ATE224896T1 - Verfahren zur herstellung von enantiomerisch reinen imidazol-verbindungen - Google Patents

Verfahren zur herstellung von enantiomerisch reinen imidazol-verbindungen

Info

Publication number: ATE224896T1
Authority: AT; Austria
Prior art keywords: addition salt; acid; mixture; enantiomer; compound
Prior art date: 1995-10-13

Application number

AT96202829T

Other languages

English (en)

Inventor

Der Meij Paulus Franciscus Van

Jan-Maarten Verbeek

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-10

Publication date

2002-10-15

1996-10-10 Application filed by Duphar Int Res filed Critical Duphar Int Res

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE224896T1 publication Critical patent/ATE224896T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 7
239000002253 acid Substances 0.000 abstract 6
239000000203 mixture Substances 0.000 abstract 6
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
239000012452 mother liquor Substances 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 abstract 2
-1 imidazolyl compound Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000000926 separation method Methods 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT96202829T 1995-10-13 1996-10-10 Verfahren zur herstellung von enantiomerisch reinen imidazol-verbindungen ATE224896T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95202765		1995-10-13

Publications (1)

Publication Number	Publication Date
ATE224896T1 true ATE224896T1 (de)	2002-10-15

Family

ID=8220714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96202829T ATE224896T1 (de)	1995-10-13	1996-10-10	Verfahren zur herstellung von enantiomerisch reinen imidazol-verbindungen

Country Status (23)

Country	Link
US (1)	US5663343A (de)
EP (1)	EP0768309B1 (de)
JP (2)	JP4590038B2 (de)
KR (1)	KR100459745B1 (de)
CN (1)	CN1060774C (de)
AT (1)	ATE224896T1 (de)
AU (1)	AU702594B2 (de)
CA (1)	CA2187484C (de)
CZ (1)	CZ288042B6 (de)
DE (1)	DE69623900T2 (de)
DK (1)	DK0768309T3 (de)
DZ (1)	DZ2104A1 (de)
ES (1)	ES2183908T3 (de)
HU (1)	HU226620B1 (de)
IL (1)	IL119400A (de)
NO (1)	NO307257B1 (de)
NZ (1)	NZ299562A (de)
PT (1)	PT768309E (de)
RU (1)	RU2162085C2 (de)
SK (1)	SK283471B6 (de)
TW (1)	TW513423B (de)
UA (1)	UA48947C2 (de)
ZA (1)	ZA968525B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19813661A1 (de) *	1997-08-01	1999-02-04	Solvay Pharm Gmbh	Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron
US6372919B1 (en) *	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
RU2213562C2 (ru) *	2001-03-14	2003-10-10	Научно-исследовательский институт фармакологии РАМН	Лекарственная композиция
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US7015333B2 (en) *	2002-11-18	2006-03-21	Solvay Pharmaceuticals B.V.	Process for preparation of imidazolyl compounds
EP1424337A1 (de) *	2002-11-26	2004-06-02	Solvay Pharmaceuticals GmbH	4-Hydroxyderivate von 5,6,9,10-Tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-on
AU2004204827B2 (en) *	2003-01-13	2006-06-29	Dynogen Pharmaceuticals, Inc.	Method of treating nausea, vomiting, retching or any combination thereof
BRPI0406749A (pt) *	2003-01-13	2005-12-20	Dynogen Pharmaceuticals Inc	Métodos relacionados ao tratamento de distúrbios fincionais do intestino e composição farmacêutica
ATE365554T1 (de) *	2003-04-04	2007-07-15	Dynogen Pharmaceuticals Inc	Methode zur behandlung von erkrankungen der unteren harnwege
CA2575975A1 (en) *	2003-11-12	2005-05-26	Dr. Reddy's Laboratories, Inc.	Preparation of escitalopram
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
US20080045725A1 (en)	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US7662831B2 (en)	2006-07-27	2010-02-16	Wyeth Llc	Tetracyclic indoles as potassium channel modulators
US7601856B2 (en)	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
JP5156222B2 (ja) *	2006-11-28	2013-03-06	エムキュアファーマシューティカルズリミテッド	制吐作用化合物の新たな製造方法
GB0910373D0 (en) *	2009-06-16	2009-07-29	Filtrona Int Ltd	Tabacco smoke filter
US9806720B1 (en) *	2016-10-07	2017-10-31	Analog Devices Global	Compound semiconductor based inverter
EP3793966A1 (de) *	2018-05-18	2021-03-24	Kura Oncology, Inc.	Synthese von tipifarnib

