ATE227734T1 - 5'-substitutierte-ribofuranosyl benzimidazolen als antivirale. - Google Patents

5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.

Info

Publication number
ATE227734T1
ATE227734T1 AT96928176T AT96928176T ATE227734T1 AT E227734 T1 ATE227734 T1 AT E227734T1 AT 96928176 T AT96928176 T AT 96928176T AT 96928176 T AT96928176 T AT 96928176T AT E227734 T1 ATE227734 T1 AT E227734T1
Authority
AT
Austria
Prior art keywords
benzimidazole
substituted
antivirals
inclusive
atomic number
Prior art date
Application number
AT96928176T
Other languages
English (en)
Inventor
Leroy B Townsend
John C Drach
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE227734T1 publication Critical patent/ATE227734T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT96928176T 1995-08-18 1996-08-16 5'-substitutierte-ribofuranosyl benzimidazolen als antivirale. ATE227734T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US254295P 1995-08-18 1995-08-18
PCT/US1996/013187 WO1997007125A1 (en) 1995-08-18 1996-08-16 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents

Publications (1)

Publication Number Publication Date
ATE227734T1 true ATE227734T1 (de) 2002-11-15

Family

ID=21701262

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928176T ATE227734T1 (de) 1995-08-18 1996-08-16 5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.

Country Status (9)

Country Link
US (1) US5874413A (de)
EP (1) EP0845001B1 (de)
JP (1) JPH11511170A (de)
AT (1) ATE227734T1 (de)
AU (1) AU721277B2 (de)
CA (1) CA2223814A1 (de)
DE (1) DE69624827T2 (de)
ES (1) ES2186799T3 (de)
WO (1) WO1997007125A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010011075A1 (en) * 1999-02-05 2001-08-02 Leroy B Townsend 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US5840743A (en) 1996-01-23 1998-11-24 The Regents Of The University Of Michigan Modified benzimidazole nucleosides as antiviral agents
US6413938B1 (en) 1997-02-13 2002-07-02 The Regents Of The University Of Michigan Benzimidazole derivatives for the treatment of viral infections
AU744176B2 (en) 1997-07-30 2002-02-14 Glaxo Group Limited Lyxofuranosyl benzimidazoles as antiviral agents
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
FI933303L (fi) * 1991-01-23 1993-08-31 Gensia Inc Adenosinkinasinhibitorer
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds

Also Published As

Publication number Publication date
ES2186799T3 (es) 2003-05-16
US5874413A (en) 1999-02-23
WO1997007125A1 (en) 1997-02-27
AU721277B2 (en) 2000-06-29
DE69624827T2 (de) 2003-09-04
AU6774596A (en) 1997-03-12
CA2223814A1 (en) 1997-02-27
DE69624827D1 (de) 2002-12-19
EP0845001B1 (de) 2002-11-13
EP0845001A1 (de) 1998-06-03
JPH11511170A (ja) 1999-09-28

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