ES2193271T3 - Procedimiento de preparacion de derivados de fenilimidazolidina. - Google Patents

Procedimiento de preparacion de derivados de fenilimidazolidina.

Info

Publication number
ES2193271T3
ES2193271T3 ES96938306T ES96938306T ES2193271T3 ES 2193271 T3 ES2193271 T3 ES 2193271T3 ES 96938306 T ES96938306 T ES 96938306T ES 96938306 T ES96938306 T ES 96938306T ES 2193271 T3 ES2193271 T3 ES 2193271T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
represent
phenylimidazolidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938306T
Other languages
English (en)
Inventor
Rapha L Bouchet
Michel Delthil
Daniel Guilmard
Philippe Mackiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2193271T3 publication Critical patent/ES2193271T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE PRODUCTOS DE FORMULA (I), EN LA CUAL: R 1 Y R 2 REPRESENTAN HIDROGENO, CIANO, HALOGENO O AMINO; R 3 REPRES ENTA HIDROGENO O HIDROXILO ALQUILO; R 4 Y R 5 REPRESENTAN UN ALQUILO, EN SU CASO SUSTITUIDO; X E Y REPRESENTAN OXIGENO O AZUFRE. SE CARACTERIZA POR QUE SE PREPARA UN PRODUCTO DE FORMULA (A), EN LA QUE W REPRESENTA UN ATOMO DE HALOGENO O UN DERIVADO DE LA HIDANTOINA, QUE SE SOMETE A DIVERSAS REACCIONES PARA OBTENER LOS PRODUCTOS DE FORMULA (I), TODOS SUS ISOMEROS Y SUS SALES.
ES96938306T 1995-11-16 1996-11-14 Procedimiento de preparacion de derivados de fenilimidazolidina. Expired - Lifetime ES2193271T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9513589A FR2741346B1 (fr) 1995-11-16 1995-11-16 Nouveau procede de preparation de derives phenylimidazolidine

Publications (1)

Publication Number Publication Date
ES2193271T3 true ES2193271T3 (es) 2003-11-01

Family

ID=9484624

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938306T Expired - Lifetime ES2193271T3 (es) 1995-11-16 1996-11-14 Procedimiento de preparacion de derivados de fenilimidazolidina.

Country Status (29)

Country Link
US (1) US6107488A (es)
EP (1) EP0877738B1 (es)
JP (1) JP2000500150A (es)
KR (1) KR100466991B1 (es)
CN (1) CN1131219C (es)
AR (1) AR004965A1 (es)
AT (1) ATE240300T1 (es)
AU (1) AU718832B2 (es)
BR (1) BR9611573A (es)
CA (1) CA2235335A1 (es)
CU (1) CU22890A3 (es)
CZ (1) CZ144498A3 (es)
DE (1) DE69628203T2 (es)
DK (1) DK0877738T3 (es)
EA (1) EA002658B1 (es)
ES (1) ES2193271T3 (es)
FR (1) FR2741346B1 (es)
HU (1) HUP9904034A3 (es)
IL (1) IL124382A0 (es)
MX (1) MX9803730A (es)
NO (1) NO316514B1 (es)
PL (1) PL189697B1 (es)
PT (1) PT877738E (es)
SI (1) SI0877738T1 (es)
TR (1) TR199800865T2 (es)
TW (1) TW404942B (es)
UA (1) UA67720C2 (es)
WO (1) WO1997018197A1 (es)
ZA (1) ZA969442B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE502298T1 (de) * 2003-12-19 2011-04-15 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
SI2656842T1 (sl) 2006-03-27 2016-10-28 The Regents Of The University Of California Modulator androgenih receptorjev za zdravljenje raka prostate in bolezni, povezanih z androgenimi receptorji
WO2007127010A2 (en) 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
EP2620432A3 (en) 2007-10-26 2013-12-18 The Regents Of the University of California Diarylhydantoin compounds
WO2011029782A1 (en) 2009-09-11 2011-03-17 Bayer Schering Pharma Aktiengesellschaft Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs
CA2768722C (en) 2009-09-15 2014-12-09 Mylan Group Copolymers, polymeric particles comprising said copolymers and copolymeric binders for radiation-sensitive coating compositions for negative-working radiation-sensitive lithographic printing plates
AU2011218173C1 (en) 2010-02-16 2015-04-16 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
JP5593447B2 (ja) 2010-09-14 2014-09-24 マイラン・グループ ポジティブワーキング感熱平板印刷基板用の近赤外線感光被覆用組成物のための共重合体
NZ744456A (en) 2012-09-26 2019-09-27 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
PL2945628T3 (pl) 2013-01-15 2020-09-21 Aragon Pharmaceuticals, Inc. Modulator receptorów androgenowych w skojarzeniu z octanem abirateronu i prednizonem do leczenia nowotworu stercza
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US10702508B2 (en) 2017-10-16 2020-07-07 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
CN108218784A (zh) * 2018-01-16 2018-06-29 吴江信凯医药科技有限公司 一种尼鲁米特的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4916937B1 (es) * 1970-01-21 1974-04-25
JPS5136332B1 (es) * 1970-12-09 1976-10-07
CH544491A (de) * 1971-03-16 1973-11-30 Ciba Geigy Ag Herbizides Mittel
MC1220A1 (fr) * 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
JPS57197268A (en) * 1981-05-29 1982-12-03 Sumitomo Chem Co Ltd Substituted phenylhydantoin derivative, its preparation, and herbicide containing the same as active ingredient
JPS62298562A (ja) * 1986-06-17 1987-12-25 Nippon Kayaku Co Ltd ブロモアニリン類の製造法
FR2656302B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
PT877738E (pt) 2003-09-30
WO1997018197A1 (fr) 1997-05-22
HUP9904034A3 (en) 2001-08-28
CN1131219C (zh) 2003-12-17
AR004965A1 (es) 1999-04-07
NO982237D0 (no) 1998-05-15
FR2741346A1 (fr) 1997-05-23
KR19990067639A (ko) 1999-08-25
ZA969442B (en) 1997-11-11
DE69628203D1 (de) 2003-06-18
KR100466991B1 (ko) 2005-04-06
BR9611573A (pt) 1999-05-11
PL326491A1 (en) 1998-09-28
PL189697B1 (pl) 2005-09-30
EA199800378A1 (ru) 1998-10-29
AU7577396A (en) 1997-06-05
JP2000500150A (ja) 2000-01-11
AU718832B2 (en) 2000-04-20
DE69628203T2 (de) 2004-02-05
NO316514B1 (no) 2004-02-02
US6107488A (en) 2000-08-22
CU22890A3 (es) 2004-01-23
CN1207732A (zh) 1999-02-10
IL124382A0 (en) 1998-12-06
FR2741346B1 (fr) 1997-12-19
ATE240300T1 (de) 2003-05-15
UA67720C2 (en) 2004-07-15
HUP9904034A2 (hu) 2000-05-28
TW404942B (en) 2000-09-11
TR199800865T2 (xx) 1998-08-21
EP0877738A1 (fr) 1998-11-18
MX9803730A (es) 1998-11-30
EA002658B1 (ru) 2002-08-29
CA2235335A1 (fr) 1997-05-22
NO982237L (no) 1998-07-10
DK0877738T3 (da) 2003-09-08
EP0877738B1 (fr) 2003-05-14
SI0877738T1 (en) 2003-10-31
CZ144498A3 (cs) 1998-09-16

