ES2186018T3 - Procedimiento para preparar tolterodina. - Google Patents
Procedimiento para preparar tolterodina.Info
- Publication number
- ES2186018T3 ES2186018T3 ES97954678T ES97954678T ES2186018T3 ES 2186018 T3 ES2186018 T3 ES 2186018T3 ES 97954678 T ES97954678 T ES 97954678T ES 97954678 T ES97954678 T ES 97954678T ES 2186018 T3 ES2186018 T3 ES 2186018T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- tolterodine
- prepare
- prepare tolterodine
- benzopiran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Optical Integrated Circuits (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3396196P | 1996-12-31 | 1996-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2186018T3 true ES2186018T3 (es) | 2003-05-01 |
Family
ID=21873473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97954678T Expired - Lifetime ES2186018T3 (es) | 1996-12-31 | 1997-12-18 | Procedimiento para preparar tolterodina. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5922914A (pl) |
| EP (1) | EP0960109B1 (pl) |
| JP (1) | JP4199310B2 (pl) |
| KR (2) | KR20000057548A (pl) |
| CN (1) | CN1151141C (pl) |
| AT (1) | ATE226949T1 (pl) |
| AU (1) | AU717985B2 (pl) |
| CA (1) | CA2273789C (pl) |
| CZ (1) | CZ295477B6 (pl) |
| DE (1) | DE69716767T2 (pl) |
| DK (1) | DK0960109T3 (pl) |
| ES (1) | ES2186018T3 (pl) |
| FI (1) | FI991477L (pl) |
| HU (1) | HUP0000527A3 (pl) |
| NO (1) | NO317158B1 (pl) |
| NZ (1) | NZ336533A (pl) |
| PL (1) | PL191603B1 (pl) |
| PT (1) | PT960109E (pl) |
| RU (1) | RU2176246C2 (pl) |
| SI (1) | SI0960109T1 (pl) |
| SK (1) | SK283591B6 (pl) |
| WO (1) | WO1998029402A1 (pl) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2235648A1 (es) * | 2003-12-22 | 2005-07-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003067A1 (en) * | 1996-07-19 | 1998-01-29 | Gunnar Aberg | S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders |
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| DE60022692T2 (de) * | 1999-07-01 | 2006-06-22 | Pharmacia & Upjohn Co. Llc, Kalamazoo | (S,S)-Reboxetin zur Behandlung von Migränekopfschmerzen |
| US6566537B2 (en) | 1999-12-30 | 2003-05-20 | Pharmacia Ab | Process and intermediates |
| SE9904850D0 (sv) * | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
| DE10028443C1 (de) * | 2000-06-14 | 2002-05-29 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen |
| DE10033016A1 (de) | 2000-07-07 | 2002-01-24 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen |
| PE20020547A1 (es) | 2000-10-24 | 2002-06-12 | Upjohn Co | Uso de la tolterodina en tratamientos del asma |
| US20030027856A1 (en) * | 2001-06-29 | 2003-02-06 | Aberg A.K. Gunnar | Tolterodine metabolites |
| IN191835B (pl) | 2001-08-03 | 2004-01-10 | Ranbaxy Lab Ltd | |
| PT1461306E (pt) * | 2001-10-26 | 2009-04-01 | Pharmacia & Upjohn Co Llc | Compostos de amónio quaternário |
| US7005449B2 (en) * | 2002-04-23 | 2006-02-28 | Pharmacia & Upjohn Company | Tolterodine salts |
| AU2002345266B2 (en) | 2002-07-08 | 2009-07-02 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| HK1079787A1 (zh) | 2002-07-31 | 2006-04-13 | Ranbaxy Laboratories Limited | 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物 |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| EP1534675B1 (en) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists |
| US7101888B2 (en) * | 2002-08-28 | 2006-09-05 | Pharmacia & Upjohn Company | Oral liquid tolterodine composition |
