ES2187518T3 - 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. - Google Patents

3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados.

Info

Publication number
ES2187518T3
ES2187518T3 ES94902374T ES94902374T ES2187518T3 ES 2187518 T3 ES2187518 T3 ES 2187518T3 ES 94902374 T ES94902374 T ES 94902374T ES 94902374 T ES94902374 T ES 94902374T ES 2187518 T3 ES2187518 T3 ES 2187518T3
Authority
ES
Spain
Prior art keywords
compounds
benzisoxazols
aminoalquilamino
substituted
related compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902374T
Other languages
English (en)
Inventor
Mark G Palermo
Gerard J O'malley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/150,301 external-priority patent/US5494908A/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2187518T3 publication Critical patent/ES2187518T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

ESTA APLICACION SE REFIERE A COMPUESTOS DE LA FORMULA (I) EN DONDE R1, X, Y Y N SON COMO SE DEFINE EN LA ESPECIFICACION; Y A SALES DE ADICION DEL MISMO ACEPTABLES FARMACEUTICAMENTE Y A MEZCLAS DE ISOMEROS OPTICOS, GEOMETRICOS O RACEMICOS DEL MISMO; CUYOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE LA MEMORIA CARACTERIZADAS POR UNA DISMINUCION DE LA FUNCION COLINERGICA TALES COMO LA ENFERMEDAD DE ALZHEIMER. LOS COMPUESTOS DE ESTE INVENTO TAMBIEN INHIBEN LA OXIDASA MONOAMINA Y POR LO TANTO SON UTILES COMO ANTIDEPRESIVOS.
ES94902374T 1992-11-23 1993-11-22 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados. Expired - Lifetime ES2187518T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98002192A 1992-11-23 1992-11-23
US08/150,301 US5494908A (en) 1992-11-23 1993-11-12 Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds

Publications (1)

Publication Number Publication Date
ES2187518T3 true ES2187518T3 (es) 2003-06-16

Family

ID=26847521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902374T Expired - Lifetime ES2187518T3 (es) 1992-11-23 1993-11-22 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados.

Country Status (14)

Country Link
US (2) US5580982A (es)
EP (1) EP0669920B1 (es)
JP (1) JP3462501B2 (es)
AT (1) ATE232529T1 (es)
AU (1) AU690529B2 (es)
CA (1) CA2149918A1 (es)
DE (1) DE69332691T2 (es)
DK (1) DK0669920T3 (es)
ES (1) ES2187518T3 (es)
FI (1) FI952481A0 (es)
MX (1) MX9307332A (es)
NO (1) NO304980B1 (es)
NZ (1) NZ258747A (es)
PT (1) PT669920E (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
RU2269523C2 (ru) * 2000-04-28 2006-02-10 Акадиа Фармасьютикалз, Инк. Мускариновые агонисты
ATE460415T1 (de) * 2004-11-29 2010-03-15 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und - indazole
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
AU2011216950A1 (en) * 2010-02-16 2012-08-23 Pfizer Inc. (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
ES2586213T3 (es) 2011-10-31 2016-10-13 Xenon Pharmaceuticals Inc. Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
BR112014029161A2 (pt) 2012-05-22 2017-06-27 Genentech Inc benzamidas n-substituídas e seu uso no tratamento de dor
BR112015000187A2 (pt) 2012-07-06 2017-06-27 Genentech Inc benzamidas substituídas com n e métodos de uso das mesmas
BR112015022488A2 (pt) 2013-03-14 2017-07-18 Genentech Inc triazolopiridinas substituídas e métodos de uso das mesmas
CN105492430B (zh) * 2013-03-15 2017-10-10 基因泰克公司 取代的苯并噁唑及其使用方法
BR112015023397A2 (pt) 2013-03-15 2017-07-18 Genentech Inc benzoxazois substituídos e métodos de uso dos mesmos
CR20160296A (es) 2013-11-27 2016-09-20 Genentech Inc Benzamidas sustituidas y métodos para usarlas
EP3166939B1 (en) 2014-07-07 2019-06-05 Genentech, Inc. Therapeutic compounds and methods of use thereof
WO2016191312A1 (en) 2015-05-22 2016-12-01 Genentech, Inc. Substituted benzamides and methods of use thereof
MA42683A (fr) 2015-08-27 2018-07-04 Genentech Inc Composés thérapeutiques et leurs méthodes utilisation
PE20181003A1 (es) 2015-09-28 2018-06-26 Genentech Inc Compuestos terapeuticos y sus metodos de uso
CN108495851A (zh) 2015-11-25 2018-09-04 基因泰克公司 取代的苯甲酰胺及其使用方法
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
SG11201903348UA (en) 2016-10-17 2019-05-30 Genentech Inc Therapeutic compounds and methods of use thereof
WO2018175707A1 (en) 2017-03-24 2018-09-27 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
EP3759098A1 (en) 2018-02-26 2021-01-06 Genentech, Inc. Pyridine-sulfonamide compounds and their use against pain and related conditions
EP3774801A1 (en) 2018-03-30 2021-02-17 F. Hoffmann-La Roche AG Fused ring hydro-pyrido compounds as sodium channel inhibitors
US11548882B2 (en) 2018-04-27 2023-01-10 Osaka University Benzisoxazole compound
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
WO2021079962A1 (ja) * 2019-10-24 2021-04-29 国立大学法人大阪大学 難聴の予防および／または治療用医薬組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681382A (en) 1969-02-07 1972-08-01 Ciba Geigy Corp 3-aminoindazoles
US3725431A (en) 1970-09-23 1973-04-03 Ciba Geigy Corp 1-aralkyl-3-aminoindazoles
EP0090972B1 (en) * 1982-03-17 1990-05-30 Asahi Kasei Kogyo Kabushiki Kaisha Indazole derivatives
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US5134236A (en) * 1987-08-07 1992-07-28 Hoechst-Roussel Pharmaceuticals Incorporated Phenylhydrazones as intermediates 1-phenyl-3-(1-piperazenyl)-1H-indazoles
US4999356A (en) * 1987-08-07 1991-03-12 Hoechst-Roussel Pharmaceuticals, Inc. 1-phenyl-3-(1-piperazinyl)-1H-indazoles
EP0302423A3 (en) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
ES2188584T3 (es) * 1991-03-28 2003-07-01 Eisai Co Ltd Derivados heterociclicos de amina.

Also Published As

Publication number Publication date
EP0669920B1 (en) 2003-02-12
ATE232529T1 (de) 2003-02-15
FI952481L (fi) 1995-05-22
NO304980B1 (no) 1999-03-15
MX9307332A (es) 1994-07-29
JP3462501B2 (ja) 2003-11-05
NZ258747A (en) 1997-02-24
FI952481A7 (fi) 1995-05-22
DK0669920T3 (da) 2003-05-26
AU690529B2 (en) 1998-04-30
CA2149918A1 (en) 1994-06-09
US5580982A (en) 1996-12-03
NO952018L (no) 1995-05-22
AU5676594A (en) 1994-06-22
FI952481A0 (fi) 1995-05-22
NO952018D0 (no) 1995-05-22
EP0669920A4 (en) 1995-10-25
JPH08506094A (ja) 1996-07-02
DE69332691T2 (de) 2003-12-18
EP0669920A1 (en) 1995-09-06
US6046203A (en) 2000-04-04
DE69332691D1 (de) 2003-03-20
PT669920E (pt) 2003-06-30

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