ES2189873T3 - Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos. - Google Patents

Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos.

Info

Publication number
ES2189873T3
ES2189873T3 ES96917061T ES96917061T ES2189873T3 ES 2189873 T3 ES2189873 T3 ES 2189873T3 ES 96917061 T ES96917061 T ES 96917061T ES 96917061 T ES96917061 T ES 96917061T ES 2189873 T3 ES2189873 T3 ES 2189873T3
Authority
ES
Spain
Prior art keywords
agents
magnetic resonance
resonance image
detection
physiological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917061T
Other languages
English (en)
Inventor
Thomas Meade
Scott Fraser
Russell Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2189873T3 publication Critical patent/ES2189873T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS AGENTES DE CONTRASTE DE IMAGEN DE RESONANCIA MAGNETICA Y A METODOS PARA DETECTAR SEÑALES O SUSTANCIAS FISIOLOGICAS.
ES96917061T 1995-06-02 1996-06-03 Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos. Expired - Lifetime ES2189873T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46051195A 1995-06-02 1995-06-02
US08/486,968 US5707605A (en) 1995-06-02 1995-06-07 Magnetic resonance imaging agents for the detection of physiological agents

Publications (1)

Publication Number Publication Date
ES2189873T3 true ES2189873T3 (es) 2003-07-16

Family

ID=27039723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917061T Expired - Lifetime ES2189873T3 (es) 1995-06-02 1996-06-03 Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos.

Country Status (10)

Country Link
US (1) US5707605A (es)
EP (1) EP0831928B1 (es)
JP (1) JPH11506455A (es)
AT (1) ATE230278T1 (es)
AU (1) AU712899B2 (es)
CA (1) CA2222974C (es)
DE (1) DE69625595T2 (es)
ES (1) ES2189873T3 (es)
NO (1) NO975517L (es)
WO (1) WO1996038184A2 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
AU726914B2 (en) * 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
JP2001524095A (ja) * 1997-04-22 2001-11-27 ニユコメド・イメージング・アクシエセルカペト Ｎｍｒ画像形成化合物
ES2297888T3 (es) * 1997-07-01 2008-05-01 Ge Healthcare As Procedimiento diagnostico para la deteccion de isquemia miocardica.
US20040170563A1 (en) * 1997-10-27 2004-09-02 Meade Thomas J. Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2307332C (en) * 1997-10-27 2008-09-16 California Institute Of Technology Magnetic resonance imaging agents for the delivery of therapeutic agents
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (en) * 1997-11-17 2000-09-06 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
RU2150961C1 (ru) * 1998-02-06 2000-06-20 Кулаков Виктор Николаевич Магнитно-резонансная контрастная композиция
GB9823175D0 (en) * 1998-10-22 1998-12-16 Nycomed Imaging As Compound
TW490454B (en) * 1999-04-23 2002-06-11 Dept Of Health R O C Triaminopentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand
US6548044B1 (en) * 1999-11-22 2003-04-15 Epix Medical, Inc. Imaging sexual response
WO2001052906A2 (en) * 2000-01-22 2001-07-26 Epix Medical, Inc. Magnetic resonance imaging using contrast agents prodrugs bioactivated by enzymatic cleavage
US20030082106A1 (en) * 2000-01-22 2003-05-01 Aleksandr Nivorozhkin Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage
US6673333B1 (en) * 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
WO2001082795A2 (en) * 2000-05-04 2001-11-08 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
US20040146463A1 (en) * 2000-05-04 2004-07-29 Meade Thomas J. Functional MRI agents for cancer imaging
WO2001089584A2 (en) * 2000-05-23 2001-11-29 Amersham Health As Contrast agents
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
WO2002032291A2 (en) * 2000-10-19 2002-04-25 The General Hospital Corporation Imaging of enzymatic activity
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
WO2002087632A1 (en) * 2001-05-02 2002-11-07 Metaprobe, Inc. High throughput screening methods using magnetic resonance imaging agents
NO20015814D0 (no) * 2001-11-28 2001-11-28 Amersham Health As Metallkompleksforbindelser
CN1649600A (zh) * 2002-02-28 2005-08-03 A&D生物科学公司 氟西汀及类似物的糖醛酰胺、苷和原酸酯苷及其应用
EP1487499B1 (en) * 2002-03-07 2009-06-10 Carnegie-Mellon University Contrast agents for magnetic resonance imaging and methods related thereto
US7998704B2 (en) * 2002-03-07 2011-08-16 Carnegie Mellon University Methods for magnetic resonance imaging
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
CA2484891A1 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
WO2003101279A2 (en) * 2002-06-03 2003-12-11 Christopher Frederickson Magnetic resonance imaging of metal concentrations
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
JP3606280B2 (ja) * 2002-07-16 2005-01-05 日産自動車株式会社 樹脂製チューブ及び燃料系配管用チューブ
US20040022735A1 (en) * 2002-08-02 2004-02-05 Uzgiris Egidijus E Enzyme activated contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US20050036947A1 (en) * 2003-08-12 2005-02-17 General Electric Company Target-specific activatable polymeric imaging agents
US20050232866A1 (en) * 2004-03-26 2005-10-20 Alerion Biomedical Inc. Biochemically-activated contrast agents for magnetic resonance imaging
FR2868320B1 (fr) * 2004-03-31 2007-11-02 Centre Nat Rech Scient Cnrse Agent de contraste pour l'imagerie par resonance magnetique
WO2005096789A2 (en) * 2004-04-12 2005-10-20 Georgia Tech Research Corporation Methods and compositions for imaging and biomedical applications
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US20070292354A1 (en) * 2004-09-23 2007-12-20 Guerbet Contrast Agents Encapsulating Systems for Cest Imaging
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8926945B2 (en) * 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8003078B2 (en) * 2006-03-29 2011-08-23 Barnes-Jewish Hospital Targeted MR imaging agents
US20090142273A1 (en) * 2006-06-08 2009-06-04 Case Western Reserve University Activatable cest MRI agent
US8133474B2 (en) * 2006-09-15 2012-03-13 Massachusetts Institute Of Technology Sensors for fluorescence and magnetic resonance imaging
WO2009032160A2 (en) * 2007-08-28 2009-03-12 Massachusetts Institute Of Technology Metalloprotein mri contrast agents and related methods
WO2009036441A2 (en) * 2007-09-14 2009-03-19 Northwestern University Contrast agents
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
WO2010042815A2 (en) * 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
RU2396983C1 (ru) * 2009-04-13 2010-08-20 Виктор Сергеевич Скуридин Контрастная композиция для медицинской диагностики на основе комплексов гадолиния
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
PL2721045T3 (pl) * 2011-06-20 2017-11-30 Radiomedix Inc. Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych
FR2980364B1 (fr) 2011-09-26 2018-08-31 Guerbet Nanoemulsions et leur utilisation comme agents de contraste
FR3001154B1 (fr) 2013-01-23 2015-06-26 Guerbet Sa Magneto-emulsion vectorisee
CA2956161A1 (en) 2014-07-23 2016-01-28 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188816A (en) * 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
AU6621586A (en) * 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5219553A (en) * 1986-08-04 1993-06-15 Salutar, Inc. Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
JP2833766B2 (ja) * 1987-07-16 1998-12-09 ニユコメド・アクシエセルカペト アミノポリカルボン酸およびその誘導体
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物
WO1992019264A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Biomodulators as universal imaging agents
US5262532A (en) * 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5407657A (en) * 1992-09-22 1995-04-18 Unger; Evan C. Hybrid magnetic resonance contrast agents
US5466439A (en) * 1992-11-12 1995-11-14 Magnetic Research, Inc. Polymeric contrast enhancing agents for magnetic resonance images
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Also Published As

