ES2183908T3 - Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros. - Google Patents

Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros.

Info

Publication number
ES2183908T3
ES2183908T3 ES96202829T ES96202829T ES2183908T3 ES 2183908 T3 ES2183908 T3 ES 2183908T3 ES 96202829 T ES96202829 T ES 96202829T ES 96202829 T ES96202829 T ES 96202829T ES 2183908 T3 ES2183908 T3 ES 2183908T3
Authority
ES
Spain
Prior art keywords
acid
addition salt
composition
imidazolil
enantiomerically pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96202829T
Other languages
English (en)
Inventor
Der Meij Paulus Franciscus Van
Jan-Maarten Verbeek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2183908T3 publication Critical patent/ES2183908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA LA PREPARACION DE UNA COMPOSICION DE IMIDAZOLILO ENANTIOMERICAMENTE PURO DE LA FORMULA GENERAL EN DONDE: N ES 0 O 1; M ES 1 O 2; R{SUB,1} ES NITROGENO, METILO O ETILO; Y C{SUP,*} DENOTA UN CENTRO QUIRAL; ASI COMO SU SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE; MEDIANTE A) AÑADIR UN ACIDO CARBOXILICO EN FORMA OPTICAMENTE ACTIVA A UNA SOLUCION DE UNA MEZCLA RACEMICA DE LA COMPOSICION I DE MAS ARRIBA, SEGUIDA DE LA SEPARACION DE LA SAL DE ADICION ACIDA CRISTALIZADA DE DICHA MEZCLA DE ENANTIOMEROS DE LA COMPOSICION I ENRIQUECIDA EN UN ENANTIOMERO, DESDE EL LICOR MADRE ENRIQUECIDO EN EL OTRO ENANTIOMERO B) CUANDO LA SAL DE ADICION ACIDA CRISTALIZADA ESTA ENRIQUECIDA EN EL ENANTIOMERO NO DESEADO, SEPARAR ENTONCES LA MEZCLA DE ENANTIOMEROS DEL LICOR MADRE DE DICHO ACIDO CARBOXILICO OPTICAMENTE ACTIVO, SEGUIDO DE LA ADICION DE UNA MEZCLA RACEMICA DE DICHO ACIDO CARBOXILICO A UNA SOLUCION DE LA MEZCLA OBTENIDA DE ISOMEROS DE I, Y LA SEPARACION DE LA SAL DE ADICION ACIDA CRISTALIZADA DE DICHA MEZCLA, ENRIQUECIDA EN EL ENANTIOMERO DESEADO, DESDE EL LICOR MADRE, Y (C) OPCIONALMENTE VOLVER A CRISTALIZAR EL PRODUCTO HASTA OBTENER LA PUREZA ENANTIOMERICA DESEADA, Y A CONTINUACION (D) CONVERTIR ESTA SAL DE ADICION ACIDA DEL ENANTIOMERO DESEADO EN LA COMPOSICION DE IMIDAZOLILO ENANTIOMERICAMENTE PURO DESEADA DE LA FORMULA GENERAL I O EN SU SAL DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE, CARACTERIZADO EN QUE SE UTILIZA ACIDO PIROGLUTAMICO COMO DICHO ACIDO CARBOXILICO. LA INVENCION SE REFIERE ADEMAS A UN METODO DE RACEMIZACION Y A UNA NUEVA SAL DE ADICION ACIDA DE ESTA COMPOSICION DE FORMULA I Y ACIDO D-PIROGLUTAMICO.
ES96202829T 1995-10-13 1996-10-10 Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros. Expired - Lifetime ES2183908T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95202765 1995-10-13

Publications (1)

Publication Number Publication Date
ES2183908T3 true ES2183908T3 (es) 2003-04-01

Family

ID=8220714

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96202829T Expired - Lifetime ES2183908T3 (es) 1995-10-13 1996-10-10 Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros.

Country Status (24)

