ES2186720T3 - Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. - Google Patents

Composiciones para inhibir la reabsorcion osea mediada por osteoclastos.

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Publication number
ES2186720T3
ES2186720T3 ES95920409T ES95920409T ES2186720T3 ES 2186720 T3 ES2186720 T3 ES 2186720T3 ES 95920409 T ES95920409 T ES 95920409T ES 95920409 T ES95920409 T ES 95920409T ES 2186720 T3 ES2186720 T3 ES 2186720T3
Authority
ES
Spain
Prior art keywords
inhibit
callast
osab
osea
reabsorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES95920409T
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English (en)
Inventor
George D Hartman
Mark E Duggan
Nathan C Ihle
William F Hoffman
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Merck and Co Inc
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Merck and Co Inc
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Publication of ES2186720T3 publication Critical patent/ES2186720T3/es
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D209/04—Indoles; Hydrogenated indoles
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPOSICIONES DE LA ESTRUCTURA GENERAL SIGUIENTE:X-Y-Z-ARIL-AB, POR EJEMPLO (I), QUE INHIBEN LA REABSORCION OSEA INFLUIDA POR OSTEOCLASTOS.
ES95920409T 1994-05-27 1995-05-12 Composiciones para inhibir la reabsorcion osea mediada por osteoclastos. Expired - Lifetime ES2186720T3 (es)

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WO1995032710A1 (en) 1995-12-07
JPH10501222A (ja) 1998-02-03
AU2586895A (en) 1995-12-21
EP0760658A4 (en) 1997-09-17
US5741796A (en) 1998-04-21
EP0760658A1 (en) 1997-03-12
EP0760658B1 (en) 2002-11-13
US5929120A (en) 1999-07-27
DE69528829T2 (de) 2003-08-07
ATE227567T1 (de) 2002-11-15
DE69528829D1 (de) 2002-12-19
CA2190870A1 (en) 1995-12-07
AU701776B2 (en) 1999-02-04

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