ES2163548T3 - Derivados de sulfonamida y procedimiento para su preparacion. - Google Patents

Derivados de sulfonamida y procedimiento para su preparacion.

Info

Publication number
ES2163548T3
ES2163548T3 ES96107694T ES96107694T ES2163548T3 ES 2163548 T3 ES2163548 T3 ES 2163548T3 ES 96107694 T ES96107694 T ES 96107694T ES 96107694 T ES96107694 T ES 96107694T ES 2163548 T3 ES2163548 T3 ES 2163548T3
Authority
ES
Spain
Prior art keywords
replaced
rented
substituted
arilo
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96107694T
Other languages
English (en)
Inventor
Koichiro Yamada
Kosuke Yasuda
Kohei Kikkawa
Rikako Kohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7116213A external-priority patent/JP3013752B2/ja
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2163548T3 publication Critical patent/ES2163548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NUEVOS DERIVADOS DE SULFAMIDA DE LA FORMULA [I]: EN DONDE EL ANILLO A Y EL ANILLO B SON HIDROCARBUROS MONOCICLICOS, BICICLICOS O TRICICLICOS SUSTITUIDOS O NO SUSTITUIDOS, O UN GRUPO HETEROCICLICO SUSTITUIDO O NO SUSTITUIDO, Q ES UN ENLACE SIMPLE, -O-, -S-, -SO-, -SO{SUB,2}- O -CH{SUB,2}-, Y ES -O-, -S- O -NH-, ALK ES ALQUILENO DE CADENA CORTA O ALQUENILENO, Z ES -OO -NH-, R ES UN HETEROCICLICO AROMATICO SUSTITUIDO O NO SUSTITUIDO O ARILO, R{SUP,1} ES H, TRIFLUOMETILO, AMINO SUSTITUIDO O NO SUSTITUIDO, ALQUILO DE CADENA CORTA SUSTITUIDO O NO SUSTITUIDO, ALQUENILO, ALQUINILO, ALQUILTIO DE CADENA CORTA SUSTITUIDO O NO SUSTITUIDO, O ALCOXI, O UN HETEROCICLICO SUSTITUIDO O NO SUSTITUIDO O ARILO, O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE SON UTILES EN LA PROFILAXIS O EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS CON ACTIVIDADES ENDOTELINAS COMO HIPERTENSION, HIPERTENSION PULMONAR, HIPERTENSION RENAL, ENFERMEDAD DE RAYNAUD, ASMA BRONQUIAL, ULCERA GASTRICA, INSUFICIENCIA CARDIACA CRONICA,ETC.
ES96107694T 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion. Expired - Lifetime ES2163548T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7116213A JP3013752B2 (ja) 1995-05-16 1995-05-16 スルホンアミド誘導体
JP14987295 1995-06-16

Publications (1)

Publication Number Publication Date
ES2163548T3 true ES2163548T3 (es) 2002-02-01

Family

ID=26454593

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99110998T Expired - Lifetime ES2184367T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.
ES96107694T Expired - Lifetime ES2163548T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99110998T Expired - Lifetime ES2184367T3 (es) 1995-05-16 1996-05-14 Derivados de sulfonamida y procedimiento para su preparacion.

Country Status (13)