Country Link
US (1) US5663343A (es)
EP (1) EP0768309B1 (es)
JP (2) JP4590038B2 (es)
KR (1) KR100459745B1 (es)
CN (1) CN1060774C (es)
AT (1) ATE224896T1 (es)
AU (1) AU702594B2 (es)
CA (1) CA2187484C (es)
CZ (1) CZ288042B6 (es)
DE (1) DE69623900T2 (es)
DK (1) DK0768309T3 (es)
DZ (1) DZ2104A1 (es)
ES (1) ES2183908T3 (es)
HK (1) HK1000446A1 (es)
HU (1) HU226620B1 (es)
IL (1) IL119400A (es)
NO (1) NO307257B1 (es)
NZ (1) NZ299562A (es)
PT (1) PT768309E (es)
RU (1) RU2162085C2 (es)
SK (1) SK283471B6 (es)
TW (1) TW513423B (es)
UA (1) UA48947C2 (es)
ZA (1) ZA968525B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19813661A1 (de) * 1997-08-01 1999-02-04 Solvay Pharm Gmbh Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
RU2213562C2 (ru) * 2001-03-14 2003-10-10 Научно-исследовательский институт фармакологии РАМН Лекарственная композиция
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
US7015333B2 (en) * 2002-11-18 2006-03-21 Solvay Pharmaceuticals B.V. Process for preparation of imidazolyl compounds
EP1424337A1 (en) * 2002-11-26 2004-06-02 Solvay Pharmaceuticals GmbH 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one
ES2285407T3 (es) * 2003-01-13 2007-11-16 Dynogen Pharmaceuticals Inc. Metodo para el tratamiento de nauseas, vomitos, arcadas o cualquiera de sus combinaciones.
KR20050111318A (ko) * 2003-01-13 2005-11-24 다이노젠 파마세우티컬스, 인코포레이티드 기능성 장 질환을 치료하는 방법
CA2519379A1 (en) * 2003-04-04 2004-10-21 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
JP5156222B2 (ja) * 2006-11-28 2013-03-06 エムキュア ファーマシューティカルズ リミテッド 制吐作用化合物の新たな製造方法
GB0910373D0 (en) * 2009-06-16 2009-07-29 Filtrona Int Ltd Tabacco smoke filter
US9806720B1 (en) * 2016-10-07 2017-10-31 Analog Devices Global Compound semiconductor based inverter
WO2019222565A1 (en) 2018-05-18 2019-11-21 Kura Oncology, Inc. Synthesis of tipifarnib

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413843A (nl) * 1974-10-23 1976-04-27 Stamicarbon Optische scheiding van fenylglycine-amide.
US4463176A (en) * 1982-09-13 1984-07-31 Mead Johnson & Company Process for resolution of optical isomers
US4849527A (en) * 1982-09-13 1989-07-18 Bristol-Myers Company Process for resolution of optical isomers
PH22672A (en) * 1984-01-25 1988-11-14 Glaxo Group Ltd Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof
DE3885357T2 (de) * 1987-06-29 1994-03-24 Duphar Int Res Anellierte Indolderivate.
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent
DE4238553A1 (de) * 1992-11-14 1994-05-19 Kali Chemie Pharma Gmbh Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel
RU2041876C1 (ru) * 1993-12-29 1995-08-20 Научно-производственный центр "Фармзащита" Способ получения 1,2,3,9- тетрагидро-9-метил-3- [(2-метил-1н- имидазол-1-ил) метил]-4н- карбазол-4-она или его солей, или их гидратов, и промежуточные продукты для их синтеза

Also Published As

Publication number Publication date
DZ2104A1 (fr) 2002-07-22
JPH09183779A (ja) 1997-07-15
TW513423B (en) 2002-12-11
US5663343A (en) 1997-09-02
PT768309E (pt) 2003-02-28
DE69623900T2 (de) 2003-07-31
HU9602778D0 (en) 1996-11-28
KR100459745B1 (ko) 2005-01-26
EP0768309A1 (en) 1997-04-16
CZ294796A3 (en) 1997-05-14
HU226620B1 (en) 2009-04-28
CZ288042B6 (cs) 2001-04-11
JP2010159292A (ja) 2010-07-22
HUP9602778A3 (en) 1997-08-28
ZA968525B (en) 1997-05-20
ATE224896T1 (de) 2002-10-15
CA2187484A1 (en) 1997-04-14
JP4590038B2 (ja) 2010-12-01
NO964282D0 (no) 1996-10-09
NO964282L (no) 1997-04-14
AU6585696A (en) 1997-04-17
AU702594B2 (en) 1999-02-25
EP0768309B1 (en) 2002-09-25
SK283471B6 (sk) 2003-08-05
CA2187484C (en) 2006-09-05
IL119400A (en) 2000-02-29
IL119400A0 (en) 1997-01-10
UA48947C2 (uk) 2002-09-16
SK128796A3 (en) 1997-05-07
NO307257B1 (no) 2000-03-06
HUP9602778A2 (en) 1997-05-28
CN1060774C (zh) 2001-01-17
HK1000446A1 (en) 2003-01-10
KR970021080A (ko) 1997-05-28
RU2162085C2 (ru) 2001-01-20
DE69623900D1 (de) 2002-10-31
NZ299562A (en) 1997-09-22
DK0768309T3 (da) 2002-12-09
CN1160053A (zh) 1997-09-24

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