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7413843A (nl) *	1974-10-23	1976-04-27	Stamicarbon	Optische scheiding van fenylglycine-amide.
US4849527A (en) *	1982-09-13	1989-07-18	Bristol-Myers Company	Process for resolution of optical isomers
US4463176A (en) *	1982-09-13	1984-07-31	Mead Johnson & Company	Process for resolution of optical isomers
HU193592B (en) *	1984-01-25	1987-11-30	Glaxo Group Ltd	Process for producing tetrahydro-carbazolone derivatives
ES2059491T3 (es) *	1987-06-29	1994-11-16	Duphar Int Res	Derivados de indol con anillos condensados.
GB8812636D0 (en) *	1988-05-27	1988-06-29	Glaxo Group Ltd	Chemical compounds
US5049563A (en) *	1988-07-07	1991-09-17	Duphar International Research B.V.	Annelated indoleketones with an imidazolylalkyl substituent
DE4238553A1 (de) *	1992-11-14	1994-05-19	Kali Chemie Pharma Gmbh	Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel
RU2041876C1 (ru) *	1993-12-29	1995-08-20	Научно-производственный центр "Фармзащита"	Способ получения 1,2,3,9- тетрагидро-9-метил-3- [(2-метил-1н- имидазол-1-ил) метил]-4н- карбазол-4-она или его солей, или их гидратов, и промежуточные продукты для их синтеза

1996
- 1996-09-26 AU AU65856/96A patent/AU702594B2/en not_active Ceased
- 1996-10-03 TW TW085112098A patent/TW513423B/zh not_active IP Right Cessation
- 1996-10-08 CZ CZ19962947A patent/CZ288042B6/cs not_active IP Right Cessation
- 1996-10-08 JP JP28461296A patent/JP4590038B2/ja not_active Expired - Fee Related
- 1996-10-08 SK SK1287-96A patent/SK283471B6/sk not_active IP Right Cessation
- 1996-10-09 NO NO964282A patent/NO307257B1/no not_active IP Right Cessation
- 1996-10-09 HU HU9602778A patent/HU226620B1/hu not_active IP Right Cessation
- 1996-10-09 ZA ZA968525A patent/ZA968525B/xx unknown
- 1996-10-09 CA CA002187484A patent/CA2187484C/en not_active Expired - Fee Related
- 1996-10-09 DZ DZ960148A patent/DZ2104A1/fr active
- 1996-10-09 RU RU96120366/04A patent/RU2162085C2/ru not_active IP Right Cessation
- 1996-10-10 AT AT96202829T patent/ATE224896T1/de active
- 1996-10-10 PT PT96202829T patent/PT768309E/pt unknown
- 1996-10-10 DE DE69623900T patent/DE69623900T2/de not_active Expired - Lifetime
- 1996-10-10 ES ES96202829T patent/ES2183908T3/es not_active Expired - Lifetime
- 1996-10-10 CN CN96122637A patent/CN1060774C/zh not_active Expired - Fee Related
- 1996-10-10 UA UA96103876A patent/UA48947C2/uk unknown
- 1996-10-10 EP EP96202829A patent/EP0768309B1/de not_active Expired - Lifetime
- 1996-10-10 IL IL11940096A patent/IL119400A/xx not_active IP Right Cessation
- 1996-10-10 DK DK96202829T patent/DK0768309T3/da active
- 1996-10-10 KR KR1019960044972A patent/KR100459745B1/ko not_active Expired - Fee Related
- 1996-10-10 US US08/728,794 patent/US5663343A/en not_active Expired - Lifetime
- 1996-10-11 NZ NZ299562A patent/NZ299562A/en not_active IP Right Cessation
2010
- 2010-04-15 JP JP2010094211A patent/JP2010159292A/ja active Pending

