ES2184367T3 - Derivados de sulfonamida y procedimiento para su preparacion. - Google Patents

Derivados de sulfonamida y procedimiento para su preparacion.

Info

Publication number
ES2184367T3
ES2184367T3 ES99110998T ES99110998T ES2184367T3 ES 2184367 T3 ES2184367 T3 ES 2184367T3 ES 99110998 T ES99110998 T ES 99110998T ES 99110998 T ES99110998 T ES 99110998T ES 2184367 T3 ES2184367 T3 ES 2184367T3
Authority
ES
Spain
Prior art keywords
replaced
rented
substitute
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99110998T
Other languages
English (en)
Inventor
Koichiro Yamada
Kosuke Yasuda
Kohei Kikkawa
Rikako Kohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7116213A external-priority patent/JP3013752B2/ja
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2184367T3 publication Critical patent/ES2184367T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE SULFONAMIDA DE FORMULA [I]: DONDE EL ANILLO A Y EL ANILLO B SON HIDROCARBURO MONOCICLICO, BICICLICO O TRICICLICO, SUSTITUIDO O SIN SUSTITUIR, O UN GRUPO HETEROCICLICO SUSTITUIDO O SIN SUSTITUIR; Q ES UN ENLACE SENCILLO, - O -, - S -, - SO -, - SO 2 - O - CH 2 -; Y ES - O -, - S - O - NH -; ALK ES ALQUILENO O ALQ UENILENO INFERIOR; Z ES - O - O - NH -; R ES ARILO O GRUPO HETEROCICLOCO AROMATICO SUSTITUIDO O SIN SUSTITUIR; R 1 ES H, TRIFLUOROMETILO, AMINO SUSTITUIDO O SIN SUSTITUIR, ALQUILO INFERIOR SUSTITUIDO O SIN SUSTITUIR, ALQUENILO, ALQUINILO, ALQUILTIO INFERIOR SUSTITUIDO O SIN SUSTITUIR, ALCOXI, ARILO O UN GRUPO HETEROCICLICO SUSTITUIDO O SIN SUSTITUIR, O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS DERIVADOS. LOS DERIVADOS DESCRITOS SON UTILES EN EL TRATAMIENTO O PROFILAXIS DE ALTERACIONES ASOCIADAS CON LAS ACTIVIDADES DE LA ENDOTELINA, COMO LA HIPERTENSION, HIPERTENSION PULMONAR, HIPERTENSION RENAL, ENFERMEDAD DE RINAUD, ASMA BRONQUIAL, ULCERA GASTRICA, INSUFICIENCIA CARDIACA CRONICA, ETC.
ES99110998T 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion. Expired - Lifetime ES2184367T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7116213A JP3013752B2 (ja) 1995-05-16 1995-05-16 スルホンアミド誘導体
JP14987295 1995-06-16

Publications (1)

Publication Number Publication Date
ES2184367T3 true ES2184367T3 (es) 2003-04-01

Family

ID=26454593

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99110998T Expired - Lifetime ES2184367T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.
ES96107694T Expired - Lifetime ES2163548T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES96107694T Expired - Lifetime ES2163548T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Country Status (13)