| ATE400553T1 (de) | 2002-12-10 | 2008-07-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors |
| DE60225195T2 (de) | 2002-12-23 | 2009-02-26 | Ranbaxy Laboratories, Ltd. | Flavaxat-derivate als muscarin-rezeptor antagonisten |
| AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1603862A1 (en) * | 2003-03-06 | 2005-12-14 | Ranbaxy Laboratories Limited | 3,3-diarylpropylamine derivatives and processes for isolation thereof |
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| US7393874B2 (en) * | 2003-04-08 | 2008-07-01 | Hetero Drugs Limited | Polymorphs of tolterodine tartrate |
| EP1618091A1 (en) | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EA009059B1 (ru) | 2003-04-10 | 2007-10-26 | Рэнбакси Лабораториз Лимитед | Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора |
| JP2006522787A (ja) | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
| ITMI20031354A1 (it) * | 2003-07-02 | 2005-01-03 | Istituto Di Chimica Biomolecolare D El Cnr Sezione | Sintesis enantioselettiva di composti enantiomericamente arricchiti. |
| EP1701932B1 (en) * | 2003-12-24 | 2012-07-18 | Cipla Ltd. | Tolterodine, compositions and uses thereof, and preparation of the same |
| EP1629834A1 (en) | 2004-08-27 | 2006-03-01 | KRKA, D.D., Novo Mesto | Sustained release pharmaceutical composition of tolterodine |
| ITMI20041920A1 (it) * | 2004-10-11 | 2005-01-11 | Chemi Spa | Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina |
| US7355077B2 (en) * | 2004-10-28 | 2008-04-08 | Dr. Reddy's Laboratories Limited | Process for preparing tolterodine |
| JP4513535B2 (ja) * | 2004-12-03 | 2010-07-28 | 住友化学株式会社 | トルテロジンの製造方法 |
| JP2007527923A (ja) * | 2005-01-10 | 2007-10-04 | テバ ファーマシューティカル インダストリーズ リミティド | トルテロジンタルトレートの調製方法 |
| US7528267B2 (en) | 2005-08-01 | 2009-05-05 | Girindus America, Inc. | Method for enantioselective hydrogenation of chromenes |
| ES2268987B1 (es) * | 2005-08-05 | 2008-02-01 | Ragactives, S.L. | Procedimiento para la obtencion de 3,3-difenilpropilaminas. |
| WO2007039918A1 (en) * | 2005-10-06 | 2007-04-12 | Natco Pharma Limited | Novel process for the preparation of tolterodine |
| AU2006305619A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| KR100686351B1 (ko) * | 2006-01-12 | 2007-02-22 | 주식회사 카이로제닉스 | 톨테로딘 라세미체의 제조방법 |
| ITMI20060110A1 (it) * | 2006-01-24 | 2007-07-25 | Dipharma Spa | Procedimento per la purificazione di tolterodina |
| ATE480531T1 (de) * | 2006-05-24 | 2010-09-15 | Pfizer Ltd | Verfahren zur herstellung von benzopyran-2- olderivaten |
| US7268257B1 (en) | 2006-05-31 | 2007-09-11 | Sumitomo Chemical Company, Limited | Process for producing tolterodine |
| CZ302585B6 (cs) * | 2007-02-26 | 2011-07-20 | Zentiva, A. S. | Krystalická sul 2-[(1R)-3-[bis(1-methylethyl)amino]-1-fenylpropyl]-4-methylfenolu s kyselinou (2R,3R)-2,3-dihydroxybutandiovou |
| US8486452B2 (en) * | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| EP2175843B1 (en) | 2007-08-08 | 2014-10-08 | Inventia Healthcare Private Limited | Extended release compositions comprising tolterodine |
| KR101188333B1 (ko) * | 2008-02-20 | 2012-10-09 | 에스케이케미칼주식회사 | 안정성이 우수하고 경피제로 유용한 톨테로딘 결정성산부가염 |
| US20090214665A1 (en) * | 2008-02-26 | 2009-08-27 | Lai Felix S | Controlled Release Muscarinic Receptor Antagonist Formulation |
| ITMI20082055A1 (it) * | 2008-11-19 | 2009-02-18 | Dipharma Francis Srl | Procedimento per la preparazione di (r)-tolterodina base libera |
| WO2010092500A2 (en) | 2009-02-12 | 2010-08-19 | Alembic Limited | A process for the preparation of tolterodine tartrate |
