ES2196011T3 - Reactivos multifuncionales restringidos para modificacion de superficie. - Google Patents

Reactivos multifuncionales restringidos para modificacion de superficie.

Info

Publication number
ES2196011T3
ES2196011T3 ES93925147T ES93925147T ES2196011T3 ES 2196011 T3 ES2196011 T3 ES 2196011T3 ES 93925147 T ES93925147 T ES 93925147T ES 93925147 T ES93925147 T ES 93925147T ES 2196011 T3 ES2196011 T3 ES 2196011T3
Authority
ES
Spain
Prior art keywords
restricted
surface modification
multifunctional reagents
molecules
multifunctional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93925147T
Other languages
English (en)
Inventor
Dale G Swan
Charles A Hastings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of ES2196011T3 publication Critical patent/ES2196011T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicinal Preparation (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

UN REACTIVO MULTIFUNCIONAL UTIL PARA LA SUJECION DE LAS MOLECULAS DESEADAS A SUPERFICIES DE APOYO APROPIADAS, PARA PROPORCIONAR UNAS SUPERFICIES CON UNAS PROPIEDADES DESEADAS. LA MOLECULA REACTIVA DEL INVENTO ESTA LIMITADA PORQUE ESTA RESTRINGIDA EN SU FORMACION Y/O QUIMICAMENTE PARA REACCIONAR BIEN CONSIGO MISMA O CON OTRAS MOLECULAS DEL MISMO REACTIVO, POR LO QUE ES ADECUADA PARA VARIAS APLICACIONES.
ES93925147T 1992-11-06 1993-11-03 Reactivos multifuncionales restringidos para modificacion de superficie. Expired - Lifetime ES2196011T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/972,533 US5414075A (en) 1992-11-06 1992-11-06 Restrained multifunctional reagent for surface modification

Publications (1)

Publication Number Publication Date
ES2196011T3 true ES2196011T3 (es) 2003-12-16

Family

ID=25519767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93925147T Expired - Lifetime ES2196011T3 (es) 1992-11-06 1993-11-03 Reactivos multifuncionales restringidos para modificacion de superficie.

Country Status (9)

Country Link
US (2) US5414075A (es)
EP (1) EP0669837B1 (es)
JP (2) JP3939748B2 (es)
AT (1) ATE236656T1 (es)
AU (1) AU688286B2 (es)
CA (1) CA2148801C (es)
DE (1) DE69332858T2 (es)
ES (1) ES2196011T3 (es)
WO (1) WO1994011032A1 (es)

