ATE236164T1 - Antiallergische triazolobenzazepinderivate - Google Patents

Antiallergische triazolobenzazepinderivate

Info

Publication number: ATE236164T1
Authority: AT; Austria
Prior art keywords: 4alkyl; pct; substituted; hydroxycarbonyl; alk
Prior art date: 1992-12-04

Application number

AT94901886T

Other languages

English (en)

Inventor

Frans Eduard Janssens

Jean Fernand Armand Lacrampe

Isabelle Noelle Consta Pilatte

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-04

Filing date

1993-11-25

Publication date

2003-04-15

1993-11-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236164T1 publication Critical patent/ATE236164T1/de

Links

230000003266 anti-allergic effect Effects 0.000 title 1
QDEVEJYEXBFIJD-UHFFFAOYSA-N triazolo[4,5-i][1]benzazepine Chemical class C1=CC2=CC=CC=NC2=C2C1=NN=N2 QDEVEJYEXBFIJD-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical group 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 3
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94901886T 1992-12-04 1993-11-25 Antiallergische triazolobenzazepinderivate ATE236164T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP92203776		1992-12-04
PCT/EP1993/003320 WO1994013671A1 (en)	1992-12-04	1993-11-25	Antiallergic triazolobenzazepine derivatives

Publications (1)

Publication Number	Publication Date
ATE236164T1 true ATE236164T1 (de)	2003-04-15

Family

ID=8211104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94901886T ATE236164T1 (de)	1992-12-04	1993-11-25	Antiallergische triazolobenzazepinderivate

Country Status (16)

Country	Link
US (1)	US5932569A (de)
EP (1)	EP0675887B1 (de)
JP (1)	JP3572074B2 (de)
KR (1)	KR100251893B1 (de)
AT (1)	ATE236164T1 (de)
AU (1)	AU676701B2 (de)
CA (1)	CA2150806C (de)
DE (1)	DE69332830T2 (de)
ES (1)	ES2196020T3 (de)
FI (1)	FI952722A0 (de)
HU (1)	HU223464B1 (de)
NO (1)	NO305250B1 (de)
NZ (1)	NZ258551A (de)
PL (1)	PL176593B1 (de)
RU (1)	RU2126802C1 (de)
WO (1)	WO1994013671A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU676703B2 (en) *	1992-12-04	1997-03-20	Janssen Pharmaceutica N.V.	Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives
CA2448735C (en)	2001-06-12	2008-10-28	Janssen Pharmaceutica N.V.	Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
EP1785424A3 (de) *	2003-04-11	2009-12-23	High Point Pharmaceuticals, LLC	Kondensierte 1,2,4-Triazole und deren pharmazeutische Verwendungen
DE602004025220D1 (de) *	2003-04-11	2010-03-11	High Point Pharmaceuticals Llc	Pharmazeutische verwendungen von kondensierten 1,2,4-triazolen
RU2239637C1 (ru) *	2003-07-17	2004-11-10	Дж.Б.Кемикалс Энд Фармасьютикалс Лтд.	Улучшенный способ получения 5-[2-этокси-5-(4-метилпиперазин-1-илсульфонил)фенил]-1 метил-3-н-пропил-1,6-дигидро-7h-пиразол [4,3-d] пиримидин-7-она
WO2006040329A1 (en) *	2004-10-12	2006-04-20	Novo Nordisk A/S	1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
BRPI0618051A2 (pt) *	2005-11-01	2011-08-16	Transtech Pharma Inc	uso farmacêutico de amidas substituìdas
KR20080076916A (ko) *	2005-11-01	2008-08-20	트랜스테크 파르마, 인크.	치환된 아미드의 약학적 사용
EP2007722A1 (de) *	2006-03-21	2008-12-31	High Point Pharmaceuticals, LLC	Adamantanderivate zur behandlung des metabolischen syndroms
KR20090014347A (ko)	2006-04-07	2009-02-10	하이 포인트 파마슈티칼스, 엘엘씨	11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
US8048908B2 (en) *	2006-07-13	2011-11-01	High Point Pharmaceuticals, Llc	11β-hydroxysteroid dehydrogenase type 1 active compounds
EP1878721A1 (de) *	2006-07-13	2008-01-16	Novo Nordisk A/S	4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1
WO2008101907A2 (en) *	2007-02-23	2008-08-28	High Point Pharmaceuticals, Llc	N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
JP2010519239A (ja) *	2007-02-23	2010-06-03	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのｎ−アドマンチルベンザミド
ZA200904916B (en)	2007-02-23	2010-09-29	High Point Pharmaceuticals Llc	N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
EP2125704A1 (de) *	2007-02-23	2009-12-02	High Point Pharmaceuticals, LLC	N-adamantylbenzamide als inhibitoren von 11-beta-hydroxysteroiddehydrogenase
CN101652359A (zh) *	2007-03-09	2010-02-17	高点制药有限责任公司	作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类
EP2141990A4 (de) *	2007-03-28	2011-07-06	High Point Pharmaceuticals Llc	Aktive 11beta-hsd1-verbindungen
CN101677562A (zh) *	2007-04-11	2010-03-24	高点制药有限责任公司	新化合物
JP2010526777A (ja) *	2007-04-24	2010-08-05	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	置換アミドの医薬用途
KR102431436B1 (ko)	2014-08-29	2022-08-10	테스 파마 에스.알.엘.	α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1211437A (en) *	1981-08-12	1986-09-16	Rene Borer	Benzazepines
US4894372A (en) *	1982-03-17	1990-01-16	Smith Kline & French Laboratories Limited	Pyridine compounds which have useful histamine-H2 antagonist activity
ATE124045T1 (de) *	1990-10-10	1995-07-15	Schering Corp	Substituierte imidazobenzazepine und imidazopyridoazepine.
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
AU676703B2 (en) *	1992-12-04	1997-03-20	Janssen Pharmaceutica N.V.	Antiallergic triazolo(pyrrolo, thieno or furano)azepine derivatives
DE69332929T2 (de) *	1992-12-04	2004-02-26	Janssen Pharmaceutica N.V.	ANTIALLERGISCHE IMIDAZO[1,2-a]THIENO[2,3-d]AZEPINDERIVATE