| US20120041235A1 (en) * | 2009-02-17 | 2012-02-16 | Pharmathen S.A. | Process for the preparation of (r)-2-(3-diisopropylamino)-1-phenylpropyl)-4methylphenol and salts thereof |
| US8729056B2 (en) | 2010-03-31 | 2014-05-20 | Ono Pharmaceutical Co., Ltd. | Preventive and/or therapeutic agent of hand-foot syndrome |
| WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| EP2476665A1 (en) | 2011-01-17 | 2012-07-18 | Cambrex Profarmaco Milano S.r.l. | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| CN102516098B (zh) * | 2011-12-09 | 2014-06-18 | 北京联本医药化学技术有限公司 | 酒石酸托特罗定制备方法 |
| CN103044274B (zh) * | 2012-11-29 | 2014-10-22 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
| GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
| CN110229072B (zh) * | 2019-06-25 | 2022-04-08 | 中国药科大学 | 一种托特罗定及其对映体的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1169945A (en) * | 1966-08-25 | 1969-11-05 | Geistlich Soehne Ag | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives |
| SE8800207D0 (sv) * | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
| US5382600A (en) * | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| EP0585913B1 (en) * | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| RU2089539C1 (ru) * | 1994-04-05 | 1997-09-10 | Стерлитамакский нефтехимических завод | Способ получения 2,5-n,n'-(диметиламинометил)-1,4-гидрохинона |
-
1997
- 1997-11-21 KR KR1019990705269A patent/KR20000057548A/ko not_active Withdrawn
- 1997-12-18 DE DE69716767T patent/DE69716767T2/de not_active Expired - Lifetime
- 1997-12-18 HU HU0000527A patent/HUP0000527A3/hu unknown
- 1997-12-18 CZ CZ19992272A patent/CZ295477B6/cs not_active IP Right Cessation
- 1997-12-18 WO PCT/US1997/022521 patent/WO1998029402A1/en not_active Ceased
- 1997-12-18 DK DK97954678T patent/DK0960109T3/da active
- 1997-12-18 KR KR10-1999-7005910A patent/KR100463614B1/ko not_active Expired - Fee Related
- 1997-12-18 EP EP97954678A patent/EP0960109B1/en not_active Expired - Lifetime
- 1997-12-18 AT AT97954678T patent/ATE226949T1/de active
- 1997-12-18 SK SK815-99A patent/SK283591B6/sk not_active IP Right Cessation
- 1997-12-18 ES ES97954678T patent/ES2186018T3/es not_active Expired - Lifetime
- 1997-12-18 SI SI9730426T patent/SI0960109T1/xx unknown
- 1997-12-18 US US08/993,257 patent/US5922914A/en not_active Expired - Lifetime
- 1997-12-18 FI FI991477A patent/FI991477L/fi unknown
- 1997-12-18 JP JP53003098A patent/JP4199310B2/ja not_active Expired - Fee Related
- 1997-12-18 PT PT97954678T patent/PT960109E/pt unknown
- 1997-12-18 NZ NZ336533A patent/NZ336533A/xx not_active IP Right Cessation
- 1997-12-18 CA CA002273789A patent/CA2273789C/en not_active Expired - Fee Related
- 1997-12-18 AU AU59569/98A patent/AU717985B2/en not_active Ceased
- 1997-12-18 CN CNB971801479A patent/CN1151141C/zh not_active Expired - Fee Related
- 1997-12-18 RU RU99116356/04A patent/RU2176246C2/ru not_active IP Right Cessation
- 1997-12-18 PL PL334375A patent/PL191603B1/pl not_active IP Right Cessation
-
1999
- 1999-06-29 NO NO19993247A patent/NO317158B1/no not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2235648A1 (es) * | 2003-12-22 | 2005-07-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| WO2005061431A1 (es) * | 2003-12-22 | 2005-07-07 | Ragactives, S.L. | Procedimiento para la obtención de tolterodina |
| ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
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