ES2196157T3 - Oligonucleotidos especificos para el virus de la hepatitis c. - Google Patents

Oligonucleotidos especificos para el virus de la hepatitis c.

Info

Publication number
ES2196157T3
ES2196157T3 ES96920788T ES96920788T ES2196157T3 ES 2196157 T3 ES2196157 T3 ES 2196157T3 ES 96920788 T ES96920788 T ES 96920788T ES 96920788 T ES96920788 T ES 96920788T ES 2196157 T3 ES2196157 T3 ES 2196157T3
Authority
ES
Spain
Prior art keywords
hcv
hepatitis
virus
specific oligonucleotides
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96920788T
Other languages
English (en)
Inventor
Bruce L Frank
John Goodchild
Henry A Hamlin Jr
Robert E Kilkuskie
Noel A Roberts
Peter C Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of ES2196157T3 publication Critical patent/ES2196157T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ESTA INVENCION PRESENTA OLIGONUCLEOTIDOS SINTETICOS COMPLEMENTARIOS A LAS REGIONES CONTIGUA Y NO CONTIGUA DEL ARN DEL VHC. TAMBIEN SE PRESENTAN LOS METODOS Y EQUIPOS DE ANALISIS PARA INHIBIR LA REPLICACION DEL VHC, INHIBIR LA EXPRESION DEL ACIDO NUCLEICO Y PROTEINAS DEL VHC Y TRATAR LAS INFECCIONES POR VHC.
ES96920788T 1995-06-06 1996-06-04 Oligonucleotidos especificos para el virus de la hepatitis c. Expired - Lifetime ES2196157T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47196895A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
ES2196157T3 true ES2196157T3 (es) 2003-12-16

Family

ID=23873702

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96920788T Expired - Lifetime ES2196157T3 (es) 1995-06-06 1996-06-04 Oligonucleotidos especificos para el virus de la hepatitis c.

Country Status (10)

Country Link
EP (2) EP0833902B1 (es)
AR (1) AR002757A1 (es)
AT (1) ATE240392T1 (es)
AU (1) AU6221996A (es)
CA (1) CA2226438A1 (es)
DE (1) DE69628167D1 (es)
ES (1) ES2196157T3 (es)
PT (1) PT833902E (es)
WO (1) WO1996039500A2 (es)
ZA (1) ZA964446B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097991A1 (es) * 2004-03-25 2005-10-20 Consejo Superior De Investigaciones Científicas Secuencia de rna, construcción de rna y dna, y composición farmacéutica inhibidoras de la proliferación del virus causante de la hepatitis tipo c (vhc), y sus aplicaciones

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1002878A3 (en) * 1998-11-19 2003-11-12 Tosoh Corporation Hepatitis C Virus RNA-binding oligo DNA and method preparing it
PT1238070E (pt) * 1999-12-13 2007-11-06 Bioniche Life Sciences Inc Oligonucleótidos sintéticos úteis sob o ponto de vista terapêutico
WO2001093905A1 (en) * 2000-06-08 2001-12-13 Intercell Biomedizinische Forschungs- Und Entwicklungs Ag Immunostimulatory oligodeoxynucleotides
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
AU2002356187A1 (en) * 2001-08-22 2003-03-10 Isis Pharmaceuticals, Inc. Molecular interaction sites of hepatitis c virus rna and methods of modulating the same
FR2884522A1 (fr) * 2005-04-19 2006-10-20 Larissa Balakireva Methode d'inhibition de la traduction et/ou la replication d'une sequence d'arn par multimerisation d'une de ses regions d'arn non codant replie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2143678A1 (en) * 1992-09-10 1994-03-17 Kevin P. Anderson Compositions and methods for treatment of hepatitis c virus-associated diseases
AU5141993A (en) * 1992-09-28 1994-04-26 Chiron Corporation Methods and compositions for controlling translation of hcv proteins
JPH10503364A (ja) * 1994-05-10 1998-03-31 ザ ジェネラル ホスピタル コーポレーション Ｃ型肝炎ウイルスのアンチセンス阻害

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097991A1 (es) * 2004-03-25 2005-10-20 Consejo Superior De Investigaciones Científicas Secuencia de rna, construcción de rna y dna, y composición farmacéutica inhibidoras de la proliferación del virus causante de la hepatitis tipo c (vhc), y sus aplicaciones
ES2270656A1 (es) * 2004-03-25 2007-04-01 Consejo Sup. Investig. Cientificas Secuencia de rna, construccion de rna y dna, y composicion farmaceutica inhibidoras de la proliferacion del virus causante de la hepatitis tipo c (vhc), y sus aplicaciones.
ES2270656B1 (es) * 2004-03-25 2008-03-16 Consejo Sup. Investig. Cientificas Secuencia de rna, construccion de rna y dna, y composicion farmaceutica inhibidoras de la proliferacion del virus causante de la hepatitis tipo c (vhc), y sus aplicaciones.

Also Published As

Publication number Publication date
AR002757A1 (es) 1998-04-29
CA2226438A1 (en) 1996-12-12
WO1996039500A2 (en) 1996-12-12
PT833902E (pt) 2003-09-30
AU6221996A (en) 1996-12-24
ZA964446B (en) 1996-12-06
EP1331267A3 (en) 2003-12-03
DE69628167D1 (de) 2003-06-18
EP0833902A2 (en) 1998-04-08
EP1331267A2 (en) 2003-07-30
WO1996039500A3 (en) 1997-03-13
EP0833902B1 (en) 2003-05-14
ATE240392T1 (de) 2003-05-15

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