ES2183884T3 - Compuestos de imidazolilo sustituidos en 4,5 para el tratamiento de la inflamacion. - Google Patents

Compuestos de imidazolilo sustituidos en 4,5 para el tratamiento de la inflamacion.

Info

Publication number
ES2183884T3
ES2183884T3 ES95929327T ES95929327T ES2183884T3 ES 2183884 T3 ES2183884 T3 ES 2183884T3 ES 95929327 T ES95929327 T ES 95929327T ES 95929327 T ES95929327 T ES 95929327T ES 2183884 T3 ES2183884 T3 ES 2183884T3
Authority
ES
Spain
Prior art keywords
low
bajo
sup
rent
inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95929327T
Other languages
English (en)
Inventor
Richard M Weier
Paul W Collins
Michael A Stealey
Thomas E Barta
Renee M Huff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2183884(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2183884T3 publication Critical patent/ES2183884T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UNA CLASE DE COMPUESTOS PARA EL TRATAMIENTO DE INFLAMACION Y TRASTORNOS RELACIONADOS CON INFLAMACION. SE DEFINEN COMPUESTOS DE INTERES PARTICULAR POR LA FORMULA (I), EN DONDE R{SUP,1} SE SELECCIONA DE ALQUILO BAJO, HALOALQUILO BAJO, HIDROXIALQUILO BAJO, ALCOXIALQUILO BAJO, ALQUENILOXIALQUILO BAJO, MERCAPTO, ALQUILCARBONILO BAJO, HALOALQUILCARBONILO BAJO, FENILCARBONILO, ARALQUILCARBONILO BAJO, ARALQUENILO BAJO, ARILOXIALQUILO BAJO, ARALQUILOXIALQUILO BAJO, ARILSULFONILO BAJO, ARALQUILOSULFONILO BAJO, ARILTIOALQUILO BAJO, HETEROARILALQUILTIOALQUILO BAJO, Y HETEROARILO SELECCIONADO DE 2-TIENILO, 2-FURILO, 3-FURILO, 2-PIRIDILO, 4-PIRIDILO, 2BENZOFURILO; EN DONDE R{SUP,2} Y R{SUP,3} SE SELECCIONAN INDEPENDIENTEMENTE DE HETEROARILO, CICLOALQUILO Y ARILO, EN DONDE LOS RADICALES DE HETEROARILO, CICLOALQUILO Y ARILO SE SUSTITUYEN EN UNA POSICION SUSTITUIBLE CON UNO O MAS RADICALES SELECCIONADOS DE HIDRIDO, HALO, ALQUILTIO BAJO, ALQUILSULFINILO BAJO, ALQUILSULFONILO BAJO, AMINOSULFONILO,ALQUILO BAJO, CIANO, CARBOXILO, ALCOXICARBONILO BAJO, HALOALQUILO BAJO, HIDROXILO, ALCOXI BAJO, HIDROXIALQUILO BAJO, ALCOXIALQUILO BAJO, HALOALCOXI BAJO, AMINO, ALQUILAMINA BAJO, FENILAMINA Y NITRO; Y EN DONDE R{SUP,4} SE SELECCIONA DE HIDRIDO, ALQUILO BAJO Y ACILO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS.
ES95929327T 1994-07-28 1995-07-27 Compuestos de imidazolilo sustituidos en 4,5 para el tratamiento de la inflamacion. Expired - Lifetime ES2183884T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/281,903 US5620999A (en) 1994-07-28 1994-07-28 Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation

Publications (1)

Publication Number Publication Date
ES2183884T3 true ES2183884T3 (es) 2003-04-01

Family

ID=23079256

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95929327T Expired - Lifetime ES2183884T3 (es) 1994-07-28 1995-07-27 Compuestos de imidazolilo sustituidos en 4,5 para el tratamiento de la inflamacion.

Country Status (10)

Country Link
US (1) US5620999A (es)
EP (2) EP1211244A3 (es)
AT (1) ATE224375T1 (es)
AU (1) AU3271695A (es)
CA (1) CA2195846A1 (es)
DE (1) DE69528274T2 (es)
DK (1) DK0772601T3 (es)
ES (1) ES2183884T3 (es)
PT (1) PT772601E (es)
WO (1) WO1996003387A1 (es)

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EP1211244A2 (en) 2002-06-05
DE69528274D1 (de) 2002-10-24
PT772601E (pt) 2003-02-28
DK0772601T3 (da) 2003-01-27
AU3271695A (en) 1996-02-22
CA2195846A1 (en) 1996-02-08
US5620999A (en) 1997-04-15
DE69528274T2 (de) 2003-08-14
EP0772601A1 (en) 1997-05-14
ATE224375T1 (de) 2002-10-15
WO1996003387A1 (en) 1996-02-08
EP0772601B1 (en) 2002-09-18

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