ES2225247T3 - Aparato y procedimiento para preparar particulas cristalinas. - Google Patents
Aparato y procedimiento para preparar particulas cristalinas.Info
- Publication number
- ES2225247T3 ES2225247T3 ES00973049T ES00973049T ES2225247T3 ES 2225247 T3 ES2225247 T3 ES 2225247T3 ES 00973049 T ES00973049 T ES 00973049T ES 00973049 T ES00973049 T ES 00973049T ES 2225247 T3 ES2225247 T3 ES 2225247T3
- Authority
- ES
- Spain
- Prior art keywords
- substance
- mixing chamber
- solvent
- liquid
- crystalline particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000010438 heat treatment Methods 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
- 229960001888 ipratropium Drugs 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 229960001268 isoetarine Drugs 0.000 description 1
- 229960001317 isoprenaline Drugs 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- HNJJXZKZRAWDPF-UHFFFAOYSA-N methapyrilene Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CS1 HNJJXZKZRAWDPF-UHFFFAOYSA-N 0.000 description 1
- 229960001869 methapyrilene Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229960001664 mometasone Drugs 0.000 description 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000002472 multi-metal deposition Methods 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
- 229960004398 nedocromil Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960004708 noscapine Drugs 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
- 229960000797 oxitropium Drugs 0.000 description 1
- RLANKEDHRWMNRO-UHFFFAOYSA-M oxtriphylline Chemical compound C[N+](C)(C)CCO.O=C1N(C)C(=O)N(C)C2=C1[N-]C=N2 RLANKEDHRWMNRO-UHFFFAOYSA-M 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
- 229960004448 pentamidine Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002720 reproterol Drugs 0.000 description 1
- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229960001457 rimiterol Drugs 0.000 description 1
- IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 description 1
- 229950004432 rofleponide Drugs 0.000 description 1
- 229940021597 salmeterol and fluticasone Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- 229960005105 terbutaline sulfate Drugs 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
- 229940110309 tiotropium Drugs 0.000 description 1
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Steroid Compounds (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9925934.3A GB9925934D0 (en) | 1999-11-03 | 1999-11-03 | Novel apparatus and process |
| GB9925934 | 1999-11-03 | ||
| GBGB0024511.8A GB0024511D0 (en) | 1999-11-03 | 2000-10-06 | Novel apparatus and process |
| GB0024511 | 2000-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2225247T3 true ES2225247T3 (es) | 2005-03-16 |
Family
ID=10863815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00973049T Expired - Lifetime ES2225247T3 (es) | 1999-11-03 | 2000-11-03 | Aparato y procedimiento para preparar particulas cristalinas. |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1225875B1 (cs) |
| JP (1) | JP4700247B2 (cs) |
| KR (1) | KR20020047322A (cs) |
| CN (1) | CN1409627A (cs) |
| AT (1) | ATE271853T1 (cs) |
| AU (1) | AU768915B2 (cs) |
| BR (1) | BR0015271A (cs) |
| CA (1) | CA2389908A1 (cs) |
| CZ (1) | CZ20021555A3 (cs) |
| DE (1) | DE60012558T2 (cs) |
| DK (1) | DK1225875T3 (cs) |
| ES (1) | ES2225247T3 (cs) |
| GB (2) | GB9925934D0 (cs) |
| HK (1) | HK1045268B (cs) |
| HU (1) | HUP0203278A3 (cs) |
| IL (1) | IL149366A0 (cs) |
| MX (1) | MXPA02004394A (cs) |
| NO (1) | NO20022059L (cs) |
| NZ (1) | NZ518565A (cs) |
| PL (1) | PL356746A1 (cs) |
| PT (1) | PT1225875E (cs) |
| SI (1) | SI1225875T1 (cs) |
| TR (1) | TR200402709T4 (cs) |
| WO (1) | WO2001032125A2 (cs) |
| ZA (1) | ZA200203434B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3860580A4 (en) * | 2018-10-01 | 2022-07-20 | Kindeva Drug Delivery L.P. | FORMULATION AND AEROSOL CANS, INHALERS AND LIKE WITH THE FORMULATION |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100892864B1 (ko) | 2001-08-02 | 2009-04-15 | 주식회사 엘지생명과학 | 4-아미노메틸렌-피롤리딘-3-온의 아미노-보호 유도체및/또는 4-아미노메틸렌-피롤리딘-3-알콕시이미노유도체들 및/또는 제미플록사신 또는 그것의 염의 제조를위한 공정 |
