ES2190440T3 - Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento. - Google Patents

Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento.

Info

Publication number
ES2190440T3
ES2190440T3 ES94912300T ES94912300T ES2190440T3 ES 2190440 T3 ES2190440 T3 ES 2190440T3 ES 94912300 T ES94912300 T ES 94912300T ES 94912300 T ES94912300 T ES 94912300T ES 2190440 T3 ES2190440 T3 ES 2190440T3
Authority
ES
Spain
Prior art keywords
treatment
pharmaceutical compositions
modes
preparation
antitumoral compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912300T
Other languages
English (en)
Inventor
Iwao Ojima
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Research Foundation of the State University of New York
Original Assignee
Indena SpA
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA, Research Foundation of the State University of New York filed Critical Indena SpA
Application granted granted Critical
Publication of ES2190440T3 publication Critical patent/ES2190440T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A TAXANAS NUEVAS UTILES COMO AGENTES QUIMIOTERAPEUTICOS O SUS PRECURSORES. LOS PROCESOS PARA PREPARAR LAS TAXANAS NUEVAS INCLUYE UNIR REACCIONES, EN LA PRESENCIA DE UNA BASE DE BACATIN DE FORMULA (III) O (IV) CON {BE}-LACTAMOS DE FORMULA (V). EL INVENTO TAMBIEN PROPORCIONA COMPOSICIONES FARMACEUTICAS INCLUYENDO LAS TAXANAS NUEVAS Y METODOS PARA EL TRATAMIENTO DE CIERTOS CANCERES CON ESTOS NUEVOS COMPUESTOS.
ES94912300T 1993-03-26 1994-03-24 Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento. Expired - Lifetime ES2190440T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (1)

Publication Number Publication Date
ES2190440T3 true ES2190440T3 (es) 2003-08-01

Family

ID=21909617

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912300T Expired - Lifetime ES2190440T3 (es) 1993-03-26 1994-03-24 Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento.

Country Status (19)

