ES2187276B1 - Composiciones orales para el tratamiento de humanos obesos y no diabeticos. - Google Patents

Composiciones orales para el tratamiento de humanos obesos y no diabeticos.

Info

Publication number
ES2187276B1
ES2187276B1 ES200101200A ES200101200A ES2187276B1 ES 2187276 B1 ES2187276 B1 ES 2187276B1 ES 200101200 A ES200101200 A ES 200101200A ES 200101200 A ES200101200 A ES 200101200A ES 2187276 B1 ES2187276 B1 ES 2187276B1
Authority
ES
Spain
Prior art keywords
diabetic humans
treatment
obesity
obese
oral compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101200A
Other languages
English (en)
Other versions
ES2187276A1 (es
Inventor
Ramon Gomis De Barbara
Marc Claret Carles
Joan Josep Guinovart Cirera
Josefa Fernandez Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Hispania SL
Original Assignee
Quimica Farmaceutica Bayer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200101200A priority Critical patent/ES2187276B1/es
Application filed by Quimica Farmaceutica Bayer SA filed Critical Quimica Farmaceutica Bayer SA
Priority to ES02732763T priority patent/ES2275873T3/es
Priority to DK02732763T priority patent/DK1400246T3/da
Priority to CA002447141A priority patent/CA2447141A1/en
Priority to EP02732763A priority patent/EP1400246B1/en
Priority to BR0210975-1A priority patent/BR0210975A/pt
Priority to US10/477,807 priority patent/US7122209B2/en
Priority to DE60215812T priority patent/DE60215812T2/de
Priority to PT02732763T priority patent/PT1400246E/pt
Priority to PCT/ES2002/000231 priority patent/WO2002098435A1/es
Priority to AT02732763T priority patent/ATE344042T1/de
Publication of ES2187276A1 publication Critical patent/ES2187276A1/es
Application granted granted Critical
Publication of ES2187276B1 publication Critical patent/ES2187276B1/es
Priority to CY20071100138T priority patent/CY1105975T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composiciones orales para el tratamiento de humanos obesos y no diabéticos. Las composiciones farmacéuticas orales que comprenden una cantidad efectiva de un compuesto de tungsteno (VI), preferiblemente de una sal de tungstato, y más preferiblemente de tungstato sódico (Na2WO4), son útiles para combatir la obesidad/sobrepeso en humanos no diabéticos. Se ha determinado en ratas el efecto anti-obesidad del dihidrato de tungstato sódico en un modelo de obesidad inducida por la dieta denominado "dieta de cafetería". Estas ratas obesas son un buen modelo de humanos obesos y no diabéticos. El tratamiento profiláctico, terapéutico y/o cosmético que se deriva de esta invención es sorprendente y, sobre los tratamientos previamente propuestos en la técnica, conlleva ventajas tales como eficacia, ausencia de toxicidad y precio relativamente bajo. Por lo tanto, las composiciones orales de la presente invención son útiles para el tratamiento de la obesidad/sobrepeso en seres humanos no diabéticos.
ES200101200A 2001-05-16 2001-05-16 Composiciones orales para el tratamiento de humanos obesos y no diabeticos. Expired - Fee Related ES2187276B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ES200101200A ES2187276B1 (es) 2001-05-16 2001-05-16 Composiciones orales para el tratamiento de humanos obesos y no diabeticos.
PT02732763T PT1400246E (pt) 2001-05-16 2002-05-16 Composições orais para o tratamento de mamíferos obesos, não diabéticos, incluindo seres humanos
CA002447141A CA2447141A1 (en) 2001-05-16 2002-05-16 Oral compositions for the treatment of non-diabetic obese mammals, including humans
EP02732763A EP1400246B1 (en) 2001-05-16 2002-05-16 Oral compositions for the treatment of obese, non-diabetic mammals, including humans
BR0210975-1A BR0210975A (pt) 2001-05-16 2002-05-16 Composição oral para uso como um agente profilático, terapêutico e/ou cosmético para a obesidade/excesso de peso em mamìferos não diabéticos, inclusive em seres humanos e preparação de uma composição oral
US10/477,807 US7122209B2 (en) 2001-05-16 2002-05-16 Oral compositions for the treatment of non-diabetic obese mammals, including humans
ES02732763T ES2275873T3 (es) 2001-05-16 2002-05-16 Composiciones orales para el tratamiento de mamiferos obesos y no diabeticos incluyendo humanos.
DK02732763T DK1400246T3 (da) 2001-05-16 2002-05-16 Orale sammensætninger til behandling af adipöse, ikke-diabetiske pattedyr, indbefattet mennesker
PCT/ES2002/000231 WO2002098435A1 (es) 2001-05-16 2002-05-16 Composiciones orales para el tratamiento de mamíferos obesos y no diabéticos, incluyendo humanos
AT02732763T ATE344042T1 (de) 2001-05-16 2002-05-16 Orale zusammensetzungen zur behandlung von adipösen, nicht diabetischen säugetieren, einschliesslich menschen
DE60215812T DE60215812T2 (de) 2001-05-16 2002-05-16 Orale zusammensetzungen zur behandlung von adipösen, nicht diabetischen säugetieren, einschliesslich menschen
CY20071100138T CY1105975T1 (el) 2001-05-16 2007-01-31 Στοματικες συνθεσεις για την θepαπεια παχυσαρκων, μη διαβητικων θηλαστικων, πepιλαμβανομενων των ανθρωπων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101200A ES2187276B1 (es) 2001-05-16 2001-05-16 Composiciones orales para el tratamiento de humanos obesos y no diabeticos.