Families Citing this family (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH671345A5 (es) 1986-08-15 1989-08-31 Castolin Sa
ATE147613T1 (de) * 1989-09-15 1997-02-15 Chiron Vision Corp Synthetisches material, das die anlagerung, das wachstum und die befestigung von epithelzellen fördert, prosthetische vorrichtung zur subepithelialen implantation sowie behandelte linse
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US6540154B1 (en) 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6782886B2 (en) 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US6085740A (en) 1996-02-21 2000-07-11 Aerogen, Inc. Liquid dispensing apparatus and methods
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5886126A (en) * 1996-08-28 1999-03-23 University Of South Florida Combinatorial method of forming cascade polymer surfaces
US6150164A (en) * 1996-09-30 2000-11-21 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5792821A (en) * 1997-01-06 1998-08-11 American Dental Association Health Foundation Polymerizable cyclodextrin derivatives
US5873362A (en) * 1997-03-18 1999-02-23 Parker Medical Limited Partnership Endotracheal tube
DE19715504C2 (de) * 1997-04-14 2000-10-26 Max Planck Gesellschaft PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen
CA2286590C (en) * 1997-04-18 2005-08-02 California Institute Of Technology Multifunctional polymeric tissue coatings
US6391655B1 (en) * 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
US6177282B1 (en) 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6506895B2 (en) 1997-08-15 2003-01-14 Surmodics, Inc. Photoactivatable nucleic acids
US6762019B2 (en) 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US5858653A (en) * 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
DE19753848A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Modifikation von Oberflächen zur Steigerung der Oberflächenspannung
US6120939A (en) * 1998-01-13 2000-09-19 Daramic, Inc. Meltblown fiber battery separator
PT1019111E (pt) * 1998-04-27 2002-10-31 Surmodics Inc Revestimento que liberta um agente bioactivo
US6254634B1 (en) 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
US6528107B2 (en) 1999-01-19 2003-03-04 Sulzer Carbomedics Inc. Method for producing antimicrobial antithrombogenic medical devices
US6514768B1 (en) * 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
JP4647792B2 (ja) * 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
US6416549B1 (en) 1999-07-19 2002-07-09 Sulzer Carbomedics Inc. Antithrombogenic annuloplasty ring having a biodegradable insert
US6416548B2 (en) 1999-07-20 2002-07-09 Sulzer Carbomedics Inc. Antimicrobial annuloplasty ring having a biodegradable insert
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
ATE270590T1 (de) * 1999-09-22 2004-07-15 Surmodics Inc Initiationsgruppentragendes wasserlösliches beschichtungsmittel und beschichtungsverfahren
US6278018B1 (en) * 1999-12-14 2001-08-21 Surmodics, Inc. Surface coating agents
US7220276B1 (en) 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US6410643B1 (en) 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
MXPA02010884A (es) 2000-05-05 2003-03-27 Aerogen Ireland Ltd Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7100600B2 (en) 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6948491B2 (en) 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
DE10041542A1 (de) * 2000-08-24 2002-03-07 Febit Ferrarius Biotech Gmbh Neue Strategie zur Synthese von Polymeren auf Oberflächen
US6562136B1 (en) 2000-09-08 2003-05-13 Surmodics, Inc. Coating apparatus and method
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6444318B1 (en) 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
US7332330B2 (en) 2001-09-11 2008-02-19 Renamed Biologics, Inc. Device for maintaining vascularization near an implant
US7348055B2 (en) * 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
WO2003057291A1 (en) 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
JP4761709B2 (ja) 2002-01-15 2011-08-31 エアロジェン，インコーポレイテッド エアロゾル発生器を作動するための方法およびシステム
US7442546B2 (en) * 2002-03-15 2008-10-28 The Regents Of The University Of Michigan Method of modulating inflammatory response
US6706408B2 (en) 2002-05-16 2004-03-16 Surmodics, Inc. Silane coating composition
US6915962B2 (en) 2002-05-20 2005-07-12 Aerogen, Inc. Apparatus for providing aerosol for medical treatment and methods
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