Country Link
US (1) US5739333A (es)
EP (3) EP0959073A1 (es)
KR (1) KR100411358B1 (es)
CN (1) CN1100043C (es)
AT (2) ATE224879T1 (es)
CA (1) CA2176776A1 (es)
DE (2) DE69624010T2 (es)
DK (2) DK0743307T3 (es)
ES (2) ES2184367T3 (es)
GR (1) GR3036611T3 (es)
MX (2) MX9601837A (es)
PT (2) PT743307E (es)
TW (1) TW350839B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6417185B1 (en) 1998-06-19 2002-07-09 Chiron Corporation Inhibitors of glycogen synthase kinase 3
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
ES2295048T3 (es) * 1999-09-03 2008-04-16 Actelion Pharmaceuticals Ltd. Bis-sulfonamidas.
US6720322B2 (en) 1999-12-22 2004-04-13 Actelion Pharamceuticals Ltd. Butyne diol derivatives
CA2389479A1 (en) * 1999-12-22 2001-06-28 Christoph Boss Butyne diol derivatives
DE60025803T2 (de) * 2000-01-25 2006-11-02 F. Hoffmann-La Roche Ag Herstellung von sulfonamiden
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
HUP0300649A3 (en) * 2000-06-13 2003-10-28 Basf Ag Fungicidal 5-phenyl substituted 2-(cyanoamino)pyrimidines, preparation and use thereof
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
NZ524172A (en) 2000-09-25 2004-09-24 Actelion Pharmaceuticals Ltd Arylalkane-sulfonamides useful as endothelin receptor antagonists
WO2002053557A1 (en) * 2000-12-18 2002-07-11 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
CN100488952C (zh) * 2001-03-15 2009-05-20 巴斯福股份公司 5-苯基嘧啶、其制备方法和中间体产物及其在防治有害真菌中的用途
US7323465B2 (en) * 2002-01-02 2008-01-29 Actelion Pharmaceuticals Ltd. Alkansulfonamides as endothelin antagonists
EP2399903A1 (en) 2002-05-24 2011-12-28 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
EP1569914B1 (en) 2002-12-02 2009-02-18 Actelion Pharmaceuticals Ltd. Pyrimidine-sulfamides and their use as endothelian receptor antagonist
ES2391636T3 (es) 2004-03-05 2012-11-28 F. Hoffmann-La Roche Ag Diaminopirimidinas como antagonistas de P2X3 y P2X2/3
DE102004044829A1 (de) * 2004-09-16 2006-04-06 Bayer Cropscience Ag 5-Heterocyclylpyrimidine
TW200628467A (en) 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
WO2007025901A1 (en) 2005-09-01 2007-03-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
ES2612890T3 (es) 2005-09-01 2017-05-19 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
JP4850912B2 (ja) 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ３ｘ２／３モジュレーターとしてのジアミノピリミジン
US20100022568A1 (en) * 2006-04-13 2010-01-28 Actelion Pharmaceeuticals Ltd. Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
WO2009004374A1 (en) * 2007-06-29 2009-01-08 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
JP2011500780A (ja) * 2007-10-24 2011-01-06 ジェネリクス・（ユーケー）・リミテッド 新規結晶形
EP2072503B1 (en) * 2007-12-18 2011-10-26 Dipharma Francis S.r.l. Process for the preparation of bosentan
US8785461B2 (en) * 2008-02-08 2014-07-22 Generics [Uk] Limited Process for preparing bosentan
WO2009112954A2 (en) * 2008-03-13 2009-09-17 Actavis Group Ptc Ehf Processes for the preparation of bosentan and related compounds using novel intermediates
EP2350028A1 (en) 2008-11-03 2011-08-03 Generics [UK] Limited Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
WO2012056468A1 (en) * 2010-10-13 2012-05-03 Matrix Laboratories Ltd A process for the preparation of bosentan
CN104892528A (zh) * 2014-12-10 2015-09-09 上海工程技术大学 一种2-硫代巴比妥酸衍生物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545944A1 (de) * 1964-06-19 1969-12-11 Hoffmann La Roche Verfahren zur Herstellung von neuen Sulfonamiden der Pyrimidinreihe
ATE20064T1 (de) * 1982-07-22 1986-06-15 Pfizer Anti-ischaemische und antihypertensive dihydropyridin-derivate.
KR920009574B1 (ko) * 1990-02-02 1992-10-19 재단법인 한국화학연구소 페닐아세트아미드 유도체 및 그의 제조방법
TW270116B (es) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
WO1998000288A1 (en) * 1996-06-28 1998-01-08 Ranpak Corp. Cushioning conversion machine

Also Published As

Publication number Publication date
DE69615085D1 (de) 2001-10-18
CN1100043C (zh) 2003-01-29
DE69624010T2 (de) 2003-05-22
CA2176776A1 (en) 1996-11-17
GR3036611T3 (en) 2001-12-31
ES2163548T3 (es) 2002-02-01
MXPA00011111A (es) 2003-04-25
ATE224879T1 (de) 2002-10-15
DK0743307T3 (da) 2001-11-26
US5739333A (en) 1998-04-14
KR960041179A (ko) 1996-12-19
DK0959072T3 (da) 2003-01-20
TW350839B (en) 1999-01-21
DE69615085T2 (de) 2002-06-06
CN1146990A (zh) 1997-04-09
KR100411358B1 (ko) 2004-07-05
EP0743307A1 (en) 1996-11-20
PT959072E (pt) 2002-12-31
ATE205482T1 (de) 2001-09-15
PT743307E (pt) 2001-12-28
MX9601837A (es) 1997-07-31
EP0959072A1 (en) 1999-11-24
EP0959073A1 (en) 1999-11-24
EP0743307B1 (en) 2001-09-12
EP0959072B1 (en) 2002-09-25
DE69624010D1 (de) 2002-10-31

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