Publications (2)

Publication Number Publication Date
ES2187276A1 ES2187276A1 (es) 2003-05-16
ES2187276B1 true ES2187276B1 (es) 2004-08-01

Family

ID=8497838

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200101200A Expired - Fee Related ES2187276B1 (es) 2001-05-16 2001-05-16 Composiciones orales para el tratamiento de humanos obesos y no diabeticos.
ES02732763T Expired - Lifetime ES2275873T3 (es) 2001-05-16 2002-05-16 Composiciones orales para el tratamiento de mamiferos obesos y no diabeticos incluyendo humanos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02732763T Expired - Lifetime ES2275873T3 (es) 2001-05-16 2002-05-16 Composiciones orales para el tratamiento de mamiferos obesos y no diabeticos incluyendo humanos.

Country Status (11)

Country Link
US (1) US7122209B2 (es)
EP (1) EP1400246B1 (es)
AT (1) ATE344042T1 (es)
BR (1) BR0210975A (es)
CA (1) CA2447141A1 (es)
CY (1) CY1105975T1 (es)
DE (1) DE60215812T2 (es)
DK (1) DK1400246T3 (es)
ES (2) ES2187276B1 (es)
PT (1) PT1400246E (es)
WO (1) WO2002098435A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080206356A1 (en) * 2005-07-29 2008-08-28 Universidad De Barcelona Pharmaceutical Compositions for the Treatment of Neurodegenerative Disorders
DE102006062250A1 (de) * 2006-12-22 2008-06-26 Roland Saur-Brosch Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden
CN100515428C (zh) * 2007-04-26 2009-07-22 暨南大学 钨酸锂在制药中的应用
ES2478790B1 (es) * 2013-01-22 2015-05-06 Oxolife, S. L. Uso de sales de tungsteno (VI) para el tratamiento de la infertilidad femenina en mamíferos no diabéticos
ES2551828B1 (es) * 2014-05-21 2016-09-12 Oxolife S.L. Composiciones alimentarias que comprenden sales de tungsteno (VI)
KR102282865B1 (ko) * 2014-07-21 2021-07-28 옥소라이프, 에스.엘. 비당뇨병 암컷 포유류에서 불임 치료를 위해, 수정 및 정상 생식을 자극하기 위해, 및 보조 생식 기술의 효과를 개선하기 위해 사용되는 텅스텐(vi) 염

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6025928A (ja) * 1983-07-21 1985-02-08 Tanaka Seinosuke 薬剤
DE4018513C1 (es) * 1989-12-20 1991-05-08 Karl Oexmann, Inh. Wolfgang Oexmann, 4650 Gelsenkirchen, De
US5192197A (en) * 1991-11-27 1993-03-09 Rockwell International Corporation Piezoelectric pump
CH689836A5 (fr) * 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropompe.
US5611214A (en) * 1994-07-29 1997-03-18 Battelle Memorial Institute Microcomponent sheet architecture
ES2108642B1 (es) * 1995-07-26 1998-08-16 Quimica Farm Bayer Sa Composiciones de tungsteno (vi) para el tratamiento oral de la diabetes mellitus.
US5595763A (en) * 1995-07-19 1997-01-21 Quimica Farmaceutica Bayer S.A. Tungsten (VI) compositions for the oral treatment of diabetes mellitus
US6148635A (en) * 1998-10-19 2000-11-21 The Board Of Trustees Of The University Of Illinois Active compressor vapor compression cycle integrated heat transfer device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. MATSUMOTO, "Vanadate, Molybdate and Tungstate for Orthomolecular Medicine". Medical Hypotheses, 1994, Vol. 43, páginas 177-182. Página 179, tabla 1. *
J.D. FOSTER et al., "Tungstate: a Potent Inhibitor of multifunctional Glucose-6-Phosphatase". Archiv. Biochem. Biophys., 1998, Vol. 354, Nº 1, páginas 125-132. *

Also Published As

Publication number Publication date
CA2447141A1 (en) 2002-12-12
PT1400246E (pt) 2007-02-28
ES2187276A1 (es) 2003-05-16
BR0210975A (pt) 2004-10-05
ATE344042T1 (de) 2006-11-15
CY1105975T1 (el) 2011-04-06
DE60215812D1 (de) 2006-12-14
US7122209B2 (en) 2006-10-17
EP1400246A1 (en) 2004-03-24
DK1400246T3 (da) 2007-03-05
US20040131697A1 (en) 2004-07-08
EP1400246B1 (en) 2006-11-02
ES2275873T3 (es) 2007-06-16
DE60215812T2 (de) 2007-08-30
WO2002098435A1 (es) 2002-12-12

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