AU2003260009A1 (en) * 2002-09-03 2004-03-29 Whatman Plc Porous composite membrane and method for making the same
US7285363B2 (en) * 2002-11-08 2007-10-23 The University Of Connecticut Photoactivators, methods of use, and the articles derived therefrom
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
US7041174B2 (en) * 2003-02-19 2006-05-09 Sunmodics,Inc. Grafting apparatus and method of using
EP1615034A4 (en) * 2003-03-31 2010-11-24 Rikagaku Kenkyusho FIXING AGENTS, METHOD FOR FIXING A SUBSTANCE USING SAID AGENTS, AND SUBSTRATE HAVING A SUBSTANCE FIXED WITH SAID AGENTS
US7077910B2 (en) 2003-04-07 2006-07-18 Surmodics, Inc. Linear rail coating apparatus and method
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
EP2974699A1 (en) 2003-04-16 2016-01-20 The Children's Hospital of Philadelphia Magnetically controllable drug and gene delivery stents
IES20030294A2 (en) * 2003-04-17 2004-10-20 Medtronic Vascular Connaught Coating for biomedical devices
TWI259106B (en) 2003-06-30 2006-08-01 China Petrochemical Technology Catalyst conversion process for increasing yield of light olefins
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
DE602004026612D1 (de) * 2003-09-09 2010-05-27 Univ Colorado Regents Verwendung der photopolymerisierung zur amplifikation und zum nachweis eines molekularen erkennungsereignisses
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
EP1732619A1 (en) * 2004-03-26 2006-12-20 SurModics, Inc. Composition and method for preparing biocompatible surfaces
EP1735024A1 (en) * 2004-03-26 2006-12-27 SurModics, Inc. Process and systems for biocompatible surfaces
CN1964749A (zh) * 2004-04-06 2007-05-16 苏莫迪克斯公司 用于生物活性剂的涂料组合物
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US20050281857A1 (en) * 2004-05-25 2005-12-22 Heyer Toni M Methods and reagents for preparing biomolecule-containing coatings
WO2006050110A2 (en) * 2004-10-28 2006-05-11 Surmodics, Inc. Pro-fibrotic coatings comprising collagen for medical implants
WO2006063181A1 (en) * 2004-12-06 2006-06-15 Surmodics, Inc. Multifunctional medical articles
US20060210603A1 (en) * 2005-02-23 2006-09-21 Williams Stuart K Implantable medical articles having laminin coatings and methods of use
EP1858438B1 (en) * 2005-03-15 2019-03-06 SurModics, Inc. Compliant polymeric coatings for insertable medical articles
NZ563360A (en) 2005-05-25 2011-04-29 Aerogen Inc Aerosolising liquid using an apertured membrane aligned within a peizoelectric ring
CA2609198A1 (en) * 2005-06-02 2006-12-07 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles
US7772393B2 (en) * 2005-06-13 2010-08-10 Innovative Surface Technologies, Inc. Photochemical crosslinkers for polymer coatings and substrate tie-layer
US7989619B2 (en) 2005-07-14 2011-08-02 Innovative Surface Technoloiges, Inc. Nanotextured surfaces
EP1904118B1 (en) * 2005-07-20 2018-01-17 Surmodics, Inc. Polymeric coatings and methods for cell attachment
EP1937796A2 (en) * 2005-07-20 2008-07-02 SurModics, Inc. Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
WO2007025059A1 (en) * 2005-08-26 2007-03-01 Surmodics, Inc. Silane coating compositions, coating systems, and methods
US20070141365A1 (en) * 2005-08-26 2007-06-21 Jelle Bruce M Silane Coating Compositions, Coating Systems, and Methods
CA2621595A1 (en) 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
WO2008006083A2 (en) * 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
US20080057298A1 (en) * 2006-08-29 2008-03-06 Surmodics, Inc. Low friction particulate coatings
US20080063627A1 (en) * 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
US20080075753A1 (en) * 2006-09-25 2008-03-27 Chappa Ralph A Multi-layered coatings and methods for controlling elution of active agents
EP2160484A2 (en) * 2007-06-22 2010-03-10 Innovative Surface Technologies, Inc. Nanofibers containing latent reactive groups
WO2009002858A2 (en) 2007-06-22 2008-12-31 Innovative Surface Technologies, Inc. Stimuli responsive nanofibers
WO2009005718A1 (en) * 2007-06-28 2009-01-08 Surmodics, Inc. Polypeptide microparticles having sustained release characteristics, methods and uses
WO2009009493A2 (en) 2007-07-09 2009-01-15 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES Aegyptin and uses thereof
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
WO2009120361A2 (en) 2008-03-28 2009-10-01 Surmodics, Inc. Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
JP5763525B2 (ja) 2008-05-07 2015-08-12 サーモディクス，インコーポレイティド 粒子からの核酸複合体の送達