Country Link
US (1) US5739333A (es)
EP (3) EP0959073A1 (es)
KR (1) KR100411358B1 (es)
CN (1) CN1100043C (es)
AT (2) ATE224879T1 (es)
CA (1) CA2176776A1 (es)
DE (2) DE69624010T2 (es)
DK (2) DK0743307T3 (es)
ES (2) ES2184367T3 (es)
GR (1) GR3036611T3 (es)
MX (2) MX9601837A (es)
PT (2) PT959072E (es)
TW (1) TW350839B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
DE69919707T2 (de) 1998-06-19 2005-09-01 Chiron Corp., Emeryville Glycogen synthase kinase 3 inhibitoren
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
CN100424079C (zh) * 1999-09-03 2008-10-08 埃科特莱茵药品有限公司 双磺胺
WO2001046156A1 (en) * 1999-12-22 2001-06-28 Actelion Pharmaceuticals Ltd. Butyne diol derivatives
US6720322B2 (en) 1999-12-22 2004-04-13 Actelion Pharamceuticals Ltd. Butyne diol derivatives
PT1254121E (pt) * 2000-01-25 2006-06-30 Hoffmann La Roche Preparacao de sulfonamidas
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
PL362551A1 (en) * 2000-06-13 2004-11-02 Basf Aktiengesellschaft Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US7091201B2 (en) * 2000-09-25 2006-08-15 Actelion Pharmaceuticals Ltd. Arylalkane-sulfonamides having endothelin-antagonist activity
EP1693372A1 (en) 2000-12-18 2006-08-23 Actelion Pharmaceuticals Ltd. Novel Sulfamides and their use as endothelin receptor antagonists
SK11422003A3 (sk) * 2001-03-15 2004-04-06 Basf Aktiengesellschaft 5-Fenylpyrimidíny, spôsoby a medziprodukty na ich prípravu a ich použitie pri ničení škodlivých húb
WO2003055863A1 (en) * 2002-01-02 2003-07-10 Actelion Pharmaceuticals Ltd Novel alkansulfonamides as endothelin antagonists
AU2003248549B2 (en) 2002-05-24 2010-04-08 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
NZ540937A (en) 2002-12-02 2008-06-30 Actelion Pharmaceuticals Ltd Pyrimidine-sulfamides and their use as endothelian receptor antagonist
PT1725540E (pt) 2004-03-05 2012-11-29 Hoffmann La Roche Diaminopirimidinas como antagonistas de p2x3 e p2x2/3
DE102004044829A1 (de) * 2004-09-16 2006-04-06 Bayer Cropscience Ag 5-Heterocyclylpyrimidine
TW200628467A (en) 2004-11-11 2006-08-16 Actelion Pharmaceuticals Ltd Novel sulfamides
AU2006286576B2 (en) 2005-09-01 2012-06-14 F. Hoffmann-La Roche Ag Diaminopyrimidines as P2X3 and P3X2/3 modulators
ES2562056T3 (es) 2005-09-01 2016-03-02 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores P2X3 y P2X2/3
ES2612890T3 (es) 2005-09-01 2017-05-19 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
WO2007119214A2 (en) * 2006-04-13 2007-10-25 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
WO2009004374A1 (en) * 2007-06-29 2009-01-08 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
US8530488B2 (en) * 2007-10-24 2013-09-10 Generics [Uk] Limited Crystalline forms of bosentan
ATE530531T1 (de) * 2007-12-18 2011-11-15 Dipharma Francis Srl Verfahren zur herstellung von bosentan
CA2712860C (en) * 2008-02-08 2014-11-18 Abhay Gaitonde Process for preparing bosentan
WO2009112954A2 (en) * 2008-03-13 2009-09-17 Actavis Group Ptc Ehf Processes for the preparation of bosentan and related compounds using novel intermediates
JP2012507497A (ja) 2008-11-03 2012-03-29 ジェネリクス・（ユーケー）・リミテッド ボセンタンおよび関連物質のｈｐｌｃ分析方法、ならびに参照スタンダードまたはマーカーとしてのこれら物質の使用
WO2012056468A1 (en) * 2010-10-13 2012-05-03 Matrix Laboratories Ltd A process for the preparation of bosentan
CN104892528A (zh) * 2014-12-10 2015-09-09 上海工程技术大学 一种2-硫代巴比妥酸衍生物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545944A1 (de) * 1964-06-19 1969-12-11 Hoffmann La Roche Verfahren zur Herstellung von neuen Sulfonamiden der Pyrimidinreihe
EP0100189B1 (en) * 1982-07-22 1986-05-28 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents
KR920009574B1 (ko) * 1990-02-02 1992-10-19 재단법인 한국화학연구소 페닐아세트아미드 유도체 및 그의 제조방법
TW270116B (es) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
AU3590297A (en) * 1996-06-28 1998-01-21 Ranpak Corp. Cushioning conversion machine

Also Published As

Publication number Publication date
US5739333A (en) 1998-04-14
MXPA00011111A (es) 2003-04-25
DE69615085T2 (de) 2002-06-06
DK0743307T3 (da) 2001-11-26
KR960041179A (ko) 1996-12-19
DE69624010D1 (de) 2002-10-31
CN1146990A (zh) 1997-04-09
EP0743307B1 (en) 2001-09-12
KR100411358B1 (ko) 2004-07-05
CN1100043C (zh) 2003-01-29
TW350839B (en) 1999-01-21
PT959072E (pt) 2002-12-31
MX9601837A (es) 1997-07-31
EP0959073A1 (en) 1999-11-24
PT743307E (pt) 2001-12-28
ATE205482T1 (de) 2001-09-15
CA2176776A1 (en) 1996-11-17
DK0959072T3 (da) 2003-01-20
DE69615085D1 (de) 2001-10-18
DE69624010T2 (de) 2003-05-22
ES2184367T3 (es) 2003-04-01
EP0743307A1 (en) 1996-11-20
ATE224879T1 (de) 2002-10-15
EP0959072A1 (en) 1999-11-24
GR3036611T3 (en) 2001-12-31
EP0959072B1 (en) 2002-09-25

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