ES2196020T3 - Derivados de triazolobenzazepina antialergicos. - Google Patents

Derivados de triazolobenzazepina antialergicos.

Info

Publication number
ES2196020T3
ES2196020T3 ES94901886T ES94901886T ES2196020T3 ES 2196020 T3 ES2196020 T3 ES 2196020T3 ES 94901886 T ES94901886 T ES 94901886T ES 94901886 T ES94901886 T ES 94901886T ES 2196020 T3 ES2196020 T3 ES 2196020T3
Authority
ES
Spain
Prior art keywords
rent
replaced
halo
alk
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901886T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Jean Fernand Armand Lacrampe
Isabelle Noelle Consta Pilatte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2196020T3 publication Critical patent/ES2196020T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTAN TRIAZOLOBENZOACEPINAS DE LA FORMULA (I), EN DONDE CADA UNA DE LAS LINEAS PUNTEADAS REPRESENTA INDEPENDIENTEMENTE UN ENLACE OPCIONAL; R1 REPRESENTA HIDROGENO, HALO, ALQUIL C1-C4, HIDROXIDO O ALCOXIDO C1-C4; R2 REPRESENTA HIDROGENO, HALO, ALQUIL C1-C4; R3 REPRESENTA HIDROGENO, ALQUIL C1-C4 O HALO; -B D- ES UN RADICAL BIVALENTE DE LA FORMULA -C(R4) N(A-1); O -N C(R5)-(A-2); R4 Y R5 REPRESENTAN HIDROGENO, ALQUIKL C1-C4, ETENIL SUSTITUIDO CON HIDROXICARBONIL O ALQUILOXICARBONIL C1-C4, ALQUIL C1-C4 SUSTITUIDO CON HIDROXICARBONIL O ALQUILOXICARBONIL C1-C4, HIDROXI(C1-C4)ALQUIL, FORMIL O HIDROXICARBONIL; R5 TAMBIEN REPRESENTA FENIL O PIRIDINIL; L REPRESENTA HIDROGENO; ALQUIL C1C6; ALQUIL C1-C6 SUSTITUIDO; ALQUENIL C3-C6; ALQUENIL C3-C6 SUSTITUIDO CON ARIL O, L REPRESENTA UN RADICAL DE LA FORMULA ALK-Y-HET1 (B-1), -ALK-NH-CO-HET2 (B-2) O -ALK-HET3 (B-3). TAMBIEN SE PRESENTAN COMPOSICIONES QUE COMPRENDEN DICHOS COMPUESTOS, PROCESOS PARA PREPARAR LOS MISMOS Y PRODUCTOS INTERMEDIOS EN LA PREPARACION DE LOS MISMOS.
ES94901886T 1992-12-04 1993-11-25 Derivados de triazolobenzazepina antialergicos. Expired - Lifetime ES2196020T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92203776 1992-12-04

Publications (1)

Publication Number Publication Date
ES2196020T3 true ES2196020T3 (es) 2003-12-16

Family

ID=8211104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901886T Expired - Lifetime ES2196020T3 (es) 1992-12-04 1993-11-25 Derivados de triazolobenzazepina antialergicos.

Country Status (16)

