ES2184367T3 - Derivados de sulfonamida y procedimiento para su preparacion. - Google Patents

Derivados de sulfonamida y procedimiento para su preparacion.

Info

Publication number
ES2184367T3
ES2184367T3 ES99110998T ES99110998T ES2184367T3 ES 2184367 T3 ES2184367 T3 ES 2184367T3 ES 99110998 T ES99110998 T ES 99110998T ES 99110998 T ES99110998 T ES 99110998T ES 2184367 T3 ES2184367 T3 ES 2184367T3
Authority
ES
Spain
Prior art keywords
replaced
rented
substitute
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99110998T
Other languages
English (en)
Inventor
Koichiro Yamada
Kosuke Yasuda
Kohei Kikkawa
Rikako Kohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7116213A external-priority patent/JP3013752B2/ja
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2184367T3 publication Critical patent/ES2184367T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE SULFONAMIDA DE FORMULA [I]: DONDE EL ANILLO A Y EL ANILLO B SON HIDROCARBURO MONOCICLICO, BICICLICO O TRICICLICO, SUSTITUIDO O SIN SUSTITUIR, O UN GRUPO HETEROCICLICO SUSTITUIDO O SIN SUSTITUIR; Q ES UN ENLACE SENCILLO, - O -, - S -, - SO -, - SO 2 - O - CH 2 -; Y ES - O -, - S - O - NH -; ALK ES ALQUILENO O ALQ UENILENO INFERIOR; Z ES - O - O - NH -; R ES ARILO O GRUPO HETEROCICLOCO AROMATICO SUSTITUIDO O SIN SUSTITUIR; R 1 ES H, TRIFLUOROMETILO, AMINO SUSTITUIDO O SIN SUSTITUIR, ALQUILO INFERIOR SUSTITUIDO O SIN SUSTITUIR, ALQUENILO, ALQUINILO, ALQUILTIO INFERIOR SUSTITUIDO O SIN SUSTITUIR, ALCOXI, ARILO O UN GRUPO HETEROCICLICO SUSTITUIDO O SIN SUSTITUIR, O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS DERIVADOS. LOS DERIVADOS DESCRITOS SON UTILES EN EL TRATAMIENTO O PROFILAXIS DE ALTERACIONES ASOCIADAS CON LAS ACTIVIDADES DE LA ENDOTELINA, COMO LA HIPERTENSION, HIPERTENSION PULMONAR, HIPERTENSION RENAL, ENFERMEDAD DE RINAUD, ASMA BRONQUIAL, ULCERA GASTRICA, INSUFICIENCIA CARDIACA CRONICA, ETC.
ES99110998T 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion. Expired - Lifetime ES2184367T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7116213A JP3013752B2 (ja) 1995-05-16 1995-05-16 スルホンアミド誘導体
JP14987295 1995-06-16

Publications (1)

Publication Number Publication Date
ES2184367T3 true ES2184367T3 (es) 2003-04-01

Family

ID=26454593

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96107694T Expired - Lifetime ES2163548T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.
ES99110998T Expired - Lifetime ES2184367T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES96107694T Expired - Lifetime ES2163548T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Country Status (13)

