ES2197618T3 - Agentes antiinflamatorios con selectividad glucocorticoide. - Google Patents
Agentes antiinflamatorios con selectividad glucocorticoide.Info
- Publication number
- ES2197618T3 ES2197618T3 ES99905971T ES99905971T ES2197618T3 ES 2197618 T3 ES2197618 T3 ES 2197618T3 ES 99905971 T ES99905971 T ES 99905971T ES 99905971 T ES99905971 T ES 99905971T ES 2197618 T3 ES2197618 T3 ES 2197618T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon
- twelve carbons
- twelve
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto de la Fórmula I **FORMULA** donde el símbolo- - - - - representa un enlace sencillo o doble, siempre que dos dobles enlaces no estén en posiciones contiguas; R1, R2, R3 y R4 son cada uno, independientemente, hidrógeno o E; o R1 y R2 juntos son -X*-Y*-Z*- donde * X* s es -O-o -CH2-, Y* es -C(O)- o - (C(R12)(R13))v donde R12 y R13 son, independientemente, hidrógeno o alquilo de uno a doce carbonos, y v es 1, 2 ó 3, y Z* se selecciona de -CH2-, -CH2S(O)t- donde t, como se utiliza aquí, es 0, 1 ó 2, -CH2O-, -CH2NR7- donde R7 se define abajo, - NR7- donde R7 se define abajo, y -O-; E es -LE-RE donde LE se selecciona de (1) un enlace covalente, (2) -O-, (3) -S(O)t-, (4) -C(X)-, donde X, como se utiliza aquí, se selecciona de O o S, (5) -NR7-, ; donde R7, como se utiliza aquí, se selecciona de (a) hidrógeno, (b) arilo (c) cicloalquilo de tres a doce carbonos, (d) alcanoílo, donde la parte alquilo es de uno a doce carbonos, (e) alcoxicarbonilo, donde la parte alquilo es de uno a doce carbonos, (f) alcoxicarbonilo, donde la parte alquilo es de uno a doce carbonos y está sustituida por 1 ó 2 grupos arilo, (g) alquilo de uno a doce carbonos, (h) alquilo de uno a doce carbonos sustituido con 1 ó 2 sustituyentes seleccionados, independientemente, de arilo o cicloalquilo de tres a doce carbonos, (i) alquenilo de tres a doce carbonos, siempre que un carbono de un doble enlace carbono-carbono no esté unidodirectamente a nitrógeno, (j) alquinilo de tres a doce carbonos, siempre que un carbono de un triple enlace carbono-carbono no esté unidodirectamente a nitrógeno, (6) -NR8C(X)NR9-, donde R8 y R9, como se utiliza aquí, son seleccionados, independientemente, de (a) hidrógeno, (b) arilo, (c) cicloalquilo de tres a doce carbonos, (d) alquilo de uno a doce carbonos, (e) alquilo de uno a doce carbonos sustituido con 1 ó 2 sustituyentes seleccionados, independientemente, de arilo o cicloalquilo de tres a doce carbonos, (f) alquenilo de tres a doce carbonos, siempre que un carbono de un doble enlace carbono-carbono no esté unido directamente a nitrógeno, alquinilo de tres a doce carbonos, siempre que un carbono de un triple enlace carbono-carbono no esté unido directamente a nitrógeno, (7) -X¿C(X)- donde X¿, como se utiliza aquí, se selecciona de O o S, (8) -C(X)X¿-, (9) -X¿C(X)X¿-, donde X¿, como se utiliza aquí, se selecciona de O o S, siempre que cuando X sea O, al menos uno de X¿ o X¿ sea O, (10) -NR8C(X)-, 25 (11) -C(X)NR8-, (12) -NR8C(X)X¿-, (13) -X¿C(X)NR8-, (14) -SO2NR8-, (15) -NR8SO2-, y (16) -NR8SO2NR9donde (6)-(16) están dibujados con sus extremos derechos unidos a RE, y RE se selecciona de (1) -OH, (2) -OG, donde G es un grupo protector de -OH, (3) -SH, (4) -CN, (5) halo, (6) haloalcoxi de uno a doce carbonos, (7) perfluoroalcoxi de uno a doce carbonos, (8) -CHO, (9) -NR7R7, , donde R7, , como se utiliza aquí, se selecciona de
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23913 | 1998-02-13 | ||