Country Link
US (1) US5932569A (es)
EP (1) EP0675887B1 (es)
JP (1) JP3572074B2 (es)
KR (1) KR100251893B1 (es)
AT (1) ATE236164T1 (es)
AU (1) AU676701B2 (es)
CA (1) CA2150806C (es)
DE (1) DE69332830T2 (es)
ES (1) ES2196020T3 (es)
FI (1) FI952722A0 (es)
HU (1) HU223464B1 (es)
NO (1) NO305250B1 (es)
NZ (1) NZ258551A (es)
PL (1) PL176593B1 (es)
RU (1) RU2126802C1 (es)
WO (1) WO1994013671A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU676703B2 (en) * 1992-12-04 1997-03-20 Janssen Pharmaceutica N.V. Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives
CA2448735C (en) 2001-06-12 2008-10-28 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
EP1785424A3 (en) * 2003-04-11 2009-12-23 High Point Pharmaceuticals, LLC Fused 1,2,4-triazoles and pharmaceutical uses thereof
DE602004025220D1 (de) * 2003-04-11 2010-03-11 High Point Pharmaceuticals Llc Pharmazeutische verwendungen von kondensierten 1,2,4-triazolen
RU2239637C1 (ru) * 2003-07-17 2004-11-10 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Улучшенный способ получения 5-[2-этокси-5-(4-метилпиперазин-1-илсульфонил)фенил]-1 метил-3-н-пропил-1,6-дигидро-7h-пиразол [4,3-d] пиримидин-7-она
WO2006040329A1 (en) * 2004-10-12 2006-04-20 Novo Nordisk A/S 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
BRPI0618051A2 (pt) * 2005-11-01 2011-08-16 Transtech Pharma Inc uso farmacêutico de amidas substituìdas
KR20080076916A (ko) * 2005-11-01 2008-08-20 트랜스테크 파르마, 인크. 치환된 아미드의 약학적 사용
EP2007722A1 (en) * 2006-03-21 2008-12-31 High Point Pharmaceuticals, LLC Adamantane derivatives for the treatment of the metabolic syndrome
KR20090014347A (ko) 2006-04-07 2009-02-10 하이 포인트 파마슈티칼스, 엘엘씨 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
US8048908B2 (en) * 2006-07-13 2011-11-01 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
WO2008101907A2 (en) * 2007-02-23 2008-08-28 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
JP2010519239A (ja) * 2007-02-23 2010-06-03 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのｎ−アドマンチルベンザミド
ZA200904916B (en) 2007-02-23 2010-09-29 High Point Pharmaceuticals Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
EP2125704A1 (en) * 2007-02-23 2009-12-02 High Point Pharmaceuticals, LLC N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
CN101652359A (zh) * 2007-03-09 2010-02-17 高点制药有限责任公司 作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类
EP2141990A4 (en) * 2007-03-28 2011-07-06 High Point Pharmaceuticals Llc ACTIVE COMPOUNDS ON 11BETA-HSD1
CN101677562A (zh) * 2007-04-11 2010-03-24 高点制药有限责任公司 新化合物
JP2010526777A (ja) * 2007-04-24 2010-08-05 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 置換アミドの医薬用途
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1211437A (en) * 1981-08-12 1986-09-16 Rene Borer Benzazepines
US4894372A (en) * 1982-03-17 1990-01-16 Smith Kline & French Laboratories Limited Pyridine compounds which have useful histamine-H2 antagonist activity
ATE124045T1 (de) * 1990-10-10 1995-07-15 Schering Corp Substituierte imidazobenzazepine und imidazopyridoazepine.
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
AU676703B2 (en) * 1992-12-04 1997-03-20 Janssen Pharmaceutica N.V. Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives
DE69332929T2 (de) * 1992-12-04 2004-02-26 Janssen Pharmaceutica N.V. ANTIALLERGISCHE IMIDAZO[1,2-a]THIENO[2,3-d]AZEPINDERIVATE

Also Published As

Publication number Publication date
EP0675887B1 (en) 2003-04-02
HU223464B1 (hu) 2004-07-28
NO952198D0 (no) 1995-06-02
HU9501621D0 (en) 1995-08-28
EP0675887A1 (en) 1995-10-11
DE69332830D1 (de) 2003-05-08
PL176593B1 (pl) 1999-06-30
RU2126802C1 (ru) 1999-02-27
US5932569A (en) 1999-08-03
FI952722A7 (fi) 1995-06-02
RU95114439A (ru) 1997-06-10
NZ258551A (en) 1996-06-25
CA2150806A1 (en) 1994-06-23
NO305250B1 (no) 1999-04-26
HUT71811A (en) 1996-02-28
PL309253A1 (en) 1995-10-02
JPH08503952A (ja) 1996-04-30
NO952198L (no) 1995-08-03
AU5627894A (en) 1994-07-04
DE69332830T2 (de) 2004-01-29
ATE236164T1 (de) 2003-04-15
CA2150806C (en) 2006-01-31
WO1994013671A1 (en) 1994-06-23
AU676701B2 (en) 1997-03-20
JP3572074B2 (ja) 2004-09-29
KR100251893B1 (ko) 2000-04-15
FI952722A0 (fi) 1995-06-02

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