Country Link
US (3) US5475011A (es)
EP (1) EP0690856B1 (es)
JP (2) JP3157165B2 (es)
KR (1) KR100223720B1 (es)
CN (1) CN1067682C (es)
AT (1) ATE229018T1 (es)
AU (1) AU676041B2 (es)
CA (1) CA2158147C (es)
CZ (1) CZ288924B6 (es)
DE (1) DE69431833T2 (es)
DK (1) DK0690856T3 (es)
ES (1) ES2190440T3 (es)
HU (1) HUT73848A (es)
NO (1) NO311722B1 (es)
PL (2) PL180708B1 (es)
PT (1) PT690856E (es)
RU (1) RU2137764C1 (es)
SK (1) SK282317B6 (es)
WO (1) WO1994022856A1 (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335362B1 (en) * 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
FR2718137B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
US5763477A (en) * 1994-07-22 1998-06-09 Dr. Reddy's Research Foundation Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US6075140A (en) 1995-04-28 2000-06-13 Daiichi Pharmaceutical Co., Ltd. Pentacyclic compound
IT1275435B (it) * 1995-05-19 1997-08-07 Indena Spa Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
EP0747372A1 (en) * 1995-06-06 1996-12-11 Dr. Reddy's Research Foundation Taxane derivatives from 14-beta-hydroxy-10 deacetybaccatin III
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
WO1997045105A1 (en) 1996-05-24 1997-12-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
WO1998000419A1 (en) * 1996-07-02 1998-01-08 Bristol-Myers Squibb Company Ortho-ester analogs of paclitaxel
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
WO1998013359A1 (de) * 1996-09-24 1998-04-02 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US6515016B2 (en) * 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
EP1019347B1 (en) * 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
RU2257387C2 (ru) * 1999-10-15 2005-07-27 Дайити Фармасьютикал Ко., Лтд. Пентациклическое соединение таксана и противоопухолевые агенты на его основе
HK1049997B (en) * 1999-11-24 2007-02-23 Immunogen, Inc. Cytotoxic agents comprising taxanes and their therapeutic use
PL350028A1 (en) * 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
PL202957B1 (pl) * 2000-02-02 2009-08-31 Univ Florida State Res Found Podstawione grupą estrową C10 taksany, kompozycja farmaceutyczna zawierająca te związki i zastosowanie tych związków do wytwarzania leku
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
HK1047934A1 (zh) 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c7碳酸酯取代的紫杉烷
US6750246B1 (en) * 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
US6449899B1 (en) * 2001-03-08 2002-09-17 Council Of Scientific And Industrial Research Method for inducing improved seed germination in Podophyllum hexandrum Royle
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ATE382624T1 (de) * 2001-11-29 2008-01-15 Daiichi Sankyo Co Ltd Kristalle von taxanderivaten und verfahren zu deren herstellung
US7390898B2 (en) * 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
EP1534674A4 (en) 2002-08-02 2007-11-28 Immunogen Inc CYTOTOXIC AGENTS CONTAINING NEW, EFFECTIVE TAXANES AND THEIR THERAPEUTIC USE
ITMI20021921A1 (it) 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
SV2006002010A (es) * 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
AU2004224925C1 (en) * 2004-08-30 2011-07-21 Biotest Ag Immunoconjugates targeting syndecan-1 expressing cells and use thereof
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
EP2428510A3 (en) * 2005-03-31 2012-06-13 Accord Healthcare Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin III
ES2435724T3 (es) * 2005-11-04 2013-12-23 Accord Healthcare Inc. Nuevos métodos para la preparación de taxanos usando auxiliares quirales
CN100516067C (zh) * 2006-01-10 2009-07-22 上海恒瑞医药有限公司 具有抗肿瘤活性的紫杉酚衍生物
US7615653B2 (en) * 2006-03-15 2009-11-10 The Research Foundation Of State University Of New York Anti-tuberculosis taxane compounds
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
RU2370261C2 (ru) * 2007-08-03 2009-10-20 Закрытое Акционерное Общество "Биокад" Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения
PL2242772T3 (pl) * 2007-12-26 2015-05-29 Biotest Ag Immunokonjugaty nakierowane na CD138 i ich zastosowanie
US9011864B2 (en) * 2007-12-26 2015-04-21 Biotest Ag Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
ES2475201T3 (es) * 2007-12-26 2014-07-10 Biotest Ag Agentes dirigidos contra CD138 y usos de los mismos
US9446146B2 (en) * 2007-12-26 2016-09-20 Biotest Ag Methods and agents for improving targeting of CD138 expressing tumor cells
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
NZ588884A (en) 2008-04-30 2013-05-31 Immunogen Inc Cross-linkers and their uses
JP5542804B2 (ja) 2008-05-23 2014-07-09 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア リポソームナノ粒子中で使用するための修飾薬物
CN101838281B (zh) * 2010-05-20 2015-02-18 上海博速医药科技有限公司 一种多西他赛手性侧链中间体的制备方法
CN103732229A (zh) 2011-08-02 2014-04-16 安斯泰来制药株式会社 基于药剂的联用的癌症治疗方法
US10117932B2 (en) 2011-12-08 2018-11-06 Biotest Ag Uses of immunoconjugates targeting CD138
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
JP6100627B2 (ja) * 2013-06-24 2017-03-22 株式会社パイロットコーポレーション 熱消色性筆記具インキ組成物及びそれを内蔵した筆記具
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
JP6417421B2 (ja) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 荷電連結体及び共役体のためのその使用
US9557445B2 (en) 2015-02-24 2017-01-31 Arkema France Optical diffusion blend materials for LED lighting
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147719A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
BR112020017053A2 (pt) 2018-02-21 2020-12-15 Celgene Corporation Anticorpos que se ligam ao bcma e usos dos mesmos
CN109485593A (zh) * 2018-12-12 2019-03-19 福建紫杉园生物有限公司 一种拉洛他赛手性侧链的合成工艺
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4857683A (en) * 1988-12-28 1989-08-15 W. H. Brady Co. Membrane switchcores with key cell contact elements connected together for continuous path testing
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5015722A (en) * 1990-04-04 1991-05-14 Hoechst Celanese Corporation Melt-processable polyester capable of forming an anisotropic melt which exhibits a highly attractive balance between its molding and heat deflection temperatures
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2698363B1 (fr) * 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Also Published As