Similar Documents

Publication Publication Date Title
ES2193271T3 (es) Procedimiento de preparacion de derivados de fenilimidazolidina.
ES2179386T3 (es) 1-arilpirazoles plaguicidas.
PT911333E (pt) Derivados de pirazolo¬4,3-d|pirimidina e composicoes farmaceuticas que os contenham
ES2148820T3 (es) Derivados de 3-pirazolcarboxamida con afinidad para el receptor de los canabinoides.
MX9206454A (es) Proceso para produccion de bicarbonato de sodio a partir de sales de sosa natural.
ES2100314T3 (es) Derivados de la pirimidina, su procedimiento de preparacion, productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que las contienen.
ES2137628T3 (es) Derivados de estilbeno y composiciones farmaceuticas que los contienen.
NO180538C (no) N-sulfonyl-2-oksoindol-derivater som har affinitet for vasopressin- og/eller ocytocin-reseptorer, farmasöytiske blandinger som inneholder dem og mellomprodukter ved fremstilling av derivatene
DK654689A (da) Phosphonsyresubstituerede aromatiske steroider som inhibitorer af steroid-5alfa-reduktase
PT848004E (pt) Derivados pirrolidina tendo actividade inibidora da fosfolipase a2
GT199700052A (es) Sales metanosulfonatode5-(2-4-(1,2-benzoisotiazol-3-il)-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-onadihidratadas
NO954768D0 (no) N-alkyltiopolyaminderivater som radiobeskyttende midler
AR029942A1 (es) Compuestos derivados de 1,3-dihidro-2h-indol-2-ona, su utilizacion, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden, medicamentos constituidos por dichos compuestos y compuestos intermediarios
DK519788A (da) 1-(benzylpiperidino)propan-2-ol-derivater og fremgangsmaade til fremstilling deraf, deres anvendelse som antimikrobielle midler samt produkter indeholdende dem
ES2053906T3 (es) Procedimiento para la obtencion de derivados de la 3,5-dimetil-4-metoxipiridina.
DE69225410D1 (de) Herstellung von n-acetylneuraminsäure-derivaten
ES2184304T3 (es) Procedimiento de preparacion de un perhidro-isoindol sustituido.
NZ228065A (en) 1,2,4-triazinediones and parasiticidal compositions; processes for preparation
FI964045A0 (fi) CCK:ta tai gastriinia säätelevä 5-heterosykli-1,5-bentsodiatsepiinejä
ES2160164T3 (es) Himenialdisina y sus derivados, procedimiento para producir un intermedio para su sintesis, y dicho intermedio.
BR9911250A (pt) Processo para preparação de compostos
ES2161446T3 (es) Taxoides, su preparacion y las composiciones farmaceuticas que les contienen.
ES2134313T3 (es) Utilizacion de derivados de pregnano para el tratamiento de tumores.
ES2143306T3 (es) Derivados del pregnano sin sustituyente en posicion 17-alfa, su aplicacion como medicamentos, procedimiento de preparacion, los productos intermedios de dicho procedimiento y composiciones que los contienen.
NO951135L (no) Syntese av N-acetyl-neuraminsyrederivater