ES2200706A1 - Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos. - Google Patents

Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos.

Info

Publication number
ES2200706A1
ES2200706A1 ES200201938A ES200201938A ES2200706A1 ES 2200706 A1 ES2200706 A1 ES 2200706A1 ES 200201938 A ES200201938 A ES 200201938A ES 200201938 A ES200201938 A ES 200201938A ES 2200706 A1 ES2200706 A1 ES 2200706A1
Authority
ES
Spain
Prior art keywords
bipyridyl
bisoxazoles
derivatives
bistiazoles
bisthiazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200201938A
Other languages
English (en)
Other versions
ES2200706B1 (es
Inventor
Sanchez Cantalejo Yolan Martin
Hormaeche Maria Jesus Villa
Pizarro Beatriz Saez
Romero Javier Soto
Brana Miguel Fernandez
Sanjuan Juan Carlos Lacal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Europea de Madrid SA
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Europea de Madrid SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Europea de Madrid SA filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES200201938A priority Critical patent/ES2200706B1/es
Priority to AU2003260515A priority patent/AU2003260515A1/en
Priority to PCT/ES2003/000424 priority patent/WO2004016622A1/es
Publication of ES2200706A1 publication Critical patent/ES2200706A1/es
Application granted granted Critical
Publication of ES2200706B1 publication Critical patent/ES2200706B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de 4-4''-Bipiridil-2-2''-bisoxazoles y 4-4''-bipiridil-2- 2''-bistiazoles como agentes antineoplásicos. La presente invención presenta nuevos derivados de 4-4''-bipiridil-2-2''- bisoxazoles y 4-4''-bipiridil-2-2''-bistiazoles de fórmula general I con actividad antiproliferativa, y concretamente, de células malignas como HT-29. Por otro lado, se indica en la presente patente el mecanismo de su producción industrial y su uso para el desarrollo de compuestos a farmacéuticos para el tratamiento de tumores humanos.
ES200201938A 2002-08-16 2002-08-16 Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos. Expired - Fee Related ES2200706B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200201938A ES2200706B1 (es) 2002-08-16 2002-08-16 Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos.
AU2003260515A AU2003260515A1 (en) 2002-08-16 2003-08-14 Derivatives of 4-4'-bipyridyl-2-2'-bisoxazoles and 4-4'-bipyridyl-2-2'-bistiazoles as antineoplasic agents
PCT/ES2003/000424 WO2004016622A1 (es) 2002-08-16 2003-08-14 Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplásicos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201938A ES2200706B1 (es) 2002-08-16 2002-08-16 Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos.

Publications (2)

Publication Number Publication Date
ES2200706A1 true ES2200706A1 (es) 2004-03-01
ES2200706B1 ES2200706B1 (es) 2005-06-01

Family

ID=31725576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200201938A Expired - Fee Related ES2200706B1 (es) 2002-08-16 2002-08-16 Derivados de 4-4'-bipiridil-2-2'-bisoxazoles y 4-4'-bipiridil-2-2'-bistiazoles como agentes antineoplasicos.

Country Status (3)

Country Link
AU (1) AU2003260515A1 (es)
ES (1) ES2200706B1 (es)
WO (1) WO2004016622A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2344780B1 (es) * 2009-03-03 2011-07-22 Universidad De Barcelona Compuestos bistiazolicos utiles para el tratamiento del cancer.
EP2612861B1 (en) 2010-09-02 2015-05-13 Universitat de Barcelona Fluorinated thiazoles for use in treating cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148194A (en) * 1961-07-03 1964-09-08 Arapahoe Chemicals Inc Certain 1, 4-bis[2(4-substituted, 5-phenyloxazolyl)] benzenes
FR2066252A5 (en) * 1970-10-20 1971-08-06 Sumitomo Chemical Co Oxazolyl optical brighteners for textiles and plastics
DD260698A1 (de) * 1986-11-27 1988-10-05 Tech Hochschule C Schorlemmer Verfahren zur herstellung von bis-oxazoliumsalzen
JP2000318313A (ja) * 1999-05-07 2000-11-21 Mitsui Chemicals Inc 光記録媒体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148194A (en) * 1961-07-03 1964-09-08 Arapahoe Chemicals Inc Certain 1, 4-bis[2(4-substituted, 5-phenyloxazolyl)] benzenes
FR2066252A5 (en) * 1970-10-20 1971-08-06 Sumitomo Chemical Co Oxazolyl optical brighteners for textiles and plastics
DD260698A1 (de) * 1986-11-27 1988-10-05 Tech Hochschule C Schorlemmer Verfahren zur herstellung von bis-oxazoliumsalzen
JP2000318313A (ja) * 1999-05-07 2000-11-21 Mitsui Chemicals Inc 光記録媒体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Patent Abstract of Japan [CD ROM] & JP 2000318313 A (YAMAMOTO CHEM INC) 21.11.2000 (resumen) *
RICE, C. et al.: New multidentate ligands for supramolecular coordination chemistry: double and triple helical complexes of ligands containing pyridil and thiazol donor units. J. Chem. Society, Dalton Transactions, 2001, Vol. 5, paginas 550-559. Pagina 551, conjunto L3. *

Also Published As

Publication number Publication date
ES2200706B1 (es) 2005-06-01
AU2003260515A8 (en) 2004-03-03
WO2004016622A1 (es) 2004-02-26
AU2003260515A1 (en) 2004-03-03

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