Publication number Publication date
RU2137764C1 (ru) 1999-09-20
WO1994022856A1 (en) 1994-10-13
KR960701045A (ko) 1996-02-24
CZ248095A3 (en) 1996-03-13
PL179587B1 (pl) 2000-09-29
US5475011A (en) 1995-12-12
NO953796L (no) 1995-11-15
PT690856E (pt) 2003-04-30
EP0690856A1 (en) 1996-01-10
EP0690856A4 (es) 1996-02-07
US5705508A (en) 1998-01-06
JPH08508497A (ja) 1996-09-10
DK0690856T3 (da) 2003-03-31
CA2158147A1 (en) 1994-10-13
SK282317B6 (sk) 2002-01-07
KR100223720B1 (ko) 1999-10-15
JP3157165B2 (ja) 2001-04-16
US5599820A (en) 1997-02-04
JPH11322737A (ja) 1999-11-24
PL180708B1 (pl) 2001-03-30
HUT73848A (en) 1996-09-30
CN1123547A (zh) 1996-05-29
AU6491694A (en) 1994-10-24
CZ288924B6 (cs) 2001-09-12
CN1067682C (zh) 2001-06-27
EP0690856B1 (en) 2002-12-04
JP3145993B2 (ja) 2001-03-12
HU9502642D0 (en) 1995-11-28
NO311722B1 (no) 2002-01-14
NO953796D0 (no) 1995-09-25
DE69431833D1 (de) 2003-01-16
ATE229018T1 (de) 2002-12-15
DE69431833T2 (de) 2003-11-06
SK118395A3 (en) 1996-06-05
CA2158147C (en) 1999-10-05
AU676041B2 (en) 1997-02-27
PL310827A1 (en) 1996-01-08

Similar Documents

Publication Publication Date Title
ECSP055738A (es) PROCESO ENANTIOSELECTIVO PARA LA PREPARACIÓN DE AMBOS ENANTIÓMEROS DE 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ-[b,f]-AZEPIN-5-CARBOXAMIDA Y SUS NUEVAS FORMAS DE CRISTAL
AR023727A1 (es) Compuestos empleados en el tratamiento de padecimientos inflamatorios
ES2161085T3 (es) Formulaciones que contienen oxaliplatino.
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
PT991653E (pt) Novos compostos
UY28510A1 (es) Compuestos quimicos
CO4810373A1 (es) Compuestos azapoliciclicos condensados con arilo
GT200500007A (es) [1,8]naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia.
ECSP055609A (es) "Uso de inhibidores de la IkB-quinasa para el tratamiento del dolor"
ATE217629T1 (de) Phosphonooxymethyl oder methylthiomethylether von taxanderivaten als antitumormittel
UY27740A1 (es) Nuevos compuestos
ITMI920528A1 (it) 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
AR028948A1 (es) Compuestos novedosos
PA8551001A1 (es) Nuevos compuestos
PA8583401A1 (es) Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante (tgf)
GT198065892A (es) Derivados de acidos 6 b-hidroxialquilpenicilanicos como inhibidores de b-lactamasa.
MXPA05008382A (es) Acidos grasos, gliceridos y analogos con longitud de cadena media como estimuladores de eritropoyesis.
DK1104425T3 (da) Hidtil ukendte thiazolopyrimidinforbindelser
FI865233A0 (fi) Pyrazolinderivat, deras framstaellning och anvaendning som medel med insekticid och akaricid verkan.
SE9702564D0 (sv) New compounds
CY1108401T1 (el) Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων
UY26370A1 (es) "imidazo-5-il-aminas bicíclicas, medicamentos que las contienen, su uso para la preparación de medicamentos y procedimiento para su preparación".
PA8586801A1 (es) Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
PA8555501A1 (es) Compuestos de benzimidazol sustituido y su uso para el tratamiento del cancer
UY27203A1 (es) Bencimidazoles útiles en el tratamiento de la disfunción sexual