Publication number Publication date
CA2222974A1 (en) 1996-12-05
EP0831928A2 (en) 1998-04-01
DE69625595T2 (de) 2003-11-27
NO975517D0 (no) 1997-12-01
US5707605A (en) 1998-01-13
CA2222974C (en) 2004-05-11
EP0831928B1 (en) 2003-01-02
ATE230278T1 (de) 2003-01-15
DE69625595D1 (de) 2003-02-06
AU712899B2 (en) 1999-11-18
JPH11506455A (ja) 1999-06-08
AU5975196A (en) 1996-12-18
WO1996038184A2 (en) 1996-12-05
WO1996038184A3 (en) 1997-03-13
NO975517L (no) 1998-01-19

Similar Documents

Publication Publication Date Title
ES2189873T3 (es) Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos.
PT788605E (pt) Deteccao de anticorpos bacterianos por polarizacao de fluorescencia
CZ111799A3 (cs) Způsob modifikace obrazového signálu
IS4833A (is) Lífefnafræðilega virkjuð skuggaefni til myndgreiningar
ATE225949T1 (de) Motorgesteuertes chirurgisches system
ES2178093T3 (es) Derivados de epotilon y su preparacion.
DE69422687D1 (de) Biosensor zur hämatokritbestimmung
DE69612017D1 (de) Emulsion zur robusten erfassung von gasen
EP0699051A4 (en) MACROMOLECULAR CONTRAST FOR IMAGE GENERATION BY MEANS OF MAGNETIC CORE RESONANCE
DE69622390D1 (de) Radar-erfassungssystem
DE69320716D1 (de) Gerät zur Detektion von Verschiebungsinformation
EP0744753A3 (en) Sensing amplifier
DE69629417D1 (de) System zur Bilddetektion
EP0838027A4 (en) Detection of small analytes
FI973418L (fi) Vasta-ainetuotannon toteaminen
IT1232345B (it) Carta di registrazione sensibile alla pressione e sviluppatore di colore per essa.
DE69626356D1 (de) Korrelation von OFDM-Signalen
DE59008444D1 (de) Geber zur zylindererkennung.
EP0626693A3 (en) Multiplex sense amplifier.
ITRM930002A0 (it) Antibiogramma e corredo diagnostico per la sua realizzazione.
EP0820186A4 (en) Signal processor
ITSV950001A0 (it) Sensore di movimento con spia di frattura
FR2700864B1 (fr) Système détecteur de falsification d'informations mémorisées.
ES1019393Y (es) Mazo de bolsas para supermercados y similares.
KR970003024U (ko) 브이.씨.알의 휘도신호 기록장치