ES2192104T3 - Compuestos de piridazinona condensados de tipo novedoso. - Google Patents

Compuestos de piridazinona condensados de tipo novedoso.

Info

Publication number
ES2192104T3
ES2192104T3 ES99971809T ES99971809T ES2192104T3 ES 2192104 T3 ES2192104 T3 ES 2192104T3 ES 99971809 T ES99971809 T ES 99971809T ES 99971809 T ES99971809 T ES 99971809T ES 2192104 T3 ES2192104 T3 ES 2192104T3
Authority
ES
Spain
Prior art keywords
group
formula
alkyl
compounds
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99971809T
Other languages
English (en)
Inventor
Ferenc Andrasi
Agnes Angyal
Pal Berzsenyi
Sandor Boros
Laszlo Harsing
Katalin Horvath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd filed Critical Institute for Drugs Research Ltd
Application granted granted Critical
Publication of ES2192104T3 publication Critical patent/ES2192104T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados nuevos de piridacino-[4, 5]-[1, 5]-oxacepinona, -tiacepinona y diacepinona de fórmula general (I) **(Fórmula)** en la que: R significa un átomo de hidrógeno o un grupo de fórmula NHR4, en la que R4 es hidrógeno, un grupo de C1-4 alquilo ó C2-5 acilo, R1 representa un grupo C1-4-alquilo ó C2-4 alquenilo, que puede substituirse por un grupo de fenilo, o un grupo fenilo. W representa un grupo de metileno o carbonilo. X y Y son, independientemente, un átomo de oxígeno o de azufre, un grupo de SO, SO2 ó un grupo NR3, en el que R3 es un átomo de hidrógeno, un grupo de C1-4 alquilo o un grupo de fórmula (II), **(Fórmula)** en la que R2 representa un átomo de hidrógeno o halógeno, un grupo de C1-4 alcoxilo o nitro o un grupo de fórmula NHR4, en la que R4 tiene el significado arriba indicado, y Z representa un grupo de metileno o carbonilo, además n tiene un valor de 0, 1 ó 2, con la condición de que si alguno de X ó Y representa un átomo de oxígeno o azufre, un grupo de SO ó SO2 o un grupo de fórmula NR3, en la que R3 representa un átomo de hidrógeno o un grupo de C1-4 alquilo, el otro represente únicamente un grupo NR3 en el que R3 representa un grupo de fórmula (II) en la que R2, Z y n tienen el significado arriba indicado sus tautómeros y las sales de adición ácida de todos estos compuestos.
ES99971809T 1998-11-09 1999-11-09 Compuestos de piridazinona condensados de tipo novedoso. Expired - Lifetime ES2192104T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9802585A HUP9802585A3 (en) 1998-11-09 1998-11-09 Pyridazinooxazepine, -thiazepine, -diazepine and thiazine derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2192104T3 true ES2192104T3 (es) 2003-09-16

Family

ID=89997316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99971809T Expired - Lifetime ES2192104T3 (es) 1998-11-09 1999-11-09 Compuestos de piridazinona condensados de tipo novedoso.

Country Status (12)

Country Link
EP (1) EP1129097B1 (es)
JP (1) JP2002529470A (es)
KR (1) KR100636515B1 (es)
AT (1) ATE231873T1 (es)
AU (1) AU762526B2 (es)
CA (1) CA2350560C (es)
DE (1) DE69905191T2 (es)
DK (1) DK1129097T3 (es)
ES (1) ES2192104T3 (es)
HU (1) HUP9802585A3 (es)
PT (1) PT1129097E (es)
WO (1) WO2000027851A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0405034D0 (en) * 2004-03-05 2004-04-07 Novartis Ag Organic compounds
WO2010011537A1 (en) 2008-07-23 2010-01-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of the plasmodial surface anion channel as antimalarials
WO2012142125A2 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
WO2000027851A1 (en) 2000-05-18
AU1401600A (en) 2000-05-29
HUP9802585A3 (en) 2000-09-28
AU762526B2 (en) 2003-06-26
PT1129097E (pt) 2003-06-30
CA2350560A1 (en) 2000-05-18
HU9802585D0 (en) 1999-01-28
DK1129097T3 (da) 2003-06-02
ATE231873T1 (de) 2003-02-15
EP1129097B1 (en) 2003-01-29
CA2350560C (en) 2006-10-31
JP2002529470A (ja) 2002-09-10
KR20010092424A (ko) 2001-10-24
DE69905191T2 (de) 2003-10-16
DE69905191D1 (de) 2003-03-06
KR100636515B1 (ko) 2006-10-18
EP1129097A1 (en) 2001-09-05
HUP9802585A2 (hu) 2000-08-28

Similar Documents

Publication Publication Date Title
ATE282614T1 (de) Phenylharnstoff und phenylthioharnstoffderivate
HUP0301607A2 (hu) Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
BR9914036A (pt) Agentes antiincrustação
DE122010000034I2 (de) Substituierte thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
CY1110104T1 (el) Παραγωγα της πιπεραζινης ως αναστολεις ταχυκινινων
AR004195A1 (es) Nuevos derivados de la 5-0 desosaminil-6-0-metil-eritronolida a, su procedimiento de preparacion, compuestos intermediarios, metodo de aplicacionde los mismos para la preparacion de productos biologicamente activos.
CO5580768A2 (es) Derivados de 4,5-diariltiazol como ligandos cb-1
ES2053609T3 (es) Derivados de urea inhibidores de lipoxigenasa.
ES2253568T3 (es) Compuestos heterociclicos para el uso en el tratamiento de los trastornos de las vias urinarias.
ES2142773B1 (es) Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
CY1106545T1 (el) Ετεροκυκλικες ενωσεις, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν
ES2083625T3 (es) Derivados de n-feniltiourea y uso farmaceutico de los mismos.
DE3785803D1 (de) 4-cyano(nitro)-5-oxy(thio)-pyrazol-derivate.
CO4980887A1 (es) Nueva 3,4-diariltiazolina-2-uno o 2-tiono derivados, sus metodos de preparacion y su uso terapeutico
ATE241607T1 (de) Epoxybernsteinsäureamid-derivate
AR004965A1 (es) Procedimiento de preparacion de derivados de fenilimidazolidina
ATE380172T1 (de) Benzylaminanalogen
DE69220048D1 (de) Imidazoacridine und ihre antineoplastische anwendung
ES2057802T3 (es) Nuevos derivados de 3-amino-cromano, procedimiento de preparacion y composiciones farmaceuticas que los contienen.
EA200101230A1 (ru) Новые ингибиторы металлопротеаз, метод их получения и содержащие их фармацевтические композиции
DE60218561D1 (de) Thio-Derivate als würzende Bestandteile
ATE261447T1 (de) Prenyltransferase-inhibitoren
ES2190781T3 (es) Derivados de 1-trifluorometil-4-hidroxi-7-piperidinil-aminometilcromano.
DK1205476T3 (da) Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer
ES2192341T3 (es) Nuevos 19-noresteroides sustituidos en posicion 11beta, procedimiento e intermedios para su preparacion, aplicacion como medicamentos y composiciones farmaceuticas que los contienen.