ATA57097A - Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung - Google Patents

Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung

Info

Publication number
ATA57097A
ATA57097A AT0057097A AT57097A ATA57097A AT A57097 A ATA57097 A AT A57097A AT 0057097 A AT0057097 A AT 0057097A AT 57097 A AT57097 A AT 57097A AT A57097 A ATA57097 A AT A57097A
Authority
AT
Austria
Prior art keywords
production
hydroxyiminoacetamido
aminothiazol
cephem
vinyl
Prior art date
Application number
AT0057097A
Other languages
English (en)
Other versions
AT405283B (de
Inventor
Johannes Dr Ludescher
Hubert Dr Sturm
Siegfried Wolf
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0057097A priority Critical patent/AT405283B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to JP54235898A priority patent/JP3421354B2/ja
Priority to BR9809745-8A priority patent/BR9809745A/pt
Priority to AT98921425T priority patent/ATE244249T1/de
Priority to PCT/EP1998/001953 priority patent/WO1998045299A1/en
Priority to IL13175598A priority patent/IL131755A0/xx
Priority to IDW991137A priority patent/ID22536A/id
Priority to AU74288/98A priority patent/AU731413B2/en
Priority to SK1343-99A priority patent/SK134399A3/sk
Priority to TR1999/02406T priority patent/TR199902406T2/xx
Priority to DE69816056T priority patent/DE69816056T2/de
Priority to KR10-1999-7008984A priority patent/KR100442717B1/ko
Priority to CA002283718A priority patent/CA2283718A1/en
Priority to HU0002987A priority patent/HUP0002987A3/hu
Priority to US09/381,947 priority patent/US6350869B1/en
Priority to EP98921425A priority patent/EP0973779B1/de
Priority to CNB988038501A priority patent/CN1139596C/zh
Priority to PL98335620A priority patent/PL335620A1/xx
Publication of ATA57097A publication Critical patent/ATA57097A/de
Application granted granted Critical
Publication of AT405283B publication Critical patent/AT405283B/de
Priority to NO994466A priority patent/NO994466L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0057097A 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung AT405283B (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
CA002283718A CA2283718A1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
PCT/EP1998/001953 WO1998045299A1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
IL13175598A IL131755A0 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
IDW991137A ID22536A (id) 1997-04-04 1998-04-02 Garam amina kristal dari cefdinir
AU74288/98A AU731413B2 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
SK1343-99A SK134399A3 (en) 1997-04-04 1998-04-02 Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use
JP54235898A JP3421354B2 (ja) 1997-04-04 1998-04-02 結晶性セフジニルアミン塩
DE69816056T DE69816056T2 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
KR10-1999-7008984A KR100442717B1 (ko) 1997-04-04 1998-04-02 세프디니르의 결정성 아민 염
BR9809745-8A BR9809745A (pt) 1997-04-04 1998-04-02 Sal cristalino de amina de cefdinir
HU0002987A HUP0002987A3 (en) 1997-04-04 1998-04-02 Dicyclohexyl-amine salt of cefdinir and process for the preparation of the salt and subsequent liberation of the free compound
US09/381,947 US6350869B1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
EP98921425A EP0973779B1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir
CNB988038501A CN1139596C (zh) 1997-04-04 1998-04-02 头孢地尼的胺盐晶体
PL98335620A PL335620A1 (en) 1997-04-04 1998-04-02 Crystalline cephdynir and amine salt
TR1999/02406T TR199902406T2 (xx) 1997-04-04 1998-04-02 Kristalli cefdinir amin tuz.
NO994466A NO994466L (no) 1997-04-04 1999-09-15 Krystallinsk aminsalt av cefdinir

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung

Publications (2)

Publication Number Publication Date
ATA57097A true ATA57097A (de) 1998-11-15
AT405283B AT405283B (de) 1999-06-25

Family

ID=3494111

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Country Status (18)

Country Link
US (1) US6350869B1 (de)
EP (1) EP0973779B1 (de)
JP (1) JP3421354B2 (de)
KR (1) KR100442717B1 (de)
CN (1) CN1139596C (de)
AT (2) AT405283B (de)
AU (1) AU731413B2 (de)
BR (1) BR9809745A (de)
CA (1) CA2283718A1 (de)
DE (1) DE69816056T2 (de)
HU (1) HUP0002987A3 (de)
ID (1) ID22536A (de)
IL (1) IL131755A0 (de)
NO (1) NO994466L (de)
PL (1) PL335620A1 (de)
SK (1) SK134399A3 (de)
TR (1) TR199902406T2 (de)
WO (1) WO1998045299A1 (de)

