ES2232860T3 - Proteinas recombinantes de ribonucleasa. - Google Patents

Proteinas recombinantes de ribonucleasa.

Info

Publication number
ES2232860T3
ES2232860T3 ES97906675T ES97906675T ES2232860T3 ES 2232860 T3 ES2232860 T3 ES 2232860T3 ES 97906675 T ES97906675 T ES 97906675T ES 97906675 T ES97906675 T ES 97906675T ES 2232860 T3 ES2232860 T3 ES 2232860T3
Authority
ES
Spain
Prior art keywords
ribonucleasa
recombinant proteins
ribonucleasas
recombinating
focus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97906675T
Other languages
English (en)
Inventor
Susanna M Rybak
Dianne L Newton
Lluis Boque
Alexander Wlodawer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2232860T3 publication Critical patent/ES2232860T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A RIBONUCLEASAS DERIVADAS DE UNA RIBONUCLEASA NATIVA ENCONTRADA EN LOS OOCITOS DE RANA PIPIENS. SE DESCRIBEN DIVERSAS FORMAS HUMANIZADAS Y RECOMBINANTES DE ESTAS MOLECULAS Y SUS USOS PARA ELLAS.
ES97906675T 1996-02-21 1997-02-19 Proteinas recombinantes de ribonucleasa. Expired - Lifetime ES2232860T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1180096P 1996-02-21 1996-02-21

Publications (1)

Publication Number Publication Date
ES2232860T3 true ES2232860T3 (es) 2005-06-01

Family

ID=21752018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97906675T Expired - Lifetime ES2232860T3 (es) 1996-02-21 1997-02-19 Proteinas recombinantes de ribonucleasa.

Country Status (10)

Country Link
EP (1) EP0896625B1 (es)
JP (1) JP3469247B2 (es)
CN (1) CN1229498C (es)
AT (1) ATE281528T1 (es)
AU (1) AU726379B2 (es)
DE (1) DE69731463T2 (es)
ES (1) ES2232860T3 (es)
IL (2) IL125771A0 (es)
NZ (1) NZ331298A (es)
WO (1) WO1997031116A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555651B2 (en) * 1997-10-09 2003-04-29 The Trustees Of Columbia University In The City Of New York Ligand binding site of rage and uses thereof
DE69831224T2 (de) * 1997-05-02 2006-03-23 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Immuntoxine, die ein onc protein enthalten, gegen bösartige zellen
EP1062348B1 (en) * 1998-03-11 2005-06-15 Immunomedics, Inc. Recombinant onconase and fusion proteins of recombinant onconase
AU755147B2 (en) * 1998-03-27 2002-12-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant anti-tumor RNASE
US6869604B1 (en) 1998-03-27 2005-03-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant anti-tumor RNAse
EP1277838A1 (en) * 1998-03-27 2003-01-22 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Recombinant anti-tumor RNASE
US6239257B1 (en) * 1998-12-30 2001-05-29 Alfacell Corporation Family of proteins belonging to the pancreatic ribonuclease a superfamily
US6175003B1 (en) * 1999-09-10 2001-01-16 Alfacell Corporation Nucleic acids encoding ribonucleases and methods of making them
ATE526981T1 (de) 2000-04-12 2011-10-15 Vib Vzw Verwendung von vegf 165 und homologen zur behandlung von neurologischen störungen
US8017356B2 (en) * 2005-07-26 2011-09-13 Takara Bio Inc. Endoribonuclease
WO2007041361A1 (en) * 2005-09-30 2007-04-12 The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Modified recombinant anti-tumor rnase
CN101450214B (zh) * 2007-12-06 2011-10-26 上海南方模式生物科技发展有限公司 转铁蛋白-蛙卵核糖核酸酶偶联物及其制法和用途
CN101613410B (zh) * 2008-06-25 2016-01-20 上海南方模式生物科技发展有限公司 核糖核酸酶与毒蛋白膜转位结构域融合蛋白及其制备方法和用途
US9919034B2 (en) 2014-03-28 2018-03-20 Tamir Biotechnology, Inc. Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V
US10835598B2 (en) 2014-08-18 2020-11-17 Orgenesis Inc. Prophylactic protection against viral infections, particularly HIV
WO2016205109A1 (en) 2015-06-15 2016-12-22 Tamir Biotechnology, Inc. Pharmaceuticals for treatment of viral infections of the eye
AU2019379287A1 (en) * 2018-11-14 2021-06-03 Dna Script Terminal deoxynucleotidyl transferase variants and uses thereof
WO2024207543A1 (zh) * 2023-04-07 2024-10-10 成都诺恩基因科技有限公司 增加共转染mRNA的蛋白表达水平和表达时长的重组基因及其应用