AU2009288009A1 (en) * 2008-09-05 2010-03-11 Innovative Surface Technologies, Inc. Photoactivatable crosslinker compositions for surface modification
US8691983B2 (en) * 2009-03-03 2014-04-08 Innovative Surface Technologies, Inc. Brush polymer coating by in situ polymerization from photoreactive surface
EP2424581B1 (en) * 2009-04-28 2017-03-01 SurModics, Inc. Devices and methods for delivery of bioactive agents
US8246576B2 (en) 2009-05-18 2012-08-21 Surmodics, Inc. Method and apparatus for delivery of a therapeutic agent with an expandable medical device
US20110144373A1 (en) * 2009-12-10 2011-06-16 Surmodics, Inc. Water-soluble degradable photo-crosslinker
US20110144746A1 (en) * 2009-12-11 2011-06-16 Vanderbilt David P Intraocular Lens
US8287890B2 (en) * 2009-12-15 2012-10-16 C.R. Bard, Inc. Hydrophilic coating
US8932694B2 (en) 2010-06-29 2015-01-13 Surmodics, Inc. Fluorinated polymers and lubricious coatings
WO2012003296A1 (en) 2010-06-30 2012-01-05 Surmodics, Inc. Catheter assembly
JP5984806B2 (ja) 2010-06-30 2016-09-06 サーモディクス，インコーポレイティド 生体活性剤を送達する医療デバイスのための脂質コーティング
US8541498B2 (en) 2010-09-08 2013-09-24 Biointeractions Ltd. Lubricious coatings for medical devices
US8961457B2 (en) 2010-09-30 2015-02-24 Surmodics, Inc. Catheter assembly with guard
US8722076B2 (en) 2010-09-30 2014-05-13 Surmodics, Inc. Photochrome- or near IR dye-coupled polymeric matrices for medical articles
US10315987B2 (en) 2010-12-13 2019-06-11 Surmodics, Inc. Photo-crosslinker
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US8668667B2 (en) 2010-12-30 2014-03-11 Surmodics, Inc. Double wall catheter for delivering therapeutic agent
WO2012092566A1 (en) 2010-12-30 2012-07-05 Surmodics, Inc. Cell attachment coatings and methods
US9757497B2 (en) 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
JP6041802B2 (ja) 2011-06-03 2016-12-14 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
EP2731429A4 (en) * 2011-07-15 2015-03-04 Univ Georgia COMPOUNDS, METHOD OF MANUFACTURING THEREFOR AND USE METHOD THEREFOR
US9375517B2 (en) 2012-01-18 2016-06-28 Surmodies, Inc. Lubricious medical device coating with low particulates
JP5763565B2 (ja) 2012-02-02 2015-08-12 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
WO2013151991A1 (en) 2012-04-02 2013-10-10 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles with visualization moiety
JP5812935B2 (ja) 2012-05-16 2015-11-17 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
CA2874824C (en) 2012-06-01 2021-10-26 Surmodics, Inc. Apparatus and methods for coating balloon catheters
US9631190B2 (en) 2012-06-29 2017-04-25 Surmodics, Inc. Cell attachment coatings and methods using phosphorous-containing photoreagent
JP6063167B2 (ja) * 2012-08-02 2017-01-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6247216B2 (ja) 2012-09-10 2017-12-13 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US9155671B2 (en) 2012-10-16 2015-10-13 Surmodics, Inc. Wound packing device and methods
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014071387A1 (en) 2012-11-05 2014-05-08 Surmodics, Inc. Composition and method for delivery of hydrophobic active agents
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
JP5620456B2 (ja) 2012-11-20 2014-11-05 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6053482B2 (ja) 2012-11-30 2016-12-27 住友ゴム工業株式会社 注射器用ガスケットの製造方法
US9629945B2 (en) 2012-12-12 2017-04-25 Surmodics, Inc. Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence
EP4276161A3 (en) 2013-01-04 2024-01-17 SurModics, Inc. Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers
JP6105292B2 (ja) * 2013-01-07 2017-03-29 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP5816222B2 (ja) 2013-04-25 2015-11-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
WO2014186729A1 (en) 2013-05-16 2014-11-20 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
JP5797239B2 (ja) 2013-06-11 2015-10-21 住友ゴム工業株式会社 立体形状物の表面改質方法及び注射器用ガスケット
CN105263995B (zh) 2013-06-20 2019-05-28 住友橡胶工业株式会社 表面改性方法和表面改性体
AU2014311454A1 (en) * 2013-08-25 2016-03-24 Biotectix, LLC Conductive polymeric coatings, medical devices, coating solutions and methods
WO2015054677A1 (en) 2013-10-12 2015-04-16 Innovative Surface Technologies, Inc. Tissue scaffolds for electrically excitable cells
JP5820489B2 (ja) 2014-01-06 2015-11-24 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP2017522140A (ja) 2014-08-01 2017-08-10 サーモディクス，インコーポレイテッド ナノテクスチャー加工された表面を有する創傷充填装置
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