1993
- 1993-11-25 AT AT94901886T patent/ATE236164T1/de not_active IP Right Cessation
- 1993-11-25 EP EP94901886A patent/EP0675887B1/de not_active Expired - Lifetime
- 1993-11-25 ES ES94901886T patent/ES2196020T3/es not_active Expired - Lifetime
- 1993-11-25 JP JP51372094A patent/JP3572074B2/ja not_active Expired - Fee Related
- 1993-11-25 HU HU9501621A patent/HU223464B1/hu not_active IP Right Cessation
- 1993-11-25 KR KR1019950702169A patent/KR100251893B1/ko not_active Expired - Fee Related
- 1993-11-25 PL PL93309253A patent/PL176593B1/pl not_active IP Right Cessation
- 1993-11-25 AU AU56278/94A patent/AU676701B2/en not_active Ceased
- 1993-11-25 RU RU95114439A patent/RU2126802C1/ru not_active IP Right Cessation
- 1993-11-25 CA CA002150806A patent/CA2150806C/en not_active Expired - Fee Related
- 1993-11-25 DE DE69332830T patent/DE69332830T2/de not_active Expired - Fee Related
- 1993-11-25 WO PCT/EP1993/003320 patent/WO1994013671A1/en not_active Ceased
- 1993-11-25 NZ NZ258551A patent/NZ258551A/en unknown
- 1993-11-25 US US08/433,388 patent/US5932569A/en not_active Expired - Fee Related
1995
- 1995-06-02 NO NO952198A patent/NO305250B1/no unknown
- 1995-06-02 FI FI952722A patent/FI952722A0/fi unknown