| US09/023,913 US6380207B2 (en) | 1998-02-13 | 1998-02-13 | Glucocortiocoid-selective antiinflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2197618T3 true ES2197618T3 (es) | 2004-01-01 |
Family
ID=21817891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99905971T Expired - Lifetime ES2197618T3 (es) | 1998-02-13 | 1999-02-15 | Agentes antiinflamatorios con selectividad glucocorticoide. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6380207B2 (es) |
| EP (1) | EP1053240B1 (es) |
| JP (1) | JP2002503666A (es) |
| KR (1) | KR20010040940A (es) |
| CN (1) | CN1153771C (es) |
| AT (1) | ATE237620T1 (es) |
| AU (1) | AU760511B2 (es) |
| BG (1) | BG64213B1 (es) |
| BR (1) | BR9907847A (es) |
| CA (1) | CA2320911A1 (es) |
| DE (1) | DE69906938T2 (es) |
| DK (1) | DK1053240T3 (es) |
| ES (1) | ES2197618T3 (es) |
| HU (1) | HUP0100846A3 (es) |
| IL (1) | IL137509A0 (es) |
| NO (1) | NO20004052L (es) |
| NZ (1) | NZ506012A (es) |
| PL (1) | PL342999A1 (es) |
| PT (1) | PT1053240E (es) |
| SK (1) | SK284076B6 (es) |
| TR (1) | TR200002345T2 (es) |
| WO (1) | WO1999041257A1 (es) |
| ZA (1) | ZA99533B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| ES2246292T3 (es) | 2000-10-30 | 2006-02-16 | Pfizer Products Inc. | Moduladores de receptor glucocorticoide. |
| US7026484B2 (en) * | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
| AU2003214879B2 (en) | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
| KR100492913B1 (ko) * | 2002-08-23 | 2005-06-03 | 주식회사 태평양 | 피부 감작 및 자극을 완화하는 피부 외용제 조성물 |
| JP2006506445A (ja) | 2002-08-28 | 2006-02-23 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 治療処置の方法 |
| US20040220153A1 (en) * | 2002-09-24 | 2004-11-04 | Jost-Price Edward Roydon | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| AU2003258047A1 (en) * | 2002-10-11 | 2004-05-04 | Ligand Pharmaceuticals Incorporated | 5-(1',1'-CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO-5H-CHROMENO(3,4-f)QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
| EP1551845A1 (en) * | 2002-10-11 | 2005-07-13 | Ligand Pharmaceuticals, Inc. | 5-CYCLOALKENYL 5 i H /i -CHROMENO 3,4-F QUINOLINE DERIV ATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS |
| DE20301728U1 (de) * | 2002-10-11 | 2004-03-11 | Ligand Pharmaceuticals, Inc., San Diego | 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen |
| US7235662B2 (en) * | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| JP4709759B2 (ja) * | 2003-08-22 | 2011-06-22 | リガンド・ファーマシューティカルズ・インコーポレイテッド | アンドロゲン受容体モジュレーター化合物としての６−シクロアミノ−２−キノリノン誘導体 |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| DE602004031356D1 (de) | 2003-11-21 | 2011-03-24 | Zalicus Inc | Verfahren und reagenzien zur behandlung von entzündlichen erkrankungen |
| US8519158B2 (en) * | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| BRPI0609191B8 (pt) | 2005-06-17 | 2021-05-25 | Ligand Pharm Inc | métodos e compostos moduladores de receptor de androgênio |
| WO2007025303A2 (en) | 2005-08-26 | 2007-03-01 | The Regents Of The University Of California | Non-steroidal antiandrogens |
| ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
| WO2007065828A1 (en) * | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Glucocorticoid receptor modulators as antiinflammatory agents |
| AU2006324090B2 (en) * | 2005-12-09 | 2012-05-31 | F. Hoffmann-La Roche Ag | Propionamide compounds as antiinflammatory agents |
| US8269612B2 (en) | 2008-07-10 | 2012-09-18 | Black & Decker Inc. | Communication protocol for remotely controlled laser devices |
| WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| US9908182B2 (en) | 2012-01-30 | 2018-03-06 | Black & Decker Inc. | Remote programming of a power tool |
