제제로서의 2-[1ｈ-벤즈이미다졸-2(3ｈ)-일리덴]-2-(피리미딘-2-일)아세트아미드 및 2-[벤조티아졸-2(3ｈ)-일리덴]-2-(피리미딘-2-일)아세트아미드
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN102199147A (zh) * 2011-03-19 2011-09-28 陕西合成药业有限公司 用于治疗的硝基咪唑衍生物
DK2714059T3 (en) 2011-06-01 2019-01-21 Celularity Inc TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS
WO2014114186A1 (zh) * 2013-01-24 2014-07-31 山东亨利医药科技有限责任公司 Jnk抑制剂
AU2014368925A1 (en) * 2013-12-20 2016-07-21 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of MEK type I and ERK inhibitors
KR101520378B1 (ko) * 2014-10-02 2015-05-26 (주)에프테크 습식 가스 스크러버의 배기유도장치
BR112017007178A2 (pt) * 2014-10-08 2017-12-19 Ass Francaise Contre Les Myopathies compostos de aminopiridina úteis como inibidores de prenilação de proteína
JP6886165B2 (ja) * 2016-02-15 2021-06-16 国立大学法人山形大学 ガン抑制薬及び抗腫瘍剤、腫瘍再発防止剤、腫瘍発生予防剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918369A (en) * 1956-06-15 1959-12-22 Gen Aniline & Film Corp Non-ionic benzimidazole cyanine dyes containing in alpha-position a cyano group on the methenyl chain
GB864131A (en) * 1957-07-17 1961-03-29 Ciba Ltd Benzimidazolyl-acetic acid derivatives
DE1963542A1 (de) 1969-12-18 1971-06-24 Siemens Ag Koppelfeldanordnung fuer Fernmelde-,insbesondere Fernsprechanlagen
JPS51123223A (en) * 1975-04-21 1976-10-27 Fuji Photo Film Co Ltd Process for producing condensation products
CH593954A5 (tr) 1975-07-21 1977-12-30 Ciba Geigy Ag
US4933341A (en) * 1988-10-08 1990-06-12 Bayer Aktiengesellschaft Substituted 1,3,5-triazinetriones, for use against parasitic protozoa
EP0364765A3 (de) * 1988-10-08 1991-07-17 Bayer Ag Substituierte 1,3,5-Triazintrione, Verfahren zu ihrer Herstellung und ihre Verwendung gegen parasitäre Protozoen
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
US6043083A (en) 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
JP4153574B2 (ja) * 1997-09-10 2008-09-24 トーアエイヨー株式会社 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine