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KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
KR20110005727A (ko) 2002-08-13 2011-01-18 산도즈 아게 세프디니르 중간체
ITMI20022076A1 (it) 2002-10-01 2004-04-02 Antibioticos Spa Sali di intermedi del cefdinir.
US7244842B2 (en) * 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
CN100357294C (zh) * 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
WO2004104010A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US20050059819A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Cefdinir pyridine salt
US20050059818A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
US20050113355A1 (en) * 2003-09-12 2005-05-26 Duerst Richard W. Cefdinir pyridine salt
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
WO2005090360A1 (en) * 2004-03-19 2005-09-29 Orchid Chemicals & Pharmaceuticals Limited Novel polymorph of cefdinir
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2006010978A1 (en) * 2004-06-30 2006-02-02 Wockhardt Limited Cefdinir polymorphic forms, and imidazole salt
US7741478B2 (en) 2004-07-05 2010-06-22 Orchid Chemicals & Pharmaceuticals Limited Salts in the preparation of cephalosporin antibiotics
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
ITMI20042231A1 (it) * 2004-11-19 2005-02-19 Antibioticos Spa Cefdinir sale d'ammonio in forma cristallina
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
GB2421024A (en) * 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) * 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
US20080287673A1 (en) * 2005-06-15 2008-11-20 Parthasaradhi Reddy Bandk Cefdinir process
CN1903860B (zh) * 2005-07-25 2012-01-18 四川抗菌素工业研究所有限公司 溶媒法制备高纯度头孢他美钠工艺及医药用途
EP1828208A2 (de) * 2005-10-31 2007-09-05 Teva Pharmaceutical Industries Ltd Kristalline form eines cefdinir-cäsiumsalzes
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
CN101481383B (zh) 2008-12-31 2012-01-11 杭州奥默医药技术有限公司 头孢地尼酸式复盐化合物及制备方法
TR200909784A1 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Yeni sefdinir tuzları
US8614315B2 (en) 2009-12-25 2013-12-24 Mahmut Bilgic Cefdinir and cefixime formulations and uses thereof
CN102010427B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的制备方法
CN101974020B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的合成方法
CN103012433B (zh) * 2012-12-13 2015-06-24 珠海保税区丽珠合成制药有限公司 头孢地尼晶型b的制备方法
CN111039958B (zh) * 2017-05-31 2022-05-20 郑州大学第一附属医院 头孢地尼的制备方法
CN107286148B (zh) * 2017-06-20 2019-10-15 广州市桐晖通医药科技有限公司 一种头孢地尼的制备方法及其新的中间体化合物
CN111635419B (zh) * 2020-07-13 2022-05-24 广药白云山化学制药(珠海)有限公司 一种头孢地尼精制母液的处理方法

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Also Published As

Publication number Publication date
CN1251590A (zh) 2000-04-26
SK134399A3 (en) 2000-05-16
TR199902406T2 (xx) 2000-02-21
DE69816056D1 (de) 2003-08-07
US6350869B1 (en) 2002-02-26
NO994466D0 (no) 1999-09-15
IL131755A0 (en) 2001-03-19
ATE244249T1 (de) 2003-07-15
PL335620A1 (en) 2000-05-08
CN1139596C (zh) 2004-02-25
BR9809745A (pt) 2000-06-20
EP0973779B1 (de) 2003-07-02
AU731413B2 (en) 2001-03-29
DE69816056T2 (de) 2004-04-15
HUP0002987A3 (en) 2001-04-28
AT405283B (de) 1999-06-25
AU7428898A (en) 1998-10-30
KR100442717B1 (ko) 2004-08-02
NO994466L (no) 1999-09-15
HUP0002987A2 (hu) 2001-02-28
CA2283718A1 (en) 1998-10-15
EP0973779A1 (de) 2000-01-26
JP3421354B2 (ja) 2003-06-30
ID22536A (id) 1999-11-04
KR20010005907A (ko) 2001-01-15
WO1998045299A1 (en) 1998-10-15
JP2000514833A (ja) 2000-11-07

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