Country Link
US (1) US5739333A (es)
EP (3) EP0959072B1 (es)
KR (1) KR100411358B1 (es)
CN (1) CN1100043C (es)
AT (2) ATE205482T1 (es)
CA (1) CA2176776A1 (es)
DE (2) DE69615085T2 (es)
DK (2) DK0959072T3 (es)
ES (2) ES2163548T3 (es)
GR (1) GR3036611T3 (es)
MX (2) MX9601837A (es)
PT (2) PT743307E (es)
TW (1) TW350839B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO1999065897A1 (en) 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
EP1137642B1 (en) * 1999-09-03 2007-12-05 Actelion Pharmaceuticals Ltd. Bis-sulfonamides
US6720322B2 (en) 1999-12-22 2004-04-13 Actelion Pharamceuticals Ltd. Butyne diol derivatives
JP2003518102A (ja) * 1999-12-22 2003-06-03 アクテリオン ファマシューティカルズ リミテッド ブチンジオール誘導体
MXPA02007192A (es) * 2000-01-25 2002-12-09 Hoffmann La Roche Preparacion de sulfonamidas.
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
JP2004503542A (ja) * 2000-06-13 2004-02-05 ビーエーエスエフ　アクチェンゲゼルシャフト 殺真菌性５−フェニル置換２−（シアノアミノ）ピリミジン誘導体
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US7091201B2 (en) * 2000-09-25 2006-08-15 Actelion Pharmaceuticals Ltd. Arylalkane-sulfonamides having endothelin-antagonist activity
AU2002227984B8 (en) * 2000-12-18 2007-01-04 Actelion Pharmaceuticals Ltd. Novel sulfamides and their use as endothelin receptor antagonists
EA007719B1 (ru) * 2001-03-15 2006-12-29 Басф Акциенгезельшафт 5-фенилпиримидины, способ и промежуточные продукты для их получения и их применение для борьбы с фитопатогенными грибами
CA2471220C (en) 2002-01-02 2010-11-16 Actelion Pharmaceuticals Ltd Novel alkansulfonamides as endothelin antagonists
NZ566263A (en) * 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
CA2507334C (en) 2002-12-02 2013-05-07 Actelion Pharmaceuticals Ltd. Pyrimidine-sulfamides and their use as endothelian receptor antagonist
CA2557372C (en) 2004-03-05 2013-01-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists
DE102004044829A1 (de) * 2004-09-16 2006-04-06 Bayer Cropscience Ag 5-Heterocyclylpyrimidine
TW200628467A (en) 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
MX2008002731A (es) 2005-09-01 2008-03-26 Hoffmann La Roche Diaminopirimidinas como moduladores de p2x3 y p3x2/3.
ES2562056T3 (es) 2005-09-01 2016-03-02 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores P2X3 y P2X2/3
EP1924564B1 (en) 2005-09-01 2016-11-09 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
SG174050A1 (en) * 2006-04-13 2011-09-29 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
US8664390B2 (en) * 2007-06-29 2014-03-04 Generics (Uk) Limited Process for the introduction of hydroxyethoxy side chain in bosentan
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
NZ585438A (en) * 2007-10-24 2012-09-28 Generics Uk Ltd Novel crystalline forms of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yI]-benzenesulfonamide
ATE530531T1 (de) * 2007-12-18 2011-11-15 Dipharma Francis Srl Verfahren zur herstellung von bosentan
CA2712860C (en) * 2008-02-08 2014-11-18 Abhay Gaitonde Process for preparing bosentan
EP2268634A2 (en) * 2008-03-13 2011-01-05 Actavis Group PTC EHF Processes for the preparation of bosentan and related compounds using novel intermediates
CA2741928A1 (en) 2008-11-03 2010-06-03 Generics [Uk] Limited Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
WO2012056468A1 (en) * 2010-10-13 2012-05-03 Matrix Laboratories Ltd A process for the preparation of bosentan
CN104892528A (zh) * 2014-12-10 2015-09-09 上海工程技术大学 一种2-硫代巴比妥酸衍生物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545944A1 (de) * 1964-06-19 1969-12-11 Hoffmann La Roche Verfahren zur Herstellung von neuen Sulfonamiden der Pyrimidinreihe
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
KR920009574B1 (ko) * 1990-02-02 1992-10-19 재단법인 한국화학연구소 페닐아세트아미드 유도체 및 그의 제조방법
TW270116B (es) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
EP0958135A1 (en) * 1996-06-28 1999-11-24 Ranpak Corp. Cushioning conversion machine

Also Published As

Publication number Publication date
ES2163548T3 (es) 2002-02-01
GR3036611T3 (en) 2001-12-31
DE69624010T2 (de) 2003-05-22
ATE205482T1 (de) 2001-09-15
MXPA00011111A (es) 2003-04-25
EP0959072A1 (en) 1999-11-24
ATE224879T1 (de) 2002-10-15
PT959072E (pt) 2002-12-31
EP0959072B1 (en) 2002-09-25
DE69624010D1 (de) 2002-10-31
CN1100043C (zh) 2003-01-29
US5739333A (en) 1998-04-14
KR100411358B1 (ko) 2004-07-05
DE69615085T2 (de) 2002-06-06
KR960041179A (ko) 1996-12-19
EP0959073A1 (en) 1999-11-24
EP0743307B1 (en) 2001-09-12
CA2176776A1 (en) 1996-11-17
TW350839B (en) 1999-01-21
MX9601837A (es) 1997-07-31
EP0743307A1 (en) 1996-11-20
CN1146990A (zh) 1997-04-09
DK0743307T3 (da) 2001-11-26
DK0959072T3 (da) 2003-01-20
PT743307E (pt) 2001-12-28
DE69615085D1 (de) 2001-10-18

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