Also Published As

Publication number	Publication date
JP4590038B2 (ja)	2010-12-01
ES2183908T3 (es)	2003-04-01
JPH09183779A (ja)	1997-07-15
IL119400A (en)	2000-02-29
UA48947C2 (uk)	2002-09-16
CN1060774C (zh)	2001-01-17
HU9602778D0 (en)	1996-11-28
HU226620B1 (en)	2009-04-28
CZ294796A3 (en)	1997-05-14
HUP9602778A3 (en)	1997-08-28
ZA968525B (en)	1997-05-20
SK283471B6 (sk)	2003-08-05
RU2162085C2 (ru)	2001-01-20
AU6585696A (en)	1997-04-17
KR100459745B1 (ko)	2005-01-26
TW513423B (en)	2002-12-11
DE69623900D1 (de)	2002-10-31
CA2187484A1 (en)	1997-04-14
DZ2104A1 (fr)	2002-07-22
KR970021080A (ko)	1997-05-28
EP0768309B1 (de)	2002-09-25
PT768309E (pt)	2003-02-28
NO964282L (no)	1997-04-14
CA2187484C (en)	2006-09-05
CZ288042B6 (cs)	2001-04-11
IL119400A0 (en)	1997-01-10
AU702594B2 (en)	1999-02-25
EP0768309A1 (de)	1997-04-16
SK128796A3 (en)	1997-05-07
CN1160053A (zh)	1997-09-24
HK1000446A1 (en)	2003-01-10
NO964282D0 (no)	1996-10-09
NO307257B1 (no)	2000-03-06
DK0768309T3 (da)	2002-12-09
DE69623900T2 (de)	2003-07-31
NZ299562A (en)	1997-09-22
HUP9602778A2 (en)	1997-05-28
US5663343A (en)	1997-09-02
JP2010159292A (ja)	2010-07-22

Legal Events

Date	Code	Title	Description
2005-10-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
DE69623900D1 (de)	2002-10-31	Verfahren zur Herstellung von enantiomerisch reinen Imidazol-Verbindungen
US5281722A (en)	1994-01-25	Preparation and use of salts of the pure enantiomers of alpha-lipoic acid
RU96120366A (ru)	1998-12-27	Способ получения энантиомерно чистых соединений имидазолила, энантиомерно чистая кислая аддитивная соль имидазолила и в-пироглутаминовой кислоты
JP4015696B2 (ja)	2007-11-28	レボブピバカインと同類のピペリジンカルボキサニリド麻酔剤の製造に用いるラセミ化法
JPH10507464A (ja)	1998-07-21	レボブピバカインとその類似体の晶出
JP2009108079A (ja)	2009-05-21	エナンチオマーに富むｎ−アシルアゼチジン−２−カルボン酸の製造方法
EP0220435B1 (de)	1990-11-14	Verfahren zur Herstellung optisch aktiver Halbester
ATE118476T1 (de)	1995-03-15	Verfahren zur herstellung von l-carnitin aus d,l- carnitinnitrilsalzen.
SK140898A3 (en)	1999-05-07	Improved process for the production of enantiomerically-pure azetidine-2-carboxylic acid
KR940002220A (ko)	1994-02-16	광학활성 메티오닌아미드를 제조하는 방법
JPS6323824A (ja)	1988-02-01	酸性α−水素を有するアミンの光学分割およびラセミ化方法
JPH10506384A (ja)	1998-06-23	二環式ラクタム鏡像体の分離法
Schjelderup et al.	1986	The absolute configuration of oxyphencyclimine, a parasympatholytic drug. Syntheses of both enantiomers
US4584313A (en)	1986-04-22	(Substituted-phenyl)-5-oxo-2-pyrrolidinepropanoic acids and esters thereof, and use for reversing electroconvulsive shock-induced amnesia
HU205594B (en)	1992-05-28	Process for producing optical isomeres of cyclopropane-carboxylic acids5
ATE212615T1 (de)	2002-02-15	Verfahren zur herstellung von (1s,2r)-1-amino-2- indanol-(r,r)-tartrate methanol solvat
DK0556909T3 (da)	1998-08-24	Fremgangsmåde til fremstilling af (R) - og (S) - 1,2-isopropylildenglycol
WO1990002118A1 (en)	1990-03-08	Derivatives and precursors of captopril and its analogues
RU96118236A (ru)	1998-12-27	8-галоген-6-гидроксиоктановые кислоты, их эфиры, соли, способы их получения и применение
WO1990002732A1 (en)	1990-03-22	Methods for preparing captopril and its analogues
DE59606235D1 (de)	2001-01-25	Synthese von optisch aktivem aminoindanol