Also Published As

Publication number	Publication date
EP0675887B1 (de)	2003-04-02
HU223464B1 (hu)	2004-07-28
NO952198D0 (no)	1995-06-02
HU9501621D0 (en)	1995-08-28
EP0675887A1 (de)	1995-10-11
DE69332830D1 (de)	2003-05-08
PL176593B1 (pl)	1999-06-30
RU2126802C1 (ru)	1999-02-27
US5932569A (en)	1999-08-03
FI952722A7 (fi)	1995-06-02
RU95114439A (ru)	1997-06-10
NZ258551A (en)	1996-06-25
CA2150806A1 (en)	1994-06-23
NO305250B1 (no)	1999-04-26
HUT71811A (en)	1996-02-28
PL309253A1 (en)	1995-10-02
JPH08503952A (ja)	1996-04-30
NO952198L (no)	1995-08-03
AU5627894A (en)	1994-07-04
DE69332830T2 (de)	2004-01-29
CA2150806C (en)	2006-01-31
WO1994013671A1 (en)	1994-06-23
AU676701B2 (en)	1997-03-20
JP3572074B2 (ja)	2004-09-29
KR100251893B1 (ko)	2000-04-15
FI952722A0 (fi)	1995-06-02
ES2196020T3 (es)	2003-12-16

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69332830D1 (de)	2003-05-08	Antiallergische triazolobenzazepinderivate
MY117557A (en)	2004-07-31	1-(1,2-disubstituted piperidinyl)-4- substituted piperidine derivatives
AR023188A1 (es)	2002-09-04	Derivados de 1,4-diazabiciclo[3.2.2]nonan-4-carboxilatos y carboxamidas, su preparacion y su aplicacion en terapeutica
DK0772610T3 (da)	2001-01-29	Dihydrobenzofuraner
DE69628466D1 (de)	2003-07-03	Zwischenverbindungen zur Herstellung von neunen Pyridoncarbonsäurederivate oder deren Salzen
NO883487D0 (no)	1988-08-05	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
EP0528858A4 (en)	1993-04-28	Inhibitors of dipeptidyl-aminopeptidase type iv
DE69705819D1 (de)	2001-08-30	Angiogenesis hemmende pyridazinamine
NO924929L (no)	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser
AU2291097A (en)	1997-10-17	Novel phenanthridines substituted in the 6 position
CA2082574A1 (en)	1993-05-19	3-isoxazolylphenyl compounds, their preparation and their use
TR199700206A2 (xx)	1997-10-21	Floralkil- ve floralkoksi ikame edilmi� heterosiklik bradikinin-antagonistleri, bunlar�n imal edilmesine mahsus usul ve bunlar�n kullan�lmalar�.
NO983472L (no)	1998-07-28	Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoidene
IT1243801B (it)	1994-06-28	Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
SE9603285D0 (sv)	1996-09-10	New compounds
ATE315026T1 (de)	2006-02-15	Amlodipin-hemimaleat
NO952200L (no)	1995-08-03	Triazol (pyrrol, Tien eller furan)-azepinderivater med antiallergisk virkning
DK1104419T3 (da)	2002-09-23	N-substituerede azabicyloheptan-derivater, deres fremstilling og anvendelse
NZ501982A (en)	2000-10-27	N-oxide forms of 2,4,4-trisubstituted-1,3-dioxolane as anti-fungal agents
SE9404192D0 (sv)	1994-12-02	New process
NO950574L (no)	1995-08-18	Akronycinanaloger
NO952292D0 (no)	1995-06-09	Nye triazolokinazoliner, deres fremstilling og anvendelse
NO932002L (no)	1993-12-06	Nye tiosemikarbazonsyreestere
DK0662081T3 (da)	1997-05-05	Ureidoacetamidderivater, deres fremstilling og lægemidler indeholdende disse derivater
NO20053117L (no)	2005-06-24	Cyklopenta[c]isoksazol-3-aminer anvendt som materialbeskyttelsesmidler..