Also Published As

Publication number Publication date
ATE281528T1 (de) 2004-11-15
EP0896625A2 (en) 1999-02-17
DE69731463D1 (de) 2004-12-09
DE69731463T2 (de) 2005-10-27
IL125771A (en) 2006-08-20
CN1229498C (zh) 2005-11-30
NZ331298A (en) 2000-03-27
WO1997031116A3 (en) 1997-09-25
CN1212016A (zh) 1999-03-24
JP3469247B2 (ja) 2003-11-25
JP2000505300A (ja) 2000-05-09
IL125771A0 (en) 1999-04-11
AU726379B2 (en) 2000-11-02
AU2130697A (en) 1997-09-10
WO1997031116A2 (en) 1997-08-28
EP0896625B1 (en) 2004-11-03

Similar Documents

Publication Publication Date Title
ES2127831T3 (es) Unidades de expresion multicistronicas y su aplicacion.
AR009436A1 (es) UNA PROTEíNA DE FUSIoN FC-OB, UNA SECUENCIA DE ÁCIDO NUCLEICO QUE LA CODIFICA, UN VECTOR, PROCEDIMIENTO DE PREPARACIoN, COMPOSICIONES FARMACÉUTICAS Y USOS.
DK1107989T3 (da) Ekspression og eksport af angiostatin og endostatin som immunfusiner
PT670899E (pt) Proteinas de choque termico e tratamento de tumores
DK1712623T3 (da) Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
CY1105895T1 (el) Χιμαιρικη πρωτεϊνη διαλυτου υποδοχεα/συνδετη ιντepλευκινης-6, αναλογα και αυτης και χρησεις αυτης
ATE339507T1 (de) Erythropoietin-analog-menschliches serum-albumin fusionsprotein
NO964862L (no) Papillomavirusvaksiner
BR0013231A (pt) Complexos citocina-anticorpo múltiplos
ES2165851T3 (es) Proteinas multivalentes que se unen a antigenos.
DE69435049D1 (de) Chimäre proteine zur vermeidung der komplementaktivierung
MX9203379A (es) Proteinas producidas por los linfocitos humanos, secuencia de adn que codifica para estas proteinas y composiciones farmaceuticas que las contienen.
ATE281528T1 (de) Rekombinante ribonuklease proteine
PE20010694A1 (es) Plasmido autonomamente reproducible en bacterias corineformes
BR9509172A (pt) Proteina de via de complemento nativa sequéncia de dna construção de dna conjugado uso de uma proteína processo para reduzir proteina de via de complemento em um mamifero e formulação farmacéutica
AR002742A1 (es) Proteina reguladora del tipo adiposo, procedimiento para producir dicha proteina, formulaciones farmaceuticas que la incluyen, molecula de adn aisladaque codifica dicha proteina, vector y celulas recombinantes que comprenden dicho adn
ES2134910T3 (es) Sintesis de bisindolilmaleimidas.
BR9606981A (pt) Processo para preparação de intermediários inibidores de protease retroviral
ES2194012T3 (es) Epitopo p1a1 y p1a2 de la gpiii a de plaquetas, su preparacion y uso.
AR009819A1 (es) Inhibidores de la proteasa proteinicos estabilizados y sus variantes
ES2186779T3 (es) Procedimiento para la estructuracion de bandas delgadas de material para reforzar y proteger superficies sin dañarlas.
ES2168282T3 (es) D-hidantoinasa recombinante, procedimiento para su preparacion y utilizacion.
AR017190A1 (es) Metodo para mejorar la resistencia o tolerancia a patogenos en una planta que comprende integrar en el genoma de dicha planta un gen que codificauna proteina de fusion que comprende una primer y segunda proteina o dominio de proteina con actividad antipatogenica, molecula de adn, su uso, proteinade
ES2090357T3 (es) Una proteina de union a colageno asi como su preparacion.
ES2146193T1 (es) Proteinas del virus del arrugado de las hojas de la vid (tipo 2) y sus usos.