Also Published As

Publication number Publication date
DK1240164T3 (da) 2004-03-01
US7259162B2 (en) 2007-08-21
KR100736012B1 (ko) 2007-07-06
HK1055730A1 (en) 2004-01-21
DE60006580D1 (de) 2003-12-18
PL356634A1 (en) 2004-06-28
EP1240164B1 (en) 2003-11-12
PT1240164E (pt) 2004-02-27
EA200200708A1 (ru) 2003-02-27
JP2003519142A (ja) 2003-06-17
BG65986B1 (bg) 2010-08-31
EA007152B1 (ru) 2006-08-25
HRP20020496A2 (en) 2006-03-31
EP1240164A1 (en) 2002-09-18
SK287546B6 (sk) 2011-01-04
RS51008B (sr) 2010-10-31
US20070259892A1 (en) 2007-11-08
HRP20020496B1 (hr) 2009-03-31
US7470686B2 (en) 2008-12-30
IL150346A0 (en) 2002-12-01
HUP0204557A3 (en) 2009-03-30
CZ300984B6 (cs) 2009-09-30
CZ20022169A3 (cs) 2002-09-11
IL150346A (en) 2010-12-30
HU229625B1 (hu) 2014-03-28
AU3161601A (en) 2001-07-09
HUP0204557A2 (en) 2003-05-28
ZA200204427B (en) 2004-02-03
EE200200318A (et) 2003-10-15
SI1240164T1 (en) 2004-04-30
TR200302320T4 (tr) 2004-01-21
EP1110957A1 (en) 2001-06-27
AU780241B2 (en) 2005-03-10
UA73151C2 (en) 2005-06-15
BR0016911A (pt) 2002-10-22
KR20020072282A (ko) 2002-09-14
SK8982002A3 (en) 2002-10-08
NZ519423A (en) 2004-04-30
JP4782344B2 (ja) 2011-09-28
AR029215A1 (es) 2003-06-18
CN1433414A (zh) 2003-07-30
US20030162794A1 (en) 2003-08-28
CA2394809A1 (en) 2001-07-05
CN1252067C (zh) 2006-04-19
NO20022997D0 (no) 2002-06-21
EE05456B1 (et) 2011-08-15
MXPA02006242A (es) 2003-01-28
ES2206351T3 (es) 2004-05-16
NO323146B1 (no) 2007-01-08
NO20022997L (no) 2002-06-21
CA2394809C (en) 2011-03-15
DE60006580T2 (de) 2004-09-16
BG106830A (bg) 2003-02-28
ATE254123T1 (de) 2003-11-15
KR20070047853A (ko) 2007-05-07
YU49202A (sh) 2006-01-16
WO2001047920A1 (en) 2001-07-05

Similar Documents

Publication Publication Date Title
TR200302320T4 (tr) Benzazol türevleri ve bunların jnk modülatörleri olarak kullanımları
IL149163A0 (en) Piperazine derivatives of carbazole, their preparation and pharmaceutical compositions containing them
YU40701A (sh) Piperidini kao modulatori ccr5
DE60041973D1 (de) Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität
AR018175A1 (es) Compuestos de indol-3-glioxilamidas sustituidas, utiles como medicamentos antitumorales, composiciones farmaceuticas formuladas con dichos derivados,utilizacion de dichos derivados para la preparacion de medicamentos antitumorales y los medicamentos asi preparados.
PT1263725E (pt) Novos compostos
TR199800436A2 (tr) Primidin türevlerinin kanserin önlenmesi için kullanilmasi.
BR0008770A (pt) Derivado de pirimidina, processo para a preparação de um derivado de pirimidina, processo para a produção de um efeito anti-câncer em um animal de sangue quente, uso de um derivado de pirimidina, e, composição farmacêutica
TR199900920T2 (tr) Nafthiridin türevleri.
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
AR017796A1 (es) DERIVADOS DE 2-ARIL-8-OXODIHIDROPURINA, PROCEDIMIENTOS PARA PREPARARLOS, COMPUESTOS INTERMEDIARIOS DE APLICACIoN EN DICHOS PROCEDIMIENTOS, COMPOSICIONES FARMACEUTICAS, Y SU USO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ESTADOS DE ANSIEDAD.
EE200100491A (et) Tetrahüdropüraani derivaadid, nende saamine ja kasutamine ravimainetena ning neid sisaldav farmatseutiline kompositsioon
PT1263730E (pt) Derivados amina para o tratamento de apoptose
TR199902995T2 (tr) 9-Oksim eritromisin türevleri
RU94036448A (ru) Производные галантамина и фармацевтическая композиция
TR200103395T2 (tr) 13-metil eritromisin türevleri.
BG100069A (bg) Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
ATE242246T1 (de) (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel
BRPI0017528B8 (pt) uso de uma composição contendo sal de cetotifeno
NO971625L (no) Nye peptider med immunomodulatoriske effekter
DE69825626D1 (de) Heterozyklische cytotoxische wirkstoffe
DE60208694D1 (de) Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors
AP9801377A0 (en) Tricyclic erythromycin derivatives.
TR200200485T2 (tr) Yeni A-500359 türevleri.
ATE285771T1 (de) Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung