ES2195598T3 - Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)piridina-3-acetamida y sus sales. - Google Patents

Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)piridina-3-acetamida y sus sales.

Info

Publication number
ES2195598T3
ES2195598T3 ES99938403T ES99938403T ES2195598T3 ES 2195598 T3 ES2195598 T3 ES 2195598T3 ES 99938403 T ES99938403 T ES 99938403T ES 99938403 T ES99938403 T ES 99938403T ES 2195598 T3 ES2195598 T3 ES 2195598T3
Authority
ES
Spain
Prior art keywords
methylpenyl
imidazo
acetamide
trimethyl
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99938403T
Other languages
English (en)
Other versions
ES2195598T5 (es
Inventor
Rafael Labriola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quimica Sintetica SA
Original Assignee
Quimica Sintetica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2195598(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quimica Sintetica SA filed Critical Quimica Sintetica SA
Application granted granted Critical
Publication of ES2195598T3 publication Critical patent/ES2195598T3/es
Publication of ES2195598T5 publication Critical patent/ES2195598T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Comprende reducir el hidroxiéster de fórmula (X) haciéndolo reaccionar en DMF sucesivamente con una sal de iminio de fórmula (XIII) formada "in situ" con cloruro de tionilo y dimetilformamida, y reducción subsiguiente con un reductor apropiado para formar el éster de fórmula (XII), que después se hace reaccionar con dimetilamina en un medio solvente polihidroxilado y a una temperatura adecuada.
ES99938403T 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo(1,2-a)piridina-3-acetamida y sus sales. Expired - Lifetime ES2195598T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9801694 1998-08-06
ES009801694A ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Publications (2)

Publication Number Publication Date
ES2195598T3 true ES2195598T3 (es) 2003-12-01
ES2195598T5 ES2195598T5 (es) 2008-05-01

Family

ID=8304817

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801694A Expired - Fee Related ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
ES99938403T Expired - Lifetime ES2195598T5 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo(1,2-a)piridina-3-acetamida y sus sales.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES009801694A Expired - Fee Related ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Country Status (25)

Country Link
US (1) US6407240B1 (es)
EP (1) EP1104765B2 (es)
JP (1) JP3544944B2 (es)
KR (1) KR100492054B1 (es)
AT (1) ATE234836T1 (es)
AU (1) AU750302B2 (es)
CA (1) CA2339594C (es)
CZ (1) CZ292446B6 (es)
DE (1) DE69906088T3 (es)
DK (1) DK1104765T4 (es)
ES (2) ES2151834B1 (es)
HR (1) HRP20010158B1 (es)
HU (1) HUP0102936A3 (es)
IL (1) IL141133A (es)
IS (1) IS5839A (es)
NO (1) NO319780B1 (es)
NZ (1) NZ510310A (es)
PL (1) PL195888B1 (es)
PT (1) PT1104765E (es)
RS (1) RS50103B (es)
RU (1) RU2221797C2 (es)
SI (1) SI1104765T2 (es)
SK (1) SK283652B6 (es)
WO (1) WO2000008021A2 (es)
ZA (1) ZA200101294B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
HRP20020471B1 (en) * 1999-11-22 2007-12-31 Egis Gy�gyszergy�r RT Process for the preparation of 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyrimidine-3-(n,n-dimethyl-acetamide) and intermediates
IT1318624B1 (it) 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
WO2004007496A1 (en) * 2002-07-15 2004-01-22 Scinopharm Taiwan, Ltd. Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
ES2320758T3 (es) 2002-12-18 2009-05-28 Mallinckrodt Inc. Sintesis de heteroaril acetamidas.
ATE451371T1 (de) * 2004-06-22 2009-12-15 Mallinckrodt Inc Synthese von heteroarylacetamiden aus reaktionsmischungen mit reduziertem wassergehalt
WO2007040995A1 (en) * 2005-10-03 2007-04-12 Mallinckrodt Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
CN103360387B (zh) * 2012-03-28 2016-12-14 江苏豪森药业集团有限公司 一种制备化合物唑吡坦的方法
CN104610253B (zh) * 2015-01-26 2016-11-16 郑州大学 2‑三氟甲基‑2‑羟基‑2‑(2‑芳基吡啶并[1,2‑α]咪唑)乙酸酯类化合物
CN114105974A (zh) * 2020-08-27 2022-03-01 鲁南制药集团股份有限公司 一种唑吡坦的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Also Published As

Publication number Publication date
KR20010072173A (ko) 2001-07-31
NZ510310A (en) 2002-11-26
CZ292446B6 (cs) 2003-09-17
CA2339594C (en) 2005-05-03
IS5839A (is) 2001-02-05
JP2002522437A (ja) 2002-07-23
JP3544944B2 (ja) 2004-07-21
RU2221797C2 (ru) 2004-01-20
NO20010613D0 (no) 2001-02-05
AU750302B2 (en) 2002-07-18
ES2195598T5 (es) 2008-05-01
ES2151834B1 (es) 2001-08-16
ES2151834A1 (es) 2001-01-01
SI1104765T2 (sl) 2008-04-30
SK1592001A3 (en) 2001-12-03
HRP20010158B1 (en) 2003-12-31
ZA200101294B (en) 2002-02-15
PL346158A1 (en) 2002-01-28
KR100492054B1 (ko) 2005-05-31
IL141133A (en) 2005-11-20
WO2000008021A2 (es) 2000-02-17
CA2339594A1 (en) 2000-02-17
DK1104765T4 (da) 2008-03-03
DE69906088D1 (de) 2003-04-24
US6407240B1 (en) 2002-06-18
PT1104765E (pt) 2003-08-29
NO20010613L (no) 2001-02-05
ATE234836T1 (de) 2003-04-15
RS50103B (sr) 2009-01-22
YU8301A (sh) 2003-10-31
NO319780B1 (no) 2005-09-12
WO2000008021A3 (es) 2000-07-06
DE69906088T3 (de) 2008-04-30
SI1104765T1 (en) 2003-08-31
HRP20010158A2 (en) 2002-02-28
HK1037624A1 (en) 2002-02-15
DK1104765T3 (da) 2003-06-30
EP1104765B2 (en) 2007-11-14
HUP0102936A2 (hu) 2002-01-28
PL195888B1 (pl) 2007-11-30
IL141133A0 (en) 2002-02-10
AU5291299A (en) 2000-02-28
SK283652B6 (sk) 2003-11-04
EP1104765B1 (en) 2003-03-19
EP1104765A2 (en) 2001-06-06
HUP0102936A3 (en) 2002-09-30
DE69906088T2 (de) 2003-12-24
CZ2001360A3 (cs) 2001-12-12

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