| WO2003032951A1 (en) * | 2001-08-29 | 2003-04-24 | Dow Global Technologies Inc. | A process for preparing crystalline drug particles by means of precipitation |
| GB0125604D0 (en) * | 2001-10-25 | 2001-12-19 | Glaxo Group Ltd | Novel process |
| GB0202564D0 (en) * | 2002-02-04 | 2002-03-20 | Glaxo Group Ltd | Process |
| JP3691459B2 (ja) * | 2002-06-14 | 2005-09-07 | 久光メディカル株式会社 | 粉末状吸入剤組成物 |
| GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
| GB0300427D0 (en) * | 2003-01-09 | 2003-02-05 | Univ Strathclyde | Pharmaceutical composition |
| US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| JP5154078B2 (ja) * | 2003-02-21 | 2013-02-27 | ザ ユニヴァーシティ オブ バース | 粒子の製造プロセス |
| JP5090729B2 (ja) * | 2003-03-04 | 2012-12-05 | ファイブ・スター・テクノロジーズ・インコーポレイテッド | 流体力学的キャビテーション結晶化装置および方法 |
| AU2003220808B2 (en) | 2003-03-27 | 2008-08-21 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| US9808471B2 (en) | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US7811606B2 (en) | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
| US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| JP2007508240A (ja) * | 2003-07-22 | 2007-04-05 | バクスター・インターナショナル・インコーポレイテッド | 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法 |
| GB0404586D0 (en) * | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
| WO2006016530A1 (ja) | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| WO2006045795A2 (en) * | 2004-10-29 | 2006-05-04 | Akzo Nobel N.V. | Processes involving the use of antisolvent crystallization |
| US20090259038A1 (en) * | 2004-12-08 | 2009-10-15 | Kuraray Co., Ltd. | Process for producing (5alpha7alpha)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate |
| MX2007009656A (es) | 2005-02-10 | 2007-11-07 | Glaxo Group Ltd | Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma. |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| GB0705159D0 (en) | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| GB0707938D0 (en) | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
| GB0724498D0 (en) | 2007-12-15 | 2008-01-30 | Univ Strathclyde | Slow release compositions |
| CA2729644C (en) * | 2008-07-18 | 2018-05-29 | Prosonix Limited | Process for improving crystallinity |
| WO2010131486A1 (en) | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| WO2011013003A2 (en) | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| PT105058B (pt) * | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
| AU2012282936B2 (en) * | 2011-07-08 | 2016-11-10 | Pfizer Limited | Process for the preparation of fluticasone propionate form 1 |
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| EP2847207B1 (en) | 2012-05-08 | 2019-03-27 | Nicox Ophthalmics, Inc. | Fluticasone propionate nanocrystals |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| EP2705838A1 (en) * | 2012-09-06 | 2014-03-12 | Xspray Microparticles Ab | Tiotropium preparations |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| MX2015015150A (es) * | 2013-04-29 | 2016-02-18 | Sanofi Sa | Composiciones farmaceuticas inhalables y los dispositivos inhaladores que las contienen. |
| PT108368B (pt) * | 2015-03-31 | 2018-11-05 | Hovione Farm S A | Produção contínua de partículas |
| PT108885B (pt) * | 2015-10-12 | 2019-02-13 | Hovione Farm S A | Método de produção de partículas compósitas inaláveis mediante a utilização de um atomizador de três fluidos |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| CN110960504A (zh) * | 2019-10-31 | 2020-04-07 | 上海新黄河制药有限公司 | 中空颗粒制备方法及干粉吸入制剂 |
| EP4210864A2 (en) * | 2020-09-08 | 2023-07-19 | Genentech, Inc. | Systems and methods for producing pharmaceutical compositions using peristaltic pumps and dampeners |
| CN112755301B (zh) * | 2021-01-20 | 2022-03-29 | 孙洪坤 | 一种血液病造血干细胞移植用皮肤清洁器 |
| CN117582373A (zh) * | 2023-08-15 | 2024-02-23 | 中国药科大学 | 一种类球形无载体妥布霉素粉雾剂颗粒的湍流强化可控制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8404749D0 (en) | 1984-02-23 | 1984-03-28 | Atomic Energy Authority Uk | Fluidic contactor |
| CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| US4826589A (en) * | 1988-06-30 | 1989-05-02 | Gene Hirs | Bar screen filter |
| GB8911259D0 (en) * | 1989-05-17 | 1989-07-05 | Fisons Plc | Inhalation medicament |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB9007027D0 (en) | 1990-03-29 | 1990-05-30 | Atomic Energy Authority Uk | Precipitation apparatus and method |
| GB9101967D0 (en) | 1991-01-30 | 1991-03-13 | Atomic Energy Authority Uk | Reagent mixing |
| GB9320455D0 (en) | 1993-10-05 | 1993-11-24 | Atomic Energy Authority Uk | Vortex mixer |
| GB9620187D0 (en) * | 1996-09-27 | 1996-11-13 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
-
1999
- 1999-11-03 GB GBGB9925934.3A patent/GB9925934D0/en not_active Ceased
-
2000
- 2000-10-06 GB GBGB0024511.8A patent/GB0024511D0/en not_active Ceased
- 2000-11-03 AU AU11604/01A patent/AU768915B2/en not_active Ceased
- 2000-11-03 KR KR1020027005660A patent/KR20020047322A/ko not_active Withdrawn
- 2000-11-03 EP EP00973049A patent/EP1225875B1/en not_active Expired - Lifetime
- 2000-11-03 CA CA002389908A patent/CA2389908A1/en not_active Abandoned
- 2000-11-03 NZ NZ518565A patent/NZ518565A/en unknown
- 2000-11-03 PT PT00973049T patent/PT1225875E/pt unknown
- 2000-11-03 HK HK02106989.8A patent/HK1045268B/en not_active IP Right Cessation
- 2000-11-03 AT AT00973049T patent/ATE271853T1/de not_active IP Right Cessation
- 2000-11-03 DK DK00973049T patent/DK1225875T3/da active
- 2000-11-03 TR TR2004/02709T patent/TR200402709T4/xx unknown
- 2000-11-03 WO PCT/GB2000/004237 patent/WO2001032125A2/en not_active Ceased
- 2000-11-03 BR BR0015271-4A patent/BR0015271A/pt not_active IP Right Cessation
- 2000-11-03 HU HU0203278A patent/HUP0203278A3/hu unknown
- 2000-11-03 CZ CZ20021555A patent/CZ20021555A3/cs unknown
- 2000-11-03 ES ES00973049T patent/ES2225247T3/es not_active Expired - Lifetime
- 2000-11-03 EP EP04077077A patent/EP1466595A1/en not_active Withdrawn
- 2000-11-03 JP JP2001534333A patent/JP4700247B2/ja not_active Expired - Fee Related
- 2000-11-03 IL IL14936600A patent/IL149366A0/xx unknown
- 2000-11-03 PL PL00356746A patent/PL356746A1/xx not_active Application Discontinuation
- 2000-11-03 CN CN00817088A patent/CN1409627A/zh active Pending
- 2000-11-03 DE DE60012558T patent/DE60012558T2/de not_active Expired - Lifetime
- 2000-11-03 SI SI200030500T patent/SI1225875T1/xx unknown
- 2000-11-03 MX MXPA02004394A patent/MXPA02004394A/es unknown
-
2002
- 2002-04-30 ZA ZA200203434A patent/ZA200203434B/xx unknown
- 2002-04-30 NO NO20022059A patent/NO20022059L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3860580A4 (en) * | 2018-10-01 | 2022-07-20 | Kindeva Drug Delivery L.P. | FORMULATION AND AEROSOL CANS, INHALERS AND LIKE WITH THE FORMULATION |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9925934D0 (en) | 1999-12-29 |
| DE60012558D1 (de) | 2004-09-02 |
| NZ518565A (en) | 2004-04-30 |
| CN1409627A (zh) | 2003-04-09 |
| GB0024511D0 (en) | 2000-11-22 |
| CZ20021555A3 (cs) | 2002-11-13 |
| HUP0203278A2 (hu) | 2003-01-28 |
| DE60012558T2 (de) | 2005-07-28 |
| EP1466595A1 (en) | 2004-10-13 |
| HK1045268A1 (en) | 2002-11-22 |
| CA2389908A1 (en) | 2001-05-10 |
| NO20022059D0 (no) | 2002-04-30 |
| BR0015271A (pt) | 2002-12-31 |
| ATE271853T1 (de) | 2004-08-15 |
| AU768915B2 (en) | 2004-01-08 |
| IL149366A0 (en) | 2002-11-10 |
| DK1225875T3 (da) | 2004-11-22 |
| AU1160401A (en) | 2001-05-14 |
| HUP0203278A3 (en) | 2004-06-28 |
| EP1225875B1 (en) | 2004-07-28 |
| HK1045268B (en) | 2005-02-18 |
| JP4700247B2 (ja) | 2011-06-15 |
| WO2001032125A2 (en) | 2001-05-10 |
| EP1225875A2 (en) | 2002-07-31 |
| PL356746A1 (en) | 2004-06-28 |
| WO2001032125A3 (en) | 2002-05-16 |
| NO20022059L (no) | 2002-06-14 |
| SI1225875T1 (en) | 2004-12-31 |
| PT1225875E (pt) | 2004-12-31 |
| TR200402709T4 (tr) | 2004-11-22 |
| MXPA02004394A (es) | 2002-09-02 |
| KR20020047322A (ko) | 2002-06-21 |
| ZA200203434B (en) | 2003-02-25 |
| JP2003512892A (ja) | 2003-04-08 |
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