EP3177332B1 (en) 2014-08-08 2021-06-30 Surmodics, Inc. Article coatings including oligomerized polyphenol layer and biological methods of use
KR20170070008A (ko) 2014-08-15 2017-06-21 더 존스 홉킨스 유니버시티 조직 복원용 복합 재료
US10124088B2 (en) 2014-09-29 2018-11-13 Surmodics, Inc. Lubricious medical device elements
JP6338504B2 (ja) 2014-10-02 2018-06-06 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
EP3244960B1 (en) * 2015-01-14 2024-01-10 SurModics, Inc. Insertion tools for medical device
CN120114655A (zh) 2015-01-29 2025-06-10 苏尔莫迪克斯公司 疏水性活性剂颗粒的递送
JP6613692B2 (ja) 2015-08-03 2019-12-04 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6551022B2 (ja) 2015-08-03 2019-07-31 住友ゴム工業株式会社 表面改質方法及び表面改質体
EP3337464B1 (en) 2015-08-17 2022-03-09 The Johns Hopkins University In situ forming composite material for tissue restoration
CN108289734B (zh) 2015-08-17 2024-06-18 约翰·霍普金斯大学 用于组织恢复的间充质细胞结合复合材料
US10478546B2 (en) 2015-09-15 2019-11-19 Surmodics, Inc. Hemodialysis catheter sleeve
US10342898B2 (en) 2015-12-29 2019-07-09 Surmodics, Inc. Lubricious coatings with surface salt groups
US11174447B2 (en) 2015-12-29 2021-11-16 Surmodics, Inc. Lubricious coatings with surface salt groups
MX386870B (es) 2016-03-31 2025-03-19 Surmodics Inc Recubrimiento lubricante para dispositivo medico.
US10806904B2 (en) 2016-03-31 2020-10-20 Surmodics, Inc. Two-part insertion tool and methods
US20170281914A1 (en) 2016-03-31 2017-10-05 Surmodics, Inc. Localized treatment of tissues through transcatheter delivery of active agents
US10918835B2 (en) 2016-03-31 2021-02-16 Surmodics, Inc. Delivery system for active agent coated balloon
US10391292B2 (en) 2016-06-15 2019-08-27 Surmodics, Inc. Hemostasis sealing device with constriction ring
AU2017325722B2 (en) 2016-09-16 2023-11-30 Surmodics, Inc. Lubricious insertion tools for medical devices and methods for using
US10758719B2 (en) 2016-12-15 2020-09-01 Surmodics, Inc. Low-friction sealing devices
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP3790602A1 (en) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
EP3793661A4 (en) 2018-05-16 2022-03-09 SurModics, Inc. CATHETER WITH STRUCTURALLY SUPPORTED EXPANDABLE ELEMENTS AND METHODS THEREOF
WO2019222335A1 (en) 2018-05-16 2019-11-21 Surmodics, Inc. High-pressure balloon catheters and methods
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US12226552B2 (en) 2019-09-30 2025-02-18 Surmodics, Inc. Active agent depots formed in situ
US12037560B2 (en) 2019-10-21 2024-07-16 Biocoat, Incorporated UV cure topcoatings for medical devices
US11359156B2 (en) 2019-10-21 2022-06-14 Biocoat, Inc. UV cure basecoatings for medical devices
US12214146B2 (en) 2019-12-11 2025-02-04 Biocoat, Incorporated Controlled release of a hydrophilic agent from a coated surface
EP4076230B1 (en) 2019-12-20 2024-10-16 SurModics, Inc. Universal scoring device
US12496612B2 (en) 2021-01-08 2025-12-16 Surmodics, Inc. Coating application system and methods for coating rotatable medical devices
CA3234508A1 (en) 2021-10-08 2023-04-13 Surmodics Md, Llc Catheter with multiple braid layers
WO2023172686A1 (en) 2022-03-09 2023-09-14 Surmodics Coatings, LLC Thromboresistant coatings, coated devices, and methods
EP4514346A1 (en) 2022-04-25 2025-03-05 SurModics, Inc. Medical device coatings with microcrystalline active agents
WO2024102465A1 (en) 2022-11-10 2024-05-16 Surmodics, Inc. Polyacrylic acid containing lubricious coatings for medical devices with enhanced properties
US20240277906A1 (en) 2023-01-05 2024-08-22 Surmodics, Inc. Lubricious coatings for medical devices with enhanced durability
WO2026090506A1 (en) 2024-10-25 2026-04-30 Surmodics, Inc. Medical device coatings and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616229A (en) * 1968-09-27 1971-10-26 Monsanto Co Polymer-enzyme products comprising plurality of enzymes covalently bound to polymer
US3959078A (en) * 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US5258041A (en) * 1982-09-29 1993-11-02 Bio-Metric Systems, Inc. Method of biomolecule attachment to hydrophobic surfaces
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
CA1335721C (en) * 1987-12-24 1995-05-30 Patrick E. Guire Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification

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JP3939748B2 (ja) 2007-07-04
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AU5456794A (en) 1994-06-08
US5414075A (en) 1995-05-09
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