| US8919456B2 (en) | 2012-06-08 | 2014-12-30 | Black & Decker Inc. | Fastener setting algorithm for drill driver |
| US20130327552A1 (en) | 2012-06-08 | 2013-12-12 | Black & Decker Inc. | Power tool having multiple operating modes |
| US10011006B2 (en) | 2013-08-08 | 2018-07-03 | Black & Decker Inc. | Fastener setting algorithm for drill driver |
| KR20220003554A (ko) | 2019-04-19 | 2022-01-10 | 리간드 파마슈티칼스 인코포레이티드 | 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996019458A2 (en) | 1994-12-22 | 1996-06-27 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US5696130A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| US5693133A (en) | 1995-05-10 | 1997-12-02 | Akzo Nobel Nv | Asbestos free roof coatings |
-
1998
- 1998-02-13 US US09/023,913 patent/US6380207B2/en not_active Expired - Fee Related
-
1999
- 1999-01-25 ZA ZA9900533A patent/ZA99533B/xx unknown
- 1999-02-15 NZ NZ506012A patent/NZ506012A/xx unknown
- 1999-02-15 BR BR9907847-3A patent/BR9907847A/pt not_active IP Right Cessation
- 1999-02-15 CN CNB998050342A patent/CN1153771C/zh not_active Expired - Fee Related
- 1999-02-15 ES ES99905971T patent/ES2197618T3/es not_active Expired - Lifetime
- 1999-02-15 WO PCT/US1999/003210 patent/WO1999041257A1/en not_active Ceased
- 1999-02-15 TR TR2000/02345T patent/TR200002345T2/xx unknown
- 1999-02-15 EP EP99905971A patent/EP1053240B1/en not_active Expired - Lifetime
- 1999-02-15 PL PL99342999A patent/PL342999A1/xx unknown
- 1999-02-15 AU AU26003/99A patent/AU760511B2/en not_active Ceased
- 1999-02-15 CA CA002320911A patent/CA2320911A1/en not_active Abandoned
- 1999-02-15 KR KR1020007008857A patent/KR20010040940A/ko not_active Ceased
- 1999-02-15 IL IL13750999A patent/IL137509A0/xx unknown
- 1999-02-15 JP JP2000531450A patent/JP2002503666A/ja not_active Withdrawn
- 1999-02-15 AT AT99905971T patent/ATE237620T1/de not_active IP Right Cessation
- 1999-02-15 HU HU0100846A patent/HUP0100846A3/hu unknown
- 1999-02-15 PT PT99905971T patent/PT1053240E/pt unknown
- 1999-02-15 DK DK99905971T patent/DK1053240T3/da active
- 1999-02-15 DE DE69906938T patent/DE69906938T2/de not_active Expired - Fee Related
- 1999-02-15 SK SK1196-2000A patent/SK284076B6/sk unknown
-
2000
- 2000-08-11 NO NO20004052A patent/NO20004052L/no not_active Application Discontinuation
- 2000-08-17 BG BG104698A patent/BG64213B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010040940A (ko) | 2001-05-15 |
| ZA99533B (en) | 1999-07-26 |
| PL342999A1 (en) | 2001-07-16 |
| BG64213B1 (bg) | 2004-05-31 |
| ATE237620T1 (de) | 2003-05-15 |
| US20010049377A1 (en) | 2001-12-06 |
| NZ506012A (en) | 2003-03-28 |
| DE69906938T2 (de) | 2004-02-26 |
| DK1053240T3 (da) | 2003-08-11 |
| HUP0100846A3 (en) | 2003-03-28 |
| WO1999041257A1 (en) | 1999-08-19 |
| BG104698A (en) | 2001-05-31 |
| EP1053240B1 (en) | 2003-04-16 |
| EP1053240A1 (en) | 2000-11-22 |
| HK1033309A1 (en) | 2001-08-24 |
| NO20004052L (no) | 2000-10-12 |
| CN1153771C (zh) | 2004-06-16 |
| PT1053240E (pt) | 2003-09-30 |
| US6380207B2 (en) | 2002-04-30 |
| BR9907847A (pt) | 2001-01-09 |
| AU760511B2 (en) | 2003-05-15 |
| SK284076B6 (sk) | 2004-09-08 |
| CN1297451A (zh) | 2001-05-30 |
| JP2002503666A (ja) | 2002-02-05 |
| DE69906938D1 (de) | 2003-05-22 |
| IL137509A0 (en) | 2001-07-24 |
| SK11962000A3 (sk) | 2001-03-12 |
| AU2600399A (en) | 1999-08-30 |
| HUP0100846A2 (hu) | 2001-09-28 |
| CA2320911A1 (en) | 1999-08-19 |
| TR200002345T2 (tr) | 2000-11-21 |
| NO20004052D0 (no) | 2000-08-11 |
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