ES2186799T3 - Bencimidazoles sustituidos en 5' utilizados como agentes antivirales. - Google Patents

Bencimidazoles sustituidos en 5' utilizados como agentes antivirales.

Info

Publication number
ES2186799T3
ES2186799T3 ES96928176T ES96928176T ES2186799T3 ES 2186799 T3 ES2186799 T3 ES 2186799T3 ES 96928176 T ES96928176 T ES 96928176T ES 96928176 T ES96928176 T ES 96928176T ES 2186799 T3 ES2186799 T3 ES 2186799T3
Authority
ES
Spain
Prior art keywords
bencimidazols
sub
replaced
antiviral agents
polisustituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96928176T
Other languages
English (en)
Inventor
Leroy B Townsend
John C Drach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
University of Michigan Ann Arbor
Original Assignee
University of Michigan System
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System, University of Michigan Ann Arbor filed Critical University of Michigan System
Application granted granted Critical
Publication of ES2186799T3 publication Critical patent/ES2186799T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A BENCIMIDAZOLES POLISUSTITUIDOS QUE TIENEN LA FORMULA (I), EN LA QUE Q ES UN GRUPO BENCIMIDAZOL SUSTITUIDO UNIDO A LA POSICION 1 DE BENCIMIDAZOL, R ES UN HALOGENO O UN NUMERO ATOMICO DE 9 A 53, INCLUSIVE, (A SABER, R SUB,1}, DONDE X ES UN CALCOGENO DE NUMERO ATOMICO DE 8 A 16, INCLUSIVE, (A SABER, LO DE CADENA LINEAL O RAMIFICADA DE 1 A 8 ATOMOS DE CARBONO; Y R SUB,2} Y R SUB,3} PUEDEN SER IGUALES O DIFERENTES Y SON POR SEPARADO BER, ES OPERATIVAS DE LOS MISMOS. TAMBIEN SE PRESENTAN EN ESTA INVENCION COMPOSICIONES QUE CONTIENE BENCIMIDAZOLES POLISUSTITUIDOS COMO LOS ARRIBA DEFINIDOS Y METODOS PARA EL USO DE LOS MISMOS.
ES96928176T 1995-08-18 1996-08-16 Bencimidazoles sustituidos en 5' utilizados como agentes antivirales. Expired - Lifetime ES2186799T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US254295P 1995-08-18 1995-08-18

Publications (1)

Publication Number Publication Date
ES2186799T3 true ES2186799T3 (es) 2003-05-16

Family

ID=21701262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96928176T Expired - Lifetime ES2186799T3 (es) 1995-08-18 1996-08-16 Bencimidazoles sustituidos en 5' utilizados como agentes antivirales.

Country Status (9)

Country Link
US (1) US5874413A (es)
EP (1) EP0845001B1 (es)
JP (1) JPH11511170A (es)
AT (1) ATE227734T1 (es)
AU (1) AU721277B2 (es)
CA (1) CA2223814A1 (es)
DE (1) DE69624827T2 (es)
ES (1) ES2186799T3 (es)
WO (1) WO1997007125A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010011075A1 (en) * 1999-02-05 2001-08-02 Leroy B Townsend 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
WO1997027205A1 (en) 1996-01-23 1997-07-31 The Regents Of The University Of Michigan Imidazo[1,2-a]pyridine c-nucleosides as antiviral agents
WO1998035977A1 (en) 1997-02-13 1998-08-20 Glaxo Group Limited Benzimidazole derivatives
EP1000080A1 (en) 1997-07-30 2000-05-17 The Regents of The University of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
FI933303L (fi) * 1991-01-23 1993-08-31 Gensia Inc Adenosinkinasinhibitorer
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds

Also Published As

Publication number Publication date
AU721277B2 (en) 2000-06-29
AU6774596A (en) 1997-03-12
ATE227734T1 (de) 2002-11-15
CA2223814A1 (en) 1997-02-27
EP0845001B1 (en) 2002-11-13
DE69624827D1 (de) 2002-12-19
DE69624827T2 (de) 2003-09-04
JPH11511170A (ja) 1999-09-28
EP0845001A1 (en) 1998-06-03
WO1997007125A1 (en) 1997-02-27
US5874